ID O11L1_HUMAN Reviewed; 322 AA. AC Q8NGX0; B9EIN8; DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-2002, sequence version 1. DT 27-MAR-2024, entry version 158. DE RecName: Full=Olfactory receptor 11L1; GN Name=OR11L1; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.; RT "Genome-wide discovery and analysis of human seven transmembrane helix RT receptor genes."; RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases. RN [2] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX PubMed=25977809; DOI=10.1038/sdata.2015.2; RA Mainland J.D., Li Y.R., Zhou T., Liu W.L., Matsunami H.; RT "Human olfactory receptor responses to odorants."; RL Sci. Data 2:150002-150002(2015). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., RA Hunkapiller M.W., Myers E.W., Venter J.C.; RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases. RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). CC -!- FUNCTION: Odorant receptor. {ECO:0000305}. CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC {ECO:0000255|PROSITE-ProRule:PRU00521}. CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE); CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR11L1"; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AB065646; BAC05872.1; -; Genomic_DNA. DR EMBL; KP290124; ALI87315.1; -; Genomic_DNA. DR EMBL; CH471148; EAW77204.1; -; Genomic_DNA. DR EMBL; BC140753; AAI40754.1; -; mRNA. DR CCDS; CCDS31098.1; -. DR RefSeq; NP_001001959.1; NM_001001959.1. DR AlphaFoldDB; Q8NGX0; -. DR SMR; Q8NGX0; -. DR STRING; 9606.ENSP00000348033; -. DR GlyCosmos; Q8NGX0; 1 site, No reported glycans. DR GlyGen; Q8NGX0; 1 site. DR BioMuta; OR11L1; -. DR DMDM; 38372779; -. DR PaxDb; 9606-ENSP00000348033; -. DR PeptideAtlas; Q8NGX0; -. DR Antibodypedia; 57422; 119 antibodies from 24 providers. DR DNASU; 391189; -. DR Ensembl; ENST00000355784.3; ENSP00000348033.2; ENSG00000197591.3. DR GeneID; 391189; -. DR KEGG; hsa:391189; -. DR MANE-Select; ENST00000355784.3; ENSP00000348033.2; NM_001001959.1; NP_001001959.1. DR UCSC; uc001idn.1; human. DR AGR; HGNC:14998; -. DR CTD; 391189; -. DR DisGeNET; 391189; -. DR GeneCards; OR11L1; -. DR HGNC; HGNC:14998; OR11L1. DR HPA; ENSG00000197591; Not detected. DR neXtProt; NX_Q8NGX0; -. DR PharmGKB; PA32025; -. DR VEuPathDB; HostDB:ENSG00000197591; -. DR eggNOG; ENOG502QTTE; Eukaryota. DR GeneTree; ENSGT01090000260045; -. DR HOGENOM; CLU_012526_1_2_1; -. DR InParanoid; Q8NGX0; -. DR OMA; PMYTFLK; -. DR OrthoDB; 5318310at2759; -. DR PhylomeDB; Q8NGX0; -. DR TreeFam; TF336512; -. DR PathwayCommons; Q8NGX0; -. DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors. DR BioGRID-ORCS; 391189; 12 hits in 756 CRISPR screens. DR GeneWiki; OR11L1; -. DR GenomeRNAi; 391189; -. DR Pharos; Q8NGX0; Tdark. DR PRO; PR:Q8NGX0; -. DR Proteomes; UP000005640; Chromosome 1. DR RNAct; Q8NGX0; Protein. DR Bgee; ENSG00000197591; Expressed in right lobe of thyroid gland and 1 other cell type or tissue. DR GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB. DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW. DR GO; GO:0005549; F:odorant binding; IBA:GO_Central. DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central. DR CDD; cd13954; 7tmA_OR; 1. DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR017452; GPCR_Rhodpsn_7TM. DR InterPro; IPR000725; Olfact_rcpt. DR PANTHER; PTHR24242; G-PROTEIN COUPLED RECEPTOR; 1. DR PANTHER; PTHR24242:SF386; OLFACTORY RECEPTOR; 1. DR Pfam; PF13853; 7tm_4; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00245; OLFACTORYR. DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. PE 2: Evidence at transcript level; KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein; KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction; KW Transducer; Transmembrane; Transmembrane helix. FT CHAIN 1..322 FT /note="Olfactory receptor 11L1" FT /id="PRO_0000150727" FT TOPO_DOM 1..25 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 26..46 FT /note="Helical; Name=1" FT /evidence="ECO:0000255" FT TOPO_DOM 47..54 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 55..75 FT /note="Helical; Name=2" FT /evidence="ECO:0000255" FT TOPO_DOM 76..99 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 100..120 FT /note="Helical; Name=3" FT /evidence="ECO:0000255" FT TOPO_DOM 121..139 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 140..160 FT /note="Helical; Name=4" FT /evidence="ECO:0000255" FT TOPO_DOM 161..197 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 198..217 FT /note="Helical; Name=5" FT /evidence="ECO:0000255" FT TOPO_DOM 218..237 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 238..258 FT /note="Helical; Name=6" FT /evidence="ECO:0000255" FT TOPO_DOM 259..271 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 272..292 FT /note="Helical; Name=7" FT /evidence="ECO:0000255" FT TOPO_DOM 293..322 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT CARBOHYD 5 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT DISULFID 97..189 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521" FT VARIANT 108 FT /note="G -> S (in dbSNP:rs10888257)" FT /evidence="ECO:0000269|PubMed:15489334, FT ECO:0000269|PubMed:25977809" FT /id="VAR_053295" FT VARIANT 117 FT /note="F -> L (in dbSNP:rs540891010)" FT /evidence="ECO:0000269|PubMed:15489334, FT ECO:0000269|PubMed:25977809" FT /id="VAR_034305" FT VARIANT 142 FT /note="A -> T (in dbSNP:rs10888256)" FT /evidence="ECO:0000269|PubMed:15489334, FT ECO:0000269|PubMed:25977809" FT /id="VAR_053296" FT VARIANT 171 FT /note="R -> P (in dbSNP:rs10888255)" FT /id="VAR_053297" SQ SEQUENCE 322 AA; 36763 MW; 9BA9A79E14B3685D CRC64; MEPQNTSTVT NFQLLGFQNL LEWQALLFVI FLLIYCLTII GNVVIITVVS QGLRLHSPMY MFLQHLSFLE VWYTSTTVPL LLANLLSWGQ AISFSACMAQ LYFFVFLGAT ECFLLAFMAY DRYLAICSPL RYPFLMHRGL CARLVVVSWC TGVSTGFLPS LMISRLDFCG RNQINHFFCD LPPLMQLSCS RVYITEVTIF ILSIAVLCIC FFLTLGPYVF IVSSILRIPS TSGRRKTFST CGSHLAVVTL YYGTMISMYV CPSPHLLPEI NKIISVFYTV VTPLLNPVIY SLRNKDFKEA VRKVMRRKCG ILWSTSKRKF LY //