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Protein

Olfactory receptor 6N1

Gene

OR6N1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 6N1
Gene namesi
Name:OR6N1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000197403.3
HGNCiHGNC:15034 OR6N1
neXtProtiNX_Q8NGY5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 25ExtracellularSequence analysisAdd BLAST25
Transmembranei26 – 46Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini47 – 54CytoplasmicSequence analysis8
Transmembranei55 – 75Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini76 – 99ExtracellularSequence analysisAdd BLAST24
Transmembranei100 – 120Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini121 – 139CytoplasmicSequence analysisAdd BLAST19
Transmembranei140 – 160Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini161 – 197ExtracellularSequence analysisAdd BLAST37
Transmembranei198 – 217Helical; Name=5Sequence analysisAdd BLAST20
Topological domaini218 – 237CytoplasmicSequence analysisAdd BLAST20
Transmembranei238 – 258Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini259 – 271ExtracellularSequence analysisAdd BLAST13
Transmembranei272 – 292Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini293 – 312CytoplasmicSequence analysisAdd BLAST20

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000197403
PharmGKBiPA32599

Polymorphism and mutation databases

BioMutaiOR6N1
DMDMi38372788

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001506331 – 312Olfactory receptor 6N1Add BLAST312

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGY5
PeptideAtlasiQ8NGY5
PRIDEiQ8NGY5

PTM databases

iPTMnetiQ8NGY5
PhosphoSitePlusiQ8NGY5

Expressioni

Gene expression databases

BgeeiENSG00000197403
CleanExiHS_OR6N1

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000335535

Structurei

3D structure databases

ProteinModelPortaliQ8NGY5
SMRiQ8NGY5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IHMU Eukaryota
ENOG410YFWH LUCA
GeneTreeiENSGT00890000139407
HOGENOMiHOG000041362
HOVERGENiHBG017625
InParanoidiQ8NGY5
KOiK04257
OMAiWSQVTEF
OrthoDBiEOG091G0AZH
PhylomeDBiQ8NGY5
TreeFamiTF337673

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8NGY5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDTGNWSQVA EFIILGFPHL QGVQIYLFLL LLLIYLMTVL GNLLIFLVVC
60 70 80 90 100
LDSRLHTPMY HFVSILSFSE LGYTAATIPK MLANLLSEKK TISFSGCLLQ
110 120 130 140 150
IYFFHSLGAT ECYLLTAMAY DRYLAICRPL HYPTLMTPTL CAEIAIGCWL
160 170 180 190 200
GGLAGPVVEI SLISRLPFCG PNRIQHVFCD FPPVLSLACT DTSINVLVDF
210 220 230 240 250
VINSCKILAT FLLILCSYVQ IICTVLRIPS AAGKRKAIST CASHFTVVLI
260 270 280 290 300
FYGSILSMYV QLKKSYSLDY DQALAVVYSV LTPFLNPFIY SLRNKEIKEA
310
VRRQLKRIGI LA
Length:312
Mass (Da):34,869
Last modified:October 1, 2002 - v1
Checksum:iC29620BD9950DCB3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti86L → F in AAK95093 (PubMed:12213199).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02410610A → T. Corresponds to variant dbSNP:rs1864346Ensembl.1
Natural variantiVAR_024107194I → T1 PublicationCorresponds to variant dbSNP:rs857827Ensembl.1
Natural variantiVAR_053223245F → L1 PublicationCorresponds to variant dbSNP:rs857826Ensembl.1
Natural variantiVAR_024108261Q → R1 PublicationCorresponds to variant dbSNP:rs857825Ensembl.1
Natural variantiVAR_024109293R → H. Corresponds to variant dbSNP:rs857824Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065631 Genomic DNA Translation: BAC05857.1
AL513205 Genomic DNA No translation available.
AF399608 Genomic DNA Translation: AAK95093.1
CCDSiCCDS30905.1
RefSeqiNP_001005185.1, NM_001005185.1
XP_016855814.1, XM_017000325.1
XP_016855815.1, XM_017000326.1
XP_016855816.1, XM_017000327.1
UniGeneiHs.553592

Genome annotation databases

EnsembliENST00000335094; ENSP00000335535; ENSG00000197403
ENST00000641846; ENSP00000493254; ENSG00000197403
GeneIDi128372
KEGGihsa:128372
UCSCiuc010piq.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiOR6N1_HUMAN
AccessioniPrimary (citable) accession number: Q8NGY5
Secondary accession number(s): Q5VUU8, Q96R35
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: February 28, 2018
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome