Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Olfactory receptor 6F1

Gene

OR6F1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 6F1
Alternative name(s):
Olfactory receptor OR1-38
Gene namesi
Name:OR6F1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000169214.3
HGNCiHGNC:15027 OR6F1
neXtProtiNX_Q8NGZ6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 25ExtracellularSequence analysisAdd BLAST25
Transmembranei26 – 46Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini47 – 54CytoplasmicSequence analysis8
Transmembranei55 – 75Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini76 – 99ExtracellularSequence analysisAdd BLAST24
Transmembranei100 – 120Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini121 – 139CytoplasmicSequence analysisAdd BLAST19
Transmembranei140 – 160Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini161 – 197ExtracellularSequence analysisAdd BLAST37
Transmembranei198 – 217Helical; Name=5Sequence analysisAdd BLAST20
Topological domaini218 – 237CytoplasmicSequence analysisAdd BLAST20
Transmembranei238 – 258Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini259 – 271ExtracellularSequence analysisAdd BLAST13
Transmembranei272 – 292Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini293 – 308CytoplasmicSequence analysisAdd BLAST16

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32585

Polymorphism and mutation databases

BioMutaiOR6F1
DMDMi38372796

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001506271 – 308Olfactory receptor 6F1Add BLAST308

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGZ6
PeptideAtlasiQ8NGZ6
PRIDEiQ8NGZ6

PTM databases

iPTMnetiQ8NGZ6
PhosphoSitePlusiQ8NGZ6

Expressioni

Gene expression databases

BgeeiENSG00000169214
CleanExiHS_OR6F1
ExpressionAtlasiQ8NGZ6 baseline and differential

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000305640

Structurei

3D structure databases

ProteinModelPortaliQ8NGZ6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410ISHC Eukaryota
ENOG410Z9YX LUCA
GeneTreeiENSGT00760000119169
HOGENOMiHOG000041364
HOVERGENiHBG017625
InParanoidiQ8NGZ6
KOiK04257
OMAiTKAVHVL
OrthoDBiEOG091G0AZH
PhylomeDBiQ8NGZ6
TreeFamiTF337475

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8NGZ6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDTGNKTLPQ DFLLLGFPGS QTLQLSLFML FLVMYILTVS GNVAILMLVS
60 70 80 90 100
TSHQLHTPMY FFLSNLSFLE IWYTTAAVPK ALAILLGRSQ TISFTSCLLQ
110 120 130 140 150
MYFVFSLGCT EYFLLAAMAY DRCLAICYPL HYGAIMSSLL SAQLALGSWV
160 170 180 190 200
CGFVAIAVPT ALISGLSFCG PRAINHFFCD IAPWIALACT NTQAVELVAF
210 220 230 240 250
VIAVVVILSS CLITFVSYVY IISTILRIPS ASGRSKAFST CSSHLTVVLI
260 270 280 290 300
WYGSTVFLHV RTSIKDALDL IKAVHVLNTV VTPVLNPFIY TLRNKEVRET

LLKKWKGK
Length:308
Mass (Da):33,961
Last modified:October 1, 2002 - v1
Checksum:i05D63EE27E50E7CC
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06205113L → P. Corresponds to variant dbSNP:rs60303431Ensembl.1
Natural variantiVAR_053221159P → A. Corresponds to variant dbSNP:rs6665599Ensembl.1
Natural variantiVAR_034247215F → L. Corresponds to variant dbSNP:rs2282316Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065619 Genomic DNA Translation: BAC05846.1
CH471148 Genomic DNA Translation: EAW77199.1
BC137142 mRNA Translation: AAI37143.1
BC137143 mRNA Translation: AAI37144.1
AF399604 Genomic DNA Translation: AAK95089.1
BK004460 Genomic DNA Translation: DAA04858.1
CCDSiCCDS31095.1
RefSeqiNP_001005286.1, NM_001005286.1
UniGeneiHs.591529

Genome annotation databases

EnsembliENST00000302084; ENSP00000305640; ENSG00000169214
ENST00000641444; ENSP00000493324; ENSG00000169214
ENST00000641470; ENSP00000493342; ENSG00000169214
GeneIDi343169
KEGGihsa:343169
UCSCiuc001idj.1 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiOR6F1_HUMAN
AccessioniPrimary (citable) accession number: Q8NGZ6
Secondary accession number(s): B2RNV6, Q6IF02, Q96R39
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: May 23, 2018
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health