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Q8NGW1 (OR6B3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 96. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Olfactory receptor 6B3
Alternative name(s):
Olfactory receptor OR2-2
Gene names
Name:OR6B3
Synonyms:OR6B3P
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length331 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Odorant receptor Potential.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence caution

The sequence DAA04687.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 331331Olfactory receptor 6B3
PRO_0000150622

Regions

Topological domain1 – 2525Extracellular Potential
Transmembrane26 – 4621Helical; Name=1; Potential
Topological domain47 – 548Cytoplasmic Potential
Transmembrane55 – 7521Helical; Name=2; Potential
Topological domain76 – 9924Extracellular Potential
Transmembrane100 – 12021Helical; Name=3; Potential
Topological domain121 – 13919Cytoplasmic Potential
Transmembrane140 – 16021Helical; Name=4; Potential
Topological domain161 – 19636Extracellular Potential
Transmembrane197 – 21721Helical; Name=5; Potential
Topological domain218 – 23720Cytoplasmic Potential
Transmembrane238 – 25821Helical; Name=6; Potential
Topological domain259 – 27113Extracellular Potential
Transmembrane272 – 29221Helical; Name=7; Potential
Topological domain293 – 33139Cytoplasmic Potential

Amino acid modifications

Glycosylation51N-linked (GlcNAc...) Potential
Disulfide bond97 ↔ 189 By similarity

Natural variations

Natural variant2341C → Y.
Corresponds to variant rs12465491 [ dbSNP | Ensembl ].
VAR_062049

Sequences

Sequence LengthMass (Da)Tools
Q8NGW1 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: 88E9369D2BAB6244

FASTA33137,232
        10         20         30         40         50         60 
MSGENVTRVG TFILVGFPTA PGLQYLLFLL FLLTYLFVLV ENLAIILTVW SSTSLHRPMY 

        70         80         90        100        110        120 
YFLSSMSFLE IWYVSDITPK MLEGFLLQQK RISFVGCMTQ LYFFSSLVCT ECVLLASMAY 

       130        140        150        160        170        180 
DRYVAICHPL RYHVLVTPGL CLQLVGFSFV SGFTISMIKV CFISSVTFCG SNVLNHFFCD 

       190        200        210        220        230        240 
ISPILKLACT DFSTAELVDF ILAFIILVFP LLATMLSYAH ITLAVLRIPS ATGCWRAFFT 

       250        260        270        280        290        300 
CASHLTVVTV FYTALLFMYV RPQAIDSRSS NKLISVLYTV ITPILNPLIY CLRNKEFKNA 

       310        320        330 
LKKAFGLTSC AVEGRLSSLL ELHLQIHSQP L 

« Hide

References

[1]"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The human olfactory receptor gene family."
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
[3]Erratum
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB065662 Genomic DNA. Translation: BAC05888.1.
BK004289 Genomic DNA. Translation: DAA04687.1. Different initiation.
RefSeqNP_775486.1. NM_173351.1.
UniGeneHs.626616.

3D structure databases

ProteinModelPortalQ8NGW1.
SMRQ8NGW1. Positions 109-140, 278-308.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid127316. 1 interaction.
IntActQ8NGW1. 1 interaction.
STRING9606.ENSP00000322435.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteQ8NGW1.

Polymorphism databases

DMDM38258179.

Proteomic databases

PRIDEQ8NGW1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000319423; ENSP00000322435; ENSG00000178586.
GeneID150681.
KEGGhsa:150681.
UCSCuc010zoe.2. human.

Organism-specific databases

CTD150681.
GeneCardsGC02M240984.
HGNCHGNC:15042. OR6B3.
HPAHPA047529.
neXtProtNX_Q8NGW1.
PharmGKBPA32578.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG47186.
HOGENOMHOG000041364.
HOVERGENHBG017625.
InParanoidQ8NGW1.
KOK04257.
OMAFFYVAML.
OrthoDBEOG7VQJDK.
PhylomeDBQ8NGW1.
TreeFamTF337475.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

GenevestigatorQ8NGW1.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiOR6B3.
GenomeRNAi150681.
NextBio86496.
PROQ8NGW1.

Entry information

Entry nameOR6B3_HUMAN
AccessionPrimary (citable) accession number: Q8NGW1
Secondary accession number(s): Q6IFH3
Entry history
Integrated into UniProtKB/Swiss-Prot: October 31, 2003
Last sequence update: October 1, 2002
Last modified: April 16, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 2

Human chromosome 2: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries