Q8NGX6 (O10R2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Olfactory receptor 10R2

Alternative name(s):
Olfactory receptor OR1-8

Gene names

Name:

OR10R2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	335 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Odorant receptor Potential.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.
Caution	It is uncertain whether Met-1 or Met-12 is the initiator.
Sequence caution	The sequence CAH70559.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Olfaction Sensory transduction
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	detection of chemical stimulus involved in sensory perception of smell Inferred from electronic annotation. Source: GOC
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Traceable author statement. Source: Reactome
Molecular_function	G-protein coupled receptor activity Inferred from electronic annotation. Source: UniProtKB-KW olfactory receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 335	335	Olfactory receptor 10R2		PRO_0000150715
Regions
	Topological domain	1 – 45	45	Extracellular Potential
	Transmembrane	46 – 66	21	Helical; Name=1; Potential
	Topological domain	67 – 74	8	Cytoplasmic Potential
	Transmembrane	75 – 95	21	Helical; Name=2; Potential
	Topological domain	96 – 119	24	Extracellular Potential
	Transmembrane	120 – 140	21	Helical; Name=3; Potential
	Topological domain	141 – 159	19	Cytoplasmic Potential
	Transmembrane	160 – 180	21	Helical; Name=4; Potential
	Topological domain	181 – 217	37	Extracellular Potential
	Transmembrane	218 – 237	20	Helical; Name=5; Potential
	Topological domain	238 – 257	20	Cytoplasmic Potential
	Transmembrane	258 – 278	21	Helical; Name=6; Potential
	Topological domain	279 – 291	13	Extracellular Potential
	Transmembrane	292 – 312	21	Helical; Name=7; Potential
	Topological domain	313 – 335	23	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	25	1	N-linked (GlcNAc...) Potential
	Disulfide bond	117 ↔ 209		By similarity
Natural variations
	Natural variant	191	1	A → T. Corresponds to variant rs3820678 [ dbSNP | Ensembl ].		VAR_054355
	Natural variant	216	1	E → G. Corresponds to variant rs6679056 [ dbSNP | Ensembl ].		VAR_054356
	Natural variant	239	1	L → F. Corresponds to variant rs1418843 [ dbSNP | Ensembl ].		VAR_054357

Sequences

	Sequence		Length	Mass (Da)
	Q8NGX6 [UniParc]. Last modified February 10, 2009. Version 3. Checksum: 9A287B3E86883A8F	FASTA	335	37,486
	10 20 30 40 50 60 MPQILIFTYL NMFYFFPPLQ ILAENLTMVT EFLLLGFSSL GEIQLALFVV FLFLYLVILS 70 80 90 100 110 120 GNVTIISVIH LDKSLHTPMY FFLGILSTSE TFYTFVILPK MLINLLSVAR TISFNCCALQ 130 140 150 160 170 180 MFFFLGFAIT NCLLLGVMGY DRYAAICHPL HYPTLMSWQV CGKLAAACAI GGFLASLTVV 190 200 210 220 230 240 NLVFSLPFCS ANKVNHYFCD ISAVILLACT NTDVNEFVIF ICGVLVLVVP FLFICVSYLC 250 260 270 280 290 300 ILRTILKIPS AEGRRKAFST CASHLSVVIV HYGCASFIYL RPTANYVSNK DRLVTVTYTI 310 320 330 VTPLLNPMVY SLRNKDVQLA IRKVLGKKGS LKLYN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes." Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y. Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"DEFOG: a practical scheme for deciphering families of genes." Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R., Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U., Lehrach H., Lancet D., Shamir R. Genomics 80:295-302(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 88-303.
[4]	"The human olfactory receptor gene family." Malnic B., Godfrey P.A., Buck L.B. Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION.
[5]	Erratum Malnic B., Godfrey P.A., Buck L.B. Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Web resources

Human Olfactory Receptor Data Exploratorium (HORDE)

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB065640 Genomic DNA. Translation: BAC05866.1. AL365440 Genomic DNA. Translation: CAH70559.1. Different initiation. AF399582 Genomic DNA. Translation: AAK95067.1. BK004191 Genomic DNA. Translation: DAA04589.1.
IPI	IPI00303717.
RefSeq	NP_001004472.1. NM_001004472.1.
UniGene	Hs.451913.
3D structure databases
ProteinModelPortal	Q8NGX6.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000357134.
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	Q8NGX6.
Polymorphism databases
DMDM	223590254.
Proteomic databases
PaxDb	Q8NGX6.
PRIDE	Q8NGX6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000368152; ENSP00000357134; ENSG00000198965.
GeneID	343406.
KEGG	hsa:343406.
UCSC	uc010pik.2. human.
Organism-specific databases
CTD	343406.
GeneCards	GC01P158449.
HGNC	HGNC:14820. OR10R2.
neXtProt	NX_Q8NGX6.
PharmGKB	PA31997.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG117659.
HOGENOM	HOG000041365.
HOVERGEN	HBG017625.
InParanoid	Q8NGX6.
KO	K04257.
OMA	CCALQMF.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction.
Gene expression databases
CleanEx	HS_OR10R2.
Genevestigator	Q8NGX6.
Family and domain databases
InterPro	IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. IPR000725. Olfact_rcpt. [Graphical view]
PRINTS	PR00237. GPCRRHODOPSN. PR00245. OLFACTORYR.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	343406.
NextBio	98524.

Entry information

Entry name

O10R2_HUMAN

Accession

Primary (citable) accession number: Q8NGX6
Secondary accession number(s): Q5VWM8, Q6IFS1, Q96R61

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 10, 2003
Last sequence update:	February 10, 2009
Last modified:	May 1, 2013
This is version 99 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.