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Q8NH05

- OR4Q3_HUMAN

UniProt

Q8NH05 - OR4Q3_HUMAN

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Protein

Olfactory receptor 4Q3

Gene

OR4Q3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 4Q3
Alternative name(s):
Olfactory receptor 4Q4
Olfactory receptor OR14-3
Gene namesi
Name:OR4Q3
Synonyms:C14orf13, OR4Q4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 14

Organism-specific databases

HGNCiHGNC:15426. OR4Q3.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32340.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 313313Olfactory receptor 4Q3PRO_0000150567Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi8 – 81N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi98 ↔ 190PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ8NH05.

PTM databases

PhosphoSiteiQ8NH05.

Expressioni

Gene expression databases

CleanExiHS_OR4Q3.
GenevestigatoriQ8NH05.

Organism-specific databases

HPAiHPA049924.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000330049.

Structurei

3D structure databases

ProteinModelPortaliQ8NH05.
SMRiQ8NH05. Positions 36-302.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2525ExtracellularSequence AnalysisAdd
BLAST
Topological domaini50 – 589CytoplasmicSequence Analysis
Topological domaini81 – 10121ExtracellularSequence AnalysisAdd
BLAST
Topological domaini122 – 14019CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini160 – 19637ExtracellularSequence AnalysisAdd
BLAST
Topological domaini221 – 23616CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini260 – 27011ExtracellularSequence AnalysisAdd
BLAST
Topological domaini291 – 31323CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei26 – 4924Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei59 – 8022Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei102 – 12120Helical; Name=3Sequence AnalysisAdd
BLAST
Transmembranei141 – 15919Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei197 – 22024Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei237 – 25923Helical; Name=6Sequence AnalysisAdd
BLAST
Transmembranei271 – 29020Helical; Name=7Sequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG146555.
GeneTreeiENSGT00760000119104.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiQ8NH05.
KOiK04257.
OMAiITLRTHF.
OrthoDBiEOG71K63J.
PhylomeDBiQ8NH05.
TreeFamiTF337350.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NH05-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKKEQDSNVT EFVLLGLSSS WELQLFLFLL FLFFYIAIVL GNLLIVVTVQ
60 70 80 90 100
AHAHLLQSPM YYFLGHLSFI DLCLSCVTVP KMLGDFLQQG KSISFSGCLA
110 120 130 140 150
QIYFLHFLGA SEMFLLTVMA YDRYVAICNP LRYLTVMNPQ LCLWLVLACW
160 170 180 190 200
CGGFIHSIMQ VILVIQLPFC GPNELDNFYC DVPQVIKLAC MDTYVVEVLV
210 220 230 240 250
IANSGLLSLV CFLVLLFSYA IILITLRTHF CQGQNKVFST CASHLTVVSL
260 270 280 290 300
IFVPCVFIYL RPFCSFSVDK IFSLFYTVIT PMLNPLIYTL RNTDMKTAMK
310
KLRIKPCGIP LPC
Length:313
Mass (Da):35,491
Last modified:October 1, 2002 - v1
Checksum:i5990F692887115DD
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti135 – 1351T → A.
Corresponds to variant rs17210864 [ dbSNP | Ensembl ].
VAR_053176
Natural varianti238 – 2381F → L.
Corresponds to variant rs12896533 [ dbSNP | Ensembl ].
VAR_053177

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB065609 Genomic DNA. Translation: BAC05836.1.
BK004488 Genomic DNA. Translation: DAA04886.1.
CCDSiCCDS32020.1.
RefSeqiNP_751944.1. NM_172194.1.
UniGeneiHs.553828.

Genome annotation databases

EnsembliENST00000331723; ENSP00000330049; ENSG00000182652.
GeneIDi441669.
KEGGihsa:441669.
UCSCiuc010tkt.2. human.

Polymorphism databases

DMDMi38372800.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB065609 Genomic DNA. Translation: BAC05836.1 .
BK004488 Genomic DNA. Translation: DAA04886.1 .
CCDSi CCDS32020.1.
RefSeqi NP_751944.1. NM_172194.1.
UniGenei Hs.553828.

3D structure databases

ProteinModelPortali Q8NH05.
SMRi Q8NH05. Positions 36-302.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000330049.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei Q8NH05.

Polymorphism databases

DMDMi 38372800.

Proteomic databases

PRIDEi Q8NH05.

Protocols and materials databases

DNASUi 441669.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000331723 ; ENSP00000330049 ; ENSG00000182652 .
GeneIDi 441669.
KEGGi hsa:441669.
UCSCi uc010tkt.2. human.

Organism-specific databases

CTDi 441669.
GeneCardsi GC14P020215.
HGNCi HGNC:15426. OR4Q3.
HPAi HPA049924.
neXtProti NX_Q8NH05.
PharmGKBi PA32340.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG146555.
GeneTreei ENSGT00760000119104.
HOGENOMi HOG000041362.
HOVERGENi HBG017625.
InParanoidi Q8NH05.
KOi K04257.
OMAi ITLRTHF.
OrthoDBi EOG71K63J.
PhylomeDBi Q8NH05.
TreeFami TF337350.

Enzyme and pathway databases

Reactomei REACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikii OR4Q3.
GenomeRNAii 441669.
NextBioi 110391.
PROi Q8NH05.

Gene expression databases

CleanExi HS_OR4Q3.
Genevestigatori Q8NH05.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: IDENTIFICATION.
  3. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiOR4Q3_HUMAN
AccessioniPrimary (citable) accession number: Q8NH05
Secondary accession number(s): Q6IEX4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: October 29, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

External Data

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