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Q8NGX0

- O11L1_HUMAN

UniProt

Q8NGX0 - O11L1_HUMAN

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Protein

Olfactory receptor 11L1

Gene

OR11L1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 11L1
Gene namesi
Name:OR11L1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:14998. OR11L1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2525ExtracellularSequence AnalysisAdd
BLAST
Transmembranei26 – 4621Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini47 – 548CytoplasmicSequence Analysis
Transmembranei55 – 7521Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini76 – 9924ExtracellularSequence AnalysisAdd
BLAST
Transmembranei100 – 12021Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini121 – 13919CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei140 – 16021Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini161 – 19737ExtracellularSequence AnalysisAdd
BLAST
Transmembranei198 – 21720Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini218 – 23720CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei238 – 25821Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini259 – 27113ExtracellularSequence AnalysisAdd
BLAST
Transmembranei272 – 29221Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini293 – 32230CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. extracellular vesicular exosome Source: UniProt
  2. integral component of membrane Source: UniProtKB-KW
  3. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32025.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 322322Olfactory receptor 11L1PRO_0000150727Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ8NGX0.

Expressioni

Gene expression databases

CleanExiHS_OR11L1.
GenevestigatoriQ8NGX0.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000348033.

Structurei

3D structure databases

ProteinModelPortaliQ8NGX0.
SMRiQ8NGX0. Positions 22-305.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG299292.
GeneTreeiENSGT00770000120492.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ8NGX0.
KOiK04257.
OMAiLEDEECV.
OrthoDBiEOG71K63J.
PhylomeDBiQ8NGX0.
TreeFamiTF336512.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGX0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEPQNTSTVT NFQLLGFQNL LEWQALLFVI FLLIYCLTII GNVVIITVVS
60 70 80 90 100
QGLRLHSPMY MFLQHLSFLE VWYTSTTVPL LLANLLSWGQ AISFSACMAQ
110 120 130 140 150
LYFFVFLGAT ECFLLAFMAY DRYLAICSPL RYPFLMHRGL CARLVVVSWC
160 170 180 190 200
TGVSTGFLPS LMISRLDFCG RNQINHFFCD LPPLMQLSCS RVYITEVTIF
210 220 230 240 250
ILSIAVLCIC FFLTLGPYVF IVSSILRIPS TSGRRKTFST CGSHLAVVTL
260 270 280 290 300
YYGTMISMYV CPSPHLLPEI NKIISVFYTV VTPLLNPVIY SLRNKDFKEA
310 320
VRKVMRRKCG ILWSTSKRKF LY
Length:322
Mass (Da):36,763
Last modified:October 1, 2002 - v1
Checksum:i9BA9A79E14B3685D
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti108 – 1081G → S.
Corresponds to variant rs10888257 [ dbSNP | Ensembl ].
VAR_053295
Natural varianti117 – 1171F → L.
Corresponds to variant rs4607924 [ dbSNP | Ensembl ].
VAR_034305
Natural varianti142 – 1421A → T.
Corresponds to variant rs10888256 [ dbSNP | Ensembl ].
VAR_053296
Natural varianti171 – 1711R → P.
Corresponds to variant rs10888255 [ dbSNP | Ensembl ].
VAR_053297

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065646 Genomic DNA. Translation: BAC05872.1.
CCDSiCCDS31098.1.
RefSeqiNP_001001959.1. NM_001001959.1.
UniGeneiHs.553781.

Genome annotation databases

EnsembliENST00000355784; ENSP00000348033; ENSG00000197591.
GeneIDi391189.
KEGGihsa:391189.
UCSCiuc001idn.1. human.

Polymorphism databases

DMDMi38372779.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065646 Genomic DNA. Translation: BAC05872.1 .
CCDSi CCDS31098.1.
RefSeqi NP_001001959.1. NM_001001959.1.
UniGenei Hs.553781.

3D structure databases

ProteinModelPortali Q8NGX0.
SMRi Q8NGX0. Positions 22-305.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000348033.

Protein family/group databases

GPCRDBi Search...

Polymorphism databases

DMDMi 38372779.

Proteomic databases

PRIDEi Q8NGX0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000355784 ; ENSP00000348033 ; ENSG00000197591 .
GeneIDi 391189.
KEGGi hsa:391189.
UCSCi uc001idn.1. human.

Organism-specific databases

CTDi 391189.
GeneCardsi GC01M248004.
HGNCi HGNC:14998. OR11L1.
neXtProti NX_Q8NGX0.
PharmGKBi PA32025.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG299292.
GeneTreei ENSGT00770000120492.
HOGENOMi HOG000041364.
HOVERGENi HBG017625.
InParanoidi Q8NGX0.
KOi K04257.
OMAi LEDEECV.
OrthoDBi EOG71K63J.
PhylomeDBi Q8NGX0.
TreeFami TF336512.

Enzyme and pathway databases

Reactomei REACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikii OR11L1.
GenomeRNAii 391189.
NextBioi 104437.
PROi Q8NGX0.

Gene expression databases

CleanExi HS_OR11L1.
Genevestigatori Q8NGX0.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiO11L1_HUMAN
AccessioniPrimary (citable) accession number: Q8NGX0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: November 26, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3