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Protein

Olfactory receptor 10Z1

Gene

OR10Z1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: InterPro
  3. transmembrane signaling receptor activity Source: GO_Central

GO - Biological processi

  1. detection of chemical stimulus involved in sensory perception Source: GO_Central
  2. G-protein coupled receptor signaling pathway Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 10Z1
Alternative name(s):
Olfactory receptor OR1-15
Gene namesi
Name:OR10Z1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:14996. OR10Z1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2525ExtracellularSequence AnalysisAdd
BLAST
Transmembranei26 – 4621Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini47 – 548CytoplasmicSequence Analysis
Transmembranei55 – 7521Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini76 – 9924ExtracellularSequence AnalysisAdd
BLAST
Transmembranei100 – 12021Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini121 – 13919CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei140 – 16021Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini161 – 19737ExtracellularSequence AnalysisAdd
BLAST
Transmembranei198 – 21720Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini218 – 23720CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei238 – 25821Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini259 – 27113ExtracellularSequence AnalysisAdd
BLAST
Transmembranei272 – 29221Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini293 – 31321CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: GO_Central
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32009.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 313313Olfactory receptor 10Z1PRO_0000150721Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ8NGY1.

PTM databases

PhosphoSiteiQ8NGY1.

Expressioni

Gene expression databases

CleanExiHS_OR10Z1.
GenevestigatoriQ8NGY1.

Organism-specific databases

HPAiHPA058072.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000354707.

Structurei

3D structure databases

ProteinModelPortaliQ8NGY1.
SMRiQ8NGY1. Positions 110-140.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG78381.
GeneTreeiENSGT00760000119043.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ8NGY1.
KOiK04257.
OMAiRNRAVQT.
OrthoDBiEOG71K63J.
PhylomeDBiQ8NGY1.
TreeFamiTF337249.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGY1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGQTNVTSWR DFVFLGFSSS GELQLLLFAL FLSLYLVTLT SNVFIIIAIR
60 70 80 90 100
LDSHLHTPMY LFLSFLSFSE TCYTLGIIPR MLSGLAGGDQ AISYVGCAAQ
110 120 130 140 150
MFFSASWACT NCFLLAAMGF DRYVAICAPL HYASHMNPTL CAQLVITSFL
160 170 180 190 200
TGYLFGLGMT LVIFHLSFCS SHEIQHFFCD TPPVLSLACG DTGPSELRIF
210 220 230 240 250
ILSLLVLLVS FFFITISYAY ILAAILRIPS AEGQKKAFST CASHLTVVII
260 270 280 290 300
HYGCASFVYL RPKASYSLER DQLIAMTYTV VTPLLNPIVY SLRNRAIQTA
310
LRNAFRGRLL GKG
Length:313
Mass (Da):34,609
Last modified:October 1, 2002 - v1
Checksum:i5B29E747D07F57FF
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti294 – 2941N → T.1 Publication
Corresponds to variant rs857685 [ dbSNP | Ensembl ].
VAR_034297

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065635 Genomic DNA. Translation: BAC05861.1.
AL353894 Genomic DNA. Translation: CAH73935.1.
CH471121 Genomic DNA. Translation: EAW52820.1.
BK004195 Genomic DNA. Translation: DAA04593.1.
CCDSiCCDS30901.1.
RefSeqiNP_001004478.1. NM_001004478.1.
UniGeneiHs.553590.

Genome annotation databases

EnsembliENST00000361284; ENSP00000354707; ENSG00000198967.
GeneIDi128368.
KEGGihsa:128368.
UCSCiuc010pio.2. human.

Polymorphism databases

DMDMi38372785.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065635 Genomic DNA. Translation: BAC05861.1.
AL353894 Genomic DNA. Translation: CAH73935.1.
CH471121 Genomic DNA. Translation: EAW52820.1.
BK004195 Genomic DNA. Translation: DAA04593.1.
CCDSiCCDS30901.1.
RefSeqiNP_001004478.1. NM_001004478.1.
UniGeneiHs.553590.

3D structure databases

ProteinModelPortaliQ8NGY1.
SMRiQ8NGY1. Positions 110-140.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000354707.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiQ8NGY1.

Polymorphism databases

DMDMi38372785.

Proteomic databases

PRIDEiQ8NGY1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000361284; ENSP00000354707; ENSG00000198967.
GeneIDi128368.
KEGGihsa:128368.
UCSCiuc010pio.2. human.

Organism-specific databases

CTDi128368.
GeneCardsiGC01P158576.
HGNCiHGNC:14996. OR10Z1.
HPAiHPA058072.
neXtProtiNX_Q8NGY1.
PharmGKBiPA32009.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG78381.
GeneTreeiENSGT00760000119043.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ8NGY1.
KOiK04257.
OMAiRNRAVQT.
OrthoDBiEOG71K63J.
PhylomeDBiQ8NGY1.
TreeFamiTF337249.

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR10Z1.
GenomeRNAii128368.
NextBioi82313.
PROiQ8NGY1.

Gene expression databases

CleanExiHS_OR10Z1.
GenevestigatoriQ8NGY1.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT THR-294.
  4. Cited for: IDENTIFICATION.
  5. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiO10Z1_HUMAN
AccessioniPrimary (citable) accession number: Q8NGY1
Secondary accession number(s): Q5VYL0, Q6IFR7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: February 4, 2015
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.