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Q8NH05 (OR4Q3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 100. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Olfactory receptor 4Q3
Alternative name(s):
Olfactory receptor 4Q4
Olfactory receptor OR14-3
Gene names
Name:OR4Q3
Synonyms:C14orf13, OR4Q4
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length313 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Odorant receptor Potential.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 313313Olfactory receptor 4Q3
PRO_0000150567

Regions

Topological domain1 – 2525Extracellular Potential
Transmembrane26 – 4924Helical; Name=1; Potential
Topological domain50 – 589Cytoplasmic Potential
Transmembrane59 – 8022Helical; Name=2; Potential
Topological domain81 – 10121Extracellular Potential
Transmembrane102 – 12120Helical; Name=3; Potential
Topological domain122 – 14019Cytoplasmic Potential
Transmembrane141 – 15919Helical; Name=4; Potential
Topological domain160 – 19637Extracellular Potential
Transmembrane197 – 22024Helical; Name=5; Potential
Topological domain221 – 23616Cytoplasmic Potential
Transmembrane237 – 25923Helical; Name=6; Potential
Topological domain260 – 27011Extracellular Potential
Transmembrane271 – 29020Helical; Name=7; Potential
Topological domain291 – 31323Cytoplasmic Potential

Amino acid modifications

Glycosylation81N-linked (GlcNAc...) Potential
Disulfide bond98 ↔ 190 By similarity

Natural variations

Natural variant1351T → A.
Corresponds to variant rs17210864 [ dbSNP | Ensembl ].
VAR_053176
Natural variant2381F → L.
Corresponds to variant rs12896533 [ dbSNP | Ensembl ].
VAR_053177

Sequences

Sequence LengthMass (Da)Tools
Q8NH05 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: 5990F692887115DD

FASTA31335,491
        10         20         30         40         50         60 
MKKEQDSNVT EFVLLGLSSS WELQLFLFLL FLFFYIAIVL GNLLIVVTVQ AHAHLLQSPM 

        70         80         90        100        110        120 
YYFLGHLSFI DLCLSCVTVP KMLGDFLQQG KSISFSGCLA QIYFLHFLGA SEMFLLTVMA 

       130        140        150        160        170        180 
YDRYVAICNP LRYLTVMNPQ LCLWLVLACW CGGFIHSIMQ VILVIQLPFC GPNELDNFYC 

       190        200        210        220        230        240 
DVPQVIKLAC MDTYVVEVLV IANSGLLSLV CFLVLLFSYA IILITLRTHF CQGQNKVFST 

       250        260        270        280        290        300 
CASHLTVVSL IFVPCVFIYL RPFCSFSVDK IFSLFYTVIT PMLNPLIYTL RNTDMKTAMK 

       310 
KLRIKPCGIP LPC 

« Hide

References

[1]"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The human olfactory receptor gene family."
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
[3]Erratum
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB065609 Genomic DNA. Translation: BAC05836.1.
BK004488 Genomic DNA. Translation: DAA04886.1.
CCDSCCDS32020.1.
RefSeqNP_751944.1. NM_172194.1.
UniGeneHs.553828.

3D structure databases

ProteinModelPortalQ8NH05.
SMRQ8NH05. Positions 36-302.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000330049.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteQ8NH05.

Polymorphism databases

DMDM38372800.

Proteomic databases

PRIDEQ8NH05.

Protocols and materials databases

DNASU441669.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000331723; ENSP00000330049; ENSG00000182652.
GeneID441669.
KEGGhsa:441669.
UCSCuc010tkt.2. human.

Organism-specific databases

CTD441669.
GeneCardsGC14P020215.
HGNCHGNC:15426. OR4Q3.
HPAHPA049924.
neXtProtNX_Q8NH05.
PharmGKBPA32340.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG146555.
HOGENOMHOG000041362.
HOVERGENHBG017625.
InParanoidQ8NH05.
KOK04257.
OMAITLRTHF.
OrthoDBEOG71K63J.
PhylomeDBQ8NH05.
TreeFamTF337350.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

CleanExHS_OR4Q3.
GenevestigatorQ8NH05.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiOR4Q3.
GenomeRNAi441669.
NextBio110391.
PROQ8NH05.

Entry information

Entry nameOR4Q3_HUMAN
AccessionPrimary (citable) accession number: Q8NH05
Secondary accession number(s): Q6IEX4
Entry history
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: July 9, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 14

Human chromosome 14: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries