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Q8NGW1

- OR6B3_HUMAN

UniProt

Q8NGW1 - OR6B3_HUMAN

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Protein

Olfactory receptor 6B3

Gene

OR6B3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 6B3
Alternative name(s):
Olfactory receptor OR2-2
Gene namesi
Name:OR6B3
Synonyms:OR6B3P
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:15042. OR6B3.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32578.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 331331Olfactory receptor 6B3PRO_0000150622Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ8NGW1.

PTM databases

PhosphoSiteiQ8NGW1.

Expressioni

Gene expression databases

GenevestigatoriQ8NGW1.

Organism-specific databases

HPAiHPA047529.

Interactioni

Protein-protein interaction databases

BioGridi127316. 1 interaction.
IntActiQ8NGW1. 1 interaction.
STRINGi9606.ENSP00000322435.

Structurei

3D structure databases

ProteinModelPortaliQ8NGW1.
SMRiQ8NGW1. Positions 109-140.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2525ExtracellularSequence AnalysisAdd
BLAST
Topological domaini47 – 548CytoplasmicSequence Analysis
Topological domaini76 – 9924ExtracellularSequence AnalysisAdd
BLAST
Topological domaini121 – 13919CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini161 – 19636ExtracellularSequence AnalysisAdd
BLAST
Topological domaini218 – 23720CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini259 – 27113ExtracellularSequence AnalysisAdd
BLAST
Topological domaini293 – 33139CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei26 – 4621Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei55 – 7521Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei100 – 12021Helical; Name=3Sequence AnalysisAdd
BLAST
Transmembranei140 – 16021Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei197 – 21721Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei238 – 25821Helical; Name=6Sequence AnalysisAdd
BLAST
Transmembranei272 – 29221Helical; Name=7Sequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG47186.
GeneTreeiENSGT00760000119047.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ8NGW1.
KOiK04257.
OMAiFFYVAML.
OrthoDBiEOG7VQJDK.
PhylomeDBiQ8NGW1.
TreeFamiTF337475.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGW1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSGENVTRVG TFILVGFPTA PGLQYLLFLL FLLTYLFVLV ENLAIILTVW
60 70 80 90 100
SSTSLHRPMY YFLSSMSFLE IWYVSDITPK MLEGFLLQQK RISFVGCMTQ
110 120 130 140 150
LYFFSSLVCT ECVLLASMAY DRYVAICHPL RYHVLVTPGL CLQLVGFSFV
160 170 180 190 200
SGFTISMIKV CFISSVTFCG SNVLNHFFCD ISPILKLACT DFSTAELVDF
210 220 230 240 250
ILAFIILVFP LLATMLSYAH ITLAVLRIPS ATGCWRAFFT CASHLTVVTV
260 270 280 290 300
FYTALLFMYV RPQAIDSRSS NKLISVLYTV ITPILNPLIY CLRNKEFKNA
310 320 330
LKKAFGLTSC AVEGRLSSLL ELHLQIHSQP L
Length:331
Mass (Da):37,232
Last modified:October 1, 2002 - v1
Checksum:i88E9369D2BAB6244
GO

Sequence cautioni

The sequence DAA04687.1 differs from that shown. Reason: Erroneous initiation.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti234 – 2341C → Y.
Corresponds to variant rs12465491 [ dbSNP | Ensembl ].
VAR_062049

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB065662 Genomic DNA. Translation: BAC05888.1.
BK004289 Genomic DNA. Translation: DAA04687.1. Different initiation.
CCDSiCCDS42837.1.
RefSeqiNP_775486.1. NM_173351.1.
UniGeneiHs.626616.

Genome annotation databases

EnsembliENST00000319423; ENSP00000322435; ENSG00000178586.
GeneIDi150681.
KEGGihsa:150681.
UCSCiuc010zoe.2. human.

Polymorphism databases

DMDMi38258179.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB065662 Genomic DNA. Translation: BAC05888.1 .
BK004289 Genomic DNA. Translation: DAA04687.1 . Different initiation.
CCDSi CCDS42837.1.
RefSeqi NP_775486.1. NM_173351.1.
UniGenei Hs.626616.

3D structure databases

ProteinModelPortali Q8NGW1.
SMRi Q8NGW1. Positions 109-140.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 127316. 1 interaction.
IntActi Q8NGW1. 1 interaction.
STRINGi 9606.ENSP00000322435.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei Q8NGW1.

Polymorphism databases

DMDMi 38258179.

Proteomic databases

PRIDEi Q8NGW1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000319423 ; ENSP00000322435 ; ENSG00000178586 .
GeneIDi 150681.
KEGGi hsa:150681.
UCSCi uc010zoe.2. human.

Organism-specific databases

CTDi 150681.
GeneCardsi GC02M240984.
HGNCi HGNC:15042. OR6B3.
HPAi HPA047529.
neXtProti NX_Q8NGW1.
PharmGKBi PA32578.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG47186.
GeneTreei ENSGT00760000119047.
HOGENOMi HOG000041364.
HOVERGENi HBG017625.
InParanoidi Q8NGW1.
KOi K04257.
OMAi FFYVAML.
OrthoDBi EOG7VQJDK.
PhylomeDBi Q8NGW1.
TreeFami TF337475.

Enzyme and pathway databases

Reactomei REACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikii OR6B3.
GenomeRNAii 150681.
NextBioi 86496.
PROi Q8NGW1.

Gene expression databases

Genevestigatori Q8NGW1.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: IDENTIFICATION.
  3. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiOR6B3_HUMAN
AccessioniPrimary (citable) accession number: Q8NGW1
Secondary accession number(s): Q6IFH3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2003
Last sequence update: October 1, 2002
Last modified: October 29, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3