OR6N1

Functionⁱ

Odorant receptor.Curated

GO - Molecular functionⁱ

G-protein coupled receptor activity Source: UniProtKB-KW
olfactory receptor activity Source: GO_Central

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

G-protein coupled receptor signaling pathway Source: GO_Central
sensory perception of smell Source: GO_Central

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	G-protein coupled receptor, Receptor, Transducer
Biological process	Olfaction, Sensory transduction

Enzyme and pathway databases

Reactomeⁱ	R-HSA-381753 Olfactory Signaling Pathway

Reactomeⁱ

R-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Olfactory receptor 6N1
Gene namesⁱ	Name:OR6N1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000197403.3
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:15034 OR6N1
neXtProtⁱ	NX_Q8NGY5

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 25	ExtracellularSequence analysisAdd BLAST	25
Transmembraneⁱ	26 – 46	Helical; Name=1Sequence analysisAdd BLAST	21
Topological domainⁱ	47 – 54	CytoplasmicSequence analysis	8
Transmembraneⁱ	55 – 75	Helical; Name=2Sequence analysisAdd BLAST	21
Topological domainⁱ	76 – 99	ExtracellularSequence analysisAdd BLAST	24
Transmembraneⁱ	100 – 120	Helical; Name=3Sequence analysisAdd BLAST	21
Topological domainⁱ	121 – 139	CytoplasmicSequence analysisAdd BLAST	19
Transmembraneⁱ	140 – 160	Helical; Name=4Sequence analysisAdd BLAST	21
Topological domainⁱ	161 – 197	ExtracellularSequence analysisAdd BLAST	37
Transmembraneⁱ	198 – 217	Helical; Name=5Sequence analysisAdd BLAST	20
Topological domainⁱ	218 – 237	CytoplasmicSequence analysisAdd BLAST	20
Transmembraneⁱ	238 – 258	Helical; Name=6Sequence analysisAdd BLAST	21
Topological domainⁱ	259 – 271	ExtracellularSequence analysisAdd BLAST	13
Transmembraneⁱ	272 – 292	Helical; Name=7Sequence analysisAdd BLAST	21
Topological domainⁱ	293 – 312	CytoplasmicSequence analysisAdd BLAST	20

Keywords - Cellular componentⁱ

Cell membrane, Membrane

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000197403
PharmGKBⁱ	PA32599

Polymorphism and mutation databases

BioMutaⁱ	OR6N1
DMDMⁱ	38372788

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000150633	1 – 312	Olfactory receptor 6N1Add BLAST		312

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Glycosylationⁱ	5	N-linked (GlcNAc...) asparagineSequence analysis		1
Disulfide bondⁱ	97 ↔ 189	PROSITE-ProRule annotation

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbⁱ	Q8NGY5
PeptideAtlas More...PeptideAtlasⁱ	Q8NGY5
PRIDEⁱ	Q8NGY5

PTM databases

iPTMnetⁱ	Q8NGY5
PhosphoSitePlusⁱ	Q8NGY5

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000197403
CleanExⁱ	HS_OR6N1

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	9606.ENSP00000335535

STRINGⁱ

9606.ENSP00000335535

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q8NGY5
SMRⁱ	Q8NGY5
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410IHMU Eukaryota ENOG410YFWH LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00890000139407
HOGENOMⁱ	HOG000041362
HOVERGENⁱ	HBG017625
InParanoidⁱ	Q8NGY5
KEGG Orthology (KO) More...KOⁱ	K04257
OMAⁱ	WSQVTEF
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0AZH
PhylomeDBⁱ	Q8NGY5
TreeFamⁱ	TF337673

Family and domain databases

InterProⁱ	View protein in InterPro IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM IPR000725 Olfact_rcpt
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF13853 7tm_4, 1 hit
PRINTSⁱ	PR00237 GPCRRHODOPSN PR00245 OLFACTORYR
PROSITEⁱ	View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q8NGY5-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MDTGNWSQVA EFIILGFPHL QGVQIYLFLL LLLIYLMTVL GNLLIFLVVC 
        60         70         80         90        100
LDSRLHTPMY HFVSILSFSE LGYTAATIPK MLANLLSEKK TISFSGCLLQ 
       110        120        130        140        150
IYFFHSLGAT ECYLLTAMAY DRYLAICRPL HYPTLMTPTL CAEIAIGCWL 
       160        170        180        190        200
GGLAGPVVEI SLISRLPFCG PNRIQHVFCD FPPVLSLACT DTSINVLVDF 
       210        220        230        240        250
VINSCKILAT FLLILCSYVQ IICTVLRIPS AAGKRKAIST CASHFTVVLI 
       260        270        280        290        300
FYGSILSMYV QLKKSYSLDY DQALAVVYSV LTPFLNPFIY SLRNKEIKEA 
       310 
VRRQLKRIGI LA

Length:312

Mass (Da):34,869

Last modified:October 1, 2002 - v1

Checksum:ⁱC29620BD9950DCB3

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	86	L → F in AAK95093 (PubMed:12213199).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_024106	10	A → T. Corresponds to variant dbSNP:rs1864346Ensembl.	1
Natural variantⁱVAR_024107	194	I → T1 PublicationCorresponds to variant dbSNP:rs857827Ensembl.	1
Natural variantⁱVAR_053223	245	F → L1 PublicationCorresponds to variant dbSNP:rs857826Ensembl.	1
Natural variantⁱVAR_024108	261	Q → R1 PublicationCorresponds to variant dbSNP:rs857825Ensembl.	1
Natural variantⁱVAR_024109	293	R → H. Corresponds to variant dbSNP:rs857824Ensembl.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB065631 Genomic DNA Translation: BAC05857.1 AL513205 Genomic DNA No translation available. AF399608 Genomic DNA Translation: AAK95093.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS30905.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001005185.1, NM_001005185.1 XP_016855814.1, XM_017000325.1 XP_016855815.1, XM_017000326.1 XP_016855816.1, XM_017000327.1
UniGeneⁱ	Hs.553592

Genome annotation databases

Ensemblⁱ	ENST00000335094; ENSP00000335535; ENSG00000197403 ENST00000641846; ENSP00000493254; ENSG00000197403
GeneIDⁱ	128372
KEGGⁱ	hsa:128372
UCSC genome browser More...UCSCⁱ	uc010piq.2 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q8NGY5	B2RUT4 Q6IFR3 F7HES3 A0A2J8VH99 F7HXL3 H2P0U2 A0A2K5L2T8 A0A0D9SAM7 G1SBV6 G3R0E9 +13	Homo sapiens (Human) Macaca mulatta (Rhesus macaque) Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) Callithrix jacchus (White-tufted-ear marmoset) Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys) Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus) Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys) Gorilla gorilla gorilla (Western lowland gorilla) Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) Pan paniscus (Pygmy chimpanzee) (Bonobo) And more	312	UniRef90_Q8NGY5	Cluster: Olfactory receptor 6N1	24

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q8NGY5	Q8NGY6 A0A126GV57 UPI00080A572E A0A2J8VHA2 H2N583 UPI0002745650 UPI0005F3ADB7 A0A2J8K5P7 H2R8J5 UPI000625396E +178	Homo sapiens (Human) Cebus capucinus imitator Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) Pan paniscus (Pygmy chimpanzee) (Bonobo) Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys) Pan troglodytes (Chimpanzee) Aotus nancymaae (Ma's night monkey) Macaca mulatta (Rhesus macaque) Mandrillus leucophaeus (Drill) (Papio leucophaeus) Saimiri boliviensis boliviensis (Bolivian squirrel monkey) And more	317	UniRef50_Q8NGY6	Cluster: Olfactory receptor 6N2	189

Cross-referencesⁱ

Web resourcesⁱ

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB065631 Genomic DNA Translation: BAC05857.1 AL513205 Genomic DNA No translation available. AF399608 Genomic DNA Translation: AAK95093.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS30905.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001005185.1, NM_001005185.1 XP_016855814.1, XM_017000325.1 XP_016855815.1, XM_017000326.1 XP_016855816.1, XM_017000327.1
UniGeneⁱ	Hs.553592

3D structure databases

ProteinModelPortalⁱ	Q8NGY5
SMRⁱ	Q8NGY5
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	9606.ENSP00000335535

STRINGⁱ

9606.ENSP00000335535

Protein family/group databases

GPCRDBⁱ	Search...

GPCRDBⁱ

Search...

PTM databases

iPTMnetⁱ	Q8NGY5
PhosphoSitePlusⁱ	Q8NGY5

Polymorphism and mutation databases

BioMutaⁱ	OR6N1
DMDMⁱ	38372788

Proteomic databases

PaxDbⁱ	Q8NGY5
PeptideAtlas More...PeptideAtlasⁱ	Q8NGY5
PRIDEⁱ	Q8NGY5

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000335094; ENSP00000335535; ENSG00000197403 ENST00000641846; ENSP00000493254; ENSG00000197403
GeneIDⁱ	128372
KEGGⁱ	hsa:128372
UCSC genome browser More...UCSCⁱ	uc010piq.2 human

Organism-specific databases

CTDⁱ	128372
EuPathDBⁱ	HostDB:ENSG00000197403.3
GeneCardsⁱ	OR6N1
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:15034 OR6N1
neXtProtⁱ	NX_Q8NGY5
Open Targets More...OpenTargetsⁱ	ENSG00000197403
PharmGKBⁱ	PA32599
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IHMU Eukaryota ENOG410YFWH LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00890000139407
HOGENOMⁱ	HOG000041362
HOVERGENⁱ	HBG017625
InParanoidⁱ	Q8NGY5
KEGG Orthology (KO) More...KOⁱ	K04257
OMAⁱ	WSQVTEF
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0AZH
PhylomeDBⁱ	Q8NGY5
TreeFamⁱ	TF337673

Enzyme and pathway databases

Reactomeⁱ	R-HSA-381753 Olfactory Signaling Pathway

Reactomeⁱ

R-HSA-381753 Olfactory Signaling Pathway

Miscellaneous databases

GeneWikiⁱ	OR6N1
GenomeRNAiⁱ	128372
Protein Ontology More...PROⁱ	PR:Q8NGY5

Gene expression databases

Bgeeⁱ	ENSG00000197403
CleanExⁱ	HS_OR6N1

Family and domain databases

InterProⁱ	View protein in InterPro IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM IPR000725 Olfact_rcpt
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF13853 7tm_4, 1 hit
PRINTSⁱ	PR00237 GPCRRHODOPSN PR00245 OLFACTORYR
PROSITEⁱ	View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	OR6N1_HUMAN
Accessionⁱ	Q8NGY5Primary (citable) accession number: Q8NGY5 Secondary accession number(s): Q5VUU8, Q96R35
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 10, 2003
	Last sequence update:	October 1, 2002
	Last modified:	February 28, 2018
	This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q8NGY5 (OR6N1_HUMAN)

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Olfactory receptor 6N1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Plasma Membrane

Other locations

Topology

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ