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Q8NGZ2

- O14K1_HUMAN

UniProt

Q8NGZ2 - O14K1_HUMAN

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Protein

Olfactory receptor 14K1

Gene
OR14K1, OR5AY1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Odorant receptor Reviewed prediction.

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 14K1
Alternative name(s):
Olfactory receptor 5AY1
Olfactory receptor OR1-39
Gene namesi
Name:OR14K1
Synonyms:OR5AY1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:15025. OR14K1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2323Extracellular Reviewed predictionAdd
BLAST
Transmembranei24 – 4421Helical; Name=1; Reviewed predictionAdd
BLAST
Topological domaini45 – 528Cytoplasmic Reviewed prediction
Transmembranei53 – 7321Helical; Name=2; Reviewed predictionAdd
BLAST
Topological domaini74 – 9724Extracellular Reviewed predictionAdd
BLAST
Transmembranei98 – 11821Helical; Name=3; Reviewed predictionAdd
BLAST
Topological domaini119 – 13113Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei132 – 15221Helical; Name=4; Reviewed predictionAdd
BLAST
Topological domaini153 – 19442Extracellular Reviewed predictionAdd
BLAST
Transmembranei195 – 21521Helical; Name=5; Reviewed predictionAdd
BLAST
Topological domaini216 – 23520Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei236 – 25621Helical; Name=6; Reviewed predictionAdd
BLAST
Topological domaini257 – 26913Extracellular Reviewed predictionAdd
BLAST
Transmembranei270 – 29021Helical; Name=7; Reviewed predictionAdd
BLAST
Topological domaini291 – 31424Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32478.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 314314Olfactory receptor 14K1PRO_0000150584Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi3 – 31N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi95 ↔ 187 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ8NGZ2.

Expressioni

Gene expression databases

GenevestigatoriQ8NGZ2.

Organism-specific databases

HPAiHPA016643.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000283225.

Structurei

3D structure databases

ProteinModelPortaliQ8NGZ2.
SMRiQ8NGZ2. Positions 23-148.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG253810.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ8NGZ2.
OMAiMAMYFFL.
OrthoDBiEOG7M98H6.
PhylomeDBiQ8NGZ2.
TreeFamiTF352740.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGZ2-1 [UniParc]FASTAAdd to Basket

« Hide

MTNQTQMMEF LLVRFTENWV LLRLHALLFS LIYLTAVLMN LVIILLMILD    50
HRLHMAMYFF LRHLSFLDLC LISATVPKSI LNSVASTDSI SFLGCVLQLF 100
LVVLLAGSEI GILTAMSYDR YAAICCPLHC EAVMSRGLCV QLMALSWLNR 150
GALGLLYTAG TFSLNFYGSD ELHQFFCDVP ALLKLTCSKE HAIISVSVAI 200
GVCYAFSCLV CIVVSYVYIF SAVLRISQRQ RQSKAFSNCV PHLIVVTVFL 250
VTGAVAYLKP GSDAPSILDL LVSVFYSVAP PTLNPVIYCL KNKDIKSALS 300
KVLWNVRSSG VMKR 314
Length:314
Mass (Da):34,861
Last modified:October 14, 2008 - v2
Checksum:i7E1A52654C6F36D8
GO

Sequence cautioni

The sequence BAC05850.1 differs from that shown. Reason: Frameshift at position 314.
The sequence DAA04775.1 differs from that shown. Reason: Frameshift at position 314.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB065624 Genomic DNA. Translation: BAC05850.1. Frameshift.
AC118470 Genomic DNA. No translation available.
CH471148 Genomic DNA. Translation: EAW77201.1.
AF399590 Genomic DNA. Translation: AAK95075.1.
BK004377 Genomic DNA. Translation: DAA04775.1. Frameshift.

Genome annotation databases

EnsembliENST00000283225; ENSP00000283225; ENSG00000153230.

Polymorphism databases

DMDMi209572655.

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB065624 Genomic DNA. Translation: BAC05850.1 . Frameshift.
AC118470 Genomic DNA. No translation available.
CH471148 Genomic DNA. Translation: EAW77201.1 .
AF399590 Genomic DNA. Translation: AAK95075.1 .
BK004377 Genomic DNA. Translation: DAA04775.1 . Frameshift.

3D structure databases

ProteinModelPortali Q8NGZ2.
SMRi Q8NGZ2. Positions 23-148.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000283225.

Protein family/group databases

GPCRDBi Search...

Polymorphism databases

DMDMi 209572655.

Proteomic databases

PRIDEi Q8NGZ2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000283225 ; ENSP00000283225 ; ENSG00000153230 .

Organism-specific databases

GeneCardsi GC01P247901.
H-InvDB HIX0028861.
HGNCi HGNC:15025. OR14K1.
HPAi HPA016643.
neXtProti NX_Q8NGZ2.
PharmGKBi PA32478.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG253810.
HOGENOMi HOG000041364.
HOVERGENi HBG017625.
InParanoidi Q8NGZ2.
OMAi MAMYFFL.
OrthoDBi EOG7M98H6.
PhylomeDBi Q8NGZ2.
TreeFami TF352740.

Enzyme and pathway databases

Reactomei REACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

PROi Q8NGZ2.

Gene expression databases

Genevestigatori Q8NGZ2.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 66-282.
  5. Cited for: IDENTIFICATION.
  6. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiO14K1_HUMAN
AccessioniPrimary (citable) accession number: Q8NGZ2
Secondary accession number(s): A8MPV5, Q6IF85, Q96R53
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 14, 2008
Last modified: September 3, 2014
This is version 94 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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