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Protein

Olfactory receptor 10R2

Gene

OR10R2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

BioCyciZFISH:G66-31807-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 10R2
Alternative name(s):
Olfactory receptor OR1-8
Gene namesi
Name:OR10R2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:14820. OR10R2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 45ExtracellularSequence analysisAdd BLAST45
Transmembranei46 – 66Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini67 – 74CytoplasmicSequence analysis8
Transmembranei75 – 95Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini96 – 119ExtracellularSequence analysisAdd BLAST24
Transmembranei120 – 140Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini141 – 159CytoplasmicSequence analysisAdd BLAST19
Transmembranei160 – 180Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini181 – 217ExtracellularSequence analysisAdd BLAST37
Transmembranei218 – 237Helical; Name=5Sequence analysisAdd BLAST20
Topological domaini238 – 257CytoplasmicSequence analysisAdd BLAST20
Transmembranei258 – 278Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini279 – 291ExtracellularSequence analysisAdd BLAST13
Transmembranei292 – 312Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini313 – 335CytoplasmicSequence analysisAdd BLAST23

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi343406.
OpenTargetsiENSG00000198965.
PharmGKBiPA31997.

Polymorphism and mutation databases

BioMutaiOR10R2.
DMDMi223590254.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001507151 – 335Olfactory receptor 10R2Add BLAST335

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi25N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi117 ↔ 209PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGX6.
PRIDEiQ8NGX6.

PTM databases

iPTMnetiQ8NGX6.
PhosphoSitePlusiQ8NGX6.

Expressioni

Gene expression databases

BgeeiENSG00000198965.
CleanExiHS_OR10R2.

Organism-specific databases

HPAiHPA059775.
HPA060399.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000357134.

Structurei

3D structure databases

ProteinModelPortaliQ8NGX6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IKCP. Eukaryota.
ENOG4111D9M. LUCA.
GeneTreeiENSGT00760000119043.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiQ8NGX6.
KOiK04257.
OMAiCTNTDVN.
OrthoDBiEOG091G0AZH.
PhylomeDBiQ8NGX6.
TreeFamiTF337249.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGX6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPQILIFTYL NMFYFFPPLQ ILAENLTMVT EFLLLGFSSL GEIQLALFVV
60 70 80 90 100
FLFLYLVILS GNVTIISVIH LDKSLHTPMY FFLGILSTSE TFYTFVILPK
110 120 130 140 150
MLINLLSVAR TISFNCCALQ MFFFLGFAIT NCLLLGVMGY DRYAAICHPL
160 170 180 190 200
HYPTLMSWQV CGKLAAACAI GGFLASLTVV NLVFSLPFCS ANKVNHYFCD
210 220 230 240 250
ISAVILLACT NTDVNEFVIF ICGVLVLVVP FLFICVSYLC ILRTILKIPS
260 270 280 290 300
AEGRRKAFST CASHLSVVIV HYGCASFIYL RPTANYVSNK DRLVTVTYTI
310 320 330
VTPLLNPMVY SLRNKDVQLA IRKVLGKKGS LKLYN
Length:335
Mass (Da):37,486
Last modified:February 10, 2009 - v3
Checksum:i9A287B3E86883A8F
GO

Sequence cautioni

The sequence CAH70559 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_054355191A → T.Corresponds to variant rs3820678dbSNPEnsembl.1
Natural variantiVAR_054356216E → G.Corresponds to variant rs6679056dbSNPEnsembl.1
Natural variantiVAR_054357239L → F.Corresponds to variant rs1418843dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065640 Genomic DNA. Translation: BAC05866.1.
AL365440 Genomic DNA. Translation: CAH70559.1. Different initiation.
AF399582 Genomic DNA. Translation: AAK95067.1.
BK004191 Genomic DNA. Translation: DAA04589.1.
CCDSiCCDS30898.1.
RefSeqiNP_001004472.1. NM_001004472.1.
UniGeneiHs.451913.

Genome annotation databases

EnsembliENST00000368152; ENSP00000357134; ENSG00000198965.
GeneIDi343406.
KEGGihsa:343406.
UCSCiuc010pik.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065640 Genomic DNA. Translation: BAC05866.1.
AL365440 Genomic DNA. Translation: CAH70559.1. Different initiation.
AF399582 Genomic DNA. Translation: AAK95067.1.
BK004191 Genomic DNA. Translation: DAA04589.1.
CCDSiCCDS30898.1.
RefSeqiNP_001004472.1. NM_001004472.1.
UniGeneiHs.451913.

3D structure databases

ProteinModelPortaliQ8NGX6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000357134.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ8NGX6.
PhosphoSitePlusiQ8NGX6.

Polymorphism and mutation databases

BioMutaiOR10R2.
DMDMi223590254.

Proteomic databases

PaxDbiQ8NGX6.
PRIDEiQ8NGX6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000368152; ENSP00000357134; ENSG00000198965.
GeneIDi343406.
KEGGihsa:343406.
UCSCiuc010pik.2. human.

Organism-specific databases

CTDi343406.
DisGeNETi343406.
GeneCardsiOR10R2.
HGNCiHGNC:14820. OR10R2.
HPAiHPA059775.
HPA060399.
neXtProtiNX_Q8NGX6.
OpenTargetsiENSG00000198965.
PharmGKBiPA31997.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IKCP. Eukaryota.
ENOG4111D9M. LUCA.
GeneTreeiENSGT00760000119043.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiQ8NGX6.
KOiK04257.
OMAiCTNTDVN.
OrthoDBiEOG091G0AZH.
PhylomeDBiQ8NGX6.
TreeFamiTF337249.

Enzyme and pathway databases

BioCyciZFISH:G66-31807-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR10R2.
GenomeRNAii343406.
PROiQ8NGX6.

Gene expression databases

BgeeiENSG00000198965.
CleanExiHS_OR10R2.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO10R2_HUMAN
AccessioniPrimary (citable) accession number: Q8NGX6
Secondary accession number(s): Q5VWM8, Q6IFS1, Q96R61
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: February 10, 2009
Last modified: November 2, 2016
This is version 122 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-12 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.