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Q8NGX6 (O10R2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 106. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Olfactory receptor 10R2
Alternative name(s):
Olfactory receptor OR1-8
Gene names
Name:OR10R2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length335 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Odorant receptor Potential.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Caution

It is uncertain whether Met-1 or Met-12 is the initiator.

Sequence caution

The sequence CAH70559.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 335335Olfactory receptor 10R2
PRO_0000150715

Regions

Topological domain1 – 4545Extracellular Potential
Transmembrane46 – 6621Helical; Name=1; Potential
Topological domain67 – 748Cytoplasmic Potential
Transmembrane75 – 9521Helical; Name=2; Potential
Topological domain96 – 11924Extracellular Potential
Transmembrane120 – 14021Helical; Name=3; Potential
Topological domain141 – 15919Cytoplasmic Potential
Transmembrane160 – 18021Helical; Name=4; Potential
Topological domain181 – 21737Extracellular Potential
Transmembrane218 – 23720Helical; Name=5; Potential
Topological domain238 – 25720Cytoplasmic Potential
Transmembrane258 – 27821Helical; Name=6; Potential
Topological domain279 – 29113Extracellular Potential
Transmembrane292 – 31221Helical; Name=7; Potential
Topological domain313 – 33523Cytoplasmic Potential

Amino acid modifications

Glycosylation251N-linked (GlcNAc...) Potential
Disulfide bond117 ↔ 209 By similarity

Natural variations

Natural variant1911A → T.
Corresponds to variant rs3820678 [ dbSNP | Ensembl ].
VAR_054355
Natural variant2161E → G.
Corresponds to variant rs6679056 [ dbSNP | Ensembl ].
VAR_054356
Natural variant2391L → F.
Corresponds to variant rs1418843 [ dbSNP | Ensembl ].
VAR_054357

Sequences

Sequence LengthMass (Da)Tools
Q8NGX6 [UniParc].

Last modified February 10, 2009. Version 3.
Checksum: 9A287B3E86883A8F

FASTA33537,486
        10         20         30         40         50         60 
MPQILIFTYL NMFYFFPPLQ ILAENLTMVT EFLLLGFSSL GEIQLALFVV FLFLYLVILS 

        70         80         90        100        110        120 
GNVTIISVIH LDKSLHTPMY FFLGILSTSE TFYTFVILPK MLINLLSVAR TISFNCCALQ 

       130        140        150        160        170        180 
MFFFLGFAIT NCLLLGVMGY DRYAAICHPL HYPTLMSWQV CGKLAAACAI GGFLASLTVV 

       190        200        210        220        230        240 
NLVFSLPFCS ANKVNHYFCD ISAVILLACT NTDVNEFVIF ICGVLVLVVP FLFICVSYLC 

       250        260        270        280        290        300 
ILRTILKIPS AEGRRKAFST CASHLSVVIV HYGCASFIYL RPTANYVSNK DRLVTVTYTI 

       310        320        330 
VTPLLNPMVY SLRNKDVQLA IRKVLGKKGS LKLYN 

« Hide

References

« Hide 'large scale' references
[1]"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"DEFOG: a practical scheme for deciphering families of genes."
Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R., Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U., Lehrach H., Lancet D., Shamir R.
Genomics 80:295-302(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 88-303.
[4]"The human olfactory receptor gene family."
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
[5]Erratum
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB065640 Genomic DNA. Translation: BAC05866.1.
AL365440 Genomic DNA. Translation: CAH70559.1. Different initiation.
AF399582 Genomic DNA. Translation: AAK95067.1.
BK004191 Genomic DNA. Translation: DAA04589.1.
RefSeqNP_001004472.1. NM_001004472.1.
UniGeneHs.451913.

3D structure databases

ProteinModelPortalQ8NGX6.
SMRQ8NGX6. Positions 298-327.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000357134.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteQ8NGX6.

Polymorphism databases

DMDM223590254.

Proteomic databases

PaxDbQ8NGX6.
PRIDEQ8NGX6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000368152; ENSP00000357134; ENSG00000198965.
GeneID343406.
KEGGhsa:343406.
UCSCuc010pik.2. human.

Organism-specific databases

CTD343406.
GeneCardsGC01P158449.
HGNCHGNC:14820. OR10R2.
HPAHPA059775.
HPA060399.
neXtProtNX_Q8NGX6.
PharmGKBPA31997.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG117659.
HOGENOMHOG000041365.
HOVERGENHBG017625.
InParanoidQ8NGX6.
KOK04257.
OMACTNTDVN.
OrthoDBEOG71VST4.
PhylomeDBQ8NGX6.
TreeFamTF337249.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

CleanExHS_OR10R2.
GenevestigatorQ8NGX6.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiOR10R2.
GenomeRNAi343406.
NextBio98524.
PROQ8NGX6.

Entry information

Entry nameO10R2_HUMAN
AccessionPrimary (citable) accession number: Q8NGX6
Secondary accession number(s): Q5VWM8, Q6IFS1, Q96R61
Entry history
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: February 10, 2009
Last modified: April 16, 2014
This is version 106 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries