Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q8NH01

- O2T11_HUMAN

UniProt

Q8NH01 - O2T11_HUMAN

Protein

Olfactory receptor 2T11

Gene

OR2T11

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 105 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Odorant receptor.Curated

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW
    2. olfactory receptor activity Source: InterPro

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Olfaction, Sensory transduction

    Enzyme and pathway databases

    ReactomeiREACT_15488. Olfactory Signaling Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Olfactory receptor 2T11
    Alternative name(s):
    Olfactory receptor OR1-65
    Gene namesi
    Name:OR2T11
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:19574. OR2T11.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134948800.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 316316Olfactory receptor 2T11PRO_0000150503Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi3 – 31N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi94 ↔ 186PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiQ8NH01.

    Expressioni

    Gene expression databases

    BgeeiQ8NH01.
    CleanExiHS_OR2T11.
    GenevestigatoriQ8NH01.

    Organism-specific databases

    HPAiHPA047416.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000328934.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8NH01.
    SMRiQ8NH01. Positions 23-222.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2222ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini47 – 548CytoplasmicSequence Analysis
    Topological domaini77 – 9721ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini118 – 13619CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini156 – 19237ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini217 – 23317CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini257 – 26913ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini290 – 31627CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei23 – 4624Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei55 – 7622Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei98 – 11720Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei137 – 15519Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei193 – 21624Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei234 – 25623Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei270 – 28920Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG44210.
    HOGENOMiHOG000041365.
    HOVERGENiHBG017625.
    InParanoidiQ8NH01.
    KOiK04257.
    OMAiVMGAFKK.
    OrthoDBiEOG71K63J.
    PhylomeDBiQ8NH01.
    TreeFamiTF337295.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8NH01-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTNTSSSDFT LLGLLVNSEA AGIVFTVILA VFLGAVTANL VMIFLIQVDS    50
    RLHTPMYFLL SQLSIMDTLF ICTTVPKLLA DMVSKEKIIS FVACGIQIFL 100
    YLTMIGSEFF LLGLMAYDCY VAVCNPLRYP VLMNRKKCLL LAAGAWFGGS 150
    LDGFLLTPIT MNVPYCGSRS INHFFCEIPA VLKLACADTS LYETLMYICC 200
    VLMLLIPISI ISTSYSLILL TIHRMPSAEG RKKAFTTCSS HLTVVSIFYG 250
    AAFYTYVLPQ SFHTPEQDKV VSAFYTIVTP MLNPLIYSLR NKDVIGAFKK 300
    VFACCSSAQK VATSDA 316
    Length:316
    Mass (Da):34,797
    Last modified:October 1, 2002 - v1
    Checksum:iE785C0F88F405FD8
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti119 – 1191C → R.
    Corresponds to variant rs1892443 [ dbSNP | Ensembl ].
    VAR_053155
    Natural varianti309 – 3091Q → R.
    Corresponds to variant rs1892442 [ dbSNP | Ensembl ].
    VAR_053156

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065614 Genomic DNA. Translation: BAC05841.1.
    BK004476 Genomic DNA. Translation: DAA04874.1.
    CCDSiCCDS31122.1.
    RefSeqiNP_001001964.1. NM_001001964.1.
    UniGeneiHs.626619.

    Genome annotation databases

    EnsembliENST00000330803; ENSP00000328934; ENSG00000183130.
    GeneIDi127077.
    KEGGihsa:127077.
    UCSCiuc001ier.1. human.

    Polymorphism databases

    DMDMi38503049.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Human Olfactory Receptor Data Exploratorium (HORDE)

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065614 Genomic DNA. Translation: BAC05841.1 .
    BK004476 Genomic DNA. Translation: DAA04874.1 .
    CCDSi CCDS31122.1.
    RefSeqi NP_001001964.1. NM_001001964.1.
    UniGenei Hs.626619.

    3D structure databases

    ProteinModelPortali Q8NH01.
    SMRi Q8NH01. Positions 23-222.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000328934.

    Protein family/group databases

    GPCRDBi Search...

    Polymorphism databases

    DMDMi 38503049.

    Proteomic databases

    PRIDEi Q8NH01.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000330803 ; ENSP00000328934 ; ENSG00000183130 .
    GeneIDi 127077.
    KEGGi hsa:127077.
    UCSCi uc001ier.1. human.

    Organism-specific databases

    CTDi 127077.
    GeneCardsi GC01M248789.
    HGNCi HGNC:19574. OR2T11.
    HPAi HPA047416.
    neXtProti NX_Q8NH01.
    PharmGKBi PA134948800.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG44210.
    HOGENOMi HOG000041365.
    HOVERGENi HBG017625.
    InParanoidi Q8NH01.
    KOi K04257.
    OMAi VMGAFKK.
    OrthoDBi EOG71K63J.
    PhylomeDBi Q8NH01.
    TreeFami TF337295.

    Enzyme and pathway databases

    Reactomei REACT_15488. Olfactory Signaling Pathway.

    Miscellaneous databases

    GeneWikii OR2T11.
    GenomeRNAii 127077.
    NextBioi 82018.
    PROi Q8NH01.

    Gene expression databases

    Bgeei Q8NH01.
    CleanExi HS_OR2T11.
    Genevestigatori Q8NH01.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
      Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
      Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: IDENTIFICATION.
    3. Erratum
      Malnic B., Godfrey P.A., Buck L.B.
      Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

    Entry informationi

    Entry nameiO2T11_HUMAN
    AccessioniPrimary (citable) accession number: Q8NH01
    Secondary accession number(s): Q6IEY6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 21, 2003
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 105 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3