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Protein

Olfactory receptor 10K1

Gene

OR10K1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

BioCyciZFISH:ENSG00000173285-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 10K1
Alternative name(s):
Olfactory receptor OR1-6
Gene namesi
Name:OR10K1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:14693. OR10K1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 25ExtracellularSequence analysisAdd BLAST25
Transmembranei26 – 46Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini47 – 54CytoplasmicSequence analysis8
Transmembranei55 – 75Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini76 – 99ExtracellularSequence analysisAdd BLAST24
Transmembranei100 – 120Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini121 – 139CytoplasmicSequence analysisAdd BLAST19
Transmembranei140 – 160Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini161 – 197ExtracellularSequence analysisAdd BLAST37
Transmembranei198 – 217Helical; Name=5Sequence analysisAdd BLAST20
Topological domaini218 – 237CytoplasmicSequence analysisAdd BLAST20
Transmembranei238 – 258Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini259 – 271ExtracellularSequence analysisAdd BLAST13
Transmembranei272 – 292Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini293 – 313CytoplasmicSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi391109.
OpenTargetsiENSG00000173285.
PharmGKBiPA31988.

Polymorphism and mutation databases

BioMutaiOR10K1.
DMDMi38372781.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001507111 – 313Olfactory receptor 10K1Add BLAST313

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...)Sequence analysis1
Glycosylationi265N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8NGX5.
PeptideAtlasiQ8NGX5.
PRIDEiQ8NGX5.

PTM databases

iPTMnetiQ8NGX5.
PhosphoSitePlusiQ8NGX5.

Expressioni

Gene expression databases

CleanExiHS_OR10K1.
ExpressionAtlasiQ8NGX5. baseline and differential.

Organism-specific databases

HPAiHPA059125.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000289451.

Structurei

3D structure databases

ProteinModelPortaliQ8NGX5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410II0G. Eukaryota.
ENOG41117G5. LUCA.
GeneTreeiENSGT00760000119043.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiQ8NGX5.
KOiK04257.
OMAiGFSQLVI.
OrthoDBiEOG091G0CYL.
PhylomeDBiQ8NGX5.
TreeFamiTF337249.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGX5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEQVNKTVVR EFVVLGFSSL ARLQQLLFVI FLLLYLFTLG TNAIIISTIV
60 70 80 90 100
LDRALHTPMY FFLAILSCSE ICYTFVIVPK MLVDLLSQKK TISFLGCAIQ
110 120 130 140 150
MFSFLFFGSS HSFLLAAMGY DRYMAICNPL RYSVLMGHGV CMGLMAAACA
160 170 180 190 200
CGFTVSLVTT SLVFHLPFHS SNQLHHFFCD ISPVLKLASQ HSGFSQLVIF
210 220 230 240 250
MLGVFALVIP LLLILVSYIR IISAILKIPS SVGRYKTFST CASHLIVVTV
260 270 280 290 300
HYSCASFIYL RPKTNYTSSQ DTLISVSYTI LTPLFNPMIY SLRNKEFKSA
310
LRRTIGQTFY PLS
Length:313
Mass (Da):35,079
Last modified:October 1, 2002 - v1
Checksum:i96E546B9EC492965
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065641 Genomic DNA. Translation: BAC05867.1.
AL365440 Genomic DNA. Translation: CAH70558.1.
CH471121 Genomic DNA. Translation: EAW52825.1.
BC137323 mRNA. Translation: AAI37324.1.
BC137324 mRNA. Translation: AAI37325.1.
BK004190 Genomic DNA. Translation: DAA04588.1.
CCDSiCCDS30897.1.
RefSeqiNP_001004473.1. NM_001004473.1.
UniGeneiHs.690410.

Genome annotation databases

EnsembliENST00000289451; ENSP00000289451; ENSG00000173285.
GeneIDi391109.
KEGGihsa:391109.
UCSCiuc010pij.2. human.

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065641 Genomic DNA. Translation: BAC05867.1.
AL365440 Genomic DNA. Translation: CAH70558.1.
CH471121 Genomic DNA. Translation: EAW52825.1.
BC137323 mRNA. Translation: AAI37324.1.
BC137324 mRNA. Translation: AAI37325.1.
BK004190 Genomic DNA. Translation: DAA04588.1.
CCDSiCCDS30897.1.
RefSeqiNP_001004473.1. NM_001004473.1.
UniGeneiHs.690410.

3D structure databases

ProteinModelPortaliQ8NGX5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000289451.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ8NGX5.
PhosphoSitePlusiQ8NGX5.

Polymorphism and mutation databases

BioMutaiOR10K1.
DMDMi38372781.

Proteomic databases

PaxDbiQ8NGX5.
PeptideAtlasiQ8NGX5.
PRIDEiQ8NGX5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000289451; ENSP00000289451; ENSG00000173285.
GeneIDi391109.
KEGGihsa:391109.
UCSCiuc010pij.2. human.

Organism-specific databases

CTDi391109.
DisGeNETi391109.
GeneCardsiOR10K1.
HGNCiHGNC:14693. OR10K1.
HPAiHPA059125.
neXtProtiNX_Q8NGX5.
OpenTargetsiENSG00000173285.
PharmGKBiPA31988.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410II0G. Eukaryota.
ENOG41117G5. LUCA.
GeneTreeiENSGT00760000119043.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiQ8NGX5.
KOiK04257.
OMAiGFSQLVI.
OrthoDBiEOG091G0CYL.
PhylomeDBiQ8NGX5.
TreeFamiTF337249.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000173285-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR10K1.
GenomeRNAii391109.
PROiQ8NGX5.

Gene expression databases

CleanExiHS_OR10K1.
ExpressionAtlasiQ8NGX5. baseline and differential.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO10K1_HUMAN
AccessioniPrimary (citable) accession number: Q8NGX5
Secondary accession number(s): Q6IFS2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: November 30, 2016
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.