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Protein

Olfactory receptor 6K6

Gene

OR6K6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 6K6
Alternative name(s):
Olfactory receptor OR1-21
Gene namesi
Name:OR6K6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:15033. OR6K6.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 5353ExtracellularSequence analysisAdd
BLAST
Transmembranei54 – 7421Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini75 – 828CytoplasmicSequence analysis
Transmembranei83 – 10321Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini104 – 12724ExtracellularSequence analysisAdd
BLAST
Transmembranei128 – 14821Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini149 – 16719CytoplasmicSequence analysisAdd
BLAST
Transmembranei168 – 18821Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini189 – 22436ExtracellularSequence analysisAdd
BLAST
Transmembranei225 – 24420Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini245 – 26420CytoplasmicSequence analysisAdd
BLAST
Transmembranei265 – 28521Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini286 – 29813ExtracellularSequence analysisAdd
BLAST
Transmembranei299 – 31921Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini320 – 34324CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32593.

Polymorphism and mutation databases

BioMutaiOR6K6.
DMDMi223590118.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 343343Olfactory receptor 6K6PRO_0000150631Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi33 – 331N-linked (GlcNAc...)Sequence analysis
Disulfide bondi125 ↔ 217PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGW6.
PeptideAtlasiQ8NGW6.
PRIDEiQ8NGW6.

PTM databases

PhosphoSiteiQ8NGW6.

Expressioni

Gene expression databases

CleanExiHS_OR6K6.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000357126.

Structurei

3D structure databases

ProteinModelPortaliQ8NGW6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IQGY. Eukaryota.
ENOG4111AD8. LUCA.
GeneTreeiENSGT00840000129709.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiQ8NGW6.
KOiK04257.
OMAiDMALHTP.
OrthoDBiEOG091G0AZH.
PhylomeDBiQ8NGW6.
TreeFamiTF337562.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGW6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKQYSVGNQH SNYRSLLFPF LCSQMTQLTA SGNQTMVTEF LFSMFPHAHR
60 70 80 90 100
GGLLFFIPLL LIYGFILTGN LIMFIVIQVG MALHTPLYFF ISVLSFLEIC
110 120 130 140 150
YTTTTIPKML SCLISEQKSI SVAGCLLQMY FFHSLGITES CVLTAMAIDR
160 170 180 190 200
YIAICNPLRY PTIMIPKLCI QLTVGSCFCG FLLVLPEIAW ISTLPFCGSN
210 220 230 240 250
QIHQIFCDFT PVLSLACTDT FLVVIVDAIH AAEIVASFLV IALSYIRIII
260 270 280 290 300
VILGMHSAEG HHKAFSTCAA HLAVFLLFFG SVAVMYLRFS ATYSVFWDTA
310 320 330 340
IAVTFVILAP FFNPIIYSLK NKDMKEAIGR LFHYQKRAGW AGK
Length:343
Mass (Da):38,362
Last modified:February 10, 2009 - v2
Checksum:i0786F45F4BA67CBB
GO

Sequence cautioni

The sequence BAC05876 differs from that shown. Reason: Erroneous initiation. Curated
The sequence CAH73791 differs from that shown. Reason: Erroneous initiation. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti39 – 391E → D.
Corresponds to variant rs16840974 [ dbSNP | Ensembl ].
VAR_057551
Natural varianti49 – 491H → Y.
Corresponds to variant rs16840976 [ dbSNP | Ensembl ].
VAR_057552
Natural varianti80 – 801G → D.
Corresponds to variant rs16840980 [ dbSNP | Ensembl ].
VAR_057553
Natural varianti134 – 1341S → L.
Corresponds to variant rs16840991 [ dbSNP | Ensembl ].
VAR_057554
Natural varianti159 – 1591R → C.
Corresponds to variant rs16841001 [ dbSNP | Ensembl ].
VAR_057555
Natural varianti197 – 1971C → R.
Corresponds to variant rs16841009 [ dbSNP | Ensembl ].
VAR_057556
Natural varianti211 – 2111P → L.
Corresponds to variant rs16841017 [ dbSNP | Ensembl ].
VAR_057557
Natural varianti247 – 2471R → Q.
Corresponds to variant rs16841038 [ dbSNP | Ensembl ].
VAR_057558
Natural varianti261 – 2611H → R.
Corresponds to variant rs16841042 [ dbSNP | Ensembl ].
VAR_057559
Natural varianti320 – 3201K → R.
Corresponds to variant rs16841045 [ dbSNP | Ensembl ].
VAR_057560

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065650 Genomic DNA. Translation: BAC05876.1. Different initiation.
AL513205 Genomic DNA. Translation: CAH73791.1. Different initiation.
BC140743 mRNA. Translation: AAI40744.1.
BK004198 Genomic DNA. Translation: DAA04596.1.
CCDSiCCDS30904.1.
RefSeqiNP_001005184.1. NM_001005184.1.
UniGeneiHs.553591.

Genome annotation databases

EnsembliENST00000368144; ENSP00000357126; ENSG00000180433.
GeneIDi128371.
KEGGihsa:128371.
UCSCiuc001fsw.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065650 Genomic DNA. Translation: BAC05876.1. Different initiation.
AL513205 Genomic DNA. Translation: CAH73791.1. Different initiation.
BC140743 mRNA. Translation: AAI40744.1.
BK004198 Genomic DNA. Translation: DAA04596.1.
CCDSiCCDS30904.1.
RefSeqiNP_001005184.1. NM_001005184.1.
UniGeneiHs.553591.

3D structure databases

ProteinModelPortaliQ8NGW6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000357126.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiQ8NGW6.

Polymorphism and mutation databases

BioMutaiOR6K6.
DMDMi223590118.

Proteomic databases

PaxDbiQ8NGW6.
PeptideAtlasiQ8NGW6.
PRIDEiQ8NGW6.

Protocols and materials databases

DNASUi128371.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000368144; ENSP00000357126; ENSG00000180433.
GeneIDi128371.
KEGGihsa:128371.
UCSCiuc001fsw.2. human.

Organism-specific databases

CTDi128371.
GeneCardsiOR6K6.
HGNCiHGNC:15033. OR6K6.
neXtProtiNX_Q8NGW6.
PharmGKBiPA32593.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IQGY. Eukaryota.
ENOG4111AD8. LUCA.
GeneTreeiENSGT00840000129709.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiQ8NGW6.
KOiK04257.
OMAiDMALHTP.
OrthoDBiEOG091G0AZH.
PhylomeDBiQ8NGW6.
TreeFamiTF337562.

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR6K6.
GenomeRNAii128371.
PROiQ8NGW6.

Gene expression databases

CleanExiHS_OR6K6.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOR6K6_HUMAN
AccessioniPrimary (citable) accession number: Q8NGW6
Secondary accession number(s): B9EIM8, Q5VUU9, Q6IFR4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: February 10, 2009
Last modified: September 7, 2016
This is version 124 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-25 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.