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Protein

Olfactory receptor 10X1

Gene

OR10X1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

BioCyciZFISH:G66-30714-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 10X1
Alternative name(s):
Olfactory receptor OR1-14
Gene namesi
Name:OR10X1
Synonyms:OR10X1P
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:14995. OR10X1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 41ExtracellularSequence analysisAdd BLAST41
Transmembranei42 – 62Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini63 – 70CytoplasmicSequence analysis8
Transmembranei71 – 91Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini92 – 115ExtracellularSequence analysisAdd BLAST24
Transmembranei116 – 136Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini137 – 155CytoplasmicSequence analysisAdd BLAST19
Transmembranei156 – 176Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini177 – 213ExtracellularSequence analysisAdd BLAST37
Transmembranei214 – 233Helical; Name=5Sequence analysisAdd BLAST20
Topological domaini234 – 253CytoplasmicSequence analysisAdd BLAST20
Transmembranei254 – 274Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini275 – 284ExtracellularSequence analysis10
Transmembranei285 – 305Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini306 – 326CytoplasmicSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi128367.
OpenTargetsiENSG00000279111.
PharmGKBiPA32007.

Polymorphism and mutation databases

BioMutaiOR10X1.
DMDMi166214962.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001507201 – 326Olfactory receptor 10X1Add BLAST326

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi21N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi113 ↔ 205PROSITE-ProRule annotation
Glycosylationi209N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGY0.
PeptideAtlasiQ8NGY0.
PRIDEiQ8NGY0.

PTM databases

iPTMnetiQ8NGY0.
PhosphoSitePlusiQ8NGY0.

Expressioni

Gene expression databases

CleanExiHS_OR10X1.

Organism-specific databases

HPAiHPA060990.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000357132.

Structurei

3D structure databases

ProteinModelPortaliQ8NGY0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IKKE. Eukaryota.
ENOG41115SF. LUCA.
GeneTreeiENSGT00760000119043.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiQ8NGY0.
KOiK04257.
OMAiRRMMGNT.
OrthoDBiEOG091G0F6Y.
PhylomeDBiQ8NGY0.
TreeFamiTF337925.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGY0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVLNVYCCFF QISDIQTMKI NQTILKEFIL VGFSVYPHVQ TFLFVVFFCL
60 70 80 90 100
YLLTLAGNLI IMGLTWVDRS LHTPMYLFLS ALSFSETCYT LTIVPKMLED
110 120 130 140 150
LLAKDRSISV TGCSLQMCFF LGLGGTNCII LTLMGYDRFL AICNPLRYPL
160 170 180 190 200
LMTNIVCGQL VASACTAGFF ISLTETALIF RDSFCRPNLV KHFFCHMLAV
210 220 230 240 250
IRLSCIDSNH TEFIITLISV SGLLGTLLLI ILTDVFIIST VLRIPSAEGK
260 270 280 290 300
QKAFTTCASH LTVVIIHFGF ASIVYLKPEA SGDDTLIAVP YTVITPFLSP
310 320
IIFSLRNKDM KNAFRRMMGN TVALKK
Length:326
Mass (Da):36,446
Last modified:January 15, 2008 - v2
Checksum:iBFB0BB8E958C15E4
GO

Sequence cautioni

The sequence BAC05862 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAH72417 differs from that shown. Reason: Erroneous initiation.Curated

Polymorphismi

A stop codon at position Trp-66 in the gene coding for this protein is responsible for functional diversity thus producing a pseudogene. The stop codon is more frequent in African-Americans than in non-Africans.

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05329060I → T.Corresponds to variant rs863363dbSNPEnsembl.1
Natural variantiVAR_05329181A → S.Corresponds to variant rs950164dbSNPEnsembl.1
Natural variantiVAR_053292172S → P.Corresponds to variant rs7550131dbSNPEnsembl.1
Natural variantiVAR_053293180F → L.Corresponds to variant rs16840360dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065636 Genomic DNA. Translation: BAC05862.1. Different initiation.
AL160283 Genomic DNA. Translation: CAH72417.1. Different initiation.
BK004194 Genomic DNA. Translation: DAA04592.1.
RefSeqiNP_001004477.1. NM_001004477.1.
UniGeneiHs.553589.

Genome annotation databases

EnsembliENST00000623167; ENSP00000485609; ENSG00000279111.
GeneIDi128367.
KEGGihsa:128367.
UCSCiuc010pin.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065636 Genomic DNA. Translation: BAC05862.1. Different initiation.
AL160283 Genomic DNA. Translation: CAH72417.1. Different initiation.
BK004194 Genomic DNA. Translation: DAA04592.1.
RefSeqiNP_001004477.1. NM_001004477.1.
UniGeneiHs.553589.

3D structure databases

ProteinModelPortaliQ8NGY0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000357132.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ8NGY0.
PhosphoSitePlusiQ8NGY0.

Polymorphism and mutation databases

BioMutaiOR10X1.
DMDMi166214962.

Proteomic databases

PaxDbiQ8NGY0.
PeptideAtlasiQ8NGY0.
PRIDEiQ8NGY0.

Protocols and materials databases

DNASUi128367.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000623167; ENSP00000485609; ENSG00000279111.
GeneIDi128367.
KEGGihsa:128367.
UCSCiuc010pin.2. human.

Organism-specific databases

CTDi128367.
DisGeNETi128367.
GeneCardsiOR10X1.
HGNCiHGNC:14995. OR10X1.
HPAiHPA060990.
neXtProtiNX_Q8NGY0.
OpenTargetsiENSG00000279111.
PharmGKBiPA32007.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IKKE. Eukaryota.
ENOG41115SF. LUCA.
GeneTreeiENSGT00760000119043.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiQ8NGY0.
KOiK04257.
OMAiRRMMGNT.
OrthoDBiEOG091G0F6Y.
PhylomeDBiQ8NGY0.
TreeFamiTF337925.

Enzyme and pathway databases

BioCyciZFISH:G66-30714-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR10X1.
GenomeRNAii128367.
PROiQ8NGY0.

Gene expression databases

CleanExiHS_OR10X1.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO10X1_HUMAN
AccessioniPrimary (citable) accession number: Q8NGY0
Secondary accession number(s): Q6IFR8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: January 15, 2008
Last modified: November 2, 2016
This is version 116 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.