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Q8NH01

- O2T11_HUMAN

UniProt

Q8NH01 - O2T11_HUMAN

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Protein
Olfactory receptor 2T11
Gene
OR2T11
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Odorant receptor Reviewed prediction.

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 2T11
Alternative name(s):
Olfactory receptor OR1-65
Gene namesi
Name:OR2T11
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:19574. OR2T11.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2222Extracellular Reviewed prediction
Add
BLAST
Transmembranei23 – 4624Helical; Name=1; Reviewed prediction
Add
BLAST
Topological domaini47 – 548Cytoplasmic Reviewed prediction
Transmembranei55 – 7622Helical; Name=2; Reviewed prediction
Add
BLAST
Topological domaini77 – 9721Extracellular Reviewed prediction
Add
BLAST
Transmembranei98 – 11720Helical; Name=3; Reviewed prediction
Add
BLAST
Topological domaini118 – 13619Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei137 – 15519Helical; Name=4; Reviewed prediction
Add
BLAST
Topological domaini156 – 19237Extracellular Reviewed prediction
Add
BLAST
Transmembranei193 – 21624Helical; Name=5; Reviewed prediction
Add
BLAST
Topological domaini217 – 23317Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei234 – 25623Helical; Name=6; Reviewed prediction
Add
BLAST
Topological domaini257 – 26913Extracellular Reviewed prediction
Add
BLAST
Transmembranei270 – 28920Helical; Name=7; Reviewed prediction
Add
BLAST
Topological domaini290 – 31627Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134948800.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 316316Olfactory receptor 2T11
PRO_0000150503Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi3 – 31N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi94 ↔ 186 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ8NH01.

Expressioni

Gene expression databases

BgeeiQ8NH01.
CleanExiHS_OR2T11.
GenevestigatoriQ8NH01.

Organism-specific databases

HPAiHPA047416.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000328934.

Structurei

3D structure databases

ProteinModelPortaliQ8NH01.
SMRiQ8NH01. Positions 23-222.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG44210.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiQ8NH01.
KOiK04257.
OMAiVMGAFKK.
OrthoDBiEOG71K63J.
PhylomeDBiQ8NH01.
TreeFamiTF337295.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NH01-1 [UniParc]FASTAAdd to Basket

« Hide

MTNTSSSDFT LLGLLVNSEA AGIVFTVILA VFLGAVTANL VMIFLIQVDS    50
RLHTPMYFLL SQLSIMDTLF ICTTVPKLLA DMVSKEKIIS FVACGIQIFL 100
YLTMIGSEFF LLGLMAYDCY VAVCNPLRYP VLMNRKKCLL LAAGAWFGGS 150
LDGFLLTPIT MNVPYCGSRS INHFFCEIPA VLKLACADTS LYETLMYICC 200
VLMLLIPISI ISTSYSLILL TIHRMPSAEG RKKAFTTCSS HLTVVSIFYG 250
AAFYTYVLPQ SFHTPEQDKV VSAFYTIVTP MLNPLIYSLR NKDVIGAFKK 300
VFACCSSAQK VATSDA 316
Length:316
Mass (Da):34,797
Last modified:October 1, 2002 - v1
Checksum:iE785C0F88F405FD8
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti119 – 1191C → R.
Corresponds to variant rs1892443 [ dbSNP | Ensembl ].
VAR_053155
Natural varianti309 – 3091Q → R.
Corresponds to variant rs1892442 [ dbSNP | Ensembl ].
VAR_053156

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB065614 Genomic DNA. Translation: BAC05841.1.
BK004476 Genomic DNA. Translation: DAA04874.1.
CCDSiCCDS31122.1.
RefSeqiNP_001001964.1. NM_001001964.1.
UniGeneiHs.626619.

Genome annotation databases

EnsembliENST00000330803; ENSP00000328934; ENSG00000183130.
GeneIDi127077.
KEGGihsa:127077.
UCSCiuc001ier.1. human.

Polymorphism databases

DMDMi38503049.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB065614 Genomic DNA. Translation: BAC05841.1 .
BK004476 Genomic DNA. Translation: DAA04874.1 .
CCDSi CCDS31122.1.
RefSeqi NP_001001964.1. NM_001001964.1.
UniGenei Hs.626619.

3D structure databases

ProteinModelPortali Q8NH01.
SMRi Q8NH01. Positions 23-222.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000328934.

Protein family/group databases

GPCRDBi Search...

Polymorphism databases

DMDMi 38503049.

Proteomic databases

PRIDEi Q8NH01.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000330803 ; ENSP00000328934 ; ENSG00000183130 .
GeneIDi 127077.
KEGGi hsa:127077.
UCSCi uc001ier.1. human.

Organism-specific databases

CTDi 127077.
GeneCardsi GC01M248789.
HGNCi HGNC:19574. OR2T11.
HPAi HPA047416.
neXtProti NX_Q8NH01.
PharmGKBi PA134948800.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG44210.
HOGENOMi HOG000041365.
HOVERGENi HBG017625.
InParanoidi Q8NH01.
KOi K04257.
OMAi VMGAFKK.
OrthoDBi EOG71K63J.
PhylomeDBi Q8NH01.
TreeFami TF337295.

Enzyme and pathway databases

Reactomei REACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikii OR2T11.
GenomeRNAii 127077.
NextBioi 82018.
PROi Q8NH01.

Gene expression databases

Bgeei Q8NH01.
CleanExi HS_OR2T11.
Genevestigatori Q8NH01.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: IDENTIFICATION.
  3. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiO2T11_HUMAN
AccessioniPrimary (citable) accession number: Q8NH01
Secondary accession number(s): Q6IEY6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 21, 2003
Last sequence update: October 1, 2002
Last modified: September 3, 2014
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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