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Q8NGX6

- O10R2_HUMAN

UniProt

Q8NGX6 - O10R2_HUMAN

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Protein

Olfactory receptor 10R2

Gene

OR10R2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 10R2
Alternative name(s):
Olfactory receptor OR1-8
Gene namesi
Name:OR10R2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:14820. OR10R2.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31997.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 335335Olfactory receptor 10R2PRO_0000150715Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi25 – 251N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi117 ↔ 209PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGX6.
PRIDEiQ8NGX6.

PTM databases

PhosphoSiteiQ8NGX6.

Expressioni

Gene expression databases

CleanExiHS_OR10R2.
GenevestigatoriQ8NGX6.

Organism-specific databases

HPAiHPA059775.
HPA060399.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000357134.

Structurei

3D structure databases

ProteinModelPortaliQ8NGX6.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4545ExtracellularSequence AnalysisAdd
BLAST
Topological domaini67 – 748CytoplasmicSequence Analysis
Topological domaini96 – 11924ExtracellularSequence AnalysisAdd
BLAST
Topological domaini141 – 15919CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini181 – 21737ExtracellularSequence AnalysisAdd
BLAST
Topological domaini238 – 25720CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini279 – 29113ExtracellularSequence AnalysisAdd
BLAST
Topological domaini313 – 33523CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei46 – 6621Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei75 – 9521Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei120 – 14021Helical; Name=3Sequence AnalysisAdd
BLAST
Transmembranei160 – 18021Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei218 – 23720Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei258 – 27821Helical; Name=6Sequence AnalysisAdd
BLAST
Transmembranei292 – 31221Helical; Name=7Sequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG117659.
GeneTreeiENSGT00760000119043.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiQ8NGX6.
KOiK04257.
OMAiCTNTDVN.
OrthoDBiEOG71VST4.
PhylomeDBiQ8NGX6.
TreeFamiTF337249.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGX6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPQILIFTYL NMFYFFPPLQ ILAENLTMVT EFLLLGFSSL GEIQLALFVV
60 70 80 90 100
FLFLYLVILS GNVTIISVIH LDKSLHTPMY FFLGILSTSE TFYTFVILPK
110 120 130 140 150
MLINLLSVAR TISFNCCALQ MFFFLGFAIT NCLLLGVMGY DRYAAICHPL
160 170 180 190 200
HYPTLMSWQV CGKLAAACAI GGFLASLTVV NLVFSLPFCS ANKVNHYFCD
210 220 230 240 250
ISAVILLACT NTDVNEFVIF ICGVLVLVVP FLFICVSYLC ILRTILKIPS
260 270 280 290 300
AEGRRKAFST CASHLSVVIV HYGCASFIYL RPTANYVSNK DRLVTVTYTI
310 320 330
VTPLLNPMVY SLRNKDVQLA IRKVLGKKGS LKLYN
Length:335
Mass (Da):37,486
Last modified:February 10, 2009 - v3
Checksum:i9A287B3E86883A8F
GO

Sequence cautioni

The sequence CAH70559.1 differs from that shown. Reason: Erroneous initiation.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti191 – 1911A → T.
Corresponds to variant rs3820678 [ dbSNP | Ensembl ].
VAR_054355
Natural varianti216 – 2161E → G.
Corresponds to variant rs6679056 [ dbSNP | Ensembl ].
VAR_054356
Natural varianti239 – 2391L → F.
Corresponds to variant rs1418843 [ dbSNP | Ensembl ].
VAR_054357

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB065640 Genomic DNA. Translation: BAC05866.1.
AL365440 Genomic DNA. Translation: CAH70559.1. Different initiation.
AF399582 Genomic DNA. Translation: AAK95067.1.
BK004191 Genomic DNA. Translation: DAA04589.1.
CCDSiCCDS30898.1.
RefSeqiNP_001004472.1. NM_001004472.1.
UniGeneiHs.451913.

Genome annotation databases

EnsembliENST00000368152; ENSP00000357134; ENSG00000198965.
GeneIDi343406.
KEGGihsa:343406.
UCSCiuc010pik.2. human.

Polymorphism databases

DMDMi223590254.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB065640 Genomic DNA. Translation: BAC05866.1 .
AL365440 Genomic DNA. Translation: CAH70559.1 . Different initiation.
AF399582 Genomic DNA. Translation: AAK95067.1 .
BK004191 Genomic DNA. Translation: DAA04589.1 .
CCDSi CCDS30898.1.
RefSeqi NP_001004472.1. NM_001004472.1.
UniGenei Hs.451913.

3D structure databases

ProteinModelPortali Q8NGX6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000357134.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei Q8NGX6.

Polymorphism databases

DMDMi 223590254.

Proteomic databases

PaxDbi Q8NGX6.
PRIDEi Q8NGX6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000368152 ; ENSP00000357134 ; ENSG00000198965 .
GeneIDi 343406.
KEGGi hsa:343406.
UCSCi uc010pik.2. human.

Organism-specific databases

CTDi 343406.
GeneCardsi GC01P158449.
HGNCi HGNC:14820. OR10R2.
HPAi HPA059775.
HPA060399.
neXtProti NX_Q8NGX6.
PharmGKBi PA31997.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG117659.
GeneTreei ENSGT00760000119043.
HOGENOMi HOG000041365.
HOVERGENi HBG017625.
InParanoidi Q8NGX6.
KOi K04257.
OMAi CTNTDVN.
OrthoDBi EOG71VST4.
PhylomeDBi Q8NGX6.
TreeFami TF337249.

Enzyme and pathway databases

Reactomei REACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikii OR10R2.
GenomeRNAii 343406.
NextBioi 98524.
PROi Q8NGX6.

Gene expression databases

CleanExi HS_OR10R2.
Genevestigatori Q8NGX6.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 88-303.
  4. Cited for: IDENTIFICATION.
  5. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiO10R2_HUMAN
AccessioniPrimary (citable) accession number: Q8NGX6
Secondary accession number(s): Q5VWM8, Q6IFS1, Q96R61
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: February 10, 2009
Last modified: October 29, 2014
This is version 111 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-12 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3