Q8NGW1 (OR6B3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Olfactory receptor 6B3

Alternative name(s):
Olfactory receptor OR2-2

Gene names

Name:	OR6B3
Synonyms:	OR6B3P

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	331 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Odorant receptor Potential.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.
Sequence caution	The sequence DAA04687.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Olfaction Sensory transduction
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	detection of chemical stimulus involved in sensory perception of smell Inferred from electronic annotation. Source: GOC
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Traceable author statement. Source: Reactome
Molecular_function	G-protein coupled receptor activity Inferred from electronic annotation. Source: UniProtKB-KW olfactory receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 331	331	Olfactory receptor 6B3		PRO_0000150622
Regions
	Topological domain	1 – 25	25	Extracellular Potential
	Transmembrane	26 – 46	21	Helical; Name=1; Potential
	Topological domain	47 – 54	8	Cytoplasmic Potential
	Transmembrane	55 – 75	21	Helical; Name=2; Potential
	Topological domain	76 – 99	24	Extracellular Potential
	Transmembrane	100 – 120	21	Helical; Name=3; Potential
	Topological domain	121 – 139	19	Cytoplasmic Potential
	Transmembrane	140 – 160	21	Helical; Name=4; Potential
	Topological domain	161 – 196	36	Extracellular Potential
	Transmembrane	197 – 217	21	Helical; Name=5; Potential
	Topological domain	218 – 237	20	Cytoplasmic Potential
	Transmembrane	238 – 258	21	Helical; Name=6; Potential
	Topological domain	259 – 271	13	Extracellular Potential
	Transmembrane	272 – 292	21	Helical; Name=7; Potential
	Topological domain	293 – 331	39	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	5	1	N-linked (GlcNAc...) Potential
	Disulfide bond	97 ↔ 189		By similarity
Natural variations
	Natural variant	234	1	C → Y. Corresponds to variant rs12465491 [ dbSNP | Ensembl ].		VAR_062049

Sequences

	Sequence		Length	Mass (Da)
	Q8NGW1 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: 88E9369D2BAB6244	FASTA	331	37,232
	10 20 30 40 50 60 MSGENVTRVG TFILVGFPTA PGLQYLLFLL FLLTYLFVLV ENLAIILTVW SSTSLHRPMY 70 80 90 100 110 120 YFLSSMSFLE IWYVSDITPK MLEGFLLQQK RISFVGCMTQ LYFFSSLVCT ECVLLASMAY 130 140 150 160 170 180 DRYVAICHPL RYHVLVTPGL CLQLVGFSFV SGFTISMIKV CFISSVTFCG SNVLNHFFCD 190 200 210 220 230 240 ISPILKLACT DFSTAELVDF ILAFIILVFP LLATMLSYAH ITLAVLRIPS ATGCWRAFFT 250 260 270 280 290 300 CASHLTVVTV FYTALLFMYV RPQAIDSRSS NKLISVLYTV ITPILNPLIY CLRNKEFKNA 310 320 330 LKKAFGLTSC AVEGRLSSLL ELHLQIHSQP L

References

[1]	"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes." Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y. Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"The human olfactory receptor gene family." Malnic B., Godfrey P.A., Buck L.B. Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION.
[3]	Erratum Malnic B., Godfrey P.A., Buck L.B. Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Web resources

Human Olfactory Receptor Data Exploratorium (HORDE)

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB065662 Genomic DNA. Translation: BAC05888.1. BK004289 Genomic DNA. Translation: DAA04687.1. Different initiation.
IPI	IPI00303685.
RefSeq	NP_775486.1. NM_173351.1.
UniGene	Hs.626616.
3D structure databases
ProteinModelPortal	Q8NGW1.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000322435.
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	Q8NGW1.
Polymorphism databases
DMDM	38258179.
Proteomic databases
PRIDE	Q8NGW1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000319423; ENSP00000322435; ENSG00000178586.
GeneID	150681.
KEGG	hsa:150681.
UCSC	uc010zoe.2. human.
Organism-specific databases
CTD	150681.
GeneCards	GC02M240984.
HGNC	HGNC:15042. OR6B3.
HPA	HPA047529.
neXtProt	NX_Q8NGW1.
PharmGKB	PA32578.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG47186.
HOGENOM	HOG000041364.
HOVERGEN	HBG017625.
InParanoid	Q8NGW1.
KO	K04257.
OMA	FFYVAML.
OrthoDB	EOG4C87SS.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction.
Gene expression databases
ArrayExpress	Q8NGW1.
Genevestigator	Q8NGW1.
Family and domain databases
InterPro	IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. IPR000725. Olfact_rcpt. [Graphical view]
PRINTS	PR00237. GPCRRHODOPSN. PR00245. OLFACTORYR.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	150681.
NextBio	86496.

Entry information

Entry name

OR6B3_HUMAN

Accession

Primary (citable) accession number: Q8NGW1
Secondary accession number(s): Q6IFH3

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 31, 2003
Last sequence update:	October 1, 2002
Last modified:	May 1, 2013
This is version 88 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.