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Q8NGY0

- O10X1_HUMAN

UniProt

Q8NGY0 - O10X1_HUMAN

Protein

Olfactory receptor 10X1

Gene

OR10X1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 99 (01 Oct 2014)
      Sequence version 2 (15 Jan 2008)
      Previous versions | rss
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    Functioni

    Odorant receptor.Curated

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW
    2. olfactory receptor activity Source: InterPro

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Olfaction, Sensory transduction

    Enzyme and pathway databases

    ReactomeiREACT_15488. Olfactory Signaling Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Olfactory receptor 10X1
    Alternative name(s):
    Olfactory receptor OR1-14
    Gene namesi
    Name:OR10X1
    Synonyms:OR10X1P
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:14995. OR10X1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA32007.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 326326Olfactory receptor 10X1PRO_0000150720Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi21 – 211N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi113 ↔ 205PROSITE-ProRule annotation
    Glycosylationi209 – 2091N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ8NGY0.
    PRIDEiQ8NGY0.

    Expressioni

    Gene expression databases

    CleanExiHS_OR10X1.
    GenevestigatoriQ8NGY0.

    Organism-specific databases

    HPAiHPA060990.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000357132.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8NGY0.
    SMRiQ8NGY0. Positions 125-156, 291-320.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 4141ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini63 – 708CytoplasmicSequence Analysis
    Topological domaini92 – 11524ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini137 – 15519CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini177 – 21337ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini234 – 25320CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini275 – 28410ExtracellularSequence Analysis
    Topological domaini306 – 32621CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei42 – 6221Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei71 – 9121Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei116 – 13621Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei156 – 17621Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei214 – 23320Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei254 – 27421Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei285 – 30521Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG44200.
    HOGENOMiHOG000041365.
    HOVERGENiHBG017625.
    InParanoidiQ8NGY0.
    KOiK04257.
    OMAiMKINQTI.
    OrthoDBiEOG7BW0K3.
    PhylomeDBiQ8NGY0.
    TreeFamiTF337925.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8NGY0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVLNVYCCFF QISDIQTMKI NQTILKEFIL VGFSVYPHVQ TFLFVVFFCL    50
    YLLTLAGNLI IMGLTWVDRS LHTPMYLFLS ALSFSETCYT LTIVPKMLED 100
    LLAKDRSISV TGCSLQMCFF LGLGGTNCII LTLMGYDRFL AICNPLRYPL 150
    LMTNIVCGQL VASACTAGFF ISLTETALIF RDSFCRPNLV KHFFCHMLAV 200
    IRLSCIDSNH TEFIITLISV SGLLGTLLLI ILTDVFIIST VLRIPSAEGK 250
    QKAFTTCASH LTVVIIHFGF ASIVYLKPEA SGDDTLIAVP YTVITPFLSP 300
    IIFSLRNKDM KNAFRRMMGN TVALKK 326
    Length:326
    Mass (Da):36,446
    Last modified:January 15, 2008 - v2
    Checksum:iBFB0BB8E958C15E4
    GO

    Sequence cautioni

    The sequence BAC05862.1 differs from that shown. Reason: Erroneous initiation.
    The sequence CAH72417.1 differs from that shown. Reason: Erroneous initiation.

    Polymorphismi

    A stop codon at position Trp-66 in the gene coding for this protein is responsible for functional diversity thus producing a pseudogene. The stop codon is more frequent in African-Americans than in non-Africans.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti60 – 601I → T.
    Corresponds to variant rs863363 [ dbSNP | Ensembl ].
    VAR_053290
    Natural varianti81 – 811A → S.
    Corresponds to variant rs950164 [ dbSNP | Ensembl ].
    VAR_053291
    Natural varianti172 – 1721S → P.
    Corresponds to variant rs7550131 [ dbSNP | Ensembl ].
    VAR_053292
    Natural varianti180 – 1801F → L.
    Corresponds to variant rs16840360 [ dbSNP | Ensembl ].
    VAR_053293

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065636 Genomic DNA. Translation: BAC05862.1. Different initiation.
    AL160283 Genomic DNA. Translation: CAH72417.1. Different initiation.
    BK004194 Genomic DNA. Translation: DAA04592.1.
    CCDSiCCDS30900.1.
    RefSeqiNP_001004477.1. NM_001004477.1.
    UniGeneiHs.553589.

    Genome annotation databases

    EnsembliENST00000368150; ENSP00000357132; ENSG00000186400.
    GeneIDi128367.
    KEGGihsa:128367.
    UCSCiuc010pin.2. human.

    Polymorphism databases

    DMDMi166214962.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Human Olfactory Receptor Data Exploratorium (HORDE)

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065636 Genomic DNA. Translation: BAC05862.1 . Different initiation.
    AL160283 Genomic DNA. Translation: CAH72417.1 . Different initiation.
    BK004194 Genomic DNA. Translation: DAA04592.1 .
    CCDSi CCDS30900.1.
    RefSeqi NP_001004477.1. NM_001004477.1.
    UniGenei Hs.553589.

    3D structure databases

    ProteinModelPortali Q8NGY0.
    SMRi Q8NGY0. Positions 125-156, 291-320.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000357132.

    Protein family/group databases

    GPCRDBi Search...

    Polymorphism databases

    DMDMi 166214962.

    Proteomic databases

    PaxDbi Q8NGY0.
    PRIDEi Q8NGY0.

    Protocols and materials databases

    DNASUi 128367.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000368150 ; ENSP00000357132 ; ENSG00000186400 .
    GeneIDi 128367.
    KEGGi hsa:128367.
    UCSCi uc010pin.2. human.

    Organism-specific databases

    CTDi 128367.
    GeneCardsi GC01M158548.
    HGNCi HGNC:14995. OR10X1.
    HPAi HPA060990.
    neXtProti NX_Q8NGY0.
    PharmGKBi PA32007.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG44200.
    HOGENOMi HOG000041365.
    HOVERGENi HBG017625.
    InParanoidi Q8NGY0.
    KOi K04257.
    OMAi MKINQTI.
    OrthoDBi EOG7BW0K3.
    PhylomeDBi Q8NGY0.
    TreeFami TF337925.

    Enzyme and pathway databases

    Reactomei REACT_15488. Olfactory Signaling Pathway.

    Miscellaneous databases

    GeneWikii OR10X1.
    GenomeRNAii 128367.
    NextBioi 82309.
    PROi Q8NGY0.

    Gene expression databases

    CleanExi HS_OR10X1.
    Genevestigatori Q8NGY0.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
      Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
      Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: IDENTIFICATION.
    4. Erratum
      Malnic B., Godfrey P.A., Buck L.B.
      Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)
    5. Cited for: POLYMORPHISM.

    Entry informationi

    Entry nameiO10X1_HUMAN
    AccessioniPrimary (citable) accession number: Q8NGY0
    Secondary accession number(s): Q6IFR8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 20, 2005
    Last sequence update: January 15, 2008
    Last modified: October 1, 2014
    This is version 99 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3