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Q8NGW1

- OR6B3_HUMAN

UniProt

Q8NGW1 - OR6B3_HUMAN

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Protein
Olfactory receptor 6B3
Gene
OR6B3, OR6B3P
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Odorant receptor Reviewed prediction.

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 6B3
Alternative name(s):
Olfactory receptor OR2-2
Gene namesi
Name:OR6B3
Synonyms:OR6B3P
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:15042. OR6B3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2525Extracellular Reviewed prediction
Add
BLAST
Transmembranei26 – 4621Helical; Name=1; Reviewed prediction
Add
BLAST
Topological domaini47 – 548Cytoplasmic Reviewed prediction
Transmembranei55 – 7521Helical; Name=2; Reviewed prediction
Add
BLAST
Topological domaini76 – 9924Extracellular Reviewed prediction
Add
BLAST
Transmembranei100 – 12021Helical; Name=3; Reviewed prediction
Add
BLAST
Topological domaini121 – 13919Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei140 – 16021Helical; Name=4; Reviewed prediction
Add
BLAST
Topological domaini161 – 19636Extracellular Reviewed prediction
Add
BLAST
Transmembranei197 – 21721Helical; Name=5; Reviewed prediction
Add
BLAST
Topological domaini218 – 23720Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei238 – 25821Helical; Name=6; Reviewed prediction
Add
BLAST
Topological domaini259 – 27113Extracellular Reviewed prediction
Add
BLAST
Transmembranei272 – 29221Helical; Name=7; Reviewed prediction
Add
BLAST
Topological domaini293 – 33139Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32578.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 331331Olfactory receptor 6B3
PRO_0000150622Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi97 ↔ 189 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ8NGW1.

PTM databases

PhosphoSiteiQ8NGW1.

Expressioni

Gene expression databases

GenevestigatoriQ8NGW1.

Organism-specific databases

HPAiHPA047529.

Interactioni

Protein-protein interaction databases

BioGridi127316. 1 interaction.
IntActiQ8NGW1. 1 interaction.
STRINGi9606.ENSP00000322435.

Structurei

3D structure databases

ProteinModelPortaliQ8NGW1.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG47186.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ8NGW1.
KOiK04257.
OMAiFFYVAML.
OrthoDBiEOG7VQJDK.
PhylomeDBiQ8NGW1.
TreeFamiTF337475.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGW1-1 [UniParc]FASTAAdd to Basket

« Hide

MSGENVTRVG TFILVGFPTA PGLQYLLFLL FLLTYLFVLV ENLAIILTVW    50
SSTSLHRPMY YFLSSMSFLE IWYVSDITPK MLEGFLLQQK RISFVGCMTQ 100
LYFFSSLVCT ECVLLASMAY DRYVAICHPL RYHVLVTPGL CLQLVGFSFV 150
SGFTISMIKV CFISSVTFCG SNVLNHFFCD ISPILKLACT DFSTAELVDF 200
ILAFIILVFP LLATMLSYAH ITLAVLRIPS ATGCWRAFFT CASHLTVVTV 250
FYTALLFMYV RPQAIDSRSS NKLISVLYTV ITPILNPLIY CLRNKEFKNA 300
LKKAFGLTSC AVEGRLSSLL ELHLQIHSQP L 331
Length:331
Mass (Da):37,232
Last modified:October 1, 2002 - v1
Checksum:i88E9369D2BAB6244
GO

Sequence cautioni

The sequence DAA04687.1 differs from that shown. Reason: Erroneous initiation.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti234 – 2341C → Y.
Corresponds to variant rs12465491 [ dbSNP | Ensembl ].
VAR_062049

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB065662 Genomic DNA. Translation: BAC05888.1.
BK004289 Genomic DNA. Translation: DAA04687.1. Different initiation.
CCDSiCCDS42837.1.
RefSeqiNP_775486.1. NM_173351.1.
UniGeneiHs.626616.

Genome annotation databases

EnsembliENST00000319423; ENSP00000322435; ENSG00000178586.
GeneIDi150681.
KEGGihsa:150681.
UCSCiuc010zoe.2. human.

Polymorphism databases

DMDMi38258179.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB065662 Genomic DNA. Translation: BAC05888.1 .
BK004289 Genomic DNA. Translation: DAA04687.1 . Different initiation.
CCDSi CCDS42837.1.
RefSeqi NP_775486.1. NM_173351.1.
UniGenei Hs.626616.

3D structure databases

ProteinModelPortali Q8NGW1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 127316. 1 interaction.
IntActi Q8NGW1. 1 interaction.
STRINGi 9606.ENSP00000322435.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei Q8NGW1.

Polymorphism databases

DMDMi 38258179.

Proteomic databases

PRIDEi Q8NGW1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000319423 ; ENSP00000322435 ; ENSG00000178586 .
GeneIDi 150681.
KEGGi hsa:150681.
UCSCi uc010zoe.2. human.

Organism-specific databases

CTDi 150681.
GeneCardsi GC02M240984.
HGNCi HGNC:15042. OR6B3.
HPAi HPA047529.
neXtProti NX_Q8NGW1.
PharmGKBi PA32578.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG47186.
HOGENOMi HOG000041364.
HOVERGENi HBG017625.
InParanoidi Q8NGW1.
KOi K04257.
OMAi FFYVAML.
OrthoDBi EOG7VQJDK.
PhylomeDBi Q8NGW1.
TreeFami TF337475.

Enzyme and pathway databases

Reactomei REACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikii OR6B3.
GenomeRNAii 150681.
NextBioi 86496.
PROi Q8NGW1.

Gene expression databases

Genevestigatori Q8NGW1.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: IDENTIFICATION.
  3. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiOR6B3_HUMAN
AccessioniPrimary (citable) accession number: Q8NGW1
Secondary accession number(s): Q6IFH3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2003
Last sequence update: October 1, 2002
Last modified: September 3, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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