ID OR5H6_HUMAN Reviewed; 325 AA. AC Q8NGV6; Q6IF88; DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot. DT 10-FEB-2009, sequence version 2. DT 27-MAR-2024, entry version 162. DE RecName: Full=Olfactory receptor 5H6; DE AltName: Full=Olfactory receptor OR3-11; GN Name=OR5H6; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.; RT "Genome-wide discovery and analysis of human seven transmembrane helix RT receptor genes."; RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases. RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [3] RP IDENTIFICATION. RX PubMed=14983052; DOI=10.1073/pnas.0307882100; RA Malnic B., Godfrey P.A., Buck L.B.; RT "The human olfactory receptor gene family."; RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004). RN [4] RP ERRATUM OF PUBMED:14983052. RA Malnic B., Godfrey P.A., Buck L.B.; RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004). CC -!- FUNCTION: Odorant receptor. {ECO:0000305}. CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC {ECO:0000255|PROSITE-ProRule:PRU00521}. CC -!- CAUTION: It is uncertain whether Met-1 or Met-17 is the initiator. CC {ECO:0000305}. CC -!- SEQUENCE CAUTION: CC Sequence=BAC05893.1; Type=Erroneous initiation; Evidence={ECO:0000305}; CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE); CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR5H6"; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AB065667; BAC05893.1; ALT_INIT; Genomic_DNA. DR EMBL; BC137523; AAI37524.1; -; mRNA. DR EMBL; BC137524; AAI37525.1; -; mRNA. DR EMBL; BK004374; DAA04772.1; -; Genomic_DNA. DR RefSeq; NP_001005479.1; NM_001005479.1. DR RefSeq; XP_011511420.1; XM_011513118.2. DR AlphaFoldDB; Q8NGV6; -. DR SMR; Q8NGV6; -. DR IntAct; Q8NGV6; 1. DR STRING; 9606.ENSP00000493340; -. DR GlyCosmos; Q8NGV6; 1 site, No reported glycans. DR GlyGen; Q8NGV6; 1 site. DR iPTMnet; Q8NGV6; -. DR PhosphoSitePlus; Q8NGV6; -. DR BioMuta; OR5H6; -. DR DMDM; 223590117; -. DR PaxDb; 9606-ENSP00000373196; -. DR PeptideAtlas; Q8NGV6; -. DR Antibodypedia; 58698; 63 antibodies from 16 providers. DR DNASU; 79295; -. DR Ensembl; ENST00000642105.1; ENSP00000493340.1; ENSG00000230301.6. DR GeneID; 79295; -. DR KEGG; hsa:79295; -. DR UCSC; uc003dsi.1; human. DR AGR; HGNC:14767; -. DR CTD; 79295; -. DR GeneCards; OR5H6; -. DR HGNC; HGNC:14767; OR5H6. DR HPA; ENSG00000230301; Not detected. DR neXtProt; NX_Q8NGV6; -. DR PharmGKB; PA32537; -. DR VEuPathDB; HostDB:ENSG00000230301; -. DR eggNOG; ENOG502T9JQ; Eukaryota. DR GeneTree; ENSGT01090000260017; -. DR HOGENOM; CLU_012526_5_5_1; -. DR InParanoid; Q8NGV6; -. DR OrthoDB; 5401587at2759; -. DR PhylomeDB; Q8NGV6; -. DR TreeFam; TF352737; -. DR PathwayCommons; Q8NGV6; -. DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors. DR SignaLink; Q8NGV6; -. DR BioGRID-ORCS; 79295; 8 hits in 639 CRISPR screens. DR GeneWiki; OR5H6; -. DR GenomeRNAi; 79295; -. DR Pharos; Q8NGV6; Tdark. DR PRO; PR:Q8NGV6; -. DR Proteomes; UP000005640; Chromosome 3. DR RNAct; Q8NGV6; Protein. DR Bgee; ENSG00000230301; Expressed in placenta. DR ExpressionAtlas; Q8NGV6; baseline and differential. DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW. DR GO; GO:0005549; F:odorant binding; IBA:GO_Central. DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central. DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR017452; GPCR_Rhodpsn_7TM. DR InterPro; IPR000725; Olfact_rcpt. DR PANTHER; PTHR26452; OLFACTORY RECEPTOR; 1. DR PANTHER; PTHR26452:SF754; OLFACTORY RECEPTOR 5H6; 1. DR Pfam; PF13853; 7tm_4; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00245; OLFACTORYR. DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. PE 2: Evidence at transcript level; KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein; KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction; KW Transducer; Transmembrane; Transmembrane helix. FT CHAIN 1..325 FT /note="Olfactory receptor 5H6" FT /id="PRO_0000150597" FT TOPO_DOM 1..41 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 42..62 FT /note="Helical; Name=1" FT /evidence="ECO:0000255" FT TOPO_DOM 63..70 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 71..91 FT /note="Helical; Name=2" FT /evidence="ECO:0000255" FT TOPO_DOM 92..115 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 116..136 FT /note="Helical; Name=3" FT /evidence="ECO:0000255" FT TOPO_DOM 137..155 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 156..176 FT /note="Helical; Name=4" FT /evidence="ECO:0000255" FT TOPO_DOM 177..212 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 213..233 FT /note="Helical; Name=5" FT /evidence="ECO:0000255" FT TOPO_DOM 234..253 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 254..274 FT /note="Helical; Name=6" FT /evidence="ECO:0000255" FT TOPO_DOM 275..287 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 288..308 FT /note="Helical; Name=7" FT /evidence="ECO:0000255" FT TOPO_DOM 309..325 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT CARBOHYD 21 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT DISULFID 113..205 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521" FT VARIANT 46 FT /note="A -> E (in dbSNP:rs4241472)" FT /id="VAR_054343" FT VARIANT 88 FT /note="S -> L (in dbSNP:rs2173236)" FT /id="VAR_060008" FT VARIANT 88 FT /note="S -> W (in dbSNP:rs2173236)" FT /id="VAR_060009" FT VARIANT 145 FT /note="A -> P (in dbSNP:rs9289564)" FT /id="VAR_054344" FT VARIANT 179 FT /note="S -> L (in dbSNP:rs16846784)" FT /id="VAR_054345" FT VARIANT 195 FT /note="C -> R (in dbSNP:rs9853887)" FT /id="VAR_054346" FT VARIANT 272 FT /note="T -> A (in dbSNP:rs9853906)" FT /id="VAR_054347" FT VARIANT 285 FT /note="D -> N (in dbSNP:rs9871143)" FT /id="VAR_054348" SQ SEQUENCE 325 AA; 36713 MW; E54F8A835C903407 CRC64; MFLYLCFIFQ RTCSEEMEEE NATLLTEFVL TGFLHQPDCK IPLFLAFLVI YLITIMGNLG LIVLIWKDPH LHIPMYLFLG SLAFVDASLS STVTPKMLIN FLAKSKMISL SECMVQFFSL VTTVTTECFL LATMAYDRYV AICKALLYPV IMTNELCIQL LVLSFIGGLL HALIHEAFSF RLTFCNSNII QHFYCDIIPL LKISCTDSSI NFLMVFIFAG SVQVFTIGTI LISYTIILFT ILEKKSIKGI RKAVSTCGAH LLSVSLYYGP LTFKYLGSAS PQADDQDMME SLFYTVIVPL LNPMIYSLRN KQVIASFTKM FKSNV //