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Q8NGX0

- O11L1_HUMAN

UniProt

Q8NGX0 - O11L1_HUMAN

Protein

Olfactory receptor 11L1

Gene

OR11L1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    Odorant receptor.Curated

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW
    2. olfactory receptor activity Source: InterPro

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Olfaction, Sensory transduction

    Enzyme and pathway databases

    ReactomeiREACT_15488. Olfactory Signaling Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Olfactory receptor 11L1
    Gene namesi
    Name:OR11L1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:14998. OR11L1.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular vesicular exosome Source: UniProt
    2. integral component of membrane Source: UniProtKB-KW
    3. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA32025.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 322322Olfactory receptor 11L1PRO_0000150727Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi5 – 51N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiQ8NGX0.

    Expressioni

    Gene expression databases

    CleanExiHS_OR11L1.
    GenevestigatoriQ8NGX0.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000348033.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8NGX0.
    SMRiQ8NGX0. Positions 22-305.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2525ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini47 – 548CytoplasmicSequence Analysis
    Topological domaini76 – 9924ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini121 – 13919CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini161 – 19737ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini218 – 23720CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini259 – 27113ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini293 – 32230CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei26 – 4621Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei55 – 7521Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei100 – 12021Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei140 – 16021Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei198 – 21720Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei238 – 25821Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei272 – 29221Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG299292.
    HOGENOMiHOG000041364.
    HOVERGENiHBG017625.
    InParanoidiQ8NGX0.
    KOiK04257.
    OMAiLEDEECV.
    OrthoDBiEOG71K63J.
    PhylomeDBiQ8NGX0.
    TreeFamiTF336512.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8NGX0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEPQNTSTVT NFQLLGFQNL LEWQALLFVI FLLIYCLTII GNVVIITVVS    50
    QGLRLHSPMY MFLQHLSFLE VWYTSTTVPL LLANLLSWGQ AISFSACMAQ 100
    LYFFVFLGAT ECFLLAFMAY DRYLAICSPL RYPFLMHRGL CARLVVVSWC 150
    TGVSTGFLPS LMISRLDFCG RNQINHFFCD LPPLMQLSCS RVYITEVTIF 200
    ILSIAVLCIC FFLTLGPYVF IVSSILRIPS TSGRRKTFST CGSHLAVVTL 250
    YYGTMISMYV CPSPHLLPEI NKIISVFYTV VTPLLNPVIY SLRNKDFKEA 300
    VRKVMRRKCG ILWSTSKRKF LY 322
    Length:322
    Mass (Da):36,763
    Last modified:October 1, 2002 - v1
    Checksum:i9BA9A79E14B3685D
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti108 – 1081G → S.
    Corresponds to variant rs10888257 [ dbSNP | Ensembl ].
    VAR_053295
    Natural varianti117 – 1171F → L.
    Corresponds to variant rs4607924 [ dbSNP | Ensembl ].
    VAR_034305
    Natural varianti142 – 1421A → T.
    Corresponds to variant rs10888256 [ dbSNP | Ensembl ].
    VAR_053296
    Natural varianti171 – 1711R → P.
    Corresponds to variant rs10888255 [ dbSNP | Ensembl ].
    VAR_053297

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065646 Genomic DNA. Translation: BAC05872.1.
    CCDSiCCDS31098.1.
    RefSeqiNP_001001959.1. NM_001001959.1.
    UniGeneiHs.553781.

    Genome annotation databases

    EnsembliENST00000355784; ENSP00000348033; ENSG00000197591.
    GeneIDi391189.
    KEGGihsa:391189.
    UCSCiuc001idn.1. human.

    Polymorphism databases

    DMDMi38372779.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Human Olfactory Receptor Data Exploratorium (HORDE)

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065646 Genomic DNA. Translation: BAC05872.1 .
    CCDSi CCDS31098.1.
    RefSeqi NP_001001959.1. NM_001001959.1.
    UniGenei Hs.553781.

    3D structure databases

    ProteinModelPortali Q8NGX0.
    SMRi Q8NGX0. Positions 22-305.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000348033.

    Protein family/group databases

    GPCRDBi Search...

    Polymorphism databases

    DMDMi 38372779.

    Proteomic databases

    PRIDEi Q8NGX0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000355784 ; ENSP00000348033 ; ENSG00000197591 .
    GeneIDi 391189.
    KEGGi hsa:391189.
    UCSCi uc001idn.1. human.

    Organism-specific databases

    CTDi 391189.
    GeneCardsi GC01M248004.
    HGNCi HGNC:14998. OR11L1.
    neXtProti NX_Q8NGX0.
    PharmGKBi PA32025.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG299292.
    HOGENOMi HOG000041364.
    HOVERGENi HBG017625.
    InParanoidi Q8NGX0.
    KOi K04257.
    OMAi LEDEECV.
    OrthoDBi EOG71K63J.
    PhylomeDBi Q8NGX0.
    TreeFami TF336512.

    Enzyme and pathway databases

    Reactomei REACT_15488. Olfactory Signaling Pathway.

    Miscellaneous databases

    GeneWikii OR11L1.
    GenomeRNAii 391189.
    NextBioi 104437.
    PROi Q8NGX0.

    Gene expression databases

    CleanExi HS_OR11L1.
    Genevestigatori Q8NGX0.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
      Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
      Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiO11L1_HUMAN
    AccessioniPrimary (citable) accession number: Q8NGX0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 10, 2003
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 100 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3