Q8NGX0 (O11L1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Olfactory receptor 11L1

Gene names

Name:

OR11L1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	322 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Odorant receptor Potential.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Biological process	Olfaction Sensory transduction
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	detection of chemical stimulus involved in sensory perception of smell Inferred from electronic annotation. Source: GOC
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	G-protein coupled receptor activity Inferred from electronic annotation. Source: UniProtKB-KW olfactory receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 322	322	Olfactory receptor 11L1		PRO_0000150727
Regions
	Topological domain	1 – 25	25	Extracellular Potential
	Transmembrane	26 – 46	21	Helical; Name=1; Potential
	Topological domain	47 – 54	8	Cytoplasmic Potential
	Transmembrane	55 – 75	21	Helical; Name=2; Potential
	Topological domain	76 – 99	24	Extracellular Potential
	Transmembrane	100 – 120	21	Helical; Name=3; Potential
	Topological domain	121 – 139	19	Cytoplasmic Potential
	Transmembrane	140 – 160	21	Helical; Name=4; Potential
	Topological domain	161 – 197	37	Extracellular Potential
	Transmembrane	198 – 217	20	Helical; Name=5; Potential
	Topological domain	218 – 237	20	Cytoplasmic Potential
	Transmembrane	238 – 258	21	Helical; Name=6; Potential
	Topological domain	259 – 271	13	Extracellular Potential
	Transmembrane	272 – 292	21	Helical; Name=7; Potential
	Topological domain	293 – 322	30	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	5	1	N-linked (GlcNAc...) Potential
	Disulfide bond	97 ↔ 189		By similarity
Natural variations
	Natural variant	108	1	G → S. Corresponds to variant rs10888257 [ dbSNP | Ensembl ].		VAR_053295
	Natural variant	117	1	F → L. Corresponds to variant rs4607924 [ dbSNP | Ensembl ].		VAR_034305
	Natural variant	142	1	A → T. Corresponds to variant rs10888256 [ dbSNP | Ensembl ].		VAR_053296
	Natural variant	171	1	R → P. Corresponds to variant rs10888255 [ dbSNP | Ensembl ].		VAR_053297

Sequences

	Sequence		Length	Mass (Da)
	Q8NGX0 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: 9BA9A79E14B3685D	FASTA	322	36,763
	10 20 30 40 50 60 MEPQNTSTVT NFQLLGFQNL LEWQALLFVI FLLIYCLTII GNVVIITVVS QGLRLHSPMY 70 80 90 100 110 120 MFLQHLSFLE VWYTSTTVPL LLANLLSWGQ AISFSACMAQ LYFFVFLGAT ECFLLAFMAY 130 140 150 160 170 180 DRYLAICSPL RYPFLMHRGL CARLVVVSWC TGVSTGFLPS LMISRLDFCG RNQINHFFCD 190 200 210 220 230 240 LPPLMQLSCS RVYITEVTIF ILSIAVLCIC FFLTLGPYVF IVSSILRIPS TSGRRKTFST 250 260 270 280 290 300 CGSHLAVVTL YYGTMISMYV CPSPHLLPEI NKIISVFYTV VTPLLNPVIY SLRNKDFKEA 310 320 VRKVMRRKCG ILWSTSKRKF LY

References

[1]

"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes." Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y. Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Web resources

Human Olfactory Receptor Data Exploratorium (HORDE)

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB065646 Genomic DNA. Translation: BAC05872.1.
IPI	IPI00303705.
RefSeq	NP_001001959.1. NM_001001959.1.
UniGene	Hs.553781.
3D structure databases
ProteinModelPortal	Q8NGX0.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000348033.
Protein family/group databases
GPCRDB	Search...
Polymorphism databases
DMDM	38372779.
Proteomic databases
PRIDE	Q8NGX0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000355784; ENSP00000348033; ENSG00000197591.
GeneID	391189.
KEGG	hsa:391189.
UCSC	uc001idn.1. human.
Organism-specific databases
CTD	391189.
GeneCards	GC01M248004.
HGNC	HGNC:14998. OR11L1.
neXtProt	NX_Q8NGX0.
PharmGKB	PA32025.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG299292.
HOGENOM	HOG000041364.
HOVERGEN	HBG017625.
InParanoid	Q8NGX0.
KO	K04257.
OMA	MISMYVR.
OrthoDB	EOG4MW86P.
PhylomeDB	Q8NGX0.
Gene expression databases
CleanEx	HS_OR11L1.
Genevestigator	Q8NGX0.
Family and domain databases
InterPro	IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. IPR000725. Olfact_rcpt. [Graphical view]
PRINTS	PR00237. GPCRRHODOPSN. PR00245. OLFACTORYR.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	391189.
NextBio	104437.

Entry information

Entry name

O11L1_HUMAN

Accession

Primary (citable) accession number: Q8NGX0

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 10, 2003
Last sequence update:	October 1, 2002
Last modified:	May 1, 2013
This is version 87 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.