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Q8NGZ9

- O2T10_HUMAN

UniProt

Q8NGZ9 - O2T10_HUMAN

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Protein

Olfactory receptor 2T10

Gene
OR2T10
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Odorant receptor Reviewed prediction.

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 2T10
Alternative name(s):
Olfactory receptor OR1-64
Gene namesi
Name:OR2T10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:19573. OR2T10.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2525Extracellular Reviewed predictionAdd
BLAST
Transmembranei26 – 4924Helical; Name=1; Reviewed predictionAdd
BLAST
Topological domaini50 – 578Cytoplasmic Reviewed prediction
Transmembranei58 – 7922Helical; Name=2; Reviewed predictionAdd
BLAST
Topological domaini80 – 10021Extracellular Reviewed predictionAdd
BLAST
Transmembranei101 – 12020Helical; Name=3; Reviewed predictionAdd
BLAST
Topological domaini121 – 13919Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei140 – 15819Helical; Name=4; Reviewed predictionAdd
BLAST
Topological domaini159 – 19537Extracellular Reviewed predictionAdd
BLAST
Transmembranei196 – 21924Helical; Name=5; Reviewed predictionAdd
BLAST
Topological domaini220 – 23617Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei237 – 25923Helical; Name=6; Reviewed predictionAdd
BLAST
Topological domaini260 – 27213Extracellular Reviewed predictionAdd
BLAST
Transmembranei273 – 29220Helical; Name=7; Reviewed predictionAdd
BLAST
Topological domaini293 – 31220Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134982857.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 312312Olfactory receptor 2T10PRO_0000150502Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi97 ↔ 189 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGZ9.
PRIDEiQ8NGZ9.

PTM databases

PhosphoSiteiQ8NGZ9.

Expressioni

Gene expression databases

BgeeiQ8NGZ9.
CleanExiHS_OR2T10.
GenevestigatoriQ8NGZ9.

Organism-specific databases

HPAiHPA052019.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000329210.

Structurei

3D structure databases

ProteinModelPortaliQ8NGZ9.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG150161.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiQ8NGZ9.
KOiK04257.
OMAiHIDSSLH.
OrthoDBiEOG7W9RV2.
PhylomeDBiQ8NGZ9.
TreeFamiTF337295.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGZ9-1 [UniParc]FASTAAdd to Basket

« Hide

MRLANQTLGG DFFLLGIFSQ ISHPGRLCLL IFSIFLMAVS WNITLILLIH    50
IDSSLHTPMY FFINQLSLID LTYISVTVPK MLVNQLAKDK TISVLGCGTQ 100
MYFYLQLGGA ECCLLAAMAY DRYVAICHPL RYSVLMSHRV CLLLASGCWF 150
VGSVDGFMLT PIAMSFPFCR SHEIQHFFCE VPAVLKLSCS DTSLYKIFMY 200
LCCVIMLLIP VTVISVSYYY IILTIHKMNS VEGRKKAFTT CSSHITVVSL 250
FYGAAIYNYM LPSSYQTPEK DMMSSFFYTI LTPVLNPIIY SFRNKDVTRA 300
LKKMLSVQKP PY 312
Length:312
Mass (Da):35,403
Last modified:October 1, 2002 - v1
Checksum:iE3E0D477D87702BF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB065616 Genomic DNA. Translation: BAC05843.1.
CH471257 Genomic DNA. Translation: EAW57528.1.
BC136937 mRNA. Translation: AAI36938.1.
BC136940 mRNA. Translation: AAI36941.1.
BK004478 Genomic DNA. Translation: DAA04876.1.
CCDSiCCDS31121.1.
RefSeqiNP_001004693.1. NM_001004693.1.
UniGeneiHs.553585.

Genome annotation databases

EnsembliENST00000330500; ENSP00000329210; ENSG00000184022.
GeneIDi127069.
KEGGihsa:127069.
UCSCiuc010pzn.2. human.

Polymorphism databases

DMDMi74762586.

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB065616 Genomic DNA. Translation: BAC05843.1 .
CH471257 Genomic DNA. Translation: EAW57528.1 .
BC136937 mRNA. Translation: AAI36938.1 .
BC136940 mRNA. Translation: AAI36941.1 .
BK004478 Genomic DNA. Translation: DAA04876.1 .
CCDSi CCDS31121.1.
RefSeqi NP_001004693.1. NM_001004693.1.
UniGenei Hs.553585.

3D structure databases

ProteinModelPortali Q8NGZ9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000329210.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei Q8NGZ9.

Polymorphism databases

DMDMi 74762586.

Proteomic databases

PaxDbi Q8NGZ9.
PRIDEi Q8NGZ9.

Protocols and materials databases

DNASUi 127069.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000330500 ; ENSP00000329210 ; ENSG00000184022 .
GeneIDi 127069.
KEGGi hsa:127069.
UCSCi uc010pzn.2. human.

Organism-specific databases

CTDi 127069.
GeneCardsi GC01M248756.
HGNCi HGNC:19573. OR2T10.
HPAi HPA052019.
neXtProti NX_Q8NGZ9.
PharmGKBi PA134982857.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG150161.
HOGENOMi HOG000041365.
HOVERGENi HBG017625.
InParanoidi Q8NGZ9.
KOi K04257.
OMAi HIDSSLH.
OrthoDBi EOG7W9RV2.
PhylomeDBi Q8NGZ9.
TreeFami TF337295.

Enzyme and pathway databases

Reactomei REACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikii OR2T10.
GenomeRNAii 127069.
NextBioi 82010.
PROi Q8NGZ9.

Gene expression databases

Bgeei Q8NGZ9.
CleanExi HS_OR2T10.
Genevestigatori Q8NGZ9.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. Cited for: IDENTIFICATION.
  5. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiO2T10_HUMAN
AccessioniPrimary (citable) accession number: Q8NGZ9
Secondary accession number(s): B2RNK7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: October 1, 2002
Last modified: September 3, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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