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Protein

Olfactory receptor 10T2

Gene

OR10T2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: InterPro
  3. transmembrane signaling receptor activity Source: GO_Central

GO - Biological processi

  1. detection of chemical stimulus involved in sensory perception Source: GO_Central
  2. G-protein coupled receptor signaling pathway Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 10T2
Alternative name(s):
Olfactory receptor OR1-3
Gene namesi
Name:OR10T2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:14816. OR10T2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2626ExtracellularSequence AnalysisAdd
BLAST
Transmembranei27 – 4721Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini48 – 558CytoplasmicSequence Analysis
Transmembranei56 – 7621Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini77 – 10024ExtracellularSequence AnalysisAdd
BLAST
Transmembranei101 – 12121Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini122 – 14019CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei141 – 16121Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini162 – 19837ExtracellularSequence AnalysisAdd
BLAST
Transmembranei199 – 21820Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini219 – 23719CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei238 – 25821Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini259 – 27113ExtracellularSequence AnalysisAdd
BLAST
Transmembranei272 – 29221Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini293 – 31422CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: GO_Central
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32001.

Polymorphism and mutation databases

BioMutaiOR10T2.
DMDMi38372780.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 314314Olfactory receptor 10T2PRO_0000150717Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi98 ↔ 190PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGX3.
PRIDEiQ8NGX3.

PTM databases

PhosphoSiteiQ8NGX3.

Expressioni

Gene expression databases

CleanExiHS_OR10T2.
GenevestigatoriQ8NGX3.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000334115.

Structurei

3D structure databases

ProteinModelPortaliQ8NGX3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG74481.
GeneTreeiENSGT00760000119043.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ8NGX3.
KOiK04257.
OMAiPMYGFLF.
OrthoDBiEOG71K63J.
PhylomeDBiQ8NGX3.
TreeFamiTF337249.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGX3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRGFNKTTVV TQFILVGFSS LGELQLLLFV IFLLLYLTIL VANVTIMAVI
60 70 80 90 100
RFSWTLHTPM YGFLFILSFS ESCYTFVIIP QLLVHLLSDT KTISFMACAT
110 120 130 140 150
QLFFFLGFAC TNCLLIAVMG YDRYVAICHP LRYTLIINKR LGLELISLSG
160 170 180 190 200
ATGFFIALVA TNLICDMRFC GPNRVNHYFC DMAPVIKLAC TDTHVKELAL
210 220 230 240 250
FSLSILVIMV PFLLILISYG FIVNTILKIP SAEGKKAFVT CASHLTVVFV
260 270 280 290 300
HYGCASIIYL RPKSKSASDK DQLVAVTYTV VTPLLNPLVY SLRNKEVKTA
310
LKRVLGMPVA TKMS
Length:314
Mass (Da):35,011
Last modified:October 1, 2002 - v1
Checksum:iABD13B73F6CDD152
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti16 – 161V → A.
Corresponds to variant rs6660222 [ dbSNP | Ensembl ].
VAR_053284
Natural varianti65 – 651F → L.
Corresponds to variant rs41488350 [ dbSNP | Ensembl ].
VAR_053285
Natural varianti78 – 781I → V.
Corresponds to variant rs6662597 [ dbSNP | Ensembl ].
VAR_053286
Natural varianti137 – 1371I → M.
Corresponds to variant rs6662382 [ dbSNP | Ensembl ].
VAR_053287
Natural varianti155 – 1551F → L.
Corresponds to variant rs12062580 [ dbSNP | Ensembl ].
VAR_053288
Natural varianti312 – 3121K → N.
Corresponds to variant rs6692949 [ dbSNP | Ensembl ].
VAR_053289

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065643 Genomic DNA. Translation: BAC05869.1.
AL121986 Genomic DNA. Translation: CAI10867.1.
BK004364 Genomic DNA. Translation: DAA04762.1.
CCDSiCCDS30895.1.
RefSeqiNP_001004475.1. NM_001004475.1.
UniGeneiHs.553588.

Genome annotation databases

EnsembliENST00000334438; ENSP00000334115; ENSG00000186306.
GeneIDi128360.
KEGGihsa:128360.
UCSCiuc010pih.2. human.

Polymorphism and mutation databases

BioMutaiOR10T2.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065643 Genomic DNA. Translation: BAC05869.1.
AL121986 Genomic DNA. Translation: CAI10867.1.
BK004364 Genomic DNA. Translation: DAA04762.1.
CCDSiCCDS30895.1.
RefSeqiNP_001004475.1. NM_001004475.1.
UniGeneiHs.553588.

3D structure databases

ProteinModelPortaliQ8NGX3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000334115.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiQ8NGX3.

Polymorphism and mutation databases

BioMutaiOR10T2.
DMDMi38372780.

Proteomic databases

PaxDbiQ8NGX3.
PRIDEiQ8NGX3.

Protocols and materials databases

DNASUi128360.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000334438; ENSP00000334115; ENSG00000186306.
GeneIDi128360.
KEGGihsa:128360.
UCSCiuc010pih.2. human.

Organism-specific databases

CTDi128360.
GeneCardsiGC01M158368.
HGNCiHGNC:14816. OR10T2.
neXtProtiNX_Q8NGX3.
PharmGKBiPA32001.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG74481.
GeneTreeiENSGT00760000119043.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ8NGX3.
KOiK04257.
OMAiPMYGFLF.
OrthoDBiEOG71K63J.
PhylomeDBiQ8NGX3.
TreeFamiTF337249.

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR10T2.
GenomeRNAii128360.
NextBioi82303.
PROiQ8NGX3.

Gene expression databases

CleanExiHS_OR10T2.
GenevestigatoriQ8NGX3.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: IDENTIFICATION.
  4. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiO10T2_HUMAN
AccessioniPrimary (citable) accession number: Q8NGX3
Secondary accession number(s): Q6IF98
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: April 29, 2015
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.