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Protein

Olfactory receptor 2G2

Gene

OR2G2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 2G2
Alternative name(s):
Olfactory receptor OR1-32
Gene namesi
Name:OR2G2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:15007. OR2G2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2828ExtracellularSequence analysisAdd
BLAST
Transmembranei29 – 5224Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini53 – 608CytoplasmicSequence analysis
Transmembranei61 – 8222Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini83 – 10321ExtracellularSequence analysisAdd
BLAST
Transmembranei104 – 12320Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini124 – 14219CytoplasmicSequence analysisAdd
BLAST
Transmembranei143 – 16119Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini162 – 19837ExtracellularSequence analysisAdd
BLAST
Transmembranei199 – 22224Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini223 – 23917CytoplasmicSequence analysisAdd
BLAST
Transmembranei240 – 26223Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini263 – 27513ExtracellularSequence analysisAdd
BLAST
Transmembranei276 – 29520Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini296 – 31722CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32159.

Polymorphism and mutation databases

BioMutaiOR2G2.
DMDMi38372795.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 317317Olfactory receptor 2G2PRO_0000150476Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi8 – 81N-linked (GlcNAc...)Sequence analysis
Disulfide bondi100 ↔ 192PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGZ5.
PRIDEiQ8NGZ5.

PTM databases

iPTMnetiQ8NGZ5.
PhosphoSiteiQ8NGZ5.

Expressioni

Organism-specific databases

HPAiCAB002449.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000326349.

Structurei

3D structure databases

ProteinModelPortaliQ8NGZ5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IVUR. Eukaryota.
ENOG41117FE. LUCA.
GeneTreeiENSGT00760000118914.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiQ8NGZ5.
KOiK04257.
OMAiPMKTITY.
OrthoDBiEOG091G0CU6.
PhylomeDBiQ8NGZ5.
TreeFamiTF336512.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGZ5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGMVRHTNES NLAGFILLGF SDYPQLQKVL FVLILILYLL TILGNTTIIL
60 70 80 90 100
VSRLEPKLHM PMYFFLSHLS FLYRCFTSSV IPQLLVNLWE PMKTIAYGGC
110 120 130 140 150
LVHLYNSHAL GSTECVLPAV MSCDRYVAVC RPLHYTVLMH IHLCMALASM
160 170 180 190 200
AWLSGIATTL VQSTLTLQLP FCGHRQVDHF ICEVPVLIKL ACVGTTFNEA
210 220 230 240 250
ELFVASILFL IVPVSFILVS SGYIAHAVLR IKSATRRQKA FGTCFSHLTV
260 270 280 290 300
VTIFYGTIIF MYLQPAKSRS RDQGKFVSLF YTVVTRMLNP LIYTLRIKEV
310
KGALKKVLAK ALGVNIL
Length:317
Mass (Da):35,559
Last modified:October 1, 2002 - v1
Checksum:i30A6D6A56EB1BBEC
GO

Sequence cautioni

The sequence DAA04870 differs from that shown. Reason: Erroneous initiation. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti24 – 241P → A.
Corresponds to variant rs12737801 [ dbSNP | Ensembl ].
VAR_034174
Natural varianti120 – 1201V → L.
Corresponds to variant rs1151687 [ dbSNP | Ensembl ].
VAR_034175
Natural varianti167 – 1671L → P.
Corresponds to variant rs10925085 [ dbSNP | Ensembl ].
VAR_034176
Natural varianti236 – 2361R → G.
Corresponds to variant rs869111 [ dbSNP | Ensembl ].
VAR_034177

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065621 Genomic DNA. Translation: BAC05847.1.
AL606804 Genomic DNA. Translation: CAI17150.1.
BK004472 Genomic DNA. Translation: DAA04870.1. Different initiation.
CCDSiCCDS31092.1.
RefSeqiNP_001001915.1. NM_001001915.1.
UniGeneiHs.690208.

Genome annotation databases

EnsembliENST00000320065; ENSP00000326349; ENSG00000177489.
GeneIDi81470.
KEGGihsa:81470.
UCSCiuc010pyy.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065621 Genomic DNA. Translation: BAC05847.1.
AL606804 Genomic DNA. Translation: CAI17150.1.
BK004472 Genomic DNA. Translation: DAA04870.1. Different initiation.
CCDSiCCDS31092.1.
RefSeqiNP_001001915.1. NM_001001915.1.
UniGeneiHs.690208.

3D structure databases

ProteinModelPortaliQ8NGZ5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000326349.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ8NGZ5.
PhosphoSiteiQ8NGZ5.

Polymorphism and mutation databases

BioMutaiOR2G2.
DMDMi38372795.

Proteomic databases

PaxDbiQ8NGZ5.
PRIDEiQ8NGZ5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000320065; ENSP00000326349; ENSG00000177489.
GeneIDi81470.
KEGGihsa:81470.
UCSCiuc010pyy.2. human.

Organism-specific databases

CTDi81470.
GeneCardsiOR2G2.
HGNCiHGNC:15007. OR2G2.
HPAiCAB002449.
neXtProtiNX_Q8NGZ5.
PharmGKBiPA32159.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IVUR. Eukaryota.
ENOG41117FE. LUCA.
GeneTreeiENSGT00760000118914.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiQ8NGZ5.
KOiK04257.
OMAiPMKTITY.
OrthoDBiEOG091G0CU6.
PhylomeDBiQ8NGZ5.
TreeFamiTF336512.

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR2G2.
GenomeRNAii81470.
PROiQ8NGZ5.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOR2G2_HUMAN
AccessioniPrimary (citable) accession number: Q8NGZ5
Secondary accession number(s): Q5JQT2, Q6IEZ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: September 7, 2016
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.