Q8NGY0 (O10X1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Olfactory receptor 10X1

Alternative name(s):
Olfactory receptor OR1-14

Gene names

Name:	OR10X1
Synonyms:	OR10X1P

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	326 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Odorant receptor Potential.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Polymorphism	A stop codon at position Trp-66 in the gene coding for this protein is responsible for functional diversity thus producing a pseudogene. The stop codon is more frequent in African-Americans than in non-Africans.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.
Sequence caution	The sequence BAC05862.1 differs from that shown. Reason: Erroneous initiation. The sequence CAH72417.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Olfaction Sensory transduction
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	detection of chemical stimulus involved in sensory perception of smell Inferred from electronic annotation. Source: GOC
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	G-protein coupled receptor activity Inferred from electronic annotation. Source: UniProtKB-KW olfactory receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 326	326	Olfactory receptor 10X1		PRO_0000150720
Regions
	Topological domain	1 – 41	41	Extracellular Potential
	Transmembrane	42 – 62	21	Helical; Name=1; Potential
	Topological domain	63 – 70	8	Cytoplasmic Potential
	Transmembrane	71 – 91	21	Helical; Name=2; Potential
	Topological domain	92 – 115	24	Extracellular Potential
	Transmembrane	116 – 136	21	Helical; Name=3; Potential
	Topological domain	137 – 155	19	Cytoplasmic Potential
	Transmembrane	156 – 176	21	Helical; Name=4; Potential
	Topological domain	177 – 213	37	Extracellular Potential
	Transmembrane	214 – 233	20	Helical; Name=5; Potential
	Topological domain	234 – 253	20	Cytoplasmic Potential
	Transmembrane	254 – 274	21	Helical; Name=6; Potential
	Topological domain	275 – 284	10	Extracellular Potential
	Transmembrane	285 – 305	21	Helical; Name=7; Potential
	Topological domain	306 – 326	21	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	21	1	N-linked (GlcNAc...) Potential
	Glycosylation	209	1	N-linked (GlcNAc...) Potential
	Disulfide bond	113 ↔ 205		By similarity
Natural variations
	Natural variant	60	1	I → T. Corresponds to variant rs863363 [ dbSNP | Ensembl ].		VAR_053290
	Natural variant	81	1	A → S. Corresponds to variant rs950164 [ dbSNP | Ensembl ].		VAR_053291
	Natural variant	172	1	S → P. Corresponds to variant rs7550131 [ dbSNP | Ensembl ].		VAR_053292
	Natural variant	180	1	F → L. Corresponds to variant rs16840360 [ dbSNP | Ensembl ].		VAR_053293

Sequences

	Sequence		Length	Mass (Da)
	Q8NGY0 [UniParc]. Last modified January 15, 2008. Version 2. Checksum: BFB0BB8E958C15E4	FASTA	326	36,446
	10 20 30 40 50 60 MVLNVYCCFF QISDIQTMKI NQTILKEFIL VGFSVYPHVQ TFLFVVFFCL YLLTLAGNLI 70 80 90 100 110 120 IMGLTWVDRS LHTPMYLFLS ALSFSETCYT LTIVPKMLED LLAKDRSISV TGCSLQMCFF 130 140 150 160 170 180 LGLGGTNCII LTLMGYDRFL AICNPLRYPL LMTNIVCGQL VASACTAGFF ISLTETALIF 190 200 210 220 230 240 RDSFCRPNLV KHFFCHMLAV IRLSCIDSNH TEFIITLISV SGLLGTLLLI ILTDVFIIST 250 260 270 280 290 300 VLRIPSAEGK QKAFTTCASH LTVVIIHFGF ASIVYLKPEA SGDDTLIAVP YTVITPFLSP 310 320 IIFSLRNKDM KNAFRRMMGN TVALKK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes." Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y. Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The human olfactory receptor gene family." Malnic B., Godfrey P.A., Buck L.B. Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION.
[4]	Erratum Malnic B., Godfrey P.A., Buck L.B. Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)
[5]	"Different noses for different people." Menashe I., Man O., Lancet D., Gilad Y. Nat. Genet. 34:143-144(2003) [PubMed] [Europe PMC] [Abstract] Cited for: POLYMORPHISM.

Web resources

Human Olfactory Receptor Data Exploratorium (HORDE)

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB065636 Genomic DNA. Translation: BAC05862.1. Different initiation. AL160283 Genomic DNA. Translation: CAH72417.1. Different initiation. BK004194 Genomic DNA. Translation: DAA04592.1.
IPI	IPI00169201.
RefSeq	NP_001004477.1. NM_001004477.1.
UniGene	Hs.553589.
3D structure databases
ProteinModelPortal	Q8NGY0.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000357132.
Protein family/group databases
GPCRDB	Search...
Polymorphism databases
DMDM	166214962.
Proteomic databases
PaxDb	Q8NGY0.
PRIDE	Q8NGY0.
Protocols and materials databases
DNASU	128367.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000368150; ENSP00000357132; ENSG00000186400.
GeneID	128367.
KEGG	hsa:128367.
UCSC	uc010pin.2. human.
Organism-specific databases
CTD	128367.
GeneCards	GC01M158548.
HGNC	HGNC:14995. OR10X1.
neXtProt	NX_Q8NGY0.
PharmGKB	PA32007.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG44200.
HOGENOM	HOG000041365.
HOVERGEN	HBG017625.
InParanoid	Q8NGY0.
KO	K04257.
OMA	QTMKINQ.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction.
Gene expression databases
CleanEx	HS_OR10X1.
Genevestigator	Q8NGY0.
Family and domain databases
InterPro	IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. IPR000725. Olfact_rcpt. [Graphical view]
PRINTS	PR00237. GPCRRHODOPSN. PR00245. OLFACTORYR.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	128367.
NextBio	82309.

Entry information

Entry name

O10X1_HUMAN

Accession

Primary (citable) accession number: Q8NGY0
Secondary accession number(s): Q6IFR8

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 20, 2005
Last sequence update:	January 15, 2008
Last modified:	May 1, 2013
This is version 88 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.