OR6N1

Functionⁱ

Odorant receptor.Curated

GO - Molecular functionⁱ

G-protein coupled receptor activity Source: UniProtKB-KW
olfactory receptor activity Source: GO_Central

Complete GO annotation...

GO - Biological processⁱ

G-protein coupled receptor signaling pathway Source: GO_Central
sensory perception of smell Source: GO_Central

Complete GO annotation...

Keywordsⁱ

Molecular function	G-protein coupled receptor, Receptor, Transducer
Biological process	Olfaction, Sensory transduction

Enzyme and pathway databases

Reactomeⁱ	R-HSA-381753. Olfactory Signaling Pathway.

Reactomeⁱ

R-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Olfactory receptor 6N1
Gene namesⁱ	Name:OR6N1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database More...HGNCⁱ	HGNC:15034. OR6N1.

HGNCⁱ

HGNC:15034. OR6N1.

Subcellular locationⁱ

Cell membrane; Multi-pass membrane protein

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 25	ExtracellularSequence analysisAdd BLAST	25
Transmembraneⁱ	26 – 46	Helical; Name=1Sequence analysisAdd BLAST	21
Topological domainⁱ	47 – 54	CytoplasmicSequence analysis	8
Transmembraneⁱ	55 – 75	Helical; Name=2Sequence analysisAdd BLAST	21
Topological domainⁱ	76 – 99	ExtracellularSequence analysisAdd BLAST	24
Transmembraneⁱ	100 – 120	Helical; Name=3Sequence analysisAdd BLAST	21
Topological domainⁱ	121 – 139	CytoplasmicSequence analysisAdd BLAST	19
Transmembraneⁱ	140 – 160	Helical; Name=4Sequence analysisAdd BLAST	21
Topological domainⁱ	161 – 197	ExtracellularSequence analysisAdd BLAST	37
Transmembraneⁱ	198 – 217	Helical; Name=5Sequence analysisAdd BLAST	20
Topological domainⁱ	218 – 237	CytoplasmicSequence analysisAdd BLAST	20
Transmembraneⁱ	238 – 258	Helical; Name=6Sequence analysisAdd BLAST	21
Topological domainⁱ	259 – 271	ExtracellularSequence analysisAdd BLAST	13
Transmembraneⁱ	272 – 292	Helical; Name=7Sequence analysisAdd BLAST	21
Topological domainⁱ	293 – 312	CytoplasmicSequence analysisAdd BLAST	20

GO - Cellular componentⁱ

integral component of membrane Source: GO_Central
plasma membrane Source: Reactome

Complete GO annotation...

Keywords - Cellular componentⁱ

Cell membrane, Membrane

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000197403.
PharmGKBⁱ	PA32599.

Polymorphism and mutation databases

BioMutaⁱ	OR6N1.
DMDMⁱ	38372788.

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000150633	1 – 312	Olfactory receptor 6N1Add BLAST		312

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Glycosylationⁱ	5	N-linked (GlcNAc...) asparagineSequence analysis		1
Disulfide bondⁱ	97 ↔ 189	PROSITE-ProRule annotation

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbⁱ	Q8NGY5.
PeptideAtlas More...PeptideAtlasⁱ	Q8NGY5.
PRIDEⁱ	Q8NGY5.

PTM databases

iPTMnetⁱ	Q8NGY5.
PhosphoSitePlusⁱ	Q8NGY5.

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000197403.
CleanExⁱ	HS_OR6N1.

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	9606.ENSP00000335535.

STRINGⁱ

9606.ENSP00000335535.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q8NGY5.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410IHMU. Eukaryota. ENOG410YFWH. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00890000139407.
HOGENOMⁱ	HOG000041362.
HOVERGENⁱ	HBG017625.
InParanoidⁱ	Q8NGY5.
KEGG Orthology (KO) More...KOⁱ	K04257.
OMAⁱ	WSQVTEF.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0AZH.
PhylomeDBⁱ	Q8NGY5.
TreeFamⁱ	TF337673.

Family and domain databases

InterProⁱ	View protein in InterPro IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. IPR000725. Olfact_rcpt.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF13853. 7tm_4. 1 hit.
PRINTSⁱ	PR00237. GPCRRHODOPSN. PR00245. OLFACTORYR.
PROSITEⁱ	View protein in PROSITE PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

Q8NGY5-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MDTGNWSQVA EFIILGFPHL QGVQIYLFLL LLLIYLMTVL GNLLIFLVVC 
        60         70         80         90        100
LDSRLHTPMY HFVSILSFSE LGYTAATIPK MLANLLSEKK TISFSGCLLQ 
       110        120        130        140        150
IYFFHSLGAT ECYLLTAMAY DRYLAICRPL HYPTLMTPTL CAEIAIGCWL 
       160        170        180        190        200
GGLAGPVVEI SLISRLPFCG PNRIQHVFCD FPPVLSLACT DTSINVLVDF 
       210        220        230        240        250
VINSCKILAT FLLILCSYVQ IICTVLRIPS AAGKRKAIST CASHFTVVLI 
       260        270        280        290        300
FYGSILSMYV QLKKSYSLDY DQALAVVYSV LTPFLNPFIY SLRNKEIKEA 
       310 
VRRQLKRIGI LA

Length:312

Mass (Da):34,869

Last modified:October 1, 2002 - v1

Checksum:ⁱC29620BD9950DCB3

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	86	L → F in AAK95093 (PubMed:12213199).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_024106	10	A → T. Corresponds to variant dbSNP:rs1864346Ensembl.	1
Natural variantⁱVAR_024107	194	I → T1 PublicationCorresponds to variant dbSNP:rs857827Ensembl.	1
Natural variantⁱVAR_053223	245	F → L1 PublicationCorresponds to variant dbSNP:rs857826Ensembl.	1
Natural variantⁱVAR_024108	261	Q → R1 PublicationCorresponds to variant dbSNP:rs857825Ensembl.	1
Natural variantⁱVAR_024109	293	R → H. Corresponds to variant dbSNP:rs857824Ensembl.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB065631 Genomic DNA. Translation: BAC05857.1. AL513205 Genomic DNA. No translation available. AF399608 Genomic DNA. Translation: AAK95093.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS30905.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_001005185.1. NM_001005185.1. XP_016855814.1. XM_017000325.1. XP_016855815.1. XM_017000326.1. XP_016855816.1. XM_017000327.1.
UniGeneⁱ	Hs.553592.

Genome annotation databases

Ensemblⁱ	ENST00000335094; ENSP00000335535; ENSG00000197403.
GeneIDⁱ	128372.
KEGGⁱ	hsa:128372.
UCSC genome browser More...UCSCⁱ	uc010piq.2. human.

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

Entry	Cluster members	Organisms	Length	Cluster ID	Cluster name	Size
Q8NGY5	B2RUT4 Q6IFR3 F7HES3 F7HXL3 G3R0E9 G7NWA2 H2P0U2 A0A0D9SAM7 A0A096MLM7 G1SBV6 +10	Homo sapiens (Human) Macaca mulatta (Rhesus macaque) Callithrix jacchus (White-tufted-ear marmoset) Gorilla gorilla gorilla (Western lowland gorilla) Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus) Papio anubis (Olive baboon) Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys) Pan paniscus (Pygmy chimpanzee) (Bonobo) And more	312	UniRef90_Q8NGY5	Cluster: Olfactory receptor 6N1	21

Entry	Cluster members	Organisms	Length	Cluster ID	Cluster name	Size
Q8NGY5	Q8NGY3 A0A0C4DFU5 UPI00027FAB9E G3RHW9 H2R8J7 UPI0000368428 A0A126GV83 UPI000625A06C UPI00080A303A UPI0003ABB2B0 +411	Homo sapiens (Human) Saimiri boliviensis boliviensis (Bolivian squirrel monkey) Gorilla gorilla gorilla (Western lowland gorilla) Pan troglodytes (Chimpanzee) Aotus nancymaae (Ma's night monkey) Cebus capucinus imitator Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) Papio anubis (Olive baboon) Panthera pardus (Leopard) (Felis pardus) Panthera tigris altaica (Siberian tiger) And more	331	UniRef50_Q8NGY3	Cluster: Olfactory receptor 6K3	422

Cross-referencesⁱ

Web resourcesⁱ

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB065631 Genomic DNA. Translation: BAC05857.1. AL513205 Genomic DNA. No translation available. AF399608 Genomic DNA. Translation: AAK95093.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS30905.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_001005185.1. NM_001005185.1. XP_016855814.1. XM_017000325.1. XP_016855815.1. XM_017000326.1. XP_016855816.1. XM_017000327.1.
UniGeneⁱ	Hs.553592.

3D structure databases

ProteinModelPortalⁱ	Q8NGY5.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	9606.ENSP00000335535.

STRINGⁱ

9606.ENSP00000335535.

Protein family/group databases

GPCRDBⁱ	Search...

GPCRDBⁱ

Search...

PTM databases

iPTMnetⁱ	Q8NGY5.
PhosphoSitePlusⁱ	Q8NGY5.

Polymorphism and mutation databases

BioMutaⁱ	OR6N1.
DMDMⁱ	38372788.

Proteomic databases

PaxDbⁱ	Q8NGY5.
PeptideAtlas More...PeptideAtlasⁱ	Q8NGY5.
PRIDEⁱ	Q8NGY5.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000335094; ENSP00000335535; ENSG00000197403.
GeneIDⁱ	128372.
KEGGⁱ	hsa:128372.
UCSC genome browser More...UCSCⁱ	uc010piq.2. human.

Organism-specific databases

CTDⁱ	128372.
GeneCardsⁱ	OR6N1.
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:15034. OR6N1.
neXtProtⁱ	NX_Q8NGY5.
Open Targets More...OpenTargetsⁱ	ENSG00000197403.
PharmGKBⁱ	PA32599.
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IHMU. Eukaryota. ENOG410YFWH. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00890000139407.
HOGENOMⁱ	HOG000041362.
HOVERGENⁱ	HBG017625.
InParanoidⁱ	Q8NGY5.
KEGG Orthology (KO) More...KOⁱ	K04257.
OMAⁱ	WSQVTEF.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0AZH.
PhylomeDBⁱ	Q8NGY5.
TreeFamⁱ	TF337673.

Enzyme and pathway databases

Reactomeⁱ	R-HSA-381753. Olfactory Signaling Pathway.

Reactomeⁱ

R-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiⁱ	OR6N1.
GenomeRNAiⁱ	128372.
Protein Ontology More...PROⁱ	PR:Q8NGY5.

Gene expression databases

Bgeeⁱ	ENSG00000197403.
CleanExⁱ	HS_OR6N1.

Family and domain databases

InterProⁱ	View protein in InterPro IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. IPR000725. Olfact_rcpt.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF13853. 7tm_4. 1 hit.
PRINTSⁱ	PR00237. GPCRRHODOPSN. PR00245. OLFACTORYR.
PROSITEⁱ	View protein in PROSITE PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	OR6N1_HUMAN
Accessionⁱ	Q8NGY5Primary (citable) accession number: Q8NGY5 Secondary accession number(s): Q5VUU8, Q96R35
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 10, 2003
	Last sequence update:	October 1, 2002
	Last modified:	August 30, 2017
	This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries
Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
SIMILARITY comments
Index of protein domains and families

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q8NGY5 (OR6N1_HUMAN)

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Olfactory receptor 6N1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ