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Protein

Olfactory receptor 6K2

Gene

OR6K2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 6K2
Alternative name(s):
Olfactory receptor OR1-17
Gene namesi
Name:OR6K2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:15029. OR6K2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2525ExtracellularSequence analysisAdd
BLAST
Transmembranei26 – 4621Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini47 – 548CytoplasmicSequence analysis
Transmembranei55 – 7521Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini76 – 9823ExtracellularSequence analysisAdd
BLAST
Transmembranei99 – 11921Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini120 – 13819CytoplasmicSequence analysisAdd
BLAST
Transmembranei139 – 15921Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini160 – 19839ExtracellularSequence analysisAdd
BLAST
Transmembranei199 – 21820Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini219 – 23820CytoplasmicSequence analysisAdd
BLAST
Transmembranei239 – 25921Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini260 – 27213ExtracellularSequence analysisAdd
BLAST
Transmembranei273 – 29321Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini294 – 32431CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32589.

Polymorphism and mutation databases

BioMutaiOR6K2.
DMDMi38372786.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 324324Olfactory receptor 6K2PRO_0000150629Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...)Sequence analysis
Disulfide bondi96 ↔ 188PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGY2.
PRIDEiQ8NGY2.

PTM databases

iPTMnetiQ8NGY2.
PhosphoSiteiQ8NGY2.

Expressioni

Gene expression databases

CleanExiHS_OR6K2.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000352626.

Structurei

3D structure databases

ProteinModelPortaliQ8NGY2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJT5. Eukaryota.
ENOG41115SN. LUCA.
GeneTreeiENSGT00840000129709.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiQ8NGY2.
KOiK04257.
OMAiMESPNRT.
OrthoDBiEOG71K63J.
PhylomeDBiQ8NGY2.
TreeFamiTF337562.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGY2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESPNRTTIQ EFIFSAFPYS WVKSVVCFVP LLFIYAFIVV GNLVIITVVQ
60 70 80 90 100
LNTHLHTPMY TFISALSFLE IWYTTATIPK MLSSLLSERS ISFNGCLLQM
110 120 130 140 150
YFFHSTGICE VCLLTVMAFD HYLAICSPLH YPSIMTPKLC TQLTLSCCVC
160 170 180 190 200
GFITPLPEIA WISTLPFCGS NHLEHIFCDF LPVLRLACTD TRAIVMIQVV
210 220 230 240 250
DVIHAVEIIT AVMLIFMSYD GIVAVILRIH SAGGRRTAFS TCVSHFIVFS
260 270 280 290 300
LFFGSVTLMY LRFSATYSLF WDIAIALAFA VLSPFFNPII YSLRNKEIKE
310 320
AIKKHIGQAK IFFSVRPGTS SKIF
Length:324
Mass (Da):36,513
Last modified:October 1, 2002 - v1
Checksum:i7A59114C5A871A86
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti6 – 61R → Q.
Corresponds to variant rs413029 [ dbSNP | Ensembl ].
VAR_034248
Natural varianti156 – 1561L → V.
Corresponds to variant rs423141 [ dbSNP | Ensembl ].
VAR_034249
Natural varianti159 – 1591I → F.
Corresponds to variant rs6686179 [ dbSNP | Ensembl ].
VAR_034250

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065634 Genomic DNA. Translation: BAC05860.1.
AL513205 Genomic DNA. Translation: CAH73787.1.
CH471121 Genomic DNA. Translation: EAW52815.1.
BC137022 mRNA. Translation: AAI37023.1.
BC137023 mRNA. Translation: AAI37024.1.
BK004196 Genomic DNA. Translation: DAA04594.1.
CCDSiCCDS30902.1.
RefSeqiNP_001005279.1. NM_001005279.1.
UniGeneiHs.554489.

Genome annotation databases

EnsembliENST00000359610; ENSP00000352626; ENSG00000196171.
GeneIDi81448.
KEGGihsa:81448.
UCSCiuc001fsu.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065634 Genomic DNA. Translation: BAC05860.1.
AL513205 Genomic DNA. Translation: CAH73787.1.
CH471121 Genomic DNA. Translation: EAW52815.1.
BC137022 mRNA. Translation: AAI37023.1.
BC137023 mRNA. Translation: AAI37024.1.
BK004196 Genomic DNA. Translation: DAA04594.1.
CCDSiCCDS30902.1.
RefSeqiNP_001005279.1. NM_001005279.1.
UniGeneiHs.554489.

3D structure databases

ProteinModelPortaliQ8NGY2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000352626.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ8NGY2.
PhosphoSiteiQ8NGY2.

Polymorphism and mutation databases

BioMutaiOR6K2.
DMDMi38372786.

Proteomic databases

PaxDbiQ8NGY2.
PRIDEiQ8NGY2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000359610; ENSP00000352626; ENSG00000196171.
GeneIDi81448.
KEGGihsa:81448.
UCSCiuc001fsu.1. human.

Organism-specific databases

CTDi81448.
GeneCardsiOR6K2.
HGNCiHGNC:15029. OR6K2.
neXtProtiNX_Q8NGY2.
PharmGKBiPA32589.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJT5. Eukaryota.
ENOG41115SN. LUCA.
GeneTreeiENSGT00840000129709.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiQ8NGY2.
KOiK04257.
OMAiMESPNRT.
OrthoDBiEOG71K63J.
PhylomeDBiQ8NGY2.
TreeFamiTF337562.

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR6K2.
GenomeRNAii81448.
PROiQ8NGY2.

Gene expression databases

CleanExiHS_OR6K2.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  5. Cited for: IDENTIFICATION.
  6. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiOR6K2_HUMAN
AccessioniPrimary (citable) accession number: Q8NGY2
Secondary accession number(s): B9EH33, Q6IFR6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: June 8, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.