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Q8NGX8 (OR6Y1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 101. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Olfactory receptor 6Y1
Alternative name(s):
Olfactory receptor 6Y2
Olfactory receptor OR1-11
Gene names
Name:OR6Y1
Synonyms:OR6Y2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length325 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Odorant receptor Potential.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 325325Olfactory receptor 6Y1
PRO_0000150641

Regions

Topological domain1 – 3030Extracellular Potential
Transmembrane31 – 5121Helical; Name=1; Potential
Topological domain52 – 598Cytoplasmic Potential
Transmembrane60 – 8021Helical; Name=2; Potential
Topological domain81 – 10424Extracellular Potential
Transmembrane105 – 12521Helical; Name=3; Potential
Topological domain126 – 14419Cytoplasmic Potential
Transmembrane145 – 16521Helical; Name=4; Potential
Topological domain166 – 20237Extracellular Potential
Transmembrane203 – 22220Helical; Name=5; Potential
Topological domain223 – 24220Cytoplasmic Potential
Transmembrane243 – 26321Helical; Name=6; Potential
Topological domain264 – 27613Extracellular Potential
Transmembrane277 – 29721Helical; Name=7; Potential
Topological domain298 – 32528Cytoplasmic Potential

Amino acid modifications

Glycosylation101N-linked (GlcNAc...) Potential
Glycosylation1911N-linked (GlcNAc...) Potential
Disulfide bond102 ↔ 194 By similarity

Natural variations

Natural variant1041T → I.
Corresponds to variant rs55665765 [ dbSNP | Ensembl ].
VAR_062055

Sequences

Sequence LengthMass (Da)Tools
Q8NGX8 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: 3BECFEBD98AB6151

FASTA32536,636
        10         20         30         40         50         60 
MTTIILEVDN HTVTTRFILL GFPTRPAFQL LFFSIFLATY LLTLLENLLI ILAIHSDGQL 

        70         80         90        100        110        120 
HKPMYFFLSH LSFLEMWYVT VISPKMLVDF LSHDKSISFN GCMTQLYFFV TFVCTEYILL 

       130        140        150        160        170        180 
AIMAFDRYVA ICNPLRYPVI MTNQLCGTLA GGCWFCGLMT AMIKMVFIAQ LHYCGMPQIN 

       190        200        210        220        230        240 
HYFCDISPLL NVSCEDASQA EMVDFFLALM VIAIPLCVVV ASYAAILATI LRIPSAQGRQ 

       250        260        270        280        290        300 
KAFSTCASHL TVVILFYSMT LFTYARPKLM YAYNSNKVVS VLYTVIVPLL NPIIYCLRNH 

       310        320 
EVKAALRKTI HCRGSGPQGN GAFSS 

« Hide

References

« Hide 'large scale' references
[1]"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The human olfactory receptor gene family."
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
[4]Erratum
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB065638 Genomic DNA. Translation: BAC05864.1.
AL365440 Genomic DNA. Translation: CAH70563.1.
BK004192 Genomic DNA. Translation: DAA04590.1.
CCDSCCDS30899.1.
RefSeqNP_001005189.1. NM_001005189.1.
UniGeneHs.553780.

3D structure databases

ProteinModelPortalQ8NGX8.
SMRQ8NGX8. Positions 31-310.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000304807.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteQ8NGX8.

Polymorphism databases

DMDM38372783.

Proteomic databases

PaxDbQ8NGX8.
PRIDEQ8NGX8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000302617; ENSP00000304807; ENSG00000197532.
GeneID391112.
KEGGhsa:391112.
UCSCuc010pil.2. human.

Organism-specific databases

CTD391112.
GeneCardsGC01M158516.
HGNCHGNC:14823. OR6Y1.
neXtProtNX_Q8NGX8.
PharmGKBPA32610.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG45783.
HOGENOMHOG000041364.
HOVERGENHBG017625.
InParanoidQ8NGX8.
KOK04257.
OMAMWYVTVI.
OrthoDBEOG71K63J.
PhylomeDBQ8NGX8.
TreeFamTF337475.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

CleanExHS_OR6Y1.
GenevestigatorQ8NGX8.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiOR6Y1.
NextBio104341.
PROQ8NGX8.

Entry information

Entry nameOR6Y1_HUMAN
AccessionPrimary (citable) accession number: Q8NGX8
Secondary accession number(s): Q6IFS0
Entry history
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: July 9, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries