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Protein

Olfactory receptor 2T11

Gene

OR2T11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

BioCyciZFISH:G66-31576-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 2T11
Alternative name(s):
Olfactory receptor OR1-65
Gene namesi
Name:OR2T11
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:19574. OR2T11.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 22ExtracellularSequence analysisAdd BLAST22
Transmembranei23 – 46Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini47 – 54CytoplasmicSequence analysis8
Transmembranei55 – 76Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini77 – 97ExtracellularSequence analysisAdd BLAST21
Transmembranei98 – 117Helical; Name=3Sequence analysisAdd BLAST20
Topological domaini118 – 136CytoplasmicSequence analysisAdd BLAST19
Transmembranei137 – 155Helical; Name=4Sequence analysisAdd BLAST19
Topological domaini156 – 192ExtracellularSequence analysisAdd BLAST37
Transmembranei193 – 216Helical; Name=5Sequence analysisAdd BLAST24
Topological domaini217 – 233CytoplasmicSequence analysisAdd BLAST17
Transmembranei234 – 256Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini257 – 269ExtracellularSequence analysisAdd BLAST13
Transmembranei270 – 289Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini290 – 316CytoplasmicSequence analysisAdd BLAST27

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000279301.
PharmGKBiPA134948800.

Polymorphism and mutation databases

BioMutaiOR2T11.
DMDMi38503049.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001505031 – 316Olfactory receptor 2T11Add BLAST316

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi3N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi94 ↔ 186PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NH01.
PeptideAtlasiQ8NH01.
PRIDEiQ8NH01.

Expressioni

Gene expression databases

CleanExiHS_OR2T11.

Organism-specific databases

HPAiHPA047416.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000328934.

Structurei

3D structure databases

ProteinModelPortaliQ8NH01.
SMRiQ8NH01.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IGYV. Eukaryota.
ENOG411199U. LUCA.
GeneTreeiENSGT00760000118850.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiQ8NH01.
KOiK04257.
OMAiHRMRSAD.
OrthoDBiEOG091G0ECW.
PhylomeDBiQ8NH01.
TreeFamiTF337295.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NH01-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTNTSSSDFT LLGLLVNSEA AGIVFTVILA VFLGAVTANL VMIFLIQVDS
60 70 80 90 100
RLHTPMYFLL SQLSIMDTLF ICTTVPKLLA DMVSKEKIIS FVACGIQIFL
110 120 130 140 150
YLTMIGSEFF LLGLMAYDCY VAVCNPLRYP VLMNRKKCLL LAAGAWFGGS
160 170 180 190 200
LDGFLLTPIT MNVPYCGSRS INHFFCEIPA VLKLACADTS LYETLMYICC
210 220 230 240 250
VLMLLIPISI ISTSYSLILL TIHRMPSAEG RKKAFTTCSS HLTVVSIFYG
260 270 280 290 300
AAFYTYVLPQ SFHTPEQDKV VSAFYTIVTP MLNPLIYSLR NKDVIGAFKK
310
VFACCSSAQK VATSDA
Length:316
Mass (Da):34,797
Last modified:October 1, 2002 - v1
Checksum:iE785C0F88F405FD8
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_053155119C → R.Corresponds to variant rs1892443dbSNPEnsembl.1
Natural variantiVAR_053156309Q → R.Corresponds to variant rs1892442dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065614 Genomic DNA. Translation: BAC05841.1.
BK004476 Genomic DNA. Translation: DAA04874.1.
RefSeqiNP_001001964.1. NM_001001964.1.
UniGeneiHs.626619.

Genome annotation databases

EnsembliENST00000625105; ENSP00000485455; ENSG00000279301.
GeneIDi127077.
KEGGihsa:127077.
UCSCiuc001ier.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065614 Genomic DNA. Translation: BAC05841.1.
BK004476 Genomic DNA. Translation: DAA04874.1.
RefSeqiNP_001001964.1. NM_001001964.1.
UniGeneiHs.626619.

3D structure databases

ProteinModelPortaliQ8NH01.
SMRiQ8NH01.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000328934.

Protein family/group databases

GPCRDBiSearch...

Polymorphism and mutation databases

BioMutaiOR2T11.
DMDMi38503049.

Proteomic databases

PaxDbiQ8NH01.
PeptideAtlasiQ8NH01.
PRIDEiQ8NH01.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000625105; ENSP00000485455; ENSG00000279301.
GeneIDi127077.
KEGGihsa:127077.
UCSCiuc001ier.1. human.

Organism-specific databases

CTDi127077.
GeneCardsiOR2T11.
HGNCiHGNC:19574. OR2T11.
HPAiHPA047416.
neXtProtiNX_Q8NH01.
OpenTargetsiENSG00000279301.
PharmGKBiPA134948800.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IGYV. Eukaryota.
ENOG411199U. LUCA.
GeneTreeiENSGT00760000118850.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiQ8NH01.
KOiK04257.
OMAiHRMRSAD.
OrthoDBiEOG091G0ECW.
PhylomeDBiQ8NH01.
TreeFamiTF337295.

Enzyme and pathway databases

BioCyciZFISH:G66-31576-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR2T11.
GenomeRNAii127077.
PROiQ8NH01.

Gene expression databases

CleanExiHS_OR2T11.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO2T11_HUMAN
AccessioniPrimary (citable) accession number: Q8NH01
Secondary accession number(s): Q6IEY6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 21, 2003
Last sequence update: October 1, 2002
Last modified: November 2, 2016
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.