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Q8NGX6

- O10R2_HUMAN

UniProt

Q8NGX6 - O10R2_HUMAN

Protein

Olfactory receptor 10R2

Gene

OR10R2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 110 (01 Oct 2014)
      Sequence version 3 (10 Feb 2009)
      Previous versions | rss
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    Functioni

    Odorant receptor.Curated

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW
    2. olfactory receptor activity Source: InterPro

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Olfaction, Sensory transduction

    Enzyme and pathway databases

    ReactomeiREACT_15488. Olfactory Signaling Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Olfactory receptor 10R2
    Alternative name(s):
    Olfactory receptor OR1-8
    Gene namesi
    Name:OR10R2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:14820. OR10R2.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA31997.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 335335Olfactory receptor 10R2PRO_0000150715Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi25 – 251N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi117 ↔ 209PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ8NGX6.
    PRIDEiQ8NGX6.

    PTM databases

    PhosphoSiteiQ8NGX6.

    Expressioni

    Gene expression databases

    CleanExiHS_OR10R2.
    GenevestigatoriQ8NGX6.

    Organism-specific databases

    HPAiHPA059775.
    HPA060399.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000357134.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8NGX6.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 4545ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini67 – 748CytoplasmicSequence Analysis
    Topological domaini96 – 11924ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini141 – 15919CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini181 – 21737ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini238 – 25720CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini279 – 29113ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini313 – 33523CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei46 – 6621Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei75 – 9521Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei120 – 14021Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei160 – 18021Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei218 – 23720Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei258 – 27821Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei292 – 31221Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG117659.
    HOGENOMiHOG000041365.
    HOVERGENiHBG017625.
    InParanoidiQ8NGX6.
    KOiK04257.
    OMAiCTNTDVN.
    OrthoDBiEOG71VST4.
    PhylomeDBiQ8NGX6.
    TreeFamiTF337249.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8NGX6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPQILIFTYL NMFYFFPPLQ ILAENLTMVT EFLLLGFSSL GEIQLALFVV    50
    FLFLYLVILS GNVTIISVIH LDKSLHTPMY FFLGILSTSE TFYTFVILPK 100
    MLINLLSVAR TISFNCCALQ MFFFLGFAIT NCLLLGVMGY DRYAAICHPL 150
    HYPTLMSWQV CGKLAAACAI GGFLASLTVV NLVFSLPFCS ANKVNHYFCD 200
    ISAVILLACT NTDVNEFVIF ICGVLVLVVP FLFICVSYLC ILRTILKIPS 250
    AEGRRKAFST CASHLSVVIV HYGCASFIYL RPTANYVSNK DRLVTVTYTI 300
    VTPLLNPMVY SLRNKDVQLA IRKVLGKKGS LKLYN 335
    Length:335
    Mass (Da):37,486
    Last modified:February 10, 2009 - v3
    Checksum:i9A287B3E86883A8F
    GO

    Sequence cautioni

    The sequence CAH70559.1 differs from that shown. Reason: Erroneous initiation.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti191 – 1911A → T.
    Corresponds to variant rs3820678 [ dbSNP | Ensembl ].
    VAR_054355
    Natural varianti216 – 2161E → G.
    Corresponds to variant rs6679056 [ dbSNP | Ensembl ].
    VAR_054356
    Natural varianti239 – 2391L → F.
    Corresponds to variant rs1418843 [ dbSNP | Ensembl ].
    VAR_054357

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065640 Genomic DNA. Translation: BAC05866.1.
    AL365440 Genomic DNA. Translation: CAH70559.1. Different initiation.
    AF399582 Genomic DNA. Translation: AAK95067.1.
    BK004191 Genomic DNA. Translation: DAA04589.1.
    CCDSiCCDS30898.1.
    RefSeqiNP_001004472.1. NM_001004472.1.
    UniGeneiHs.451913.

    Genome annotation databases

    EnsembliENST00000368152; ENSP00000357134; ENSG00000198965.
    GeneIDi343406.
    KEGGihsa:343406.
    UCSCiuc010pik.2. human.

    Polymorphism databases

    DMDMi223590254.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Human Olfactory Receptor Data Exploratorium (HORDE)

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065640 Genomic DNA. Translation: BAC05866.1 .
    AL365440 Genomic DNA. Translation: CAH70559.1 . Different initiation.
    AF399582 Genomic DNA. Translation: AAK95067.1 .
    BK004191 Genomic DNA. Translation: DAA04589.1 .
    CCDSi CCDS30898.1.
    RefSeqi NP_001004472.1. NM_001004472.1.
    UniGenei Hs.451913.

    3D structure databases

    ProteinModelPortali Q8NGX6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000357134.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q8NGX6.

    Polymorphism databases

    DMDMi 223590254.

    Proteomic databases

    PaxDbi Q8NGX6.
    PRIDEi Q8NGX6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000368152 ; ENSP00000357134 ; ENSG00000198965 .
    GeneIDi 343406.
    KEGGi hsa:343406.
    UCSCi uc010pik.2. human.

    Organism-specific databases

    CTDi 343406.
    GeneCardsi GC01P158449.
    HGNCi HGNC:14820. OR10R2.
    HPAi HPA059775.
    HPA060399.
    neXtProti NX_Q8NGX6.
    PharmGKBi PA31997.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG117659.
    HOGENOMi HOG000041365.
    HOVERGENi HBG017625.
    InParanoidi Q8NGX6.
    KOi K04257.
    OMAi CTNTDVN.
    OrthoDBi EOG71VST4.
    PhylomeDBi Q8NGX6.
    TreeFami TF337249.

    Enzyme and pathway databases

    Reactomei REACT_15488. Olfactory Signaling Pathway.

    Miscellaneous databases

    GeneWikii OR10R2.
    GenomeRNAii 343406.
    NextBioi 98524.
    PROi Q8NGX6.

    Gene expression databases

    CleanExi HS_OR10R2.
    Genevestigatori Q8NGX6.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
      Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
      Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 88-303.
    4. Cited for: IDENTIFICATION.
    5. Erratum
      Malnic B., Godfrey P.A., Buck L.B.
      Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

    Entry informationi

    Entry nameiO10R2_HUMAN
    AccessioniPrimary (citable) accession number: Q8NGX6
    Secondary accession number(s): Q5VWM8, Q6IFS1, Q96R61
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 10, 2003
    Last sequence update: February 10, 2009
    Last modified: October 1, 2014
    This is version 110 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    It is uncertain whether Met-1 or Met-12 is the initiator.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3