UniProtKB - Q8NGY5 (OR6N1_HUMAN)
(max 400 entries)x
Your basket is currently empty. i
Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)
Protein
Olfactory receptor 6N1
Gene
OR6N1
Organism
Homo sapiens (Human)
Status
Functioni
Odorant receptor.Curated
GO - Molecular functioni
- G-protein coupled receptor activity Source: UniProtKB-KW
- olfactory receptor activity Source: GO_Central
GO - Biological processi
- G-protein coupled receptor signaling pathway Source: GO_Central
- sensory perception of smell Source: GO_Central
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Biological process | Olfaction, Sensory transduction |
Enzyme and pathway databases
Reactomei | R-HSA-381753 Olfactory Signaling Pathway |
Names & Taxonomyi
Protein namesi | Recommended name: Olfactory receptor 6N1 |
Gene namesi | Name:OR6N1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000197403.3 |
HGNCi | HGNC:15034 OR6N1 |
neXtProti | NX_Q8NGY5 |
Subcellular locationi
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 25 | ExtracellularSequence analysisAdd BLAST | 25 | |
Transmembranei | 26 – 46 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Topological domaini | 47 – 54 | CytoplasmicSequence analysis | 8 | |
Transmembranei | 55 – 75 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 76 – 99 | ExtracellularSequence analysisAdd BLAST | 24 | |
Transmembranei | 100 – 120 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Topological domaini | 121 – 139 | CytoplasmicSequence analysisAdd BLAST | 19 | |
Transmembranei | 140 – 160 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 161 – 197 | ExtracellularSequence analysisAdd BLAST | 37 | |
Transmembranei | 198 – 217 | Helical; Name=5Sequence analysisAdd BLAST | 20 | |
Topological domaini | 218 – 237 | CytoplasmicSequence analysisAdd BLAST | 20 | |
Transmembranei | 238 – 258 | Helical; Name=6Sequence analysisAdd BLAST | 21 | |
Topological domaini | 259 – 271 | ExtracellularSequence analysisAdd BLAST | 13 | |
Transmembranei | 272 – 292 | Helical; Name=7Sequence analysisAdd BLAST | 21 | |
Topological domaini | 293 – 312 | CytoplasmicSequence analysisAdd BLAST | 20 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000197403 |
PharmGKBi | PA32599 |
Polymorphism and mutation databases
BioMutai | OR6N1 |
DMDMi | 38372788 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000150633 | 1 – 312 | Olfactory receptor 6N1Add BLAST | 312 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 5 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 97 ↔ 189 | PROSITE-ProRule annotation |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
PaxDbi | Q8NGY5 |
PeptideAtlasi | Q8NGY5 |
PRIDEi | Q8NGY5 |
PTM databases
iPTMneti | Q8NGY5 |
PhosphoSitePlusi | Q8NGY5 |
Structurei
3D structure databases
ProteinModelPortali | Q8NGY5 |
SMRi | Q8NGY5 |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG410IHMU Eukaryota ENOG410YFWH LUCA |
GeneTreei | ENSGT00890000139407 |
HOGENOMi | HOG000041362 |
HOVERGENi | HBG017625 |
InParanoidi | Q8NGY5 |
KOi | K04257 |
OMAi | WSQVTEF |
OrthoDBi | EOG091G0AZH |
PhylomeDBi | Q8NGY5 |
TreeFami | TF337673 |
Family and domain databases
InterProi | View protein in InterPro IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM IPR000725 Olfact_rcpt |
Pfami | View protein in Pfam PF13853 7tm_4, 1 hit |
PRINTSi | PR00237 GPCRRHODOPSN PR00245 OLFACTORYR |
PROSITEi | View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q8NGY5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDTGNWSQVA EFIILGFPHL QGVQIYLFLL LLLIYLMTVL GNLLIFLVVC
60 70 80 90 100
LDSRLHTPMY HFVSILSFSE LGYTAATIPK MLANLLSEKK TISFSGCLLQ
110 120 130 140 150
IYFFHSLGAT ECYLLTAMAY DRYLAICRPL HYPTLMTPTL CAEIAIGCWL
160 170 180 190 200
GGLAGPVVEI SLISRLPFCG PNRIQHVFCD FPPVLSLACT DTSINVLVDF
210 220 230 240 250
VINSCKILAT FLLILCSYVQ IICTVLRIPS AAGKRKAIST CASHFTVVLI
260 270 280 290 300
FYGSILSMYV QLKKSYSLDY DQALAVVYSV LTPFLNPFIY SLRNKEIKEA
310
VRRQLKRIGI LA
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 86 | L → F in AAK95093 (PubMed:12213199).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_024106 | 10 | A → T. Corresponds to variant dbSNP:rs1864346Ensembl. | 1 | |
Natural variantiVAR_024107 | 194 | I → T1 PublicationCorresponds to variant dbSNP:rs857827Ensembl. | 1 | |
Natural variantiVAR_053223 | 245 | F → L1 PublicationCorresponds to variant dbSNP:rs857826Ensembl. | 1 | |
Natural variantiVAR_024108 | 261 | Q → R1 PublicationCorresponds to variant dbSNP:rs857825Ensembl. | 1 | |
Natural variantiVAR_024109 | 293 | R → H. Corresponds to variant dbSNP:rs857824Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB065631 Genomic DNA Translation: BAC05857.1 AL513205 Genomic DNA No translation available. AF399608 Genomic DNA Translation: AAK95093.1 |
CCDSi | CCDS30905.1 |
RefSeqi | NP_001005185.1, NM_001005185.1 XP_016855814.1, XM_017000325.1 XP_016855815.1, XM_017000326.1 XP_016855816.1, XM_017000327.1 |
UniGenei | Hs.553592 |
Genome annotation databases
Ensembli | ENST00000335094; ENSP00000335535; ENSG00000197403 ENST00000641846; ENSP00000493254; ENSG00000197403 |
GeneIDi | 128372 |
KEGGi | hsa:128372 |
UCSCi | uc010piq.2 human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Entry informationi
Entry namei | OR6N1_HUMAN | |
Accessioni | Q8NGY5Primary (citable) accession number: Q8NGY5 Secondary accession number(s): Q5VUU8, Q96R35 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 10, 2003 |
Last sequence update: | October 1, 2002 | |
Last modified: | February 28, 2018 | |
This is version 133 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |