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Protein

Olfactory receptor 2T4

Gene

OR2T4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

BioCyciZFISH:G66-33354-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 2T4
Alternative name(s):
Olfactory receptor OR1-60
Gene namesi
Name:OR2T4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:15016. OR2T4.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 57ExtracellularSequence analysisAdd BLAST57
Transmembranei58 – 81Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini82 – 89CytoplasmicSequence analysis8
Transmembranei90 – 111Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini112 – 132ExtracellularSequence analysisAdd BLAST21
Transmembranei133 – 152Helical; Name=3Sequence analysisAdd BLAST20
Topological domaini153 – 171CytoplasmicSequence analysisAdd BLAST19
Transmembranei172 – 190Helical; Name=4Sequence analysisAdd BLAST19
Topological domaini191 – 227ExtracellularSequence analysisAdd BLAST37
Transmembranei228 – 251Helical; Name=5Sequence analysisAdd BLAST24
Topological domaini252 – 268CytoplasmicSequence analysisAdd BLAST17
Transmembranei269 – 291Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini292 – 304ExtracellularSequence analysisAdd BLAST13
Transmembranei305 – 324Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini325 – 348CytoplasmicSequence analysisAdd BLAST24

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi127074.
OpenTargetsiENSG00000196944.
ENSG00000274870.
ENSG00000275617.
PharmGKBiPA134876557.

Polymorphism and mutation databases

BioMutaiOR2T4.
DMDMi229462930.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001504991 – 348Olfactory receptor 2T4Add BLAST348

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi31N-linked (GlcNAc...)Sequence analysis1
Glycosylationi37N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi129 ↔ 221PROSITE-ProRule annotation
Glycosylationi218N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NH00.
PRIDEiQ8NH00.

PTM databases

iPTMnetiQ8NH00.
PhosphoSitePlusiQ8NH00.

Expressioni

Gene expression databases

CleanExiHS_OR2T4.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000355431.

Structurei

3D structure databases

ProteinModelPortaliQ8NH00.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IVTG. Eukaryota.
ENOG41114MM. LUCA.
GeneTreeiENSGT00760000118850.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiQ8NH00.
KOiK04257.
OMAiNITWMAN.
OrthoDBiEOG091G0DUZ.
PhylomeDBiQ8NH00.
TreeFamiTF337295.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NH00-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDNITWMASH TGWSDFILMG LFRQSKHPMA NITWMANHTG WSDFILLGLF
60 70 80 90 100
RQSKHPALLC VVIFVVFLMA LSGNAVLILL IHCDAHLHTP MYFFISQLSL
110 120 130 140 150
MDMAYISVTV PKMLLDQVMG VNKISAPECG MQMFFYVTLA GSEFFLLATM
160 170 180 190 200
AYDRYVAICH PLRYPVLMNH RVCLFLSSGC WFLGSVDGFT FTPITMTFPF
210 220 230 240 250
RGSREIHHFF CEVPAVLNLS CSDTSLYEIF MYLCCVLMLL IPVVIISSSY
260 270 280 290 300
LLILLTIHGM NSAEGRKKAF ATCSSHLTVV ILFYGAAIYT YMLPSSYHTP
310 320 330 340
EKDMMVSVFY TILTPVVNPL IYSLRNKDVM GALKKMLTVE PAFQKAME
Length:348
Mass (Da):39,414
Last modified:May 5, 2009 - v2
Checksum:i93469A947E1E0618
GO

Sequence cautioni

The sequence BAC05842 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06202731N → S.Corresponds to variant rs57795102dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065615 Genomic DNA. Translation: BAC05842.1. Different initiation.
AC138089 Genomic DNA. No translation available.
BK004464 Genomic DNA. Translation: DAA04862.1.
CCDSiCCDS31113.1.
RefSeqiNP_001004696.1. NM_001004696.1.
UniGeneiHs.553586.

Genome annotation databases

EnsembliENST00000366475; ENSP00000355431; ENSG00000196944.
ENST00000621754; ENSP00000478105; ENSG00000274870.
ENST00000622637; ENSP00000484014; ENSG00000275617.
GeneIDi127074.
KEGGihsa:127074.
UCSCiuc001ieh.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065615 Genomic DNA. Translation: BAC05842.1. Different initiation.
AC138089 Genomic DNA. No translation available.
BK004464 Genomic DNA. Translation: DAA04862.1.
CCDSiCCDS31113.1.
RefSeqiNP_001004696.1. NM_001004696.1.
UniGeneiHs.553586.

3D structure databases

ProteinModelPortaliQ8NH00.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000355431.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ8NH00.
PhosphoSitePlusiQ8NH00.

Polymorphism and mutation databases

BioMutaiOR2T4.
DMDMi229462930.

Proteomic databases

PaxDbiQ8NH00.
PRIDEiQ8NH00.

Protocols and materials databases

DNASUi127074.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000366475; ENSP00000355431; ENSG00000196944.
ENST00000621754; ENSP00000478105; ENSG00000274870.
ENST00000622637; ENSP00000484014; ENSG00000275617.
GeneIDi127074.
KEGGihsa:127074.
UCSCiuc001ieh.1. human.

Organism-specific databases

CTDi127074.
DisGeNETi127074.
GeneCardsiOR2T4.
HGNCiHGNC:15016. OR2T4.
neXtProtiNX_Q8NH00.
OpenTargetsiENSG00000196944.
ENSG00000274870.
ENSG00000275617.
PharmGKBiPA134876557.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IVTG. Eukaryota.
ENOG41114MM. LUCA.
GeneTreeiENSGT00760000118850.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiQ8NH00.
KOiK04257.
OMAiNITWMAN.
OrthoDBiEOG091G0DUZ.
PhylomeDBiQ8NH00.
TreeFamiTF337295.

Enzyme and pathway databases

BioCyciZFISH:G66-33354-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR2T4.
GenomeRNAii127074.
PROiQ8NH00.

Gene expression databases

CleanExiHS_OR2T4.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOR2T4_HUMAN
AccessioniPrimary (citable) accession number: Q8NH00
Secondary accession number(s): Q6IEZ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: May 5, 2009
Last modified: November 2, 2016
This is version 123 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-29 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.