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Q8NGW1

- OR6B3_HUMAN

UniProt

Q8NGW1 - OR6B3_HUMAN

Protein

Olfactory receptor 6B3

Gene

OR6B3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    Odorant receptor.Curated

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW
    2. olfactory receptor activity Source: InterPro

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Olfaction, Sensory transduction

    Enzyme and pathway databases

    ReactomeiREACT_15488. Olfactory Signaling Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Olfactory receptor 6B3
    Alternative name(s):
    Olfactory receptor OR2-2
    Gene namesi
    Name:OR6B3
    Synonyms:OR6B3P
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:15042. OR6B3.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA32578.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 331331Olfactory receptor 6B3PRO_0000150622Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi5 – 51N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiQ8NGW1.

    PTM databases

    PhosphoSiteiQ8NGW1.

    Expressioni

    Gene expression databases

    GenevestigatoriQ8NGW1.

    Organism-specific databases

    HPAiHPA047529.

    Interactioni

    Protein-protein interaction databases

    BioGridi127316. 1 interaction.
    IntActiQ8NGW1. 1 interaction.
    STRINGi9606.ENSP00000322435.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8NGW1.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2525ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini47 – 548CytoplasmicSequence Analysis
    Topological domaini76 – 9924ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini121 – 13919CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini161 – 19636ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini218 – 23720CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini259 – 27113ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini293 – 33139CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei26 – 4621Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei55 – 7521Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei100 – 12021Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei140 – 16021Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei197 – 21721Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei238 – 25821Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei272 – 29221Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG47186.
    HOGENOMiHOG000041364.
    HOVERGENiHBG017625.
    InParanoidiQ8NGW1.
    KOiK04257.
    OMAiFFYVAML.
    OrthoDBiEOG7VQJDK.
    PhylomeDBiQ8NGW1.
    TreeFamiTF337475.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8NGW1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSGENVTRVG TFILVGFPTA PGLQYLLFLL FLLTYLFVLV ENLAIILTVW    50
    SSTSLHRPMY YFLSSMSFLE IWYVSDITPK MLEGFLLQQK RISFVGCMTQ 100
    LYFFSSLVCT ECVLLASMAY DRYVAICHPL RYHVLVTPGL CLQLVGFSFV 150
    SGFTISMIKV CFISSVTFCG SNVLNHFFCD ISPILKLACT DFSTAELVDF 200
    ILAFIILVFP LLATMLSYAH ITLAVLRIPS ATGCWRAFFT CASHLTVVTV 250
    FYTALLFMYV RPQAIDSRSS NKLISVLYTV ITPILNPLIY CLRNKEFKNA 300
    LKKAFGLTSC AVEGRLSSLL ELHLQIHSQP L 331
    Length:331
    Mass (Da):37,232
    Last modified:October 1, 2002 - v1
    Checksum:i88E9369D2BAB6244
    GO

    Sequence cautioni

    The sequence DAA04687.1 differs from that shown. Reason: Erroneous initiation.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti234 – 2341C → Y.
    Corresponds to variant rs12465491 [ dbSNP | Ensembl ].
    VAR_062049

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065662 Genomic DNA. Translation: BAC05888.1.
    BK004289 Genomic DNA. Translation: DAA04687.1. Different initiation.
    CCDSiCCDS42837.1.
    RefSeqiNP_775486.1. NM_173351.1.
    UniGeneiHs.626616.

    Genome annotation databases

    EnsembliENST00000319423; ENSP00000322435; ENSG00000178586.
    GeneIDi150681.
    KEGGihsa:150681.
    UCSCiuc010zoe.2. human.

    Polymorphism databases

    DMDMi38258179.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Human Olfactory Receptor Data Exploratorium (HORDE)

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065662 Genomic DNA. Translation: BAC05888.1 .
    BK004289 Genomic DNA. Translation: DAA04687.1 . Different initiation.
    CCDSi CCDS42837.1.
    RefSeqi NP_775486.1. NM_173351.1.
    UniGenei Hs.626616.

    3D structure databases

    ProteinModelPortali Q8NGW1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 127316. 1 interaction.
    IntActi Q8NGW1. 1 interaction.
    STRINGi 9606.ENSP00000322435.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q8NGW1.

    Polymorphism databases

    DMDMi 38258179.

    Proteomic databases

    PRIDEi Q8NGW1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000319423 ; ENSP00000322435 ; ENSG00000178586 .
    GeneIDi 150681.
    KEGGi hsa:150681.
    UCSCi uc010zoe.2. human.

    Organism-specific databases

    CTDi 150681.
    GeneCardsi GC02M240984.
    HGNCi HGNC:15042. OR6B3.
    HPAi HPA047529.
    neXtProti NX_Q8NGW1.
    PharmGKBi PA32578.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG47186.
    HOGENOMi HOG000041364.
    HOVERGENi HBG017625.
    InParanoidi Q8NGW1.
    KOi K04257.
    OMAi FFYVAML.
    OrthoDBi EOG7VQJDK.
    PhylomeDBi Q8NGW1.
    TreeFami TF337475.

    Enzyme and pathway databases

    Reactomei REACT_15488. Olfactory Signaling Pathway.

    Miscellaneous databases

    GeneWikii OR6B3.
    GenomeRNAii 150681.
    NextBioi 86496.
    PROi Q8NGW1.

    Gene expression databases

    Genevestigatori Q8NGW1.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
      Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
      Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: IDENTIFICATION.
    3. Erratum
      Malnic B., Godfrey P.A., Buck L.B.
      Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

    Entry informationi

    Entry nameiOR6B3_HUMAN
    AccessioniPrimary (citable) accession number: Q8NGW1
    Secondary accession number(s): Q6IFH3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 31, 2003
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 100 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3