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Q8NGX3

- O10T2_HUMAN

UniProt

Q8NGX3 - O10T2_HUMAN

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Protein

Olfactory receptor 10T2

Gene
OR10T2
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Odorant receptor Reviewed prediction.

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 10T2
Alternative name(s):
Olfactory receptor OR1-3
Gene namesi
Name:OR10T2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:14816. OR10T2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2626Extracellular Reviewed predictionAdd
BLAST
Transmembranei27 – 4721Helical; Name=1; Reviewed predictionAdd
BLAST
Topological domaini48 – 558Cytoplasmic Reviewed prediction
Transmembranei56 – 7621Helical; Name=2; Reviewed predictionAdd
BLAST
Topological domaini77 – 10024Extracellular Reviewed predictionAdd
BLAST
Transmembranei101 – 12121Helical; Name=3; Reviewed predictionAdd
BLAST
Topological domaini122 – 14019Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei141 – 16121Helical; Name=4; Reviewed predictionAdd
BLAST
Topological domaini162 – 19837Extracellular Reviewed predictionAdd
BLAST
Transmembranei199 – 21820Helical; Name=5; Reviewed predictionAdd
BLAST
Topological domaini219 – 23719Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei238 – 25821Helical; Name=6; Reviewed predictionAdd
BLAST
Topological domaini259 – 27113Extracellular Reviewed predictionAdd
BLAST
Transmembranei272 – 29221Helical; Name=7; Reviewed predictionAdd
BLAST
Topological domaini293 – 31422Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32001.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 314314Olfactory receptor 10T2PRO_0000150717Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi98 ↔ 190 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGX3.
PRIDEiQ8NGX3.

PTM databases

PhosphoSiteiQ8NGX3.

Expressioni

Gene expression databases

CleanExiHS_OR10T2.
GenevestigatoriQ8NGX3.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000334115.

Structurei

3D structure databases

ProteinModelPortaliQ8NGX3.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG74481.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ8NGX3.
KOiK04257.
OMAiFNKTTVV.
OrthoDBiEOG71K63J.
PhylomeDBiQ8NGX3.
TreeFamiTF337249.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGX3-1 [UniParc]FASTAAdd to Basket

« Hide

MRGFNKTTVV TQFILVGFSS LGELQLLLFV IFLLLYLTIL VANVTIMAVI    50
RFSWTLHTPM YGFLFILSFS ESCYTFVIIP QLLVHLLSDT KTISFMACAT 100
QLFFFLGFAC TNCLLIAVMG YDRYVAICHP LRYTLIINKR LGLELISLSG 150
ATGFFIALVA TNLICDMRFC GPNRVNHYFC DMAPVIKLAC TDTHVKELAL 200
FSLSILVIMV PFLLILISYG FIVNTILKIP SAEGKKAFVT CASHLTVVFV 250
HYGCASIIYL RPKSKSASDK DQLVAVTYTV VTPLLNPLVY SLRNKEVKTA 300
LKRVLGMPVA TKMS 314
Length:314
Mass (Da):35,011
Last modified:October 1, 2002 - v1
Checksum:iABD13B73F6CDD152
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti16 – 161V → A.
Corresponds to variant rs6660222 [ dbSNP | Ensembl ].
VAR_053284
Natural varianti65 – 651F → L.
Corresponds to variant rs41488350 [ dbSNP | Ensembl ].
VAR_053285
Natural varianti78 – 781I → V.
Corresponds to variant rs6662597 [ dbSNP | Ensembl ].
VAR_053286
Natural varianti137 – 1371I → M.
Corresponds to variant rs6662382 [ dbSNP | Ensembl ].
VAR_053287
Natural varianti155 – 1551F → L.
Corresponds to variant rs12062580 [ dbSNP | Ensembl ].
VAR_053288
Natural varianti312 – 3121K → N.
Corresponds to variant rs6692949 [ dbSNP | Ensembl ].
VAR_053289

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB065643 Genomic DNA. Translation: BAC05869.1.
AL121986 Genomic DNA. Translation: CAI10867.1.
BK004364 Genomic DNA. Translation: DAA04762.1.
CCDSiCCDS30895.1.
RefSeqiNP_001004475.1. NM_001004475.1.
UniGeneiHs.553588.

Genome annotation databases

EnsembliENST00000334438; ENSP00000334115; ENSG00000186306.
GeneIDi128360.
KEGGihsa:128360.
UCSCiuc010pih.2. human.

Polymorphism databases

DMDMi38372780.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB065643 Genomic DNA. Translation: BAC05869.1 .
AL121986 Genomic DNA. Translation: CAI10867.1 .
BK004364 Genomic DNA. Translation: DAA04762.1 .
CCDSi CCDS30895.1.
RefSeqi NP_001004475.1. NM_001004475.1.
UniGenei Hs.553588.

3D structure databases

ProteinModelPortali Q8NGX3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000334115.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei Q8NGX3.

Polymorphism databases

DMDMi 38372780.

Proteomic databases

PaxDbi Q8NGX3.
PRIDEi Q8NGX3.

Protocols and materials databases

DNASUi 128360.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000334438 ; ENSP00000334115 ; ENSG00000186306 .
GeneIDi 128360.
KEGGi hsa:128360.
UCSCi uc010pih.2. human.

Organism-specific databases

CTDi 128360.
GeneCardsi GC01M158368.
HGNCi HGNC:14816. OR10T2.
neXtProti NX_Q8NGX3.
PharmGKBi PA32001.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG74481.
HOGENOMi HOG000041364.
HOVERGENi HBG017625.
InParanoidi Q8NGX3.
KOi K04257.
OMAi FNKTTVV.
OrthoDBi EOG71K63J.
PhylomeDBi Q8NGX3.
TreeFami TF337249.

Enzyme and pathway databases

Reactomei REACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikii OR10T2.
GenomeRNAii 128360.
NextBioi 82303.
PROi Q8NGX3.

Gene expression databases

CleanExi HS_OR10T2.
Genevestigatori Q8NGX3.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: IDENTIFICATION.
  4. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiO10T2_HUMAN
AccessioniPrimary (citable) accession number: Q8NGX3
Secondary accession number(s): Q6IF98
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: September 3, 2014
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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