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Protein

Olfactory receptor 2T27

Gene

OR2T27

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 2T27
Alternative name(s):
Olfactory receptor OR1-67
Gene namesi
Name:OR2T27
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:31252. OR2T27.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2222ExtracellularSequence analysisAdd
BLAST
Transmembranei23 – 4321Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini44 – 6017CytoplasmicSequence analysisAdd
BLAST
Transmembranei61 – 8323Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini84 – 9714ExtracellularSequence analysisAdd
BLAST
Transmembranei98 – 11821Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini119 – 13921CytoplasmicSequence analysisAdd
BLAST
Transmembranei140 – 16021Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini161 – 19737ExtracellularSequence analysisAdd
BLAST
Transmembranei198 – 21821Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini219 – 24426CytoplasmicSequence analysisAdd
BLAST
Transmembranei245 – 26521Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini266 – 2716ExtracellularSequence analysis
Transmembranei272 – 29221Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini293 – 31725CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134945560.

Polymorphism and mutation databases

BioMutaiOR2T27.
DMDMi73621333.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 317317Olfactory receptor 2T27PRO_0000150505Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...)Sequence analysis
Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NH04.
PRIDEiQ8NH04.

Expressioni

Gene expression databases

CleanExiHS_OR2T27.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000342008.

Structurei

3D structure databases

ProteinModelPortaliQ8NH04.
SMRiQ8NH04. Positions 23-222.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJ8C. Eukaryota.
ENOG41120HT. LUCA.
GeneTreeiENSGT00760000118850.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiQ8NH04.
KOiK04257.
OMAiIASNTIM.
OrthoDBiEOG71K63J.
PhylomeDBiQ8NH04.
TreeFamiTF337295.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NH04-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEQSNYSVYA DFILLGLFSN ARFPWLLFAL ILLVFLTSIA SNVVKIILIH
60 70 80 90 100
IDSRLHTPMY FLLSQLSLRD ILYISTIVPK MLVDQVMSQR AISFAGCTAQ
110 120 130 140 150
HFLYLTLAGA EFFLLGLMSY DRYVAICNPL HYPVLMSRKI CWLIVAAAWL
160 170 180 190 200
GGSIDGFLLT PVTMQFPFCA SREINHFFCE VPALLKLSCT DTSAYETAMY
210 220 230 240 250
VCCIMMLLIP FSVISGSYTR ILITVYRMSE AEGRGKAVAT CSSHMVVVSL
260 270 280 290 300
FYGAAMYTYV LPHSYHTPEQ DKAVSAFYTI LTPMLNPLIY SLRNKDVTGA
310
LQKVVGRCVS SGKVTTF
Length:317
Mass (Da):35,514
Last modified:October 1, 2002 - v1
Checksum:iE271C5F00CFDE7F7
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti36 – 361L → V.
Corresponds to variant rs1782242 [ dbSNP | Ensembl ].
VAR_053158
Natural varianti45 – 451K → M.
Corresponds to variant rs28533004 [ dbSNP | Ensembl ].
VAR_062030

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065611 Genomic DNA. Translation: BAC05838.1.
BK004474 Genomic DNA. Translation: DAA04872.1.
CCDSiCCDS31124.1.
RefSeqiNP_001001824.1. NM_001001824.1.
UniGeneiHs.553814.

Genome annotation databases

EnsembliENST00000344889; ENSP00000342008; ENSG00000187701.
GeneIDi403239.
KEGGihsa:403239.
UCSCiuc010pzo.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065611 Genomic DNA. Translation: BAC05838.1.
BK004474 Genomic DNA. Translation: DAA04872.1.
CCDSiCCDS31124.1.
RefSeqiNP_001001824.1. NM_001001824.1.
UniGeneiHs.553814.

3D structure databases

ProteinModelPortaliQ8NH04.
SMRiQ8NH04. Positions 23-222.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000342008.

Protein family/group databases

GPCRDBiSearch...

Polymorphism and mutation databases

BioMutaiOR2T27.
DMDMi73621333.

Proteomic databases

PaxDbiQ8NH04.
PRIDEiQ8NH04.

Protocols and materials databases

DNASUi403239.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000344889; ENSP00000342008; ENSG00000187701.
GeneIDi403239.
KEGGihsa:403239.
UCSCiuc010pzo.2. human.

Organism-specific databases

CTDi403239.
GeneCardsiOR2T27.
HGNCiHGNC:31252. OR2T27.
neXtProtiNX_Q8NH04.
PharmGKBiPA134945560.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJ8C. Eukaryota.
ENOG41120HT. LUCA.
GeneTreeiENSGT00760000118850.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiQ8NH04.
KOiK04257.
OMAiIASNTIM.
OrthoDBiEOG71K63J.
PhylomeDBiQ8NH04.
TreeFamiTF337295.

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR2T27.
GenomeRNAii403239.
PROiQ8NH04.

Gene expression databases

CleanExiHS_OR2T27.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: IDENTIFICATION.
  3. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiO2T27_HUMAN
AccessioniPrimary (citable) accession number: Q8NH04
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: October 1, 2002
Last modified: June 8, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.