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Q8NGX0 (O11L1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 95. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Olfactory receptor 11L1
Gene names
Name:OR11L1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length322 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Odorant receptor Potential.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 322322Olfactory receptor 11L1
PRO_0000150727

Regions

Topological domain1 – 2525Extracellular Potential
Transmembrane26 – 4621Helical; Name=1; Potential
Topological domain47 – 548Cytoplasmic Potential
Transmembrane55 – 7521Helical; Name=2; Potential
Topological domain76 – 9924Extracellular Potential
Transmembrane100 – 12021Helical; Name=3; Potential
Topological domain121 – 13919Cytoplasmic Potential
Transmembrane140 – 16021Helical; Name=4; Potential
Topological domain161 – 19737Extracellular Potential
Transmembrane198 – 21720Helical; Name=5; Potential
Topological domain218 – 23720Cytoplasmic Potential
Transmembrane238 – 25821Helical; Name=6; Potential
Topological domain259 – 27113Extracellular Potential
Transmembrane272 – 29221Helical; Name=7; Potential
Topological domain293 – 32230Cytoplasmic Potential

Amino acid modifications

Glycosylation51N-linked (GlcNAc...) Potential
Disulfide bond97 ↔ 189 By similarity

Natural variations

Natural variant1081G → S.
Corresponds to variant rs10888257 [ dbSNP | Ensembl ].
VAR_053295
Natural variant1171F → L.
Corresponds to variant rs4607924 [ dbSNP | Ensembl ].
VAR_034305
Natural variant1421A → T.
Corresponds to variant rs10888256 [ dbSNP | Ensembl ].
VAR_053296
Natural variant1711R → P.
Corresponds to variant rs10888255 [ dbSNP | Ensembl ].
VAR_053297

Sequences

Sequence LengthMass (Da)Tools
Q8NGX0 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: 9BA9A79E14B3685D

FASTA32236,763
        10         20         30         40         50         60 
MEPQNTSTVT NFQLLGFQNL LEWQALLFVI FLLIYCLTII GNVVIITVVS QGLRLHSPMY 

        70         80         90        100        110        120 
MFLQHLSFLE VWYTSTTVPL LLANLLSWGQ AISFSACMAQ LYFFVFLGAT ECFLLAFMAY 

       130        140        150        160        170        180 
DRYLAICSPL RYPFLMHRGL CARLVVVSWC TGVSTGFLPS LMISRLDFCG RNQINHFFCD 

       190        200        210        220        230        240 
LPPLMQLSCS RVYITEVTIF ILSIAVLCIC FFLTLGPYVF IVSSILRIPS TSGRRKTFST 

       250        260        270        280        290        300 
CGSHLAVVTL YYGTMISMYV CPSPHLLPEI NKIISVFYTV VTPLLNPVIY SLRNKDFKEA 

       310        320 
VRKVMRRKCG ILWSTSKRKF LY 

« Hide

References

[1]"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB065646 Genomic DNA. Translation: BAC05872.1.
RefSeqNP_001001959.1. NM_001001959.1.
UniGeneHs.553781.

3D structure databases

ProteinModelPortalQ8NGX0.
SMRQ8NGX0. Positions 22-307.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000348033.

Protein family/group databases

GPCRDBSearch...

Polymorphism databases

DMDM38372779.

Proteomic databases

PRIDEQ8NGX0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000355784; ENSP00000348033; ENSG00000197591.
GeneID391189.
KEGGhsa:391189.
UCSCuc001idn.1. human.

Organism-specific databases

CTD391189.
GeneCardsGC01M248004.
HGNCHGNC:14998. OR11L1.
neXtProtNX_Q8NGX0.
PharmGKBPA32025.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG299292.
HOGENOMHOG000041364.
HOVERGENHBG017625.
InParanoidQ8NGX0.
KOK04257.
OrthoDBEOG71K63J.
PhylomeDBQ8NGX0.
TreeFamTF336512.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

CleanExHS_OR11L1.
GenevestigatorQ8NGX0.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiOR11L1.
GenomeRNAi391189.
NextBio104437.
PROQ8NGX0.

Entry information

Entry nameO11L1_HUMAN
AccessionPrimary (citable) accession number: Q8NGX0
Entry history
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: April 16, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries