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Q8NH05

- OR4Q3_HUMAN

UniProt

Q8NH05 - OR4Q3_HUMAN

Protein

Olfactory receptor 4Q3

Gene

OR4Q3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    Odorant receptor.Curated

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW
    2. olfactory receptor activity Source: InterPro

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Olfaction, Sensory transduction

    Enzyme and pathway databases

    ReactomeiREACT_15488. Olfactory Signaling Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Olfactory receptor 4Q3
    Alternative name(s):
    Olfactory receptor 4Q4
    Olfactory receptor OR14-3
    Gene namesi
    Name:OR4Q3
    Synonyms:C14orf13, OR4Q4
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 14

    Organism-specific databases

    HGNCiHGNC:15426. OR4Q3.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA32340.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 313313Olfactory receptor 4Q3PRO_0000150567Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi8 – 81N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi98 ↔ 190PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiQ8NH05.

    PTM databases

    PhosphoSiteiQ8NH05.

    Expressioni

    Gene expression databases

    CleanExiHS_OR4Q3.
    GenevestigatoriQ8NH05.

    Organism-specific databases

    HPAiHPA049924.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000330049.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8NH05.
    SMRiQ8NH05. Positions 36-302.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2525ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini50 – 589CytoplasmicSequence Analysis
    Topological domaini81 – 10121ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini122 – 14019CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini160 – 19637ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini221 – 23616CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini260 – 27011ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini291 – 31323CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei26 – 4924Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei59 – 8022Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei102 – 12120Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei141 – 15919Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei197 – 22024Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei237 – 25923Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei271 – 29020Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG146555.
    HOGENOMiHOG000041362.
    HOVERGENiHBG017625.
    InParanoidiQ8NH05.
    KOiK04257.
    OMAiITLRTHF.
    OrthoDBiEOG71K63J.
    PhylomeDBiQ8NH05.
    TreeFamiTF337350.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8NH05-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKKEQDSNVT EFVLLGLSSS WELQLFLFLL FLFFYIAIVL GNLLIVVTVQ    50
    AHAHLLQSPM YYFLGHLSFI DLCLSCVTVP KMLGDFLQQG KSISFSGCLA 100
    QIYFLHFLGA SEMFLLTVMA YDRYVAICNP LRYLTVMNPQ LCLWLVLACW 150
    CGGFIHSIMQ VILVIQLPFC GPNELDNFYC DVPQVIKLAC MDTYVVEVLV 200
    IANSGLLSLV CFLVLLFSYA IILITLRTHF CQGQNKVFST CASHLTVVSL 250
    IFVPCVFIYL RPFCSFSVDK IFSLFYTVIT PMLNPLIYTL RNTDMKTAMK 300
    KLRIKPCGIP LPC 313
    Length:313
    Mass (Da):35,491
    Last modified:October 1, 2002 - v1
    Checksum:i5990F692887115DD
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti135 – 1351T → A.
    Corresponds to variant rs17210864 [ dbSNP | Ensembl ].
    VAR_053176
    Natural varianti238 – 2381F → L.
    Corresponds to variant rs12896533 [ dbSNP | Ensembl ].
    VAR_053177

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065609 Genomic DNA. Translation: BAC05836.1.
    BK004488 Genomic DNA. Translation: DAA04886.1.
    CCDSiCCDS32020.1.
    RefSeqiNP_751944.1. NM_172194.1.
    UniGeneiHs.553828.

    Genome annotation databases

    EnsembliENST00000331723; ENSP00000330049; ENSG00000182652.
    GeneIDi441669.
    KEGGihsa:441669.
    UCSCiuc010tkt.2. human.

    Polymorphism databases

    DMDMi38372800.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Human Olfactory Receptor Data Exploratorium (HORDE)

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065609 Genomic DNA. Translation: BAC05836.1 .
    BK004488 Genomic DNA. Translation: DAA04886.1 .
    CCDSi CCDS32020.1.
    RefSeqi NP_751944.1. NM_172194.1.
    UniGenei Hs.553828.

    3D structure databases

    ProteinModelPortali Q8NH05.
    SMRi Q8NH05. Positions 36-302.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000330049.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q8NH05.

    Polymorphism databases

    DMDMi 38372800.

    Proteomic databases

    PRIDEi Q8NH05.

    Protocols and materials databases

    DNASUi 441669.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000331723 ; ENSP00000330049 ; ENSG00000182652 .
    GeneIDi 441669.
    KEGGi hsa:441669.
    UCSCi uc010tkt.2. human.

    Organism-specific databases

    CTDi 441669.
    GeneCardsi GC14P020215.
    HGNCi HGNC:15426. OR4Q3.
    HPAi HPA049924.
    neXtProti NX_Q8NH05.
    PharmGKBi PA32340.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG146555.
    HOGENOMi HOG000041362.
    HOVERGENi HBG017625.
    InParanoidi Q8NH05.
    KOi K04257.
    OMAi ITLRTHF.
    OrthoDBi EOG71K63J.
    PhylomeDBi Q8NH05.
    TreeFami TF337350.

    Enzyme and pathway databases

    Reactomei REACT_15488. Olfactory Signaling Pathway.

    Miscellaneous databases

    GeneWikii OR4Q3.
    GenomeRNAii 441669.
    NextBioi 110391.
    PROi Q8NH05.

    Gene expression databases

    CleanExi HS_OR4Q3.
    Genevestigatori Q8NH05.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
      Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
      Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: IDENTIFICATION.
    3. Erratum
      Malnic B., Godfrey P.A., Buck L.B.
      Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

    Entry informationi

    Entry nameiOR4Q3_HUMAN
    AccessioniPrimary (citable) accession number: Q8NH05
    Secondary accession number(s): Q6IEX4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 10, 2003
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 102 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 14
      Human chromosome 14: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3