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Q8NGV6

- OR5H6_HUMAN

UniProt

Q8NGV6 - OR5H6_HUMAN

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Protein

Olfactory receptor 5H6

Gene

OR5H6

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 5H6
Alternative name(s):
Olfactory receptor OR3-11
Gene namesi
Name:OR5H6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:14767. OR5H6.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4141ExtracellularSequence AnalysisAdd
BLAST
Transmembranei42 – 6221Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini63 – 708CytoplasmicSequence Analysis
Transmembranei71 – 9121Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini92 – 11524ExtracellularSequence AnalysisAdd
BLAST
Transmembranei116 – 13621Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini137 – 15519CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei156 – 17621Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini177 – 21236ExtracellularSequence AnalysisAdd
BLAST
Transmembranei213 – 23321Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini234 – 25320CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei254 – 27421Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini275 – 28713ExtracellularSequence AnalysisAdd
BLAST
Transmembranei288 – 30821Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini309 – 32517CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32537.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 325325Olfactory receptor 5H6PRO_0000150597Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi21 – 211N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi113 ↔ 205PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGV6.
PRIDEiQ8NGV6.

PTM databases

PhosphoSiteiQ8NGV6.

Expressioni

Gene expression databases

CleanExiHS_OR5H6.
GenevestigatoriQ8NGV6.

Interactioni

Protein-protein interaction databases

IntActiQ8NGV6. 1 interaction.
STRINGi9606.ENSP00000373196.

Structurei

3D structure databases

ProteinModelPortaliQ8NGV6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGieuNOG03640.
GeneTreeiENSGT00550000074564.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ8NGV6.
KOiK04257.
OMAiTCSEEME.
OrthoDBiEOG7NKKKV.
PhylomeDBiQ8NGV6.
TreeFamiTF352737.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGV6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MFLYLCFIFQ RTCSEEMEEE NATLLTEFVL TGFLHQPDCK IPLFLAFLVI
60 70 80 90 100
YLITIMGNLG LIVLIWKDPH LHIPMYLFLG SLAFVDASLS STVTPKMLIN
110 120 130 140 150
FLAKSKMISL SECMVQFFSL VTTVTTECFL LATMAYDRYV AICKALLYPV
160 170 180 190 200
IMTNELCIQL LVLSFIGGLL HALIHEAFSF RLTFCNSNII QHFYCDIIPL
210 220 230 240 250
LKISCTDSSI NFLMVFIFAG SVQVFTIGTI LISYTIILFT ILEKKSIKGI
260 270 280 290 300
RKAVSTCGAH LLSVSLYYGP LTFKYLGSAS PQADDQDMME SLFYTVIVPL
310 320
LNPMIYSLRN KQVIASFTKM FKSNV
Length:325
Mass (Da):36,713
Last modified:February 10, 2009 - v2
Checksum:iE54F8A835C903407
GO

Sequence cautioni

The sequence BAC05893.1 differs from that shown. Reason: Erroneous initiation. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti46 – 461A → E.
Corresponds to variant rs4241472 [ dbSNP | Ensembl ].
VAR_054343
Natural varianti88 – 881S → L.
Corresponds to variant rs2173236 [ dbSNP | Ensembl ].
VAR_060008
Natural varianti88 – 881S → W.
Corresponds to variant rs2173236 [ dbSNP | Ensembl ].
VAR_060009
Natural varianti145 – 1451A → P.
Corresponds to variant rs9289564 [ dbSNP | Ensembl ].
VAR_054344
Natural varianti179 – 1791S → L.
Corresponds to variant rs16846784 [ dbSNP | Ensembl ].
VAR_054345
Natural varianti195 – 1951C → R.
Corresponds to variant rs9853887 [ dbSNP | Ensembl ].
VAR_054346
Natural varianti272 – 2721T → A.
Corresponds to variant rs9853906 [ dbSNP | Ensembl ].
VAR_054347
Natural varianti285 – 2851D → N.
Corresponds to variant rs9871143 [ dbSNP | Ensembl ].
VAR_054348

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065667 Genomic DNA. Translation: BAC05893.1. Different initiation.
BC137523 mRNA. Translation: AAI37524.1.
BC137524 mRNA. Translation: AAI37525.1.
BK004374 Genomic DNA. Translation: DAA04772.1.
CCDSiCCDS33800.1.
RefSeqiNP_001005479.1. NM_001005479.1.
UniGeneiHs.554712.

Genome annotation databases

EnsembliENST00000383696; ENSP00000373196; ENSG00000230301.
ENST00000623332; ENSP00000485611; ENSG00000279922.
ENST00000623942; ENSP00000485045; ENSG00000279922.
GeneIDi79295.
KEGGihsa:79295.
UCSCiuc003dsi.1. human.

Polymorphism databases

DMDMi223590117.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065667 Genomic DNA. Translation: BAC05893.1 . Different initiation.
BC137523 mRNA. Translation: AAI37524.1 .
BC137524 mRNA. Translation: AAI37525.1 .
BK004374 Genomic DNA. Translation: DAA04772.1 .
CCDSi CCDS33800.1.
RefSeqi NP_001005479.1. NM_001005479.1.
UniGenei Hs.554712.

3D structure databases

ProteinModelPortali Q8NGV6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q8NGV6. 1 interaction.
STRINGi 9606.ENSP00000373196.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei Q8NGV6.

Polymorphism databases

DMDMi 223590117.

Proteomic databases

PaxDbi Q8NGV6.
PRIDEi Q8NGV6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000383696 ; ENSP00000373196 ; ENSG00000230301 .
ENST00000623332 ; ENSP00000485611 ; ENSG00000279922 .
ENST00000623942 ; ENSP00000485045 ; ENSG00000279922 .
GeneIDi 79295.
KEGGi hsa:79295.
UCSCi uc003dsi.1. human.

Organism-specific databases

CTDi 79295.
GeneCardsi GC03P097983.
H-InvDB HIX0200564.
HGNCi HGNC:14767. OR5H6.
neXtProti NX_Q8NGV6.
PharmGKBi PA32537.
GenAtlasi Search...

Phylogenomic databases

eggNOGi euNOG03640.
GeneTreei ENSGT00550000074564.
HOGENOMi HOG000041364.
HOVERGENi HBG017625.
InParanoidi Q8NGV6.
KOi K04257.
OMAi TCSEEME.
OrthoDBi EOG7NKKKV.
PhylomeDBi Q8NGV6.
TreeFami TF352737.

Enzyme and pathway databases

Reactomei REACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikii OR5H6.
GenomeRNAii 79295.
NextBioi 68252.
PROi Q8NGV6.

Gene expression databases

CleanExi HS_OR5H6.
Genevestigatori Q8NGV6.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. Cited for: IDENTIFICATION.
  4. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiOR5H6_HUMAN
AccessioniPrimary (citable) accession number: Q8NGV6
Secondary accession number(s): Q6IF88
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: February 10, 2009
Last modified: November 26, 2014
This is version 105 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-17 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3