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Q8NGX8

- OR6Y1_HUMAN

UniProt

Q8NGX8 - OR6Y1_HUMAN

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Protein

Olfactory receptor 6Y1

Gene

OR6Y1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 6Y1
Alternative name(s):
Olfactory receptor 6Y2
Olfactory receptor OR1-11
Gene namesi
Name:OR6Y1
Synonyms:OR6Y2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:14823. OR6Y1.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32610.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 325325Olfactory receptor 6Y1PRO_0000150641Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi10 – 101N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi102 ↔ 194PROSITE-ProRule annotation
Glycosylationi191 – 1911N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGX8.
PRIDEiQ8NGX8.

PTM databases

PhosphoSiteiQ8NGX8.

Expressioni

Gene expression databases

CleanExiHS_OR6Y1.
GenevestigatoriQ8NGX8.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000304807.

Structurei

3D structure databases

ProteinModelPortaliQ8NGX8.
SMRiQ8NGX8. Positions 31-310.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3030ExtracellularSequence AnalysisAdd
BLAST
Topological domaini52 – 598CytoplasmicSequence Analysis
Topological domaini81 – 10424ExtracellularSequence AnalysisAdd
BLAST
Topological domaini126 – 14419CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini166 – 20237ExtracellularSequence AnalysisAdd
BLAST
Topological domaini223 – 24220CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini264 – 27613ExtracellularSequence AnalysisAdd
BLAST
Topological domaini298 – 32528CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei31 – 5121Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei60 – 8021Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei105 – 12521Helical; Name=3Sequence AnalysisAdd
BLAST
Transmembranei145 – 16521Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei203 – 22220Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei243 – 26321Helical; Name=6Sequence AnalysisAdd
BLAST
Transmembranei277 – 29721Helical; Name=7Sequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG45783.
GeneTreeiENSGT00760000119047.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ8NGX8.
KOiK04257.
OMAiMWYVTVI.
OrthoDBiEOG71K63J.
PhylomeDBiQ8NGX8.
TreeFamiTF337475.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGX8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTTIILEVDN HTVTTRFILL GFPTRPAFQL LFFSIFLATY LLTLLENLLI
60 70 80 90 100
ILAIHSDGQL HKPMYFFLSH LSFLEMWYVT VISPKMLVDF LSHDKSISFN
110 120 130 140 150
GCMTQLYFFV TFVCTEYILL AIMAFDRYVA ICNPLRYPVI MTNQLCGTLA
160 170 180 190 200
GGCWFCGLMT AMIKMVFIAQ LHYCGMPQIN HYFCDISPLL NVSCEDASQA
210 220 230 240 250
EMVDFFLALM VIAIPLCVVV ASYAAILATI LRIPSAQGRQ KAFSTCASHL
260 270 280 290 300
TVVILFYSMT LFTYARPKLM YAYNSNKVVS VLYTVIVPLL NPIIYCLRNH
310 320
EVKAALRKTI HCRGSGPQGN GAFSS
Length:325
Mass (Da):36,636
Last modified:October 1, 2002 - v1
Checksum:i3BECFEBD98AB6151
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti104 – 1041T → I.
Corresponds to variant rs55665765 [ dbSNP | Ensembl ].
VAR_062055

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB065638 Genomic DNA. Translation: BAC05864.1.
AL365440 Genomic DNA. Translation: CAH70563.1.
BK004192 Genomic DNA. Translation: DAA04590.1.
CCDSiCCDS30899.1.
RefSeqiNP_001005189.1. NM_001005189.1.
UniGeneiHs.553780.

Genome annotation databases

EnsembliENST00000302617; ENSP00000304807; ENSG00000197532.
GeneIDi391112.
KEGGihsa:391112.
UCSCiuc010pil.2. human.

Polymorphism databases

DMDMi38372783.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB065638 Genomic DNA. Translation: BAC05864.1 .
AL365440 Genomic DNA. Translation: CAH70563.1 .
BK004192 Genomic DNA. Translation: DAA04590.1 .
CCDSi CCDS30899.1.
RefSeqi NP_001005189.1. NM_001005189.1.
UniGenei Hs.553780.

3D structure databases

ProteinModelPortali Q8NGX8.
SMRi Q8NGX8. Positions 31-310.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000304807.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei Q8NGX8.

Polymorphism databases

DMDMi 38372783.

Proteomic databases

PaxDbi Q8NGX8.
PRIDEi Q8NGX8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000302617 ; ENSP00000304807 ; ENSG00000197532 .
GeneIDi 391112.
KEGGi hsa:391112.
UCSCi uc010pil.2. human.

Organism-specific databases

CTDi 391112.
GeneCardsi GC01M158516.
HGNCi HGNC:14823. OR6Y1.
neXtProti NX_Q8NGX8.
PharmGKBi PA32610.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG45783.
GeneTreei ENSGT00760000119047.
HOGENOMi HOG000041364.
HOVERGENi HBG017625.
InParanoidi Q8NGX8.
KOi K04257.
OMAi MWYVTVI.
OrthoDBi EOG71K63J.
PhylomeDBi Q8NGX8.
TreeFami TF337475.

Enzyme and pathway databases

Reactomei REACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikii OR6Y1.
GenomeRNAii 391112.
NextBioi 104341.
PROi Q8NGX8.

Gene expression databases

CleanExi HS_OR6Y1.
Genevestigatori Q8NGX8.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: IDENTIFICATION.
  4. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiOR6Y1_HUMAN
AccessioniPrimary (citable) accession number: Q8NGX8
Secondary accession number(s): Q6IFS0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: October 29, 2014
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3