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Q8NGY0 (O10X1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 97. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Olfactory receptor 10X1
Alternative name(s):
Olfactory receptor OR1-14
Gene names
Name:OR10X1
Synonyms:OR10X1P
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length326 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Odorant receptor Potential.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Polymorphism

A stop codon at position Trp-66 in the gene coding for this protein is responsible for functional diversity thus producing a pseudogene. The stop codon is more frequent in African-Americans than in non-Africans.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence caution

The sequence BAC05862.1 differs from that shown. Reason: Erroneous initiation.

The sequence CAH72417.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 326326Olfactory receptor 10X1
PRO_0000150720

Regions

Topological domain1 – 4141Extracellular Potential
Transmembrane42 – 6221Helical; Name=1; Potential
Topological domain63 – 708Cytoplasmic Potential
Transmembrane71 – 9121Helical; Name=2; Potential
Topological domain92 – 11524Extracellular Potential
Transmembrane116 – 13621Helical; Name=3; Potential
Topological domain137 – 15519Cytoplasmic Potential
Transmembrane156 – 17621Helical; Name=4; Potential
Topological domain177 – 21337Extracellular Potential
Transmembrane214 – 23320Helical; Name=5; Potential
Topological domain234 – 25320Cytoplasmic Potential
Transmembrane254 – 27421Helical; Name=6; Potential
Topological domain275 – 28410Extracellular Potential
Transmembrane285 – 30521Helical; Name=7; Potential
Topological domain306 – 32621Cytoplasmic Potential

Amino acid modifications

Glycosylation211N-linked (GlcNAc...) Potential
Glycosylation2091N-linked (GlcNAc...) Potential
Disulfide bond113 ↔ 205 By similarity

Natural variations

Natural variant601I → T.
Corresponds to variant rs863363 [ dbSNP | Ensembl ].
VAR_053290
Natural variant811A → S.
Corresponds to variant rs950164 [ dbSNP | Ensembl ].
VAR_053291
Natural variant1721S → P.
Corresponds to variant rs7550131 [ dbSNP | Ensembl ].
VAR_053292
Natural variant1801F → L.
Corresponds to variant rs16840360 [ dbSNP | Ensembl ].
VAR_053293

Sequences

Sequence LengthMass (Da)Tools
Q8NGY0 [UniParc].

Last modified January 15, 2008. Version 2.
Checksum: BFB0BB8E958C15E4

FASTA32636,446
        10         20         30         40         50         60 
MVLNVYCCFF QISDIQTMKI NQTILKEFIL VGFSVYPHVQ TFLFVVFFCL YLLTLAGNLI 

        70         80         90        100        110        120 
IMGLTWVDRS LHTPMYLFLS ALSFSETCYT LTIVPKMLED LLAKDRSISV TGCSLQMCFF 

       130        140        150        160        170        180 
LGLGGTNCII LTLMGYDRFL AICNPLRYPL LMTNIVCGQL VASACTAGFF ISLTETALIF 

       190        200        210        220        230        240 
RDSFCRPNLV KHFFCHMLAV IRLSCIDSNH TEFIITLISV SGLLGTLLLI ILTDVFIIST 

       250        260        270        280        290        300 
VLRIPSAEGK QKAFTTCASH LTVVIIHFGF ASIVYLKPEA SGDDTLIAVP YTVITPFLSP 

       310        320 
IIFSLRNKDM KNAFRRMMGN TVALKK 

« Hide

References

« Hide 'large scale' references
[1]"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The human olfactory receptor gene family."
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
[4]Erratum
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)
[5]"Different noses for different people."
Menashe I., Man O., Lancet D., Gilad Y.
Nat. Genet. 34:143-144(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: POLYMORPHISM.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB065636 Genomic DNA. Translation: BAC05862.1. Different initiation.
AL160283 Genomic DNA. Translation: CAH72417.1. Different initiation.
BK004194 Genomic DNA. Translation: DAA04592.1.
CCDSCCDS30900.1.
RefSeqNP_001004477.1. NM_001004477.1.
UniGeneHs.553589.

3D structure databases

ProteinModelPortalQ8NGY0.
SMRQ8NGY0. Positions 125-156, 291-320.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000357132.

Protein family/group databases

GPCRDBSearch...

Polymorphism databases

DMDM166214962.

Proteomic databases

PaxDbQ8NGY0.
PRIDEQ8NGY0.

Protocols and materials databases

DNASU128367.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000368150; ENSP00000357132; ENSG00000186400.
GeneID128367.
KEGGhsa:128367.
UCSCuc010pin.2. human.

Organism-specific databases

CTD128367.
GeneCardsGC01M158548.
HGNCHGNC:14995. OR10X1.
HPAHPA060990.
neXtProtNX_Q8NGY0.
PharmGKBPA32007.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG44200.
HOGENOMHOG000041365.
HOVERGENHBG017625.
InParanoidQ8NGY0.
KOK04257.
OMAMKINQTI.
OrthoDBEOG7BW0K3.
PhylomeDBQ8NGY0.
TreeFamTF337925.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

CleanExHS_OR10X1.
GenevestigatorQ8NGY0.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiOR10X1.
GenomeRNAi128367.
NextBio82309.
PROQ8NGY0.

Entry information

Entry nameO10X1_HUMAN
AccessionPrimary (citable) accession number: Q8NGY0
Secondary accession number(s): Q6IFR8
Entry history
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: January 15, 2008
Last modified: July 9, 2014
This is version 97 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries