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Q8NGY0

- O10X1_HUMAN

UniProt

Q8NGY0 - O10X1_HUMAN

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Protein

Olfactory receptor 10X1

Gene

OR10X1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 10X1
Alternative name(s):
Olfactory receptor OR1-14
Gene namesi
Name:OR10X1
Synonyms:OR10X1P
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:14995. OR10X1.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32007.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 326326Olfactory receptor 10X1PRO_0000150720Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi21 – 211N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi113 ↔ 205PROSITE-ProRule annotation
Glycosylationi209 – 2091N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGY0.
PRIDEiQ8NGY0.

Expressioni

Gene expression databases

CleanExiHS_OR10X1.
GenevestigatoriQ8NGY0.

Organism-specific databases

HPAiHPA060990.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000357132.

Structurei

3D structure databases

ProteinModelPortaliQ8NGY0.
SMRiQ8NGY0. Positions 125-156.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4141ExtracellularSequence AnalysisAdd
BLAST
Topological domaini63 – 708CytoplasmicSequence Analysis
Topological domaini92 – 11524ExtracellularSequence AnalysisAdd
BLAST
Topological domaini137 – 15519CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini177 – 21337ExtracellularSequence AnalysisAdd
BLAST
Topological domaini234 – 25320CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini275 – 28410ExtracellularSequence Analysis
Topological domaini306 – 32621CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei42 – 6221Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei71 – 9121Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei116 – 13621Helical; Name=3Sequence AnalysisAdd
BLAST
Transmembranei156 – 17621Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei214 – 23320Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei254 – 27421Helical; Name=6Sequence AnalysisAdd
BLAST
Transmembranei285 – 30521Helical; Name=7Sequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG44200.
GeneTreeiENSGT00760000119043.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiQ8NGY0.
KOiK04257.
OMAiMKINQTI.
OrthoDBiEOG7BW0K3.
PhylomeDBiQ8NGY0.
TreeFamiTF337925.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGY0 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVLNVYCCFF QISDIQTMKI NQTILKEFIL VGFSVYPHVQ TFLFVVFFCL
60 70 80 90 100
YLLTLAGNLI IMGLTWVDRS LHTPMYLFLS ALSFSETCYT LTIVPKMLED
110 120 130 140 150
LLAKDRSISV TGCSLQMCFF LGLGGTNCII LTLMGYDRFL AICNPLRYPL
160 170 180 190 200
LMTNIVCGQL VASACTAGFF ISLTETALIF RDSFCRPNLV KHFFCHMLAV
210 220 230 240 250
IRLSCIDSNH TEFIITLISV SGLLGTLLLI ILTDVFIIST VLRIPSAEGK
260 270 280 290 300
QKAFTTCASH LTVVIIHFGF ASIVYLKPEA SGDDTLIAVP YTVITPFLSP
310 320
IIFSLRNKDM KNAFRRMMGN TVALKK
Length:326
Mass (Da):36,446
Last modified:January 15, 2008 - v2
Checksum:iBFB0BB8E958C15E4
GO

Sequence cautioni

The sequence BAC05862.1 differs from that shown. Reason: Erroneous initiation.
The sequence CAH72417.1 differs from that shown. Reason: Erroneous initiation.

Polymorphismi

A stop codon at position Trp-66 in the gene coding for this protein is responsible for functional diversity thus producing a pseudogene. The stop codon is more frequent in African-Americans than in non-Africans.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti60 – 601I → T.
Corresponds to variant rs863363 [ dbSNP | Ensembl ].
VAR_053290
Natural varianti81 – 811A → S.
Corresponds to variant rs950164 [ dbSNP | Ensembl ].
VAR_053291
Natural varianti172 – 1721S → P.
Corresponds to variant rs7550131 [ dbSNP | Ensembl ].
VAR_053292
Natural varianti180 – 1801F → L.
Corresponds to variant rs16840360 [ dbSNP | Ensembl ].
VAR_053293

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB065636 Genomic DNA. Translation: BAC05862.1. Different initiation.
AL160283 Genomic DNA. Translation: CAH72417.1. Different initiation.
BK004194 Genomic DNA. Translation: DAA04592.1.
CCDSiCCDS30900.1.
RefSeqiNP_001004477.1. NM_001004477.1.
UniGeneiHs.553589.

Genome annotation databases

EnsembliENST00000368150; ENSP00000357132; ENSG00000186400.
GeneIDi128367.
KEGGihsa:128367.
UCSCiuc010pin.2. human.

Polymorphism databases

DMDMi166214962.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB065636 Genomic DNA. Translation: BAC05862.1 . Different initiation.
AL160283 Genomic DNA. Translation: CAH72417.1 . Different initiation.
BK004194 Genomic DNA. Translation: DAA04592.1 .
CCDSi CCDS30900.1.
RefSeqi NP_001004477.1. NM_001004477.1.
UniGenei Hs.553589.

3D structure databases

ProteinModelPortali Q8NGY0.
SMRi Q8NGY0. Positions 125-156.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000357132.

Protein family/group databases

GPCRDBi Search...

Polymorphism databases

DMDMi 166214962.

Proteomic databases

PaxDbi Q8NGY0.
PRIDEi Q8NGY0.

Protocols and materials databases

DNASUi 128367.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000368150 ; ENSP00000357132 ; ENSG00000186400 .
GeneIDi 128367.
KEGGi hsa:128367.
UCSCi uc010pin.2. human.

Organism-specific databases

CTDi 128367.
GeneCardsi GC01M158548.
HGNCi HGNC:14995. OR10X1.
HPAi HPA060990.
neXtProti NX_Q8NGY0.
PharmGKBi PA32007.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG44200.
GeneTreei ENSGT00760000119043.
HOGENOMi HOG000041365.
HOVERGENi HBG017625.
InParanoidi Q8NGY0.
KOi K04257.
OMAi MKINQTI.
OrthoDBi EOG7BW0K3.
PhylomeDBi Q8NGY0.
TreeFami TF337925.

Enzyme and pathway databases

Reactomei REACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikii OR10X1.
GenomeRNAii 128367.
NextBioi 82309.
PROi Q8NGY0.

Gene expression databases

CleanExi HS_OR10X1.
Genevestigatori Q8NGY0.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: IDENTIFICATION.
  4. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)
  5. Cited for: POLYMORPHISM.

Entry informationi

Entry nameiO10X1_HUMAN
AccessioniPrimary (citable) accession number: Q8NGY0
Secondary accession number(s): Q6IFR8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: January 15, 2008
Last modified: October 29, 2014
This is version 100 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3