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Protein

Olfactory receptor 11L1

Gene

OR11L1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

BioCyciZFISH:ENSG00000177356-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 11L1
Gene namesi
Name:OR11L1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:14998. OR11L1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 25ExtracellularSequence analysisAdd BLAST25
Transmembranei26 – 46Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini47 – 54CytoplasmicSequence analysis8
Transmembranei55 – 75Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini76 – 99ExtracellularSequence analysisAdd BLAST24
Transmembranei100 – 120Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini121 – 139CytoplasmicSequence analysisAdd BLAST19
Transmembranei140 – 160Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini161 – 197ExtracellularSequence analysisAdd BLAST37
Transmembranei198 – 217Helical; Name=5Sequence analysisAdd BLAST20
Topological domaini218 – 237CytoplasmicSequence analysisAdd BLAST20
Transmembranei238 – 258Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini259 – 271ExtracellularSequence analysisAdd BLAST13
Transmembranei272 – 292Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini293 – 322CytoplasmicSequence analysisAdd BLAST30

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000197591.
PharmGKBiPA32025.

Polymorphism and mutation databases

BioMutaiOR11L1.
DMDMi38372779.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001507271 – 322Olfactory receptor 11L1Add BLAST322

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGX0.
PRIDEiQ8NGX0.

Expressioni

Gene expression databases

CleanExiHS_OR11L1.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000348033.

Structurei

3D structure databases

ProteinModelPortaliQ8NGX0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IVPB. Eukaryota.
ENOG410ZE2Y. LUCA.
GeneTreeiENSGT00800000124041.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ8NGX0.
KOiK04257.
OMAiHITEMAI.
OrthoDBiEOG091G0AZH.
PhylomeDBiQ8NGX0.
TreeFamiTF336512.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGX0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPQNTSTVT NFQLLGFQNL LEWQALLFVI FLLIYCLTII GNVVIITVVS
60 70 80 90 100
QGLRLHSPMY MFLQHLSFLE VWYTSTTVPL LLANLLSWGQ AISFSACMAQ
110 120 130 140 150
LYFFVFLGAT ECFLLAFMAY DRYLAICSPL RYPFLMHRGL CARLVVVSWC
160 170 180 190 200
TGVSTGFLPS LMISRLDFCG RNQINHFFCD LPPLMQLSCS RVYITEVTIF
210 220 230 240 250
ILSIAVLCIC FFLTLGPYVF IVSSILRIPS TSGRRKTFST CGSHLAVVTL
260 270 280 290 300
YYGTMISMYV CPSPHLLPEI NKIISVFYTV VTPLLNPVIY SLRNKDFKEA
310 320
VRKVMRRKCG ILWSTSKRKF LY
Length:322
Mass (Da):36,763
Last modified:October 1, 2002 - v1
Checksum:i9BA9A79E14B3685D
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_053295108G → S.Corresponds to variant rs10888257dbSNPEnsembl.1
Natural variantiVAR_034305117F → L.Corresponds to variant rs540891010dbSNPEnsembl.1
Natural variantiVAR_053296142A → T.Corresponds to variant rs10888256dbSNPEnsembl.1
Natural variantiVAR_053297171R → P.Corresponds to variant rs10888255dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065646 Genomic DNA. Translation: BAC05872.1.
CCDSiCCDS31098.1.
RefSeqiNP_001001959.1. NM_001001959.1.
UniGeneiHs.553781.

Genome annotation databases

EnsembliENST00000355784; ENSP00000348033; ENSG00000197591.
GeneIDi391189.
KEGGihsa:391189.
UCSCiuc001idn.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065646 Genomic DNA. Translation: BAC05872.1.
CCDSiCCDS31098.1.
RefSeqiNP_001001959.1. NM_001001959.1.
UniGeneiHs.553781.

3D structure databases

ProteinModelPortaliQ8NGX0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000348033.

Protein family/group databases

GPCRDBiSearch...

Polymorphism and mutation databases

BioMutaiOR11L1.
DMDMi38372779.

Proteomic databases

PaxDbiQ8NGX0.
PRIDEiQ8NGX0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000355784; ENSP00000348033; ENSG00000197591.
GeneIDi391189.
KEGGihsa:391189.
UCSCiuc001idn.1. human.

Organism-specific databases

CTDi391189.
GeneCardsiOR11L1.
HGNCiHGNC:14998. OR11L1.
neXtProtiNX_Q8NGX0.
OpenTargetsiENSG00000197591.
PharmGKBiPA32025.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IVPB. Eukaryota.
ENOG410ZE2Y. LUCA.
GeneTreeiENSGT00800000124041.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ8NGX0.
KOiK04257.
OMAiHITEMAI.
OrthoDBiEOG091G0AZH.
PhylomeDBiQ8NGX0.
TreeFamiTF336512.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000177356-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR11L1.
GenomeRNAii391189.
PROiQ8NGX0.

Gene expression databases

CleanExiHS_OR11L1.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO11L1_HUMAN
AccessioniPrimary (citable) accession number: Q8NGX0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: November 2, 2016
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.