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Q8NGX1 (O2T34_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 95. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Olfactory receptor 2T34
Alternative name(s):
Olfactory receptor OR1-63
Gene names
Name:OR2T34
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length318 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Odorant receptor Potential.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence caution

The sequence DAA04875.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 318318Olfactory receptor 2T34
PRO_0000150508

Regions

Topological domain1 – 3030Extracellular Potential
Transmembrane31 – 5424Helical; Name=1; Potential
Topological domain55 – 628Cytoplasmic Potential
Transmembrane63 – 8422Helical; Name=2; Potential
Topological domain85 – 10521Extracellular Potential
Transmembrane106 – 12520Helical; Name=3; Potential
Topological domain126 – 14419Cytoplasmic Potential
Transmembrane145 – 16319Helical; Name=4; Potential
Topological domain164 – 20037Extracellular Potential
Transmembrane201 – 22424Helical; Name=5; Potential
Topological domain225 – 24117Cytoplasmic Potential
Transmembrane242 – 26423Helical; Name=6; Potential
Topological domain265 – 27713Extracellular Potential
Transmembrane278 – 29720Helical; Name=7; Potential
Topological domain298 – 31821Cytoplasmic Potential

Amino acid modifications

Glycosylation51N-linked (GlcNAc...) Potential
Glycosylation101N-linked (GlcNAc...) Potential
Disulfide bond102 ↔ 194 By similarity

Natural variations

Natural variant2671R → P. Ref.4 Ref.5
Corresponds to variant rs1770107 [ dbSNP | Ensembl ].
VAR_067439

Sequences

Sequence LengthMass (Da)Tools
Q8NGX1 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: E804D51F54F58C0F

FASTA31835,681
        10         20         30         40         50         60 
MCSGNQTSQN QTASTDFTLT GLFAESKHAA LLYTVTFLLF LMALTGNALL ILLIHSEPRL 

        70         80         90        100        110        120 
HTPMYFFISQ LALMDLMYLC VTVPKMLVGQ VTGDDTISPS GCGIQMFFHL TLAGAEVFLL 

       130        140        150        160        170        180 
AAMAYDRYAA VCRPLHYPLL MNQRVCQLLV SACWVLGMVD GLLLTPITMS FPFCQSRKIL 

       190        200        210        220        230        240 
SFFCETPALL KLSCSDVSLY KMLTYLCCIL MLLTPIMVIS SSYTLILHLI HRMNSAAGRR 

       250        260        270        280        290        300 
KALATCSSHM IIVLLLFGAS FYTYMLRSSY HTAEQDMMVS AFYTIFTPVL NPLIYSLRNK 

       310 
DVTRALRSMM QSRMNQEK 

« Hide

References

« Hide 'large scale' references
[1]"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT PRO-267.
[5]"DEFOG: a practical scheme for deciphering families of genes."
Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R., Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U., Lehrach H., Lancet D., Shamir R.
Genomics 80:295-302(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 73-289, VARIANT PRO-267.
[6]"The human olfactory receptor gene family."
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
[7]Erratum
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB065645 Genomic DNA. Translation: BAC05871.1.
AC098483 Genomic DNA. No translation available.
CH471257 Genomic DNA. Translation: EAW57527.1.
CH471148 Genomic DNA. Translation: EAW77228.1.
BC136926 mRNA. Translation: AAI36927.1.
AF399612 Genomic DNA. Translation: AAK95097.1.
BK004477 Genomic DNA. Translation: DAA04875.1. Different initiation.
RefSeqNP_001001821.1. NM_001001821.1.
UniGeneHs.553584.

3D structure databases

ProteinModelPortalQ8NGX1.
SMRQ8NGX1. Positions 29-312.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000330904.

Protein family/group databases

GPCRDBSearch...

Polymorphism databases

DMDM51339202.

Proteomic databases

PaxDbQ8NGX1.
PRIDEQ8NGX1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000328782; ENSP00000330904; ENSG00000183310.
GeneID127068.
KEGGhsa:127068.
UCSCuc001iep.1. human.

Organism-specific databases

CTD127068.
GeneCardsGC01M248737.
H-InvDBHIX0200081.
HGNCHGNC:31256. OR2T34.
neXtProtNX_Q8NGX1.
PharmGKBPA134944535.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG147931.
HOGENOMHOG000041365.
HOVERGENHBG017625.
InParanoidQ8NGX1.
KOK04257.
OMAPGSYHTA.
OrthoDBEOG7W9RV2.
PhylomeDBQ8NGX1.
TreeFamTF337295.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

CleanExHS_OR2T34.
GenevestigatorQ8NGX1.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiOR2T34.
GenomeRNAi127068.
NextBio82006.
PROQ8NGX1.

Entry information

Entry nameO2T34_HUMAN
AccessionPrimary (citable) accession number: Q8NGX1
Secondary accession number(s): B2RNJ8, Q6IEY5, Q96R31
Entry history
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: October 1, 2002
Last modified: April 16, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries