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Q8NGV6 (OR5H6_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 101. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Olfactory receptor 5H6
Alternative name(s):
Olfactory receptor OR3-11
Gene names
Name:OR5H6
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length325 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Odorant receptor Potential.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Caution

It is uncertain whether Met-1 or Met-17 is the initiator.

Sequence caution

The sequence BAC05893.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 325325Olfactory receptor 5H6
PRO_0000150597

Regions

Topological domain1 – 4141Extracellular Potential
Transmembrane42 – 6221Helical; Name=1; Potential
Topological domain63 – 708Cytoplasmic Potential
Transmembrane71 – 9121Helical; Name=2; Potential
Topological domain92 – 11524Extracellular Potential
Transmembrane116 – 13621Helical; Name=3; Potential
Topological domain137 – 15519Cytoplasmic Potential
Transmembrane156 – 17621Helical; Name=4; Potential
Topological domain177 – 21236Extracellular Potential
Transmembrane213 – 23321Helical; Name=5; Potential
Topological domain234 – 25320Cytoplasmic Potential
Transmembrane254 – 27421Helical; Name=6; Potential
Topological domain275 – 28713Extracellular Potential
Transmembrane288 – 30821Helical; Name=7; Potential
Topological domain309 – 32517Cytoplasmic Potential

Amino acid modifications

Glycosylation211N-linked (GlcNAc...) Potential
Disulfide bond113 ↔ 205 By similarity

Natural variations

Natural variant461A → E.
Corresponds to variant rs4241472 [ dbSNP | Ensembl ].
VAR_054343
Natural variant881S → L.
Corresponds to variant rs2173236 [ dbSNP | Ensembl ].
VAR_060008
Natural variant881S → W.
Corresponds to variant rs2173236 [ dbSNP | Ensembl ].
VAR_060009
Natural variant1451A → P.
Corresponds to variant rs9289564 [ dbSNP | Ensembl ].
VAR_054344
Natural variant1791S → L.
Corresponds to variant rs16846784 [ dbSNP | Ensembl ].
VAR_054345
Natural variant1951C → R.
Corresponds to variant rs9853887 [ dbSNP | Ensembl ].
VAR_054346
Natural variant2721T → A.
Corresponds to variant rs9853906 [ dbSNP | Ensembl ].
VAR_054347
Natural variant2851D → N.
Corresponds to variant rs9871143 [ dbSNP | Ensembl ].
VAR_054348

Sequences

Sequence LengthMass (Da)Tools
Q8NGV6 [UniParc].

Last modified February 10, 2009. Version 2.
Checksum: E54F8A835C903407

FASTA32536,713
        10         20         30         40         50         60 
MFLYLCFIFQ RTCSEEMEEE NATLLTEFVL TGFLHQPDCK IPLFLAFLVI YLITIMGNLG 

        70         80         90        100        110        120 
LIVLIWKDPH LHIPMYLFLG SLAFVDASLS STVTPKMLIN FLAKSKMISL SECMVQFFSL 

       130        140        150        160        170        180 
VTTVTTECFL LATMAYDRYV AICKALLYPV IMTNELCIQL LVLSFIGGLL HALIHEAFSF 

       190        200        210        220        230        240 
RLTFCNSNII QHFYCDIIPL LKISCTDSSI NFLMVFIFAG SVQVFTIGTI LISYTIILFT 

       250        260        270        280        290        300 
ILEKKSIKGI RKAVSTCGAH LLSVSLYYGP LTFKYLGSAS PQADDQDMME SLFYTVIVPL 

       310        320 
LNPMIYSLRN KQVIASFTKM FKSNV 

« Hide

References

« Hide 'large scale' references
[1]"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]"The human olfactory receptor gene family."
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
[4]Erratum
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB065667 Genomic DNA. Translation: BAC05893.1. Different initiation.
BC137523 mRNA. Translation: AAI37524.1.
BC137524 mRNA. Translation: AAI37525.1.
BK004374 Genomic DNA. Translation: DAA04772.1.
CCDSCCDS33800.1.
RefSeqNP_001005479.1. NM_001005479.1.
UniGeneHs.554712.

3D structure databases

ProteinModelPortalQ8NGV6.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ8NGV6. 1 interaction.
STRING9606.ENSP00000373196.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteQ8NGV6.

Polymorphism databases

DMDM223590117.

Proteomic databases

PaxDbQ8NGV6.
PRIDEQ8NGV6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000383696; ENSP00000373196; ENSG00000230301.
GeneID79295.
KEGGhsa:79295.
UCSCuc003dsi.1. human.

Organism-specific databases

CTD79295.
GeneCardsGC03P097983.
H-InvDBHIX0200564.
HGNCHGNC:14767. OR5H6.
neXtProtNX_Q8NGV6.
PharmGKBPA32537.
GenAtlasSearch...

Phylogenomic databases

eggNOGeuNOG03640.
HOGENOMHOG000041364.
HOVERGENHBG017625.
InParanoidQ8NGV6.
KOK04257.
OMATCSEEME.
OrthoDBEOG7NKKKV.
PhylomeDBQ8NGV6.
TreeFamTF352737.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

CleanExHS_OR5H6.
GenevestigatorQ8NGV6.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiOR5H6.
GenomeRNAi79295.
NextBio68252.
PROQ8NGV6.

Entry information

Entry nameOR5H6_HUMAN
AccessionPrimary (citable) accession number: Q8NGV6
Secondary accession number(s): Q6IF88
Entry history
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: February 10, 2009
Last modified: July 9, 2014
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 3

Human chromosome 3: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries