ID   OR6Y1_HUMAN             Reviewed;         325 AA.
AC   Q8NGX8; Q6IFS0;
DT   10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   27-MAR-2024, entry version 157.
DE   RecName: Full=Olfactory receptor 6Y1;
DE   AltName: Full=Olfactory receptor 6Y2;
DE   AltName: Full=Olfactory receptor OR1-11;
GN   Name=OR6Y1; Synonyms=OR6Y2;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA   Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT   "Genome-wide discovery and analysis of human seven transmembrane helix
RT   receptor genes.";
RL   Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16710414; DOI=10.1038/nature04727;
RA   Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA   Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA   Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA   Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA   Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA   Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA   Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA   Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA   Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA   Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA   Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA   Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA   Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA   Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA   Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA   Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA   Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA   Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA   Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA   McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA   Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA   Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA   Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA   Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA   Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA   White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA   Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA   Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA   Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT   "The DNA sequence and biological annotation of human chromosome 1.";
RL   Nature 441:315-321(2006).
RN   [3]
RP   IDENTIFICATION.
RX   PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA   Malnic B., Godfrey P.A., Buck L.B.;
RT   "The human olfactory receptor gene family.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN   [4]
RP   ERRATUM OF PUBMED:14983052.
RA   Malnic B., Godfrey P.A., Buck L.B.;
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC   -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC   -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC       URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR6Y1";
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DR   EMBL; AB065638; BAC05864.1; -; Genomic_DNA.
DR   EMBL; AL365440; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BK004192; DAA04590.1; -; Genomic_DNA.
DR   CCDS; CCDS30899.1; -.
DR   RefSeq; NP_001005189.1; NM_001005189.1.
DR   AlphaFoldDB; Q8NGX8; -.
DR   SMR; Q8NGX8; -.
DR   STRING; 9606.ENSP00000492894; -.
DR   GlyCosmos; Q8NGX8; 2 sites, No reported glycans.
DR   GlyGen; Q8NGX8; 2 sites.
DR   iPTMnet; Q8NGX8; -.
DR   PhosphoSitePlus; Q8NGX8; -.
DR   BioMuta; OR6Y1; -.
DR   DMDM; 38372783; -.
DR   MassIVE; Q8NGX8; -.
DR   PaxDb; 9606-ENSP00000304807; -.
DR   PeptideAtlas; Q8NGX8; -.
DR   Antibodypedia; 64509; 8 antibodies from 8 providers.
DR   DNASU; 391112; -.
DR   Ensembl; ENST00000641282.1; ENSP00000493253.1; ENSG00000197532.3.
DR   Ensembl; ENST00000641622.1; ENSP00000492894.1; ENSG00000197532.3.
DR   GeneID; 391112; -.
DR   KEGG; hsa:391112; -.
DR   MANE-Select; ENST00000641622.1; ENSP00000492894.1; NM_001005189.2; NP_001005189.1.
DR   UCSC; uc010pil.2; human.
DR   AGR; HGNC:14823; -.
DR   CTD; 391112; -.
DR   DisGeNET; 391112; -.
DR   GeneCards; OR6Y1; -.
DR   HGNC; HGNC:14823; OR6Y1.
DR   HPA; ENSG00000197532; Tissue enhanced (retina).
DR   neXtProt; NX_Q8NGX8; -.
DR   OpenTargets; ENSG00000197532; -.
DR   PharmGKB; PA32610; -.
DR   VEuPathDB; HostDB:ENSG00000197532; -.
DR   eggNOG; ENOG502RIR8; Eukaryota.
DR   GeneTree; ENSGT01090000260024; -.
DR   HOGENOM; CLU_012526_0_0_1; -.
DR   InParanoid; Q8NGX8; -.
DR   OMA; HYCGTPH; -.
DR   OrthoDB; 5309199at2759; -.
DR   PhylomeDB; Q8NGX8; -.
DR   TreeFam; TF337475; -.
DR   PathwayCommons; Q8NGX8; -.
DR   Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR   BioGRID-ORCS; 391112; 8 hits in 746 CRISPR screens.
DR   GeneWiki; OR6Y1; -.
DR   GenomeRNAi; 391112; -.
DR   Pharos; Q8NGX8; Tdark.
DR   PRO; PR:Q8NGX8; -.
DR   Proteomes; UP000005640; Chromosome 1.
DR   RNAct; Q8NGX8; Protein.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR   GO; GO:0050911; P:detection of chemical stimulus involved in sensory perception of smell; IBA:GO_Central.
DR   CDD; cd15224; 7tmA_OR6B-like; 1.
DR   Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR000725; Olfact_rcpt.
DR   PANTHER; PTHR26452; OLFACTORY RECEPTOR; 1.
DR   PANTHER; PTHR26452:SF99; OLFACTORY RECEPTOR; 1.
DR   Pfam; PF13853; 7tm_4; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR00245; OLFACTORYR.
DR   SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW   Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW   Transducer; Transmembrane; Transmembrane helix.
FT   CHAIN           1..325
FT                   /note="Olfactory receptor 6Y1"
FT                   /id="PRO_0000150641"
FT   TOPO_DOM        1..30
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        31..51
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        52..59
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        60..80
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        81..104
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        105..125
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        126..144
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        145..165
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        166..202
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        203..222
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        223..242
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        243..263
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        264..276
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        277..297
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        298..325
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        10
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        191
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        102..194
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT   VARIANT         104
FT                   /note="T -> I (in dbSNP:rs55665765)"
FT                   /id="VAR_062055"
SQ   SEQUENCE   325 AA;  36636 MW;  3BECFEBD98AB6151 CRC64;
     MTTIILEVDN HTVTTRFILL GFPTRPAFQL LFFSIFLATY LLTLLENLLI ILAIHSDGQL
     HKPMYFFLSH LSFLEMWYVT VISPKMLVDF LSHDKSISFN GCMTQLYFFV TFVCTEYILL
     AIMAFDRYVA ICNPLRYPVI MTNQLCGTLA GGCWFCGLMT AMIKMVFIAQ LHYCGMPQIN
     HYFCDISPLL NVSCEDASQA EMVDFFLALM VIAIPLCVVV ASYAAILATI LRIPSAQGRQ
     KAFSTCASHL TVVILFYSMT LFTYARPKLM YAYNSNKVVS VLYTVIVPLL NPIIYCLRNH
     EVKAALRKTI HCRGSGPQGN GAFSS
//