Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Olfactory receptor 2G3

Gene

OR2G3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

BioCyciZFISH:ENSG00000177476-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 2G3
Alternative name(s):
Olfactory receptor OR1-33
Gene namesi
Name:OR2G3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:15008. OR2G3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 25ExtracellularSequence analysisAdd BLAST25
Transmembranei26 – 49Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini50 – 57CytoplasmicSequence analysis8
Transmembranei58 – 79Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini80 – 100ExtracellularSequence analysisAdd BLAST21
Transmembranei101 – 120Helical; Name=3Sequence analysisAdd BLAST20
Topological domaini121 – 139CytoplasmicSequence analysisAdd BLAST19
Transmembranei140 – 158Helical; Name=4Sequence analysisAdd BLAST19
Topological domaini159 – 195ExtracellularSequence analysisAdd BLAST37
Transmembranei196 – 219Helical; Name=5Sequence analysisAdd BLAST24
Topological domaini220 – 236CytoplasmicSequence analysisAdd BLAST17
Transmembranei237 – 259Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini260 – 272ExtracellularSequence analysisAdd BLAST13
Transmembranei273 – 292Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini293 – 309CytoplasmicSequence analysisAdd BLAST17

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi81469.
OpenTargetsiENSG00000177476.
PharmGKBiPA32160.

Polymorphism and mutation databases

BioMutaiOR2G3.
DMDMi38372794.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001504771 – 309Olfactory receptor 2G3Add BLAST309

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGZ4.
PeptideAtlasiQ8NGZ4.
PRIDEiQ8NGZ4.

PTM databases

iPTMnetiQ8NGZ4.
PhosphoSitePlusiQ8NGZ4.

Expressioni

Gene expression databases

CleanExiHS_OR2G3.
ExpressionAtlasiQ8NGZ4. baseline.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000326301.

Structurei

3D structure databases

ProteinModelPortaliQ8NGZ4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IVPF. Eukaryota.
ENOG411156X. LUCA.
GeneTreeiENSGT00760000118914.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiQ8NGZ4.
KOiK04257.
OMAiPSDSYAQ.
OrthoDBiEOG091G0CU6.
PhylomeDBiQ8NGZ4.
TreeFamiTF336512.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
IPR030778. OR2G3.
[Graphical view]
PANTHERiPTHR26453:SF300. PTHR26453:SF300. 1 hit.
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGZ4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLGNESSLM DFILLGFSDH PRLEAVLFVF VLFFYLLTLV GNFTIIIISY
60 70 80 90 100
LDPPLHTPMY FFLSNLSLLD ICFTTSLAPQ TLVNLQRPKK TITYGGCVAQ
110 120 130 140 150
LYISLALGST ECILLADMAL DRYIAVCKPL HYVVIMNPRL CQQLASISWL
160 170 180 190 200
SGLASSLIHA TFTLQLPLCG NHRLDHFICE VPALLKLACV DTTVNELVLF
210 220 230 240 250
VVSVLFVVIP PALISISYGF ITQAVLRIKS VEARHKAFST CSSHLTVVII
260 270 280 290 300
FYGTIIYVYL QPSDSYAQDQ GKFISLFYTM VTPTLNPIIY TLRNKDMKEA

LRKLLSGKL
Length:309
Mass (Da):34,506
Last modified:October 1, 2002 - v1
Checksum:iF72A80E3A753695C
GO

Sequence cautioni

The sequence DAA04815 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_053141164L → S.Corresponds to variant rs6658792dbSNPEnsembl.1
Natural variantiVAR_034178258V → M.Corresponds to variant rs12072304dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065622 Genomic DNA. Translation: BAC05848.1.
AL606804 Genomic DNA. Translation: CAI17151.1.
CH471148 Genomic DNA. Translation: EAW77196.1.
BC136712 mRNA. Translation: AAI36713.1.
BC136713 mRNA. Translation: AAI36714.1.
BK004417 Genomic DNA. Translation: DAA04815.1. Different initiation.
CCDSiCCDS31093.1.
RefSeqiNP_001001914.1. NM_001001914.1.
UniGeneiHs.653227.

Genome annotation databases

EnsembliENST00000320002; ENSP00000326301; ENSG00000177476.
GeneIDi81469.
KEGGihsa:81469.
UCSCiuc010pyz.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065622 Genomic DNA. Translation: BAC05848.1.
AL606804 Genomic DNA. Translation: CAI17151.1.
CH471148 Genomic DNA. Translation: EAW77196.1.
BC136712 mRNA. Translation: AAI36713.1.
BC136713 mRNA. Translation: AAI36714.1.
BK004417 Genomic DNA. Translation: DAA04815.1. Different initiation.
CCDSiCCDS31093.1.
RefSeqiNP_001001914.1. NM_001001914.1.
UniGeneiHs.653227.

3D structure databases

ProteinModelPortaliQ8NGZ4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000326301.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ8NGZ4.
PhosphoSitePlusiQ8NGZ4.

Polymorphism and mutation databases

BioMutaiOR2G3.
DMDMi38372794.

Proteomic databases

PaxDbiQ8NGZ4.
PeptideAtlasiQ8NGZ4.
PRIDEiQ8NGZ4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000320002; ENSP00000326301; ENSG00000177476.
GeneIDi81469.
KEGGihsa:81469.
UCSCiuc010pyz.2. human.

Organism-specific databases

CTDi81469.
DisGeNETi81469.
GeneCardsiOR2G3.
HGNCiHGNC:15008. OR2G3.
neXtProtiNX_Q8NGZ4.
OpenTargetsiENSG00000177476.
PharmGKBiPA32160.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IVPF. Eukaryota.
ENOG411156X. LUCA.
GeneTreeiENSGT00760000118914.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiQ8NGZ4.
KOiK04257.
OMAiPSDSYAQ.
OrthoDBiEOG091G0CU6.
PhylomeDBiQ8NGZ4.
TreeFamiTF336512.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000177476-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR2G3.
GenomeRNAii81469.
PROiQ8NGZ4.

Gene expression databases

CleanExiHS_OR2G3.
ExpressionAtlasiQ8NGZ4. baseline.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
IPR030778. OR2G3.
[Graphical view]
PANTHERiPTHR26453:SF300. PTHR26453:SF300. 1 hit.
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOR2G3_HUMAN
AccessioniPrimary (citable) accession number: Q8NGZ4
Secondary accession number(s): B2RN64, Q5JQT1, Q6IF45
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: November 30, 2016
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.