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Protein

Olfactory receptor 13G1

Gene

OR13G1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 13G1
Alternative name(s):
Olfactory receptor OR1-37
Gene namesi
Name:OR13G1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:14999. OR13G1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2222ExtracellularSequence analysisAdd
BLAST
Transmembranei23 – 4321Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini44 – 518CytoplasmicSequence analysis
Transmembranei52 – 7221Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini73 – 9624ExtracellularSequence analysisAdd
BLAST
Transmembranei97 – 11721Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini118 – 13619CytoplasmicSequence analysisAdd
BLAST
Transmembranei137 – 15721Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini158 – 19437ExtracellularSequence analysisAdd
BLAST
Transmembranei195 – 21420Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini215 – 23420CytoplasmicSequence analysisAdd
BLAST
Transmembranei235 – 25521Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini256 – 26813ExtracellularSequence analysisAdd
BLAST
Transmembranei269 – 28921Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini290 – 30718CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32046.

Polymorphism and mutation databases

BioMutaiOR13G1.
DMDMi38372793.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 307307Olfactory receptor 13G1PRO_0000150739Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi2 – 21N-linked (GlcNAc...)Sequence analysis
Disulfide bondi94 ↔ 186PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGZ3.
PRIDEiQ8NGZ3.

Expressioni

Gene expression databases

BgeeiQ8NGZ3.
CleanExiHS_OR13G1.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000352717.

Structurei

3D structure databases

ProteinModelPortaliQ8NGZ3.
SMRiQ8NGZ3. Positions 25-155.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IKYT. Eukaryota.
ENOG410YX9S. LUCA.
GeneTreeiENSGT00440000034500.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiQ8NGZ3.
KOiK04257.
OMAiMYVFLLT.
OrthoDBiEOG71K63J.
PhylomeDBiQ8NGZ3.
TreeFamiTF339741.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGZ3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNHSVVTEFI ILGLTKKPEL QGIIFLFFLI VYLVAFLGNM LIIIAKIYNN
60 70 80 90 100
TLHTPMYVFL LTLAVVDIIC TTSIIPKMLG TMLTSENTIS YAGCMSQLFL
110 120 130 140 150
FTWSLGAEMV LFTTMAYDRY VAICFPLHYS TIMNHHMCVA LLSMVMAIAV
160 170 180 190 200
TNSWVHTALI MRLTFCGPNT IDHFFCEIPP LLALSCSPVR INEVMVYVAD
210 220 230 240 250
ITLAIGDFIL TCISYGFIIV AILRIRTVEG KRKAFSTCSS HLTVVTLYYS
260 270 280 290 300
PVIYTYIRPA SSYTFERDKV VAALYTLVTP TLNPMVYSFQ NREMQAGIRK

VFAFLKH
Length:307
Mass (Da):34,672
Last modified:October 1, 2002 - v1
Checksum:i5862C4DBB79414D6
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti46 – 461K → I.
Corresponds to variant rs28711149 [ dbSNP | Ensembl ].
VAR_062067
Natural varianti132 – 1321I → V.
Corresponds to variant rs1151640 [ dbSNP | Ensembl ].
VAR_048038
Natural varianti146 – 1461M → L.
Corresponds to variant rs28556931 [ dbSNP | Ensembl ].
VAR_062068
Natural varianti224 – 2241R → C.
Corresponds to variant rs28446289 [ dbSNP | Ensembl ].
VAR_062069

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065623 Genomic DNA. Translation: BAC05849.1.
AL390860 Genomic DNA. Translation: CAI16305.1.
CH471148 Genomic DNA. Translation: EAW77198.1.
BC136736 mRNA. Translation: AAI36737.1.
BC136738 mRNA. Translation: AAI36739.1.
BK004376 Genomic DNA. Translation: DAA04774.1.
CCDSiCCDS31094.1.
RefSeqiNP_001005487.1. NM_001005487.1.
UniGeneiHs.553834.

Genome annotation databases

EnsembliENST00000359688; ENSP00000352717; ENSG00000197437.
GeneIDi441933.
KEGGihsa:441933.
UCSCiuc001idi.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065623 Genomic DNA. Translation: BAC05849.1.
AL390860 Genomic DNA. Translation: CAI16305.1.
CH471148 Genomic DNA. Translation: EAW77198.1.
BC136736 mRNA. Translation: AAI36737.1.
BC136738 mRNA. Translation: AAI36739.1.
BK004376 Genomic DNA. Translation: DAA04774.1.
CCDSiCCDS31094.1.
RefSeqiNP_001005487.1. NM_001005487.1.
UniGeneiHs.553834.

3D structure databases

ProteinModelPortaliQ8NGZ3.
SMRiQ8NGZ3. Positions 25-155.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000352717.

Protein family/group databases

GPCRDBiSearch...

Polymorphism and mutation databases

BioMutaiOR13G1.
DMDMi38372793.

Proteomic databases

PaxDbiQ8NGZ3.
PRIDEiQ8NGZ3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000359688; ENSP00000352717; ENSG00000197437.
GeneIDi441933.
KEGGihsa:441933.
UCSCiuc001idi.1. human.

Organism-specific databases

CTDi441933.
GeneCardsiOR13G1.
HGNCiHGNC:14999. OR13G1.
MIMi611677. gene.
neXtProtiNX_Q8NGZ3.
PharmGKBiPA32046.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IKYT. Eukaryota.
ENOG410YX9S. LUCA.
GeneTreeiENSGT00440000034500.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiQ8NGZ3.
KOiK04257.
OMAiMYVFLLT.
OrthoDBiEOG71K63J.
PhylomeDBiQ8NGZ3.
TreeFamiTF339741.

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR13G1.
GenomeRNAii441933.
NextBioi110597.
PROiQ8NGZ3.
SOURCEiSearch...

Gene expression databases

BgeeiQ8NGZ3.
CleanExiHS_OR13G1.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. Cited for: IDENTIFICATION.
  6. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiO13G1_HUMAN
AccessioniPrimary (citable) accession number: Q8NGZ3
Secondary accession number(s): B2RN80, Q5T2T2, Q6IF86
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: January 20, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.