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Q8NGZ9

- O2T10_HUMAN

UniProt

Q8NGZ9 - O2T10_HUMAN

Protein

Olfactory receptor 2T10

Gene

OR2T10

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 98 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    Odorant receptor.Curated

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW
    2. olfactory receptor activity Source: InterPro

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Olfaction, Sensory transduction

    Enzyme and pathway databases

    ReactomeiREACT_15488. Olfactory Signaling Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Olfactory receptor 2T10
    Alternative name(s):
    Olfactory receptor OR1-64
    Gene namesi
    Name:OR2T10
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:19573. OR2T10.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134982857.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 312312Olfactory receptor 2T10PRO_0000150502Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi5 – 51N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ8NGZ9.
    PRIDEiQ8NGZ9.

    PTM databases

    PhosphoSiteiQ8NGZ9.

    Expressioni

    Gene expression databases

    BgeeiQ8NGZ9.
    CleanExiHS_OR2T10.
    GenevestigatoriQ8NGZ9.

    Organism-specific databases

    HPAiHPA052019.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000329210.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8NGZ9.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2525ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini50 – 578CytoplasmicSequence Analysis
    Topological domaini80 – 10021ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini121 – 13919CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini159 – 19537ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini220 – 23617CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini260 – 27213ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini293 – 31220CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei26 – 4924Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei58 – 7922Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei101 – 12020Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei140 – 15819Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei196 – 21924Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei237 – 25923Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei273 – 29220Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG150161.
    HOGENOMiHOG000041365.
    HOVERGENiHBG017625.
    InParanoidiQ8NGZ9.
    KOiK04257.
    OMAiHIDSSLH.
    OrthoDBiEOG7W9RV2.
    PhylomeDBiQ8NGZ9.
    TreeFamiTF337295.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8NGZ9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRLANQTLGG DFFLLGIFSQ ISHPGRLCLL IFSIFLMAVS WNITLILLIH    50
    IDSSLHTPMY FFINQLSLID LTYISVTVPK MLVNQLAKDK TISVLGCGTQ 100
    MYFYLQLGGA ECCLLAAMAY DRYVAICHPL RYSVLMSHRV CLLLASGCWF 150
    VGSVDGFMLT PIAMSFPFCR SHEIQHFFCE VPAVLKLSCS DTSLYKIFMY 200
    LCCVIMLLIP VTVISVSYYY IILTIHKMNS VEGRKKAFTT CSSHITVVSL 250
    FYGAAIYNYM LPSSYQTPEK DMMSSFFYTI LTPVLNPIIY SFRNKDVTRA 300
    LKKMLSVQKP PY 312
    Length:312
    Mass (Da):35,403
    Last modified:October 1, 2002 - v1
    Checksum:iE3E0D477D87702BF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065616 Genomic DNA. Translation: BAC05843.1.
    CH471257 Genomic DNA. Translation: EAW57528.1.
    BC136937 mRNA. Translation: AAI36938.1.
    BC136940 mRNA. Translation: AAI36941.1.
    BK004478 Genomic DNA. Translation: DAA04876.1.
    CCDSiCCDS31121.1.
    RefSeqiNP_001004693.1. NM_001004693.1.
    UniGeneiHs.553585.

    Genome annotation databases

    EnsembliENST00000330500; ENSP00000329210; ENSG00000184022.
    GeneIDi127069.
    KEGGihsa:127069.
    UCSCiuc010pzn.2. human.

    Polymorphism databases

    DMDMi74762586.

    Cross-referencesi

    Web resourcesi

    Human Olfactory Receptor Data Exploratorium (HORDE)

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065616 Genomic DNA. Translation: BAC05843.1 .
    CH471257 Genomic DNA. Translation: EAW57528.1 .
    BC136937 mRNA. Translation: AAI36938.1 .
    BC136940 mRNA. Translation: AAI36941.1 .
    BK004478 Genomic DNA. Translation: DAA04876.1 .
    CCDSi CCDS31121.1.
    RefSeqi NP_001004693.1. NM_001004693.1.
    UniGenei Hs.553585.

    3D structure databases

    ProteinModelPortali Q8NGZ9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000329210.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q8NGZ9.

    Polymorphism databases

    DMDMi 74762586.

    Proteomic databases

    PaxDbi Q8NGZ9.
    PRIDEi Q8NGZ9.

    Protocols and materials databases

    DNASUi 127069.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000330500 ; ENSP00000329210 ; ENSG00000184022 .
    GeneIDi 127069.
    KEGGi hsa:127069.
    UCSCi uc010pzn.2. human.

    Organism-specific databases

    CTDi 127069.
    GeneCardsi GC01M248756.
    HGNCi HGNC:19573. OR2T10.
    HPAi HPA052019.
    neXtProti NX_Q8NGZ9.
    PharmGKBi PA134982857.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG150161.
    HOGENOMi HOG000041365.
    HOVERGENi HBG017625.
    InParanoidi Q8NGZ9.
    KOi K04257.
    OMAi HIDSSLH.
    OrthoDBi EOG7W9RV2.
    PhylomeDBi Q8NGZ9.
    TreeFami TF337295.

    Enzyme and pathway databases

    Reactomei REACT_15488. Olfactory Signaling Pathway.

    Miscellaneous databases

    GeneWikii OR2T10.
    GenomeRNAii 127069.
    NextBioi 82010.
    PROi Q8NGZ9.

    Gene expression databases

    Bgeei Q8NGZ9.
    CleanExi HS_OR2T10.
    Genevestigatori Q8NGZ9.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
      Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
      Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. Cited for: IDENTIFICATION.
    5. Erratum
      Malnic B., Godfrey P.A., Buck L.B.
      Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

    Entry informationi

    Entry nameiO2T10_HUMAN
    AccessioniPrimary (citable) accession number: Q8NGZ9
    Secondary accession number(s): B2RNK7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 20, 2005
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 98 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3