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Q8NGX1

- O2T34_HUMAN

UniProt

Q8NGX1 - O2T34_HUMAN

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Protein

Olfactory receptor 2T34

Gene

OR2T34

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 2T34
Alternative name(s):
Olfactory receptor OR1-63
Gene namesi
Name:OR2T34
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:31256. OR2T34.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134944535.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 318318Olfactory receptor 2T34PRO_0000150508Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...)Sequence Analysis
Glycosylationi10 – 101N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi102 ↔ 194PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGX1.
PRIDEiQ8NGX1.

Expressioni

Gene expression databases

CleanExiHS_OR2T34.
GenevestigatoriQ8NGX1.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000330904.

Structurei

3D structure databases

ProteinModelPortaliQ8NGX1.
SMRiQ8NGX1. Positions 29-310.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3030ExtracellularSequence AnalysisAdd
BLAST
Topological domaini55 – 628CytoplasmicSequence Analysis
Topological domaini85 – 10521ExtracellularSequence AnalysisAdd
BLAST
Topological domaini126 – 14419CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini164 – 20037ExtracellularSequence AnalysisAdd
BLAST
Topological domaini225 – 24117CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini265 – 27713ExtracellularSequence AnalysisAdd
BLAST
Topological domaini298 – 31821CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei31 – 5424Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei63 – 8422Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei106 – 12520Helical; Name=3Sequence AnalysisAdd
BLAST
Transmembranei145 – 16319Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei201 – 22424Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei242 – 26423Helical; Name=6Sequence AnalysisAdd
BLAST
Transmembranei278 – 29720Helical; Name=7Sequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG147931.
GeneTreeiENSGT00760000118850.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiQ8NGX1.
KOiK04257.
OMAiPGSYHTA.
OrthoDBiEOG7W9RV2.
PhylomeDBiQ8NGX1.
TreeFamiTF337295.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGX1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MCSGNQTSQN QTASTDFTLT GLFAESKHAA LLYTVTFLLF LMALTGNALL
60 70 80 90 100
ILLIHSEPRL HTPMYFFISQ LALMDLMYLC VTVPKMLVGQ VTGDDTISPS
110 120 130 140 150
GCGIQMFFHL TLAGAEVFLL AAMAYDRYAA VCRPLHYPLL MNQRVCQLLV
160 170 180 190 200
SACWVLGMVD GLLLTPITMS FPFCQSRKIL SFFCETPALL KLSCSDVSLY
210 220 230 240 250
KMLTYLCCIL MLLTPIMVIS SSYTLILHLI HRMNSAAGRR KALATCSSHM
260 270 280 290 300
IIVLLLFGAS FYTYMLRSSY HTAEQDMMVS AFYTIFTPVL NPLIYSLRNK
310
DVTRALRSMM QSRMNQEK
Length:318
Mass (Da):35,681
Last modified:October 1, 2002 - v1
Checksum:iE804D51F54F58C0F
GO

Sequence cautioni

The sequence DAA04875.1 differs from that shown. Reason: Erroneous initiation.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti267 – 2671R → P.2 Publications
Corresponds to variant rs1770107 [ dbSNP | Ensembl ].
VAR_067439

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB065645 Genomic DNA. Translation: BAC05871.1.
AC098483 Genomic DNA. No translation available.
CH471257 Genomic DNA. Translation: EAW57527.1.
CH471148 Genomic DNA. Translation: EAW77228.1.
BC136926 mRNA. Translation: AAI36927.1.
AF399612 Genomic DNA. Translation: AAK95097.1.
BK004477 Genomic DNA. Translation: DAA04875.1. Different initiation.
CCDSiCCDS31120.1.
RefSeqiNP_001001821.1. NM_001001821.1.
UniGeneiHs.553584.

Genome annotation databases

EnsembliENST00000328782; ENSP00000330904; ENSG00000183310.
GeneIDi127068.
KEGGihsa:127068.
UCSCiuc001iep.1. human.

Polymorphism databases

DMDMi51339202.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB065645 Genomic DNA. Translation: BAC05871.1 .
AC098483 Genomic DNA. No translation available.
CH471257 Genomic DNA. Translation: EAW57527.1 .
CH471148 Genomic DNA. Translation: EAW77228.1 .
BC136926 mRNA. Translation: AAI36927.1 .
AF399612 Genomic DNA. Translation: AAK95097.1 .
BK004477 Genomic DNA. Translation: DAA04875.1 . Different initiation.
CCDSi CCDS31120.1.
RefSeqi NP_001001821.1. NM_001001821.1.
UniGenei Hs.553584.

3D structure databases

ProteinModelPortali Q8NGX1.
SMRi Q8NGX1. Positions 29-310.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000330904.

Protein family/group databases

GPCRDBi Search...

Polymorphism databases

DMDMi 51339202.

Proteomic databases

PaxDbi Q8NGX1.
PRIDEi Q8NGX1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000328782 ; ENSP00000330904 ; ENSG00000183310 .
GeneIDi 127068.
KEGGi hsa:127068.
UCSCi uc001iep.1. human.

Organism-specific databases

CTDi 127068.
GeneCardsi GC01M248737.
H-InvDB HIX0200081.
HGNCi HGNC:31256. OR2T34.
neXtProti NX_Q8NGX1.
PharmGKBi PA134944535.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG147931.
GeneTreei ENSGT00760000118850.
HOGENOMi HOG000041365.
HOVERGENi HBG017625.
InParanoidi Q8NGX1.
KOi K04257.
OMAi PGSYHTA.
OrthoDBi EOG7W9RV2.
PhylomeDBi Q8NGX1.
TreeFami TF337295.

Enzyme and pathway databases

Reactomei REACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikii OR2T34.
GenomeRNAii 127068.
NextBioi 82006.
PROi Q8NGX1.

Gene expression databases

CleanExi HS_OR2T34.
Genevestigatori Q8NGX1.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT PRO-267.
  5. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 73-289, VARIANT PRO-267.
  6. Cited for: IDENTIFICATION.
  7. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiO2T34_HUMAN
AccessioniPrimary (citable) accession number: Q8NGX1
Secondary accession number(s): B2RNJ8, Q6IEY5, Q96R31
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: October 1, 2002
Last modified: October 29, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3