ID   O10T2_HUMAN             Reviewed;         314 AA.
AC   Q8NGX3; Q6IF98;
DT   10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   24-JAN-2024, entry version 160.
DE   RecName: Full=Olfactory receptor 10T2;
DE   AltName: Full=Olfactory receptor OR1-3;
GN   Name=OR10T2;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA   Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT   "Genome-wide discovery and analysis of human seven transmembrane helix
RT   receptor genes.";
RL   Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16710414; DOI=10.1038/nature04727;
RA   Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA   Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA   Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA   Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA   Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA   Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA   Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA   Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA   Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA   Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA   Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA   Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA   Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA   Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA   Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA   Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA   Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA   Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA   Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA   McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA   Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA   Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA   Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA   Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA   Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA   White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA   Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA   Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA   Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT   "The DNA sequence and biological annotation of human chromosome 1.";
RL   Nature 441:315-321(2006).
RN   [3]
RP   IDENTIFICATION.
RX   PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA   Malnic B., Godfrey P.A., Buck L.B.;
RT   "The human olfactory receptor gene family.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN   [4]
RP   ERRATUM OF PUBMED:14983052.
RA   Malnic B., Godfrey P.A., Buck L.B.;
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC   -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC   -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC       URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR10T2";
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DR   EMBL; AB065643; BAC05869.1; -; Genomic_DNA.
DR   EMBL; AL121986; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BK004364; DAA04762.1; -; Genomic_DNA.
DR   CCDS; CCDS30895.1; -.
DR   RefSeq; NP_001004475.1; NM_001004475.1.
DR   AlphaFoldDB; Q8NGX3; -.
DR   SMR; Q8NGX3; -.
DR   STRING; 9606.ENSP00000334115; -.
DR   GlyCosmos; Q8NGX3; 1 site, No reported glycans.
DR   GlyGen; Q8NGX3; 1 site.
DR   iPTMnet; Q8NGX3; -.
DR   PhosphoSitePlus; Q8NGX3; -.
DR   BioMuta; OR10T2; -.
DR   DMDM; 38372780; -.
DR   MassIVE; Q8NGX3; -.
DR   PaxDb; 9606-ENSP00000334115; -.
DR   PeptideAtlas; Q8NGX3; -.
DR   Antibodypedia; 57095; 94 antibodies from 19 providers.
DR   DNASU; 128360; -.
DR   Ensembl; ENST00000334438.1; ENSP00000334115.1; ENSG00000186306.1.
DR   GeneID; 128360; -.
DR   KEGG; hsa:128360; -.
DR   MANE-Select; ENST00000334438.1; ENSP00000334115.1; NM_001004475.1; NP_001004475.1.
DR   UCSC; uc010pih.2; human.
DR   AGR; HGNC:14816; -.
DR   CTD; 128360; -.
DR   DisGeNET; 128360; -.
DR   GeneCards; OR10T2; -.
DR   HGNC; HGNC:14816; OR10T2.
DR   HPA; ENSG00000186306; Not detected.
DR   neXtProt; NX_Q8NGX3; -.
DR   PharmGKB; PA32001; -.
DR   VEuPathDB; HostDB:ENSG00000186306; -.
DR   eggNOG; ENOG502QVH7; Eukaryota.
DR   GeneTree; ENSGT00940000164107; -.
DR   HOGENOM; CLU_012526_1_0_1; -.
DR   InParanoid; Q8NGX3; -.
DR   OMA; YFCDMAP; -.
DR   OrthoDB; 4630415at2759; -.
DR   PhylomeDB; Q8NGX3; -.
DR   TreeFam; TF337249; -.
DR   PathwayCommons; Q8NGX3; -.
DR   Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR   BioGRID-ORCS; 128360; 12 hits in 748 CRISPR screens.
DR   GeneWiki; OR10T2; -.
DR   GenomeRNAi; 128360; -.
DR   Pharos; Q8NGX3; Tdark.
DR   PRO; PR:Q8NGX3; -.
DR   Proteomes; UP000005640; Chromosome 1.
DR   RNAct; Q8NGX3; Protein.
DR   Bgee; ENSG00000186306; Expressed in primordial germ cell in gonad.
DR   ExpressionAtlas; Q8NGX3; baseline and differential.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0005549; F:odorant binding; IBA:GO_Central.
DR   GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR   GO; GO:0050911; P:detection of chemical stimulus involved in sensory perception of smell; IBA:GO_Central.
DR   CDD; cd15225; 7tmA_OR10A-like; 1.
DR   Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR000725; Olfact_rcpt.
DR   PANTHER; PTHR26453; OLFACTORY RECEPTOR; 1.
DR   PANTHER; PTHR26453:SF622; OLFACTORY RECEPTOR; 1.
DR   Pfam; PF13853; 7tm_4; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR00245; OLFACTORYR.
DR   SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW   Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW   Transducer; Transmembrane; Transmembrane helix.
FT   CHAIN           1..314
FT                   /note="Olfactory receptor 10T2"
FT                   /id="PRO_0000150717"
FT   TOPO_DOM        1..26
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        27..47
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        48..55
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        56..76
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        77..100
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        101..121
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        122..140
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        141..161
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        162..198
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        199..218
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        219..237
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        238..258
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        259..271
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        272..292
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        293..314
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        5
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        98..190
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT   VARIANT         16
FT                   /note="V -> A (in dbSNP:rs6660222)"
FT                   /id="VAR_053284"
FT   VARIANT         65
FT                   /note="F -> L (in dbSNP:rs41488350)"
FT                   /id="VAR_053285"
FT   VARIANT         78
FT                   /note="I -> V (in dbSNP:rs6662597)"
FT                   /id="VAR_053286"
FT   VARIANT         137
FT                   /note="I -> M (in dbSNP:rs6662382)"
FT                   /id="VAR_053287"
FT   VARIANT         155
FT                   /note="F -> L (in dbSNP:rs12062580)"
FT                   /id="VAR_053288"
FT   VARIANT         312
FT                   /note="K -> N (in dbSNP:rs6692949)"
FT                   /id="VAR_053289"
SQ   SEQUENCE   314 AA;  35011 MW;  ABD13B73F6CDD152 CRC64;
     MRGFNKTTVV TQFILVGFSS LGELQLLLFV IFLLLYLTIL VANVTIMAVI RFSWTLHTPM
     YGFLFILSFS ESCYTFVIIP QLLVHLLSDT KTISFMACAT QLFFFLGFAC TNCLLIAVMG
     YDRYVAICHP LRYTLIINKR LGLELISLSG ATGFFIALVA TNLICDMRFC GPNRVNHYFC
     DMAPVIKLAC TDTHVKELAL FSLSILVIMV PFLLILISYG FIVNTILKIP SAEGKKAFVT
     CASHLTVVFV HYGCASIIYL RPKSKSASDK DQLVAVTYTV VTPLLNPLVY SLRNKEVKTA
     LKRVLGMPVA TKMS
//