Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q8NGV6

- OR5H6_HUMAN

UniProt

Q8NGV6 - OR5H6_HUMAN

Protein

Olfactory receptor 5H6

Gene

OR5H6

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 103 (01 Oct 2014)
      Sequence version 2 (10 Feb 2009)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Odorant receptor.Curated

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW
    2. olfactory receptor activity Source: InterPro

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Olfaction, Sensory transduction

    Enzyme and pathway databases

    ReactomeiREACT_15488. Olfactory Signaling Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Olfactory receptor 5H6
    Alternative name(s):
    Olfactory receptor OR3-11
    Gene namesi
    Name:OR5H6
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:14767. OR5H6.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA32537.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 325325Olfactory receptor 5H6PRO_0000150597Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi21 – 211N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi113 ↔ 205PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ8NGV6.
    PRIDEiQ8NGV6.

    PTM databases

    PhosphoSiteiQ8NGV6.

    Expressioni

    Gene expression databases

    CleanExiHS_OR5H6.
    GenevestigatoriQ8NGV6.

    Interactioni

    Protein-protein interaction databases

    IntActiQ8NGV6. 1 interaction.
    STRINGi9606.ENSP00000373196.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8NGV6.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 4141ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini63 – 708CytoplasmicSequence Analysis
    Topological domaini92 – 11524ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini137 – 15519CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini177 – 21236ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini234 – 25320CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini275 – 28713ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini309 – 32517CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei42 – 6221Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei71 – 9121Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei116 – 13621Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei156 – 17621Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei213 – 23321Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei254 – 27421Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei288 – 30821Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGieuNOG03640.
    HOGENOMiHOG000041364.
    HOVERGENiHBG017625.
    InParanoidiQ8NGV6.
    KOiK04257.
    OMAiTCSEEME.
    OrthoDBiEOG7NKKKV.
    PhylomeDBiQ8NGV6.
    TreeFamiTF352737.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8NGV6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFLYLCFIFQ RTCSEEMEEE NATLLTEFVL TGFLHQPDCK IPLFLAFLVI    50
    YLITIMGNLG LIVLIWKDPH LHIPMYLFLG SLAFVDASLS STVTPKMLIN 100
    FLAKSKMISL SECMVQFFSL VTTVTTECFL LATMAYDRYV AICKALLYPV 150
    IMTNELCIQL LVLSFIGGLL HALIHEAFSF RLTFCNSNII QHFYCDIIPL 200
    LKISCTDSSI NFLMVFIFAG SVQVFTIGTI LISYTIILFT ILEKKSIKGI 250
    RKAVSTCGAH LLSVSLYYGP LTFKYLGSAS PQADDQDMME SLFYTVIVPL 300
    LNPMIYSLRN KQVIASFTKM FKSNV 325
    Length:325
    Mass (Da):36,713
    Last modified:February 10, 2009 - v2
    Checksum:iE54F8A835C903407
    GO

    Sequence cautioni

    The sequence BAC05893.1 differs from that shown. Reason: Erroneous initiation.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti46 – 461A → E.
    Corresponds to variant rs4241472 [ dbSNP | Ensembl ].
    VAR_054343
    Natural varianti88 – 881S → L.
    Corresponds to variant rs2173236 [ dbSNP | Ensembl ].
    VAR_060008
    Natural varianti88 – 881S → W.
    Corresponds to variant rs2173236 [ dbSNP | Ensembl ].
    VAR_060009
    Natural varianti145 – 1451A → P.
    Corresponds to variant rs9289564 [ dbSNP | Ensembl ].
    VAR_054344
    Natural varianti179 – 1791S → L.
    Corresponds to variant rs16846784 [ dbSNP | Ensembl ].
    VAR_054345
    Natural varianti195 – 1951C → R.
    Corresponds to variant rs9853887 [ dbSNP | Ensembl ].
    VAR_054346
    Natural varianti272 – 2721T → A.
    Corresponds to variant rs9853906 [ dbSNP | Ensembl ].
    VAR_054347
    Natural varianti285 – 2851D → N.
    Corresponds to variant rs9871143 [ dbSNP | Ensembl ].
    VAR_054348

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065667 Genomic DNA. Translation: BAC05893.1. Different initiation.
    BC137523 mRNA. Translation: AAI37524.1.
    BC137524 mRNA. Translation: AAI37525.1.
    BK004374 Genomic DNA. Translation: DAA04772.1.
    CCDSiCCDS33800.1.
    RefSeqiNP_001005479.1. NM_001005479.1.
    UniGeneiHs.554712.

    Genome annotation databases

    EnsembliENST00000383696; ENSP00000373196; ENSG00000230301.
    GeneIDi79295.
    KEGGihsa:79295.
    UCSCiuc003dsi.1. human.

    Polymorphism databases

    DMDMi223590117.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Human Olfactory Receptor Data Exploratorium (HORDE)

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065667 Genomic DNA. Translation: BAC05893.1 . Different initiation.
    BC137523 mRNA. Translation: AAI37524.1 .
    BC137524 mRNA. Translation: AAI37525.1 .
    BK004374 Genomic DNA. Translation: DAA04772.1 .
    CCDSi CCDS33800.1.
    RefSeqi NP_001005479.1. NM_001005479.1.
    UniGenei Hs.554712.

    3D structure databases

    ProteinModelPortali Q8NGV6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q8NGV6. 1 interaction.
    STRINGi 9606.ENSP00000373196.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q8NGV6.

    Polymorphism databases

    DMDMi 223590117.

    Proteomic databases

    PaxDbi Q8NGV6.
    PRIDEi Q8NGV6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000383696 ; ENSP00000373196 ; ENSG00000230301 .
    GeneIDi 79295.
    KEGGi hsa:79295.
    UCSCi uc003dsi.1. human.

    Organism-specific databases

    CTDi 79295.
    GeneCardsi GC03P097983.
    H-InvDB HIX0200564.
    HGNCi HGNC:14767. OR5H6.
    neXtProti NX_Q8NGV6.
    PharmGKBi PA32537.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi euNOG03640.
    HOGENOMi HOG000041364.
    HOVERGENi HBG017625.
    InParanoidi Q8NGV6.
    KOi K04257.
    OMAi TCSEEME.
    OrthoDBi EOG7NKKKV.
    PhylomeDBi Q8NGV6.
    TreeFami TF352737.

    Enzyme and pathway databases

    Reactomei REACT_15488. Olfactory Signaling Pathway.

    Miscellaneous databases

    GeneWikii OR5H6.
    GenomeRNAii 79295.
    NextBioi 68252.
    PROi Q8NGV6.

    Gene expression databases

    CleanExi HS_OR5H6.
    Genevestigatori Q8NGV6.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
      Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
      Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. Cited for: IDENTIFICATION.
    4. Erratum
      Malnic B., Godfrey P.A., Buck L.B.
      Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

    Entry informationi

    Entry nameiOR5H6_HUMAN
    AccessioniPrimary (citable) accession number: Q8NGV6
    Secondary accession number(s): Q6IF88
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 10, 2003
    Last sequence update: February 10, 2009
    Last modified: October 1, 2014
    This is version 103 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    It is uncertain whether Met-1 or Met-17 is the initiator.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3