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Q8NGX8

- OR6Y1_HUMAN

UniProt

Q8NGX8 - OR6Y1_HUMAN

Protein

Olfactory receptor 6Y1

Gene

OR6Y1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 103 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    Odorant receptor.Curated

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW
    2. olfactory receptor activity Source: InterPro

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Olfaction, Sensory transduction

    Enzyme and pathway databases

    ReactomeiREACT_15488. Olfactory Signaling Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Olfactory receptor 6Y1
    Alternative name(s):
    Olfactory receptor 6Y2
    Olfactory receptor OR1-11
    Gene namesi
    Name:OR6Y1
    Synonyms:OR6Y2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:14823. OR6Y1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA32610.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 325325Olfactory receptor 6Y1PRO_0000150641Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi10 – 101N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi102 ↔ 194PROSITE-ProRule annotation
    Glycosylationi191 – 1911N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ8NGX8.
    PRIDEiQ8NGX8.

    PTM databases

    PhosphoSiteiQ8NGX8.

    Expressioni

    Gene expression databases

    CleanExiHS_OR6Y1.
    GenevestigatoriQ8NGX8.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000304807.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8NGX8.
    SMRiQ8NGX8. Positions 31-310.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3030ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini52 – 598CytoplasmicSequence Analysis
    Topological domaini81 – 10424ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini126 – 14419CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini166 – 20237ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini223 – 24220CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini264 – 27613ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini298 – 32528CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei31 – 5121Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei60 – 8021Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei105 – 12521Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei145 – 16521Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei203 – 22220Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei243 – 26321Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei277 – 29721Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG45783.
    HOGENOMiHOG000041364.
    HOVERGENiHBG017625.
    InParanoidiQ8NGX8.
    KOiK04257.
    OMAiMWYVTVI.
    OrthoDBiEOG71K63J.
    PhylomeDBiQ8NGX8.
    TreeFamiTF337475.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8NGX8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTTIILEVDN HTVTTRFILL GFPTRPAFQL LFFSIFLATY LLTLLENLLI    50
    ILAIHSDGQL HKPMYFFLSH LSFLEMWYVT VISPKMLVDF LSHDKSISFN 100
    GCMTQLYFFV TFVCTEYILL AIMAFDRYVA ICNPLRYPVI MTNQLCGTLA 150
    GGCWFCGLMT AMIKMVFIAQ LHYCGMPQIN HYFCDISPLL NVSCEDASQA 200
    EMVDFFLALM VIAIPLCVVV ASYAAILATI LRIPSAQGRQ KAFSTCASHL 250
    TVVILFYSMT LFTYARPKLM YAYNSNKVVS VLYTVIVPLL NPIIYCLRNH 300
    EVKAALRKTI HCRGSGPQGN GAFSS 325
    Length:325
    Mass (Da):36,636
    Last modified:October 1, 2002 - v1
    Checksum:i3BECFEBD98AB6151
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti104 – 1041T → I.
    Corresponds to variant rs55665765 [ dbSNP | Ensembl ].
    VAR_062055

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065638 Genomic DNA. Translation: BAC05864.1.
    AL365440 Genomic DNA. Translation: CAH70563.1.
    BK004192 Genomic DNA. Translation: DAA04590.1.
    CCDSiCCDS30899.1.
    RefSeqiNP_001005189.1. NM_001005189.1.
    UniGeneiHs.553780.

    Genome annotation databases

    EnsembliENST00000302617; ENSP00000304807; ENSG00000197532.
    GeneIDi391112.
    KEGGihsa:391112.
    UCSCiuc010pil.2. human.

    Polymorphism databases

    DMDMi38372783.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Human Olfactory Receptor Data Exploratorium (HORDE)

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065638 Genomic DNA. Translation: BAC05864.1 .
    AL365440 Genomic DNA. Translation: CAH70563.1 .
    BK004192 Genomic DNA. Translation: DAA04590.1 .
    CCDSi CCDS30899.1.
    RefSeqi NP_001005189.1. NM_001005189.1.
    UniGenei Hs.553780.

    3D structure databases

    ProteinModelPortali Q8NGX8.
    SMRi Q8NGX8. Positions 31-310.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000304807.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q8NGX8.

    Polymorphism databases

    DMDMi 38372783.

    Proteomic databases

    PaxDbi Q8NGX8.
    PRIDEi Q8NGX8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000302617 ; ENSP00000304807 ; ENSG00000197532 .
    GeneIDi 391112.
    KEGGi hsa:391112.
    UCSCi uc010pil.2. human.

    Organism-specific databases

    CTDi 391112.
    GeneCardsi GC01M158516.
    HGNCi HGNC:14823. OR6Y1.
    neXtProti NX_Q8NGX8.
    PharmGKBi PA32610.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG45783.
    HOGENOMi HOG000041364.
    HOVERGENi HBG017625.
    InParanoidi Q8NGX8.
    KOi K04257.
    OMAi MWYVTVI.
    OrthoDBi EOG71K63J.
    PhylomeDBi Q8NGX8.
    TreeFami TF337475.

    Enzyme and pathway databases

    Reactomei REACT_15488. Olfactory Signaling Pathway.

    Miscellaneous databases

    GeneWikii OR6Y1.
    NextBioi 104341.
    PROi Q8NGX8.

    Gene expression databases

    CleanExi HS_OR6Y1.
    Genevestigatori Q8NGX8.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
      Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
      Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: IDENTIFICATION.
    4. Erratum
      Malnic B., Godfrey P.A., Buck L.B.
      Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

    Entry informationi

    Entry nameiOR6Y1_HUMAN
    AccessioniPrimary (citable) accession number: Q8NGX8
    Secondary accession number(s): Q6IFS0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 10, 2003
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 103 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3