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Protein

Olfactory receptor 2T10

Gene

OR2T10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 2T10
Alternative name(s):
Olfactory receptor OR1-64
Gene namesi
Name:OR2T10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:19573. OR2T10.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 25ExtracellularSequence analysisAdd BLAST25
Transmembranei26 – 49Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini50 – 57CytoplasmicSequence analysis8
Transmembranei58 – 79Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini80 – 100ExtracellularSequence analysisAdd BLAST21
Transmembranei101 – 120Helical; Name=3Sequence analysisAdd BLAST20
Topological domaini121 – 139CytoplasmicSequence analysisAdd BLAST19
Transmembranei140 – 158Helical; Name=4Sequence analysisAdd BLAST19
Topological domaini159 – 195ExtracellularSequence analysisAdd BLAST37
Transmembranei196 – 219Helical; Name=5Sequence analysisAdd BLAST24
Topological domaini220 – 236CytoplasmicSequence analysisAdd BLAST17
Transmembranei237 – 259Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini260 – 272ExtracellularSequence analysisAdd BLAST13
Transmembranei273 – 292Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini293 – 312CytoplasmicSequence analysisAdd BLAST20

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi127069.
OpenTargetsiENSG00000184022.
PharmGKBiPA134982857.

Polymorphism and mutation databases

BioMutaiOR2T10.
DMDMi74762586.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001505021 – 312Olfactory receptor 2T10Add BLAST312

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGZ9.
PRIDEiQ8NGZ9.

PTM databases

iPTMnetiQ8NGZ9.
PhosphoSitePlusiQ8NGZ9.

Expressioni

Gene expression databases

BgeeiENSG00000184022.
CleanExiHS_OR2T10.
ExpressionAtlasiQ8NGZ9. baseline and differential.

Organism-specific databases

HPAiHPA052019.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000329210.

Structurei

3D structure databases

ProteinModelPortaliQ8NGZ9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IVTG. Eukaryota.
ENOG41114MM. LUCA.
GeneTreeiENSGT00760000118850.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiQ8NGZ9.
KOiK04257.
OMAiHIDSSLH.
OrthoDBiEOG091G0AZH.
PhylomeDBiQ8NGZ9.
TreeFamiTF337295.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGZ9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLANQTLGG DFFLLGIFSQ ISHPGRLCLL IFSIFLMAVS WNITLILLIH
60 70 80 90 100
IDSSLHTPMY FFINQLSLID LTYISVTVPK MLVNQLAKDK TISVLGCGTQ
110 120 130 140 150
MYFYLQLGGA ECCLLAAMAY DRYVAICHPL RYSVLMSHRV CLLLASGCWF
160 170 180 190 200
VGSVDGFMLT PIAMSFPFCR SHEIQHFFCE VPAVLKLSCS DTSLYKIFMY
210 220 230 240 250
LCCVIMLLIP VTVISVSYYY IILTIHKMNS VEGRKKAFTT CSSHITVVSL
260 270 280 290 300
FYGAAIYNYM LPSSYQTPEK DMMSSFFYTI LTPVLNPIIY SFRNKDVTRA
310
LKKMLSVQKP PY
Length:312
Mass (Da):35,403
Last modified:October 1, 2002 - v1
Checksum:iE3E0D477D87702BF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065616 Genomic DNA. Translation: BAC05843.1.
CH471257 Genomic DNA. Translation: EAW57528.1.
BC136937 mRNA. Translation: AAI36938.1.
BC136940 mRNA. Translation: AAI36941.1.
BK004478 Genomic DNA. Translation: DAA04876.1.
CCDSiCCDS31121.1.
RefSeqiNP_001004693.1. NM_001004693.1.
XP_016855762.1. XM_017000273.1.
UniGeneiHs.553585.

Genome annotation databases

EnsembliENST00000330500; ENSP00000329210; ENSG00000184022.
GeneIDi127069.
KEGGihsa:127069.
UCSCiuc010pzn.2. human.

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065616 Genomic DNA. Translation: BAC05843.1.
CH471257 Genomic DNA. Translation: EAW57528.1.
BC136937 mRNA. Translation: AAI36938.1.
BC136940 mRNA. Translation: AAI36941.1.
BK004478 Genomic DNA. Translation: DAA04876.1.
CCDSiCCDS31121.1.
RefSeqiNP_001004693.1. NM_001004693.1.
XP_016855762.1. XM_017000273.1.
UniGeneiHs.553585.

3D structure databases

ProteinModelPortaliQ8NGZ9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000329210.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ8NGZ9.
PhosphoSitePlusiQ8NGZ9.

Polymorphism and mutation databases

BioMutaiOR2T10.
DMDMi74762586.

Proteomic databases

PaxDbiQ8NGZ9.
PRIDEiQ8NGZ9.

Protocols and materials databases

DNASUi127069.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000330500; ENSP00000329210; ENSG00000184022.
GeneIDi127069.
KEGGihsa:127069.
UCSCiuc010pzn.2. human.

Organism-specific databases

CTDi127069.
DisGeNETi127069.
GeneCardsiOR2T10.
HGNCiHGNC:19573. OR2T10.
HPAiHPA052019.
neXtProtiNX_Q8NGZ9.
OpenTargetsiENSG00000184022.
PharmGKBiPA134982857.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IVTG. Eukaryota.
ENOG41114MM. LUCA.
GeneTreeiENSGT00760000118850.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiQ8NGZ9.
KOiK04257.
OMAiHIDSSLH.
OrthoDBiEOG091G0AZH.
PhylomeDBiQ8NGZ9.
TreeFamiTF337295.

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR2T10.
GenomeRNAii127069.
PROiQ8NGZ9.

Gene expression databases

BgeeiENSG00000184022.
CleanExiHS_OR2T10.
ExpressionAtlasiQ8NGZ9. baseline and differential.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO2T10_HUMAN
AccessioniPrimary (citable) accession number: Q8NGZ9
Secondary accession number(s): B2RNK7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: October 1, 2002
Last modified: November 30, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.