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Protein

Olfactory receptor 14K1

Gene

OR14K1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 14K1
Alternative name(s):
Olfactory receptor 5AY1
Olfactory receptor OR1-39
Gene namesi
Name:OR14K1
Synonyms:OR5AY1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:15025. OR14K1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2323ExtracellularSequence AnalysisAdd
BLAST
Transmembranei24 – 4421Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini45 – 528CytoplasmicSequence Analysis
Transmembranei53 – 7321Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini74 – 9724ExtracellularSequence AnalysisAdd
BLAST
Transmembranei98 – 11821Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini119 – 13113CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei132 – 15221Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini153 – 19442ExtracellularSequence AnalysisAdd
BLAST
Transmembranei195 – 21521Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini216 – 23520CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei236 – 25621Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini257 – 26913ExtracellularSequence AnalysisAdd
BLAST
Transmembranei270 – 29021Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini291 – 31424CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32478.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 314314Olfactory receptor 14K1PRO_0000150584Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi3 – 31N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi95 ↔ 187PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ8NGZ2.

Expressioni

Gene expression databases

GenevestigatoriQ8NGZ2.

Organism-specific databases

HPAiHPA016643.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000283225.

Structurei

3D structure databases

ProteinModelPortaliQ8NGZ2.
SMRiQ8NGZ2. Positions 23-148.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG253810.
GeneTreeiENSGT00760000118849.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ8NGZ2.
OMAiMAMYFFL.
OrthoDBiEOG7M98H6.
PhylomeDBiQ8NGZ2.
TreeFamiTF352740.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGZ2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTNQTQMMEF LLVRFTENWV LLRLHALLFS LIYLTAVLMN LVIILLMILD
60 70 80 90 100
HRLHMAMYFF LRHLSFLDLC LISATVPKSI LNSVASTDSI SFLGCVLQLF
110 120 130 140 150
LVVLLAGSEI GILTAMSYDR YAAICCPLHC EAVMSRGLCV QLMALSWLNR
160 170 180 190 200
GALGLLYTAG TFSLNFYGSD ELHQFFCDVP ALLKLTCSKE HAIISVSVAI
210 220 230 240 250
GVCYAFSCLV CIVVSYVYIF SAVLRISQRQ RQSKAFSNCV PHLIVVTVFL
260 270 280 290 300
VTGAVAYLKP GSDAPSILDL LVSVFYSVAP PTLNPVIYCL KNKDIKSALS
310
KVLWNVRSSG VMKR
Length:314
Mass (Da):34,861
Last modified:October 14, 2008 - v2
Checksum:i7E1A52654C6F36D8
GO

Sequence cautioni

The sequence BAC05850.1 differs from that shown. Reason: Frameshift at position 314. Curated
The sequence DAA04775.1 differs from that shown. Reason: Frameshift at position 314. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065624 Genomic DNA. Translation: BAC05850.1. Frameshift.
AC118470 Genomic DNA. No translation available.
CH471148 Genomic DNA. Translation: EAW77201.1.
AF399590 Genomic DNA. Translation: AAK95075.1.
BK004377 Genomic DNA. Translation: DAA04775.1. Frameshift.

Genome annotation databases

EnsembliENST00000283225; ENSP00000283225; ENSG00000153230.

Polymorphism databases

DMDMi209572655.

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065624 Genomic DNA. Translation: BAC05850.1. Frameshift.
AC118470 Genomic DNA. No translation available.
CH471148 Genomic DNA. Translation: EAW77201.1.
AF399590 Genomic DNA. Translation: AAK95075.1.
BK004377 Genomic DNA. Translation: DAA04775.1. Frameshift.

3D structure databases

ProteinModelPortaliQ8NGZ2.
SMRiQ8NGZ2. Positions 23-148.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000283225.

Protein family/group databases

GPCRDBiSearch...

Polymorphism databases

DMDMi209572655.

Proteomic databases

PRIDEiQ8NGZ2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000283225; ENSP00000283225; ENSG00000153230.

Organism-specific databases

GeneCardsiGC01P247901.
H-InvDBHIX0028861.
HGNCiHGNC:15025. OR14K1.
HPAiHPA016643.
neXtProtiNX_Q8NGZ2.
PharmGKBiPA32478.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG253810.
GeneTreeiENSGT00760000118849.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ8NGZ2.
OMAiMAMYFFL.
OrthoDBiEOG7M98H6.
PhylomeDBiQ8NGZ2.
TreeFamiTF352740.

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

PROiQ8NGZ2.

Gene expression databases

GenevestigatoriQ8NGZ2.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 66-282.
  5. Cited for: IDENTIFICATION.
  6. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiO14K1_HUMAN
AccessioniPrimary (citable) accession number: Q8NGZ2
Secondary accession number(s): A8MPV5, Q6IF85, Q96R53
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 14, 2008
Last modified: January 7, 2015
This is version 97 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.