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Protein

Olfactory receptor 2T4

Gene

OR2T4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 2T4
Alternative name(s):
Olfactory receptor OR1-60
Gene namesi
Name:OR2T4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:15016. OR2T4.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 57ExtracellularSequence analysisAdd BLAST57
Transmembranei58 – 81Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini82 – 89CytoplasmicSequence analysis8
Transmembranei90 – 111Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini112 – 132ExtracellularSequence analysisAdd BLAST21
Transmembranei133 – 152Helical; Name=3Sequence analysisAdd BLAST20
Topological domaini153 – 171CytoplasmicSequence analysisAdd BLAST19
Transmembranei172 – 190Helical; Name=4Sequence analysisAdd BLAST19
Topological domaini191 – 227ExtracellularSequence analysisAdd BLAST37
Transmembranei228 – 251Helical; Name=5Sequence analysisAdd BLAST24
Topological domaini252 – 268CytoplasmicSequence analysisAdd BLAST17
Transmembranei269 – 291Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini292 – 304ExtracellularSequence analysisAdd BLAST13
Transmembranei305 – 324Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini325 – 348CytoplasmicSequence analysisAdd BLAST24

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134876557.

Polymorphism and mutation databases

BioMutaiOR2T4.
DMDMi229462930.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001504991 – 348Olfactory receptor 2T4Add BLAST348

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi31N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi37N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi129 ↔ 221PROSITE-ProRule annotation
Glycosylationi218N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NH00.
PRIDEiQ8NH00.

PTM databases

iPTMnetiQ8NH00.
PhosphoSitePlusiQ8NH00.

Expressioni

Gene expression databases

BgeeiENSG00000196944.
CleanExiHS_OR2T4.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000355431.

Structurei

3D structure databases

ProteinModelPortaliQ8NH00.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IVTG. Eukaryota.
ENOG41114MM. LUCA.
GeneTreeiENSGT00760000118850.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiQ8NH00.
KOiK04257.
OMAiQISAPEC.
OrthoDBiEOG091G0DUZ.
PhylomeDBiQ8NH00.
TreeFamiTF337295.

Family and domain databases

InterProiView protein in InterPro
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
PfamiView protein in Pfam
PF13853. 7tm_4. 1 hit.
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiView protein in PROSITE
PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8NH00-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDNITWMASH TGWSDFILMG LFRQSKHPMA NITWMANHTG WSDFILLGLF
60 70 80 90 100
RQSKHPALLC VVIFVVFLMA LSGNAVLILL IHCDAHLHTP MYFFISQLSL
110 120 130 140 150
MDMAYISVTV PKMLLDQVMG VNKISAPECG MQMFFYVTLA GSEFFLLATM
160 170 180 190 200
AYDRYVAICH PLRYPVLMNH RVCLFLSSGC WFLGSVDGFT FTPITMTFPF
210 220 230 240 250
RGSREIHHFF CEVPAVLNLS CSDTSLYEIF MYLCCVLMLL IPVVIISSSY
260 270 280 290 300
LLILLTIHGM NSAEGRKKAF ATCSSHLTVV ILFYGAAIYT YMLPSSYHTP
310 320 330 340
EKDMMVSVFY TILTPVVNPL IYSLRNKDVM GALKKMLTVE PAFQKAME
Length:348
Mass (Da):39,414
Last modified:May 5, 2009 - v2
Checksum:i93469A947E1E0618
GO

Sequence cautioni

The sequence BAC05842 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06202731N → S. Corresponds to variant dbSNP:rs57795102Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065615 Genomic DNA. Translation: BAC05842.1. Different initiation.
AC138089 Genomic DNA. No translation available.
BK004464 Genomic DNA. Translation: DAA04862.1.
CCDSiCCDS31113.1.
RefSeqiNP_001004696.1. NM_001004696.1.
UniGeneiHs.553586.

Genome annotation databases

EnsembliENST00000366475; ENSP00000355431; ENSG00000196944.
ENST00000621754; ENSP00000478105; ENSG00000274870.
ENST00000622637; ENSP00000484014; ENSG00000275617.
GeneIDi127074.
KEGGihsa:127074.
UCSCiuc001ieh.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiOR2T4_HUMAN
AccessioniPrimary (citable) accession number: Q8NH00
Secondary accession number(s): Q6IEZ8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: May 5, 2009
Last modified: August 30, 2017
This is version 128 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-29 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families