Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Olfactory receptor 5H6

Gene

OR5H6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

BioCyciZFISH:ENSG00000181845-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 5H6
Alternative name(s):
Olfactory receptor OR3-11
Gene namesi
Name:OR5H6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:14767. OR5H6.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 41ExtracellularSequence analysisAdd BLAST41
Transmembranei42 – 62Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini63 – 70CytoplasmicSequence analysis8
Transmembranei71 – 91Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini92 – 115ExtracellularSequence analysisAdd BLAST24
Transmembranei116 – 136Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini137 – 155CytoplasmicSequence analysisAdd BLAST19
Transmembranei156 – 176Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini177 – 212ExtracellularSequence analysisAdd BLAST36
Transmembranei213 – 233Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini234 – 253CytoplasmicSequence analysisAdd BLAST20
Transmembranei254 – 274Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini275 – 287ExtracellularSequence analysisAdd BLAST13
Transmembranei288 – 308Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini309 – 325CytoplasmicSequence analysisAdd BLAST17

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi79295.
OpenTargetsiENSG00000230301.
PharmGKBiPA32537.

Polymorphism and mutation databases

BioMutaiOR5H6.
DMDMi223590117.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001505971 – 325Olfactory receptor 5H6Add BLAST325

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi21N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi113 ↔ 205PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGV6.
PeptideAtlasiQ8NGV6.
PRIDEiQ8NGV6.

PTM databases

iPTMnetiQ8NGV6.
PhosphoSitePlusiQ8NGV6.

Expressioni

Gene expression databases

CleanExiHS_OR5H6.

Interactioni

Protein-protein interaction databases

IntActiQ8NGV6. 1 interactor.
STRINGi9606.ENSP00000373196.

Structurei

3D structure databases

ProteinModelPortaliQ8NGV6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J97S. Eukaryota.
ENOG4111537. LUCA.
GeneTreeiENSGT00550000074564.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ8NGV6.
KOiK04257.
OMAiTCSEEME.
OrthoDBiEOG091G0C7C.
PhylomeDBiQ8NGV6.
TreeFamiTF352737.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGV6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFLYLCFIFQ RTCSEEMEEE NATLLTEFVL TGFLHQPDCK IPLFLAFLVI
60 70 80 90 100
YLITIMGNLG LIVLIWKDPH LHIPMYLFLG SLAFVDASLS STVTPKMLIN
110 120 130 140 150
FLAKSKMISL SECMVQFFSL VTTVTTECFL LATMAYDRYV AICKALLYPV
160 170 180 190 200
IMTNELCIQL LVLSFIGGLL HALIHEAFSF RLTFCNSNII QHFYCDIIPL
210 220 230 240 250
LKISCTDSSI NFLMVFIFAG SVQVFTIGTI LISYTIILFT ILEKKSIKGI
260 270 280 290 300
RKAVSTCGAH LLSVSLYYGP LTFKYLGSAS PQADDQDMME SLFYTVIVPL
310 320
LNPMIYSLRN KQVIASFTKM FKSNV
Length:325
Mass (Da):36,713
Last modified:February 10, 2009 - v2
Checksum:iE54F8A835C903407
GO

Sequence cautioni

The sequence BAC05893 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05434346A → E.Corresponds to variant rs4241472dbSNPEnsembl.1
Natural variantiVAR_06000888S → L.Corresponds to variant rs2173236dbSNPEnsembl.1
Natural variantiVAR_06000988S → W.Corresponds to variant rs2173236dbSNPEnsembl.1
Natural variantiVAR_054344145A → P.Corresponds to variant rs9289564dbSNPEnsembl.1
Natural variantiVAR_054345179S → L.Corresponds to variant rs16846784dbSNPEnsembl.1
Natural variantiVAR_054346195C → R.Corresponds to variant rs9853887dbSNPEnsembl.1
Natural variantiVAR_054347272T → A.Corresponds to variant rs9853906dbSNPEnsembl.1
Natural variantiVAR_054348285D → N.Corresponds to variant rs9871143dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065667 Genomic DNA. Translation: BAC05893.1. Different initiation.
BC137523 mRNA. Translation: AAI37524.1.
BC137524 mRNA. Translation: AAI37525.1.
BK004374 Genomic DNA. Translation: DAA04772.1.
CCDSiCCDS33800.1.
RefSeqiNP_001005479.1. NM_001005479.1.
XP_011511420.1. XM_011513118.2.
UniGeneiHs.554712.

Genome annotation databases

EnsembliENST00000383696; ENSP00000373196; ENSG00000230301.
GeneIDi79295.
KEGGihsa:79295.
UCSCiuc003dsi.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065667 Genomic DNA. Translation: BAC05893.1. Different initiation.
BC137523 mRNA. Translation: AAI37524.1.
BC137524 mRNA. Translation: AAI37525.1.
BK004374 Genomic DNA. Translation: DAA04772.1.
CCDSiCCDS33800.1.
RefSeqiNP_001005479.1. NM_001005479.1.
XP_011511420.1. XM_011513118.2.
UniGeneiHs.554712.

3D structure databases

ProteinModelPortaliQ8NGV6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8NGV6. 1 interactor.
STRINGi9606.ENSP00000373196.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ8NGV6.
PhosphoSitePlusiQ8NGV6.

Polymorphism and mutation databases

BioMutaiOR5H6.
DMDMi223590117.

Proteomic databases

PaxDbiQ8NGV6.
PeptideAtlasiQ8NGV6.
PRIDEiQ8NGV6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000383696; ENSP00000373196; ENSG00000230301.
GeneIDi79295.
KEGGihsa:79295.
UCSCiuc003dsi.1. human.

Organism-specific databases

CTDi79295.
DisGeNETi79295.
GeneCardsiOR5H6.
H-InvDBHIX0200564.
HGNCiHGNC:14767. OR5H6.
neXtProtiNX_Q8NGV6.
OpenTargetsiENSG00000230301.
PharmGKBiPA32537.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J97S. Eukaryota.
ENOG4111537. LUCA.
GeneTreeiENSGT00550000074564.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ8NGV6.
KOiK04257.
OMAiTCSEEME.
OrthoDBiEOG091G0C7C.
PhylomeDBiQ8NGV6.
TreeFamiTF352737.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000181845-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR5H6.
GenomeRNAii79295.
PROiQ8NGV6.

Gene expression databases

CleanExiHS_OR5H6.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOR5H6_HUMAN
AccessioniPrimary (citable) accession number: Q8NGV6
Secondary accession number(s): Q6IF88
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: February 10, 2009
Last modified: November 2, 2016
This is version 120 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-17 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.