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Protein

Olfactory receptor 2L8

Gene

OR2L8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

BioCyciZFISH:G66-31164-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 2L8
Alternative name(s):
Olfactory receptor OR1-46
Gene namesi
Name:OR2L8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:15014. OR2L8.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 24ExtracellularSequence analysisAdd BLAST24
Transmembranei25 – 48Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini49 – 56CytoplasmicSequence analysis8
Transmembranei57 – 78Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini79 – 99ExtracellularSequence analysisAdd BLAST21
Transmembranei100 – 119Helical; Name=3Sequence analysisAdd BLAST20
Topological domaini120 – 138CytoplasmicSequence analysisAdd BLAST19
Transmembranei139 – 157Helical; Name=4Sequence analysisAdd BLAST19
Topological domaini158 – 194ExtracellularSequence analysisAdd BLAST37
Transmembranei195 – 218Helical; Name=5Sequence analysisAdd BLAST24
Topological domaini219 – 235CytoplasmicSequence analysisAdd BLAST17
Transmembranei236 – 258Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini259 – 271ExtracellularSequence analysisAdd BLAST13
Transmembranei272 – 291Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini292 – 312CytoplasmicSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000279263.
PharmGKBiPA32189.

Polymorphism and mutation databases

BioMutaiOR2L8.
DMDMi38372791.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001504891 – 312Olfactory receptor 2L8Add BLAST312

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...)Sequence analysis1
Glycosylationi88N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi96 ↔ 188PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGY9.
PeptideAtlasiQ8NGY9.
PRIDEiQ8NGY9.

Expressioni

Gene expression databases

CleanExiHS_OR2L8.

Organism-specific databases

HPAiCAB069423.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000349719.

Structurei

3D structure databases

ProteinModelPortaliQ8NGY9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IIYV. Eukaryota.
ENOG41116WC. LUCA.
GeneTreeiENSGT00760000119248.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiQ8NGY9.
KOiK04257.
OMAiSASMAYD.
OrthoDBiEOG091G0F82.
PhylomeDBiQ8NGY9.
TreeFamiTF337295.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGY9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MENYNQTSTD FILLGLFPPS RIDLFFFILI VFIFLMALIG NLSMILLIFL
60 70 80 90 100
DTHLHTPMYF LLSQLSLIDL NYISTIVPKM ASDFLHGNKS ISFTGCGIQS
110 120 130 140 150
FFFLALGGAE ALLLASMAYD RYIAICFPLH YLIRMSKRVC VLMITGSWII
160 170 180 190 200
GSINACAHTV YVLHIPYCRS RAINHFFCDV PAMVTLACMD TWVYEGTVFL
210 220 230 240 250
SATIFLVFPF IGISCSYGQV LFAVYHMKSA EGRKKAYLTC STHLTVVTFY
260 270 280 290 300
YAPFVYTYLR PRSLRSPTED KVLAVFYTIL TPMLNPIIYS LRNKEVMGAL
310
TRVSQRICSV KM
Length:312
Mass (Da):35,444
Last modified:October 1, 2002 - v1
Checksum:i845325F98685A4D4
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_059987196G → C.Corresponds to variant rs4925788dbSNPEnsembl.1
Natural variantiVAR_059988202A → T.Corresponds to variant rs4925790dbSNPEnsembl.1
Natural variantiVAR_053147217Y → C.Corresponds to variant rs4925583dbSNPEnsembl.1
Natural variantiVAR_062024226H → R.Corresponds to variant rs4925792dbSNPEnsembl.1
Natural variantiVAR_059989294K → R.Corresponds to variant rs10888282dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065627 Genomic DNA. Translation: BAC05853.1.
BK004459 Genomic DNA. Translation: DAA04857.1.
RefSeqiNP_001001963.1. NM_001001963.1.
UniGeneiHs.690212.

Genome annotation databases

EnsembliENST00000623922; ENSP00000485287; ENSG00000279263.
GeneIDi391190.
KEGGihsa:391190.
UCSCiuc001idt.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065627 Genomic DNA. Translation: BAC05853.1.
BK004459 Genomic DNA. Translation: DAA04857.1.
RefSeqiNP_001001963.1. NM_001001963.1.
UniGeneiHs.690212.

3D structure databases

ProteinModelPortaliQ8NGY9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000349719.

Protein family/group databases

GPCRDBiSearch...

Polymorphism and mutation databases

BioMutaiOR2L8.
DMDMi38372791.

Proteomic databases

PaxDbiQ8NGY9.
PeptideAtlasiQ8NGY9.
PRIDEiQ8NGY9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000623922; ENSP00000485287; ENSG00000279263.
GeneIDi391190.
KEGGihsa:391190.
UCSCiuc001idt.1. human.

Organism-specific databases

CTDi391190.
GeneCardsiOR2L8.
H-InvDBHIX0028952.
HGNCiHGNC:15014. OR2L8.
HPAiCAB069423.
neXtProtiNX_Q8NGY9.
OpenTargetsiENSG00000279263.
PharmGKBiPA32189.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IIYV. Eukaryota.
ENOG41116WC. LUCA.
GeneTreeiENSGT00760000119248.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiQ8NGY9.
KOiK04257.
OMAiSASMAYD.
OrthoDBiEOG091G0F82.
PhylomeDBiQ8NGY9.
TreeFamiTF337295.

Enzyme and pathway databases

BioCyciZFISH:G66-31164-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR2L8.
GenomeRNAii391190.
PROiQ8NGY9.

Gene expression databases

CleanExiHS_OR2L8.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOR2L8_HUMAN
AccessioniPrimary (citable) accession number: Q8NGY9
Secondary accession number(s): Q6IF03
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: November 2, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.