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Protein

Olfactory receptor 6N2

Gene

OR6N2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 6N2
Alternative name(s):
Olfactory receptor OR1-23
Gene namesi
Name:OR6N2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:15035. OR6N2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2525ExtracellularSequence analysisAdd
BLAST
Transmembranei26 – 4621Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini47 – 548CytoplasmicSequence analysis
Transmembranei55 – 7521Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini76 – 9924ExtracellularSequence analysisAdd
BLAST
Transmembranei100 – 12021Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini121 – 13919CytoplasmicSequence analysisAdd
BLAST
Transmembranei140 – 16021Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini161 – 19737ExtracellularSequence analysisAdd
BLAST
Transmembranei198 – 21720Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini218 – 23720CytoplasmicSequence analysisAdd
BLAST
Transmembranei238 – 25821Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini259 – 27113ExtracellularSequence analysisAdd
BLAST
Transmembranei272 – 29221Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini293 – 31725CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32600.

Polymorphism and mutation databases

BioMutaiOR6N2.
DMDMi38372789.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 317317Olfactory receptor 6N2PRO_0000150634Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...)Sequence analysis
Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGY6.
PeptideAtlasiQ8NGY6.
PRIDEiQ8NGY6.

PTM databases

iPTMnetiQ8NGY6.

Expressioni

Gene expression databases

CleanExiHS_OR6N2.

Organism-specific databases

HPAiHPA056637.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000344101.

Structurei

3D structure databases

ProteinModelPortaliQ8NGY6.
SMRiQ8NGY6. Positions 36-305.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IHMU. Eukaryota.
ENOG410YFWH. LUCA.
GeneTreeiENSGT00840000129709.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiQ8NGY6.
KOiK04257.
OMAiFTICGNM.
OrthoDBiEOG71K63J.
PhylomeDBiQ8NGY6.
TreeFamiTF337673.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGY6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDQYNHSSLA EFVFLGFASV GYVRGWLFVL LLLAYLFTIC GNMLIFSVIR
60 70 80 90 100
LDAALHTPMY HFVSVLSFLE LWYTATTIPK MLSNILSEKK TISFAGCLLQ
110 120 130 140 150
TYFFHSLGAS ECYLLTAMAY DRYLAICRPL HYPIIMTTTL CAKMAAACWT
160 170 180 190 200
CGFLCPISEV ILASQLPFCA YNEIQHIFCD FPPLLSLACK DTSANILVDF
210 220 230 240 250
AINAFIILIT FFFIMISYAR IIGAVLKIKT ASGRKKAFST CASHLAVVLI
260 270 280 290 300
FFGSIIFMYV RLKKSYSLTL DRTLAIVYSV LTPMVNPIIY SLRNKEIIKA
310
IKRTIFQKGD KASLAHL
Length:317
Mass (Da):35,692
Last modified:October 1, 2002 - v1
Checksum:iD6CAD3D00B0C981D
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti204 – 2041A → V.
Corresponds to variant rs12027473 [ dbSNP | Ensembl ].
VAR_053224
Natural varianti250 – 2501I → V.
Corresponds to variant rs41273541 [ dbSNP | Ensembl ].
VAR_062054

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065630 Genomic DNA. Translation: BAC05856.1.
AL513205 Genomic DNA. Translation: CAH73793.1.
CH471121 Genomic DNA. Translation: EAW52809.1.
BK004200 Genomic DNA. Translation: DAA04598.1.
CCDSiCCDS30906.1.
RefSeqiNP_001005278.1. NM_001005278.1.
UniGeneiHs.554487.

Genome annotation databases

EnsembliENST00000339258; ENSP00000344101; ENSG00000188340.
GeneIDi81442.
KEGGihsa:81442.
UCSCiuc010pir.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065630 Genomic DNA. Translation: BAC05856.1.
AL513205 Genomic DNA. Translation: CAH73793.1.
CH471121 Genomic DNA. Translation: EAW52809.1.
BK004200 Genomic DNA. Translation: DAA04598.1.
CCDSiCCDS30906.1.
RefSeqiNP_001005278.1. NM_001005278.1.
UniGeneiHs.554487.

3D structure databases

ProteinModelPortaliQ8NGY6.
SMRiQ8NGY6. Positions 36-305.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000344101.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ8NGY6.

Polymorphism and mutation databases

BioMutaiOR6N2.
DMDMi38372789.

Proteomic databases

PaxDbiQ8NGY6.
PeptideAtlasiQ8NGY6.
PRIDEiQ8NGY6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000339258; ENSP00000344101; ENSG00000188340.
GeneIDi81442.
KEGGihsa:81442.
UCSCiuc010pir.2. human.

Organism-specific databases

CTDi81442.
GeneCardsiOR6N2.
HGNCiHGNC:15035. OR6N2.
HPAiHPA056637.
neXtProtiNX_Q8NGY6.
PharmGKBiPA32600.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IHMU. Eukaryota.
ENOG410YFWH. LUCA.
GeneTreeiENSGT00840000129709.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiQ8NGY6.
KOiK04257.
OMAiFTICGNM.
OrthoDBiEOG71K63J.
PhylomeDBiQ8NGY6.
TreeFamiTF337673.

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR6N2.
GenomeRNAii81442.
PROiQ8NGY6.

Gene expression databases

CleanExiHS_OR6N2.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: IDENTIFICATION.
  5. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiOR6N2_HUMAN
AccessioniPrimary (citable) accession number: Q8NGY6
Secondary accession number(s): Q6IFR2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: June 8, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.