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Protein

Olfactory receptor 4Q3

Gene

OR4Q3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

BioCyciZFISH:G66-32028-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 4Q3
Alternative name(s):
Olfactory receptor 4Q4
Olfactory receptor OR14-3
Gene namesi
Name:OR4Q3
Synonyms:C14orf13, OR4Q4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:15426. OR4Q3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 25ExtracellularSequence analysisAdd BLAST25
Transmembranei26 – 49Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini50 – 58CytoplasmicSequence analysis9
Transmembranei59 – 80Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini81 – 101ExtracellularSequence analysisAdd BLAST21
Transmembranei102 – 121Helical; Name=3Sequence analysisAdd BLAST20
Topological domaini122 – 140CytoplasmicSequence analysisAdd BLAST19
Transmembranei141 – 159Helical; Name=4Sequence analysisAdd BLAST19
Topological domaini160 – 196ExtracellularSequence analysisAdd BLAST37
Transmembranei197 – 220Helical; Name=5Sequence analysisAdd BLAST24
Topological domaini221 – 236CytoplasmicSequence analysisAdd BLAST16
Transmembranei237 – 259Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini260 – 270ExtracellularSequence analysisAdd BLAST11
Transmembranei271 – 290Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini291 – 313CytoplasmicSequence analysisAdd BLAST23

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000182652.
PharmGKBiPA32340.

Polymorphism and mutation databases

BioMutaiOR4Q3.
DMDMi38372800.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001505671 – 313Olfactory receptor 4Q3Add BLAST313

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi8N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi98 ↔ 190PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NH05.
PeptideAtlasiQ8NH05.
PRIDEiQ8NH05.

Expressioni

Gene expression databases

CleanExiHS_OR4Q3.
ExpressionAtlasiQ8NH05. baseline and differential.

Organism-specific databases

HPAiHPA049924.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000330049.

Structurei

3D structure databases

ProteinModelPortaliQ8NH05.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IGKW. Eukaryota.
ENOG4111BJW. LUCA.
GeneTreeiENSGT00760000119104.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiQ8NH05.
KOiK04257.
OMAiITLRTHF.
OrthoDBiEOG091G0CY9.
PhylomeDBiQ8NH05.
TreeFamiTF337350.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NH05-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKEQDSNVT EFVLLGLSSS WELQLFLFLL FLFFYIAIVL GNLLIVVTVQ
60 70 80 90 100
AHAHLLQSPM YYFLGHLSFI DLCLSCVTVP KMLGDFLQQG KSISFSGCLA
110 120 130 140 150
QIYFLHFLGA SEMFLLTVMA YDRYVAICNP LRYLTVMNPQ LCLWLVLACW
160 170 180 190 200
CGGFIHSIMQ VILVIQLPFC GPNELDNFYC DVPQVIKLAC MDTYVVEVLV
210 220 230 240 250
IANSGLLSLV CFLVLLFSYA IILITLRTHF CQGQNKVFST CASHLTVVSL
260 270 280 290 300
IFVPCVFIYL RPFCSFSVDK IFSLFYTVIT PMLNPLIYTL RNTDMKTAMK
310
KLRIKPCGIP LPC
Length:313
Mass (Da):35,491
Last modified:October 1, 2002 - v1
Checksum:i5990F692887115DD
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_053176135T → A.Corresponds to variant rs17210864dbSNPEnsembl.1
Natural variantiVAR_053177238F → L.Corresponds to variant rs12896533dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065609 Genomic DNA. Translation: BAC05836.1.
BK004488 Genomic DNA. Translation: DAA04886.1.
CCDSiCCDS32020.1.
RefSeqiNP_751944.1. NM_172194.1.
UniGeneiHs.553828.

Genome annotation databases

EnsembliENST00000331723; ENSP00000330049; ENSG00000182652.
GeneIDi441669.
KEGGihsa:441669.
UCSCiuc010tkt.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065609 Genomic DNA. Translation: BAC05836.1.
BK004488 Genomic DNA. Translation: DAA04886.1.
CCDSiCCDS32020.1.
RefSeqiNP_751944.1. NM_172194.1.
UniGeneiHs.553828.

3D structure databases

ProteinModelPortaliQ8NH05.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000330049.

Protein family/group databases

GPCRDBiSearch...

Polymorphism and mutation databases

BioMutaiOR4Q3.
DMDMi38372800.

Proteomic databases

PaxDbiQ8NH05.
PeptideAtlasiQ8NH05.
PRIDEiQ8NH05.

Protocols and materials databases

DNASUi441669.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000331723; ENSP00000330049; ENSG00000182652.
GeneIDi441669.
KEGGihsa:441669.
UCSCiuc010tkt.2. human.

Organism-specific databases

CTDi441669.
GeneCardsiOR4Q3.
HGNCiHGNC:15426. OR4Q3.
HPAiHPA049924.
neXtProtiNX_Q8NH05.
OpenTargetsiENSG00000182652.
PharmGKBiPA32340.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IGKW. Eukaryota.
ENOG4111BJW. LUCA.
GeneTreeiENSGT00760000119104.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiQ8NH05.
KOiK04257.
OMAiITLRTHF.
OrthoDBiEOG091G0CY9.
PhylomeDBiQ8NH05.
TreeFamiTF337350.

Enzyme and pathway databases

BioCyciZFISH:G66-32028-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR4Q3.
GenomeRNAii441669.
PROiQ8NH05.

Gene expression databases

CleanExiHS_OR4Q3.
ExpressionAtlasiQ8NH05. baseline and differential.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOR4Q3_HUMAN
AccessioniPrimary (citable) accession number: Q8NH05
Secondary accession number(s): Q6IEX4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: November 30, 2016
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.