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Protein

Olfactory receptor 2T35

Gene

OR2T35

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 2T35
Alternative name(s):
Olfactory receptor OR1-66
Gene namesi
Name:OR2T35
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:31257. OR2T35.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2626ExtracellularSequence analysisAdd
BLAST
Transmembranei27 – 5024Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini51 – 588CytoplasmicSequence analysis
Transmembranei59 – 8022Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini81 – 10121ExtracellularSequence analysisAdd
BLAST
Transmembranei102 – 12019Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini121 – 13919CytoplasmicSequence analysisAdd
BLAST
Transmembranei140 – 15819Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini159 – 19537ExtracellularSequence analysisAdd
BLAST
Transmembranei196 – 21924Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini220 – 23617CytoplasmicSequence analysisAdd
BLAST
Transmembranei237 – 25923Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini260 – 27213ExtracellularSequence analysisAdd
BLAST
Transmembranei273 – 29220Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini293 – 32331CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134968902.

Polymorphism and mutation databases

BioMutaiOR2T35.
DMDMi38258180.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 323323Olfactory receptor 2T35PRO_0000150509Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi9 – 91N-linked (GlcNAc...)Sequence analysis
Disulfide bondi98 ↔ 189PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGX2.
PRIDEiQ8NGX2.

PTM databases

iPTMnetiQ8NGX2.
PhosphoSiteiQ8NGX2.

Expressioni

Gene expression databases

CleanExiHS_OR2T35.

Interactioni

Protein-protein interaction databases

BioGridi135579. 2 interactions.
STRINGi9606.ENSP00000324369.

Structurei

3D structure databases

ProteinModelPortaliQ8NGX2.
SMRiQ8NGX2. Positions 27-295.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IICX. Eukaryota.
ENOG41113GT. LUCA.
GeneTreeiENSGT00760000118850.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiQ8NGX2.
OMAiCAVQIFY.
OrthoDBiEOG71K63J.
PhylomeDBiQ8NGX2.
TreeFamiTF337295.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGX2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGMEGLLQNS TNFVLTGLIT HPAFPGLLFA VVFSIFVVAI TANLVMILLI
60 70 80 90 100
HMDSRLHTPM YFLLSQLSIM DTIYICITVP KMLQDLLSKD KTISFLGCAV
110 120 130 140 150
QIFYLTLIGG EFFLLGLMAY DRYVAVCNPL RYPLLMNRRV CLFMVVGSWV
160 170 180 190 200
GGSLDGFMLT PVTMSFPFCR SREINHFFCE IPAVLKLSCT DTSLYETLMY
210 220 230 240 250
ACCVLMLLIP LSVISVSYTH ILLTVHRMNS AEGRRKAFAT CSSHIMVVSV
260 270 280 290 300
FYGAAFYTNV LPHSYHTPEK DKVVSAFYTI LTPMLNPLIY SLRNKDVAAA
310 320
LRKVLGRCGS SQSIRVATVI RKG
Length:323
Mass (Da):36,101
Last modified:October 1, 2002 - v1
Checksum:i4F6ADED325AF9E79
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065644 Genomic DNA. Translation: BAC05870.1.
BK004475 Genomic DNA. Translation: DAA04873.1.
CCDSiCCDS31123.1.
RefSeqiNP_001001827.1. NM_001001827.1.
XP_011542493.1. XM_011544191.1.
UniGeneiHs.534846.

Genome annotation databases

EnsembliENST00000317450; ENSP00000324369; ENSG00000177151.
GeneIDi403244.
KEGGihsa:403244.
UCSCiuc001ies.1. human.

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065644 Genomic DNA. Translation: BAC05870.1.
BK004475 Genomic DNA. Translation: DAA04873.1.
CCDSiCCDS31123.1.
RefSeqiNP_001001827.1. NM_001001827.1.
XP_011542493.1. XM_011544191.1.
UniGeneiHs.534846.

3D structure databases

ProteinModelPortaliQ8NGX2.
SMRiQ8NGX2. Positions 27-295.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi135579. 2 interactions.
STRINGi9606.ENSP00000324369.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ8NGX2.
PhosphoSiteiQ8NGX2.

Polymorphism and mutation databases

BioMutaiOR2T35.
DMDMi38258180.

Proteomic databases

PaxDbiQ8NGX2.
PRIDEiQ8NGX2.

Protocols and materials databases

DNASUi403244.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000317450; ENSP00000324369; ENSG00000177151.
GeneIDi403244.
KEGGihsa:403244.
UCSCiuc001ies.1. human.

Organism-specific databases

CTDi403244.
GeneCardsiOR2T35.
HGNCiHGNC:31257. OR2T35.
neXtProtiNX_Q8NGX2.
PharmGKBiPA134968902.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IICX. Eukaryota.
ENOG41113GT. LUCA.
GeneTreeiENSGT00760000118850.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiQ8NGX2.
OMAiCAVQIFY.
OrthoDBiEOG71K63J.
PhylomeDBiQ8NGX2.
TreeFamiTF337295.

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GenomeRNAii403244.
PROiQ8NGX2.

Gene expression databases

CleanExiHS_OR2T35.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: IDENTIFICATION.
  3. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiO2T35_HUMAN
AccessioniPrimary (citable) accession number: Q8NGX2
Secondary accession number(s): Q6IEY7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2003
Last sequence update: October 1, 2002
Last modified: June 8, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.