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Protein

Olfactory receptor 2T35

Gene

OR2T35

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 2T35
Alternative name(s):
Olfactory receptor OR1-66
Gene namesi
Name:OR2T35
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000177151.3.
HGNCiHGNC:31257. OR2T35.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 26ExtracellularSequence analysisAdd BLAST26
Transmembranei27 – 50Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini51 – 58CytoplasmicSequence analysis8
Transmembranei59 – 80Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini81 – 101ExtracellularSequence analysisAdd BLAST21
Transmembranei102 – 120Helical; Name=3Sequence analysisAdd BLAST19
Topological domaini121 – 139CytoplasmicSequence analysisAdd BLAST19
Transmembranei140 – 158Helical; Name=4Sequence analysisAdd BLAST19
Topological domaini159 – 195ExtracellularSequence analysisAdd BLAST37
Transmembranei196 – 219Helical; Name=5Sequence analysisAdd BLAST24
Topological domaini220 – 236CytoplasmicSequence analysisAdd BLAST17
Transmembranei237 – 259Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini260 – 272ExtracellularSequence analysisAdd BLAST13
Transmembranei273 – 292Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini293 – 323CytoplasmicSequence analysisAdd BLAST31

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134968902.

Polymorphism and mutation databases

BioMutaiOR2T35.
DMDMi38258180.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001505091 – 323Olfactory receptor 2T35Add BLAST323

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi9N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi98 ↔ 189PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGX2.
PeptideAtlasiQ8NGX2.
PRIDEiQ8NGX2.

PTM databases

iPTMnetiQ8NGX2.
PhosphoSitePlusiQ8NGX2.

Expressioni

Gene expression databases

BgeeiENSG00000177151.
CleanExiHS_OR2T35.

Interactioni

Protein-protein interaction databases

BioGridi135579. 2 interactors.
STRINGi9606.ENSP00000324369.

Structurei

3D structure databases

ProteinModelPortaliQ8NGX2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IICX. Eukaryota.
ENOG41113GT. LUCA.
GeneTreeiENSGT00760000118850.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiQ8NGX2.
OMAiCAVQIFY.
OrthoDBiEOG091G0ECW.
PhylomeDBiQ8NGX2.
TreeFamiTF337295.

Family and domain databases

InterProiView protein in InterPro
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
PfamiView protein in Pfam
PF13853. 7tm_4. 1 hit.
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiView protein in PROSITE
PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8NGX2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGMEGLLQNS TNFVLTGLIT HPAFPGLLFA VVFSIFVVAI TANLVMILLI
60 70 80 90 100
HMDSRLHTPM YFLLSQLSIM DTIYICITVP KMLQDLLSKD KTISFLGCAV
110 120 130 140 150
QIFYLTLIGG EFFLLGLMAY DRYVAVCNPL RYPLLMNRRV CLFMVVGSWV
160 170 180 190 200
GGSLDGFMLT PVTMSFPFCR SREINHFFCE IPAVLKLSCT DTSLYETLMY
210 220 230 240 250
ACCVLMLLIP LSVISVSYTH ILLTVHRMNS AEGRRKAFAT CSSHIMVVSV
260 270 280 290 300
FYGAAFYTNV LPHSYHTPEK DKVVSAFYTI LTPMLNPLIY SLRNKDVAAA
310 320
LRKVLGRCGS SQSIRVATVI RKG
Length:323
Mass (Da):36,101
Last modified:October 1, 2002 - v1
Checksum:i4F6ADED325AF9E79
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065644 Genomic DNA. Translation: BAC05870.1.
BK004475 Genomic DNA. Translation: DAA04873.1.
CCDSiCCDS31123.1.
RefSeqiNP_001001827.1. NM_001001827.1.
UniGeneiHs.534846.

Genome annotation databases

EnsembliENST00000317450; ENSP00000324369; ENSG00000177151.
GeneIDi403244.
KEGGihsa:403244.
UCSCiuc001ies.1. human.

Similar proteinsi

Entry informationi

Entry nameiO2T35_HUMAN
AccessioniPrimary (citable) accession number: Q8NGX2
Secondary accession number(s): Q6IEY7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2003
Last sequence update: October 1, 2002
Last modified: September 27, 2017
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. SIMILARITY comments
    Index of protein domains and families