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Protein

Olfactory receptor 6N1

Gene

OR6N1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

BioCyciZFISH:G66-32566-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 6N1
Gene namesi
Name:OR6N1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:15034. OR6N1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 25ExtracellularSequence analysisAdd BLAST25
Transmembranei26 – 46Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini47 – 54CytoplasmicSequence analysis8
Transmembranei55 – 75Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini76 – 99ExtracellularSequence analysisAdd BLAST24
Transmembranei100 – 120Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini121 – 139CytoplasmicSequence analysisAdd BLAST19
Transmembranei140 – 160Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini161 – 197ExtracellularSequence analysisAdd BLAST37
Transmembranei198 – 217Helical; Name=5Sequence analysisAdd BLAST20
Topological domaini218 – 237CytoplasmicSequence analysisAdd BLAST20
Transmembranei238 – 258Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini259 – 271ExtracellularSequence analysisAdd BLAST13
Transmembranei272 – 292Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini293 – 312CytoplasmicSequence analysisAdd BLAST20

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi128372.
OpenTargetsiENSG00000197403.
PharmGKBiPA32599.

Polymorphism and mutation databases

BioMutaiOR6N1.
DMDMi38372788.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001506331 – 312Olfactory receptor 6N1Add BLAST312

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGY5.
PRIDEiQ8NGY5.

PTM databases

iPTMnetiQ8NGY5.
PhosphoSitePlusiQ8NGY5.

Expressioni

Gene expression databases

CleanExiHS_OR6N1.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000335535.

Structurei

3D structure databases

ProteinModelPortaliQ8NGY5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IHMU. Eukaryota.
ENOG410YFWH. LUCA.
GeneTreeiENSGT00840000129709.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiQ8NGY5.
KOiK04257.
OMAiWSQVTEF.
OrthoDBiEOG091G0AZH.
PhylomeDBiQ8NGY5.
TreeFamiTF337673.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGY5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDTGNWSQVA EFIILGFPHL QGVQIYLFLL LLLIYLMTVL GNLLIFLVVC
60 70 80 90 100
LDSRLHTPMY HFVSILSFSE LGYTAATIPK MLANLLSEKK TISFSGCLLQ
110 120 130 140 150
IYFFHSLGAT ECYLLTAMAY DRYLAICRPL HYPTLMTPTL CAEIAIGCWL
160 170 180 190 200
GGLAGPVVEI SLISRLPFCG PNRIQHVFCD FPPVLSLACT DTSINVLVDF
210 220 230 240 250
VINSCKILAT FLLILCSYVQ IICTVLRIPS AAGKRKAIST CASHFTVVLI
260 270 280 290 300
FYGSILSMYV QLKKSYSLDY DQALAVVYSV LTPFLNPFIY SLRNKEIKEA
310
VRRQLKRIGI LA
Length:312
Mass (Da):34,869
Last modified:October 1, 2002 - v1
Checksum:iC29620BD9950DCB3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti86L → F in AAK95093 (PubMed:12213199).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02410610A → T.Corresponds to variant rs1864346dbSNPEnsembl.1
Natural variantiVAR_024107194I → T.1 PublicationCorresponds to variant rs857827dbSNPEnsembl.1
Natural variantiVAR_053223245F → L.1 PublicationCorresponds to variant rs857826dbSNPEnsembl.1
Natural variantiVAR_024108261Q → R.1 PublicationCorresponds to variant rs857825dbSNPEnsembl.1
Natural variantiVAR_024109293R → H.Corresponds to variant rs857824dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065631 Genomic DNA. Translation: BAC05857.1.
AL513205 Genomic DNA. Translation: CAH73792.1.
AF399608 Genomic DNA. Translation: AAK95093.1.
CCDSiCCDS30905.1.
RefSeqiNP_001005185.1. NM_001005185.1.
XP_016855814.1. XM_017000325.1.
XP_016855815.1. XM_017000326.1.
XP_016855816.1. XM_017000327.1.
UniGeneiHs.553592.

Genome annotation databases

EnsembliENST00000335094; ENSP00000335535; ENSG00000197403.
GeneIDi128372.
KEGGihsa:128372.
UCSCiuc010piq.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065631 Genomic DNA. Translation: BAC05857.1.
AL513205 Genomic DNA. Translation: CAH73792.1.
AF399608 Genomic DNA. Translation: AAK95093.1.
CCDSiCCDS30905.1.
RefSeqiNP_001005185.1. NM_001005185.1.
XP_016855814.1. XM_017000325.1.
XP_016855815.1. XM_017000326.1.
XP_016855816.1. XM_017000327.1.
UniGeneiHs.553592.

3D structure databases

ProteinModelPortaliQ8NGY5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000335535.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ8NGY5.
PhosphoSitePlusiQ8NGY5.

Polymorphism and mutation databases

BioMutaiOR6N1.
DMDMi38372788.

Proteomic databases

PaxDbiQ8NGY5.
PRIDEiQ8NGY5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000335094; ENSP00000335535; ENSG00000197403.
GeneIDi128372.
KEGGihsa:128372.
UCSCiuc010piq.2. human.

Organism-specific databases

CTDi128372.
DisGeNETi128372.
GeneCardsiOR6N1.
HGNCiHGNC:15034. OR6N1.
neXtProtiNX_Q8NGY5.
OpenTargetsiENSG00000197403.
PharmGKBiPA32599.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IHMU. Eukaryota.
ENOG410YFWH. LUCA.
GeneTreeiENSGT00840000129709.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiQ8NGY5.
KOiK04257.
OMAiWSQVTEF.
OrthoDBiEOG091G0AZH.
PhylomeDBiQ8NGY5.
TreeFamiTF337673.

Enzyme and pathway databases

BioCyciZFISH:G66-32566-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR6N1.
GenomeRNAii128372.
PROiQ8NGY5.

Gene expression databases

CleanExiHS_OR6N1.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOR6N1_HUMAN
AccessioniPrimary (citable) accession number: Q8NGY5
Secondary accession number(s): Q5VUU8, Q96R35
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: November 2, 2016
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.