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Protein

Olfactory receptor 5H2

Gene

OR5H2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

BioCyciZFISH:ENSG00000174314-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 5H2
Alternative name(s):
Olfactory receptor OR3-10
Gene namesi
Name:OR5H2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:14752. OR5H2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 33ExtracellularSequence analysisAdd BLAST33
Transmembranei34 – 54Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini55 – 61CytoplasmicSequence analysis7
Transmembranei62 – 82Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini83 – 102ExtracellularSequence analysisAdd BLAST20
Transmembranei103 – 123Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini124 – 148CytoplasmicSequence analysisAdd BLAST25
Transmembranei149 – 169Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini170 – 198ExtracellularSequence analysisAdd BLAST29
Transmembranei199 – 219Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini220 – 244CytoplasmicSequence analysisAdd BLAST25
Transmembranei245 – 265Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini266 – 276ExtracellularSequence analysisAdd BLAST11
Transmembranei277 – 297Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini298 – 314CytoplasmicSequence analysisAdd BLAST17

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000197938.
PharmGKBiPA32533.

Polymorphism and mutation databases

BioMutaiOR5H2.
DMDMi212276497.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001505961 – 314Olfactory receptor 5H2Add BLAST314

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi10N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi102 ↔ 184PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGV7.
PeptideAtlasiQ8NGV7.
PRIDEiQ8NGV7.

Expressioni

Gene expression databases

CleanExiHS_OR5H2.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000347418.

Structurei

3D structure databases

ProteinModelPortaliQ8NGV7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J97S. Eukaryota.
ENOG4111537. LUCA.
GeneTreeiENSGT00550000074564.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ8NGV7.
KOiK04257.
OMAiIPLFMIS.
OrthoDBiEOG091G0C7C.
PhylomeDBiQ8NGV7.
TreeFamiTF352737.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGV7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNEDMEQDN TTLLTEFVLT GLTYQPEWKM PLFLVFLVIY LITIVWNLGL
60 70 80 90 100
IALIWNDPQL HIPMYFFLGS LAFVDAWISS TVTPKMLVNF LAKNRMISLS
110 120 130 140 150
ECMIQFFSFA FGGTTECFLL ATMAYDRYVA ICKPLLYPVI MNNSLCIRLL
160 170 180 190 200
AFSFLGGFLH ALIHEVLIFR LTFCNSNIIH HFYCDIIPLF MISCTDPSIN
210 220 230 240 250
FLMVFILSGS IQVFTIVTVL NSYTFALFTI LKKKSVRGVR KAFSTCGAHL
260 270 280 290 300
LSVSLYYGPL IFMYLRPASP QADDQDMIDS VFYTIIIPLL NPIIYSLRNK
310
QVIDSFTKMV KRNV
Length:314
Mass (Da):35,974
Last modified:November 4, 2008 - v3
Checksum:iCBAD88D263E03204
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_053195230I → V.Corresponds to variant rs16839214dbSNPEnsembl.1
Natural variantiVAR_053196266R → C.Corresponds to variant rs17787561dbSNPEnsembl.1
Natural variantiVAR_053197286I → V.Corresponds to variant rs16839611dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065666 Genomic DNA. Translation: BAC05892.1.
AC117473 Genomic DNA. No translation available.
BK004375 Genomic DNA. Translation: DAA04773.1.
CCDSiCCDS33801.1.
RefSeqiNP_001005482.1. NM_001005482.1.
UniGeneiHs.554711.

Genome annotation databases

EnsembliENST00000355273; ENSP00000347418; ENSG00000197938.
GeneIDi79310.
KEGGihsa:79310.
UCSCiuc003dsj.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065666 Genomic DNA. Translation: BAC05892.1.
AC117473 Genomic DNA. No translation available.
BK004375 Genomic DNA. Translation: DAA04773.1.
CCDSiCCDS33801.1.
RefSeqiNP_001005482.1. NM_001005482.1.
UniGeneiHs.554711.

3D structure databases

ProteinModelPortaliQ8NGV7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000347418.

Protein family/group databases

GPCRDBiSearch...

Polymorphism and mutation databases

BioMutaiOR5H2.
DMDMi212276497.

Proteomic databases

PaxDbiQ8NGV7.
PeptideAtlasiQ8NGV7.
PRIDEiQ8NGV7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000355273; ENSP00000347418; ENSG00000197938.
GeneIDi79310.
KEGGihsa:79310.
UCSCiuc003dsj.1. human.

Organism-specific databases

CTDi79310.
GeneCardsiOR5H2.
H-InvDBHIX0200574.
HGNCiHGNC:14752. OR5H2.
neXtProtiNX_Q8NGV7.
OpenTargetsiENSG00000197938.
PharmGKBiPA32533.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J97S. Eukaryota.
ENOG4111537. LUCA.
GeneTreeiENSGT00550000074564.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ8NGV7.
KOiK04257.
OMAiIPLFMIS.
OrthoDBiEOG091G0C7C.
PhylomeDBiQ8NGV7.
TreeFamiTF352737.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000174314-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR5H2.
GenomeRNAii79310.
PROiQ8NGV7.

Gene expression databases

CleanExiHS_OR5H2.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOR5H2_HUMAN
AccessioniPrimary (citable) accession number: Q8NGV7
Secondary accession number(s): Q6IF87
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: November 4, 2008
Last modified: November 2, 2016
This is version 120 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-6 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.