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Protein

Olfactory receptor 10T2

Gene

OR10T2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

BioCyciZFISH:G66-31692-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 10T2
Alternative name(s):
Olfactory receptor OR1-3
Gene namesi
Name:OR10T2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:14816. OR10T2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 26ExtracellularSequence analysisAdd BLAST26
Transmembranei27 – 47Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini48 – 55CytoplasmicSequence analysis8
Transmembranei56 – 76Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini77 – 100ExtracellularSequence analysisAdd BLAST24
Transmembranei101 – 121Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini122 – 140CytoplasmicSequence analysisAdd BLAST19
Transmembranei141 – 161Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini162 – 198ExtracellularSequence analysisAdd BLAST37
Transmembranei199 – 218Helical; Name=5Sequence analysisAdd BLAST20
Topological domaini219 – 237CytoplasmicSequence analysisAdd BLAST19
Transmembranei238 – 258Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini259 – 271ExtracellularSequence analysisAdd BLAST13
Transmembranei272 – 292Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini293 – 314CytoplasmicSequence analysisAdd BLAST22

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi128360.
OpenTargetsiENSG00000186306.
PharmGKBiPA32001.

Polymorphism and mutation databases

BioMutaiOR10T2.
DMDMi38372780.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001507171 – 314Olfactory receptor 10T2Add BLAST314

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi98 ↔ 190PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGX3.
PeptideAtlasiQ8NGX3.
PRIDEiQ8NGX3.

PTM databases

iPTMnetiQ8NGX3.
PhosphoSitePlusiQ8NGX3.

Expressioni

Gene expression databases

CleanExiHS_OR10T2.
ExpressionAtlasiQ8NGX3. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000334115.

Structurei

3D structure databases

ProteinModelPortaliQ8NGX3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410II0G. Eukaryota.
ENOG41117G5. LUCA.
GeneTreeiENSGT00760000119043.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ8NGX3.
KOiK04257.
OMAiPMYGFLF.
OrthoDBiEOG091G0AZH.
PhylomeDBiQ8NGX3.
TreeFamiTF337249.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGX3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRGFNKTTVV TQFILVGFSS LGELQLLLFV IFLLLYLTIL VANVTIMAVI
60 70 80 90 100
RFSWTLHTPM YGFLFILSFS ESCYTFVIIP QLLVHLLSDT KTISFMACAT
110 120 130 140 150
QLFFFLGFAC TNCLLIAVMG YDRYVAICHP LRYTLIINKR LGLELISLSG
160 170 180 190 200
ATGFFIALVA TNLICDMRFC GPNRVNHYFC DMAPVIKLAC TDTHVKELAL
210 220 230 240 250
FSLSILVIMV PFLLILISYG FIVNTILKIP SAEGKKAFVT CASHLTVVFV
260 270 280 290 300
HYGCASIIYL RPKSKSASDK DQLVAVTYTV VTPLLNPLVY SLRNKEVKTA
310
LKRVLGMPVA TKMS
Length:314
Mass (Da):35,011
Last modified:October 1, 2002 - v1
Checksum:iABD13B73F6CDD152
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05328416V → A.Corresponds to variant rs6660222dbSNPEnsembl.1
Natural variantiVAR_05328565F → L.Corresponds to variant rs41488350dbSNPEnsembl.1
Natural variantiVAR_05328678I → V.Corresponds to variant rs6662597dbSNPEnsembl.1
Natural variantiVAR_053287137I → M.Corresponds to variant rs6662382dbSNPEnsembl.1
Natural variantiVAR_053288155F → L.Corresponds to variant rs12062580dbSNPEnsembl.1
Natural variantiVAR_053289312K → N.Corresponds to variant rs6692949dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065643 Genomic DNA. Translation: BAC05869.1.
AL121986 Genomic DNA. Translation: CAI10867.1.
BK004364 Genomic DNA. Translation: DAA04762.1.
CCDSiCCDS30895.1.
RefSeqiNP_001004475.1. NM_001004475.1.
UniGeneiHs.553588.

Genome annotation databases

EnsembliENST00000334438; ENSP00000334115; ENSG00000186306.
GeneIDi128360.
KEGGihsa:128360.
UCSCiuc010pih.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065643 Genomic DNA. Translation: BAC05869.1.
AL121986 Genomic DNA. Translation: CAI10867.1.
BK004364 Genomic DNA. Translation: DAA04762.1.
CCDSiCCDS30895.1.
RefSeqiNP_001004475.1. NM_001004475.1.
UniGeneiHs.553588.

3D structure databases

ProteinModelPortaliQ8NGX3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000334115.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ8NGX3.
PhosphoSitePlusiQ8NGX3.

Polymorphism and mutation databases

BioMutaiOR10T2.
DMDMi38372780.

Proteomic databases

PaxDbiQ8NGX3.
PeptideAtlasiQ8NGX3.
PRIDEiQ8NGX3.

Protocols and materials databases

DNASUi128360.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000334438; ENSP00000334115; ENSG00000186306.
GeneIDi128360.
KEGGihsa:128360.
UCSCiuc010pih.2. human.

Organism-specific databases

CTDi128360.
DisGeNETi128360.
GeneCardsiOR10T2.
HGNCiHGNC:14816. OR10T2.
neXtProtiNX_Q8NGX3.
OpenTargetsiENSG00000186306.
PharmGKBiPA32001.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410II0G. Eukaryota.
ENOG41117G5. LUCA.
GeneTreeiENSGT00760000119043.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ8NGX3.
KOiK04257.
OMAiPMYGFLF.
OrthoDBiEOG091G0AZH.
PhylomeDBiQ8NGX3.
TreeFamiTF337249.

Enzyme and pathway databases

BioCyciZFISH:G66-31692-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR10T2.
GenomeRNAii128360.
PROiQ8NGX3.

Gene expression databases

CleanExiHS_OR10T2.
ExpressionAtlasiQ8NGX3. baseline and differential.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO10T2_HUMAN
AccessioniPrimary (citable) accession number: Q8NGX3
Secondary accession number(s): Q6IF98
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: November 30, 2016
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.