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Q8NGV5

- O13D1_HUMAN

UniProt

Q8NGV5 - O13D1_HUMAN

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Protein

Olfactory receptor 13D1

Gene

OR13D1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 13D1
Alternative name(s):
Olfactory receptor OR9-15
Gene namesi
Name:OR13D1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 9

Organism-specific databases

HGNCiHGNC:14695. OR13D1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 5757ExtracellularSequence AnalysisAdd
BLAST
Transmembranei58 – 7821Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini79 – 868CytoplasmicSequence Analysis
Transmembranei87 – 10721Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini108 – 13124ExtracellularSequence AnalysisAdd
BLAST
Transmembranei132 – 15221Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini153 – 17119CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei172 – 19221Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini193 – 22937ExtracellularSequence AnalysisAdd
BLAST
Transmembranei230 – 24920Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini250 – 26920CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei270 – 29021Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini291 – 30313ExtracellularSequence AnalysisAdd
BLAST
Transmembranei304 – 32421Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini325 – 34622CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32040.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 346346Olfactory receptor 13D1PRO_0000150737Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi37 – 371N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi129 ↔ 221PROSITE-ProRule annotation
Glycosylationi300 – 3001N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ8NGV5.

Expressioni

Gene expression databases

CleanExiHS_OR13D1.
GenevestigatoriQ8NGV5.

Organism-specific databases

HPAiHPA055921.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000317357.

Structurei

3D structure databases

ProteinModelPortaliQ8NGV5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG72440.
GeneTreeiENSGT00760000119058.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiQ8NGV5.
KOiK04257.
OMAiLIIFMSE.
OrthoDBiEOG71K63J.
PhylomeDBiQ8NGV5.
TreeFamiTF352686.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGV5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MYRFTDFDVS NISIYLNHVL FYTTQQAGDL EHMETRNYSA MTEFFLVGLS
60 70 80 90 100
QYPELQLFLF LLCLIMYMII LLGNSLLIII TILDSRLHTP MYFFLGNLSF
110 120 130 140 150
LDICYTSSSI PPMLIIFMSE RKSISFIGCA LQMVVSLGLG STECVLLAVM
160 170 180 190 200
AYDHYVAICN PLRYSIIMNG VLYVQMAAWS WIIGCLTSLL QTVLTMMLPF
210 220 230 240 250
CGNNVIDHIT CEILALLKLV CSDITINVLI MTVTNIVSLV ILLLLIFISY
260 270 280 290 300
VFILSSILRI NCAEGRKKAF STCSAHSIVV ILFYGSALFM YMKPKSKNTN
310 320 330 340
TSDEIIGLSY GVVSPMLNPI IYSLRNKEVK EAVKKVLSRH LHLLKM
Length:346
Mass (Da):39,125
Last modified:May 5, 2009 - v3
Checksum:iD7E7908A875922D8
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti21 – 211F → L.
Corresponds to variant rs10991359 [ dbSNP | Ensembl ].
VAR_055070
Natural varianti64 – 641L → V.1 Publication
Corresponds to variant rs13294411 [ dbSNP | Ensembl ].
VAR_055071
Natural varianti113 – 1131M → V.
Corresponds to variant rs56241491 [ dbSNP | Ensembl ].
VAR_062066
Natural varianti191 – 1911Q → H.1 Publication
Corresponds to variant rs10820709 [ dbSNP | Ensembl ].
VAR_055072
Natural varianti277 – 2771S → L.1 Publication
Corresponds to variant rs10761073 [ dbSNP | Ensembl ].
VAR_055073

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065671 Genomic DNA. Translation: BAC05896.1.
AL359846 Genomic DNA. Translation: CAH73577.1.
BC140916 mRNA. Translation: AAI40917.1.
BK004251 Genomic DNA. Translation: DAA04649.1.
CCDSiCCDS35094.1.
RefSeqiNP_001004484.1. NM_001004484.1.
UniGeneiHs.553683.

Genome annotation databases

EnsembliENST00000318763; ENSP00000317357; ENSG00000179055.
GeneIDi286365.
KEGGihsa:286365.
UCSCiuc011lvs.2. human.

Polymorphism databases

DMDMi229462944.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065671 Genomic DNA. Translation: BAC05896.1 .
AL359846 Genomic DNA. Translation: CAH73577.1 .
BC140916 mRNA. Translation: AAI40917.1 .
BK004251 Genomic DNA. Translation: DAA04649.1 .
CCDSi CCDS35094.1.
RefSeqi NP_001004484.1. NM_001004484.1.
UniGenei Hs.553683.

3D structure databases

ProteinModelPortali Q8NGV5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000317357.

Protein family/group databases

GPCRDBi Search...

Polymorphism databases

DMDMi 229462944.

Proteomic databases

PRIDEi Q8NGV5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000318763 ; ENSP00000317357 ; ENSG00000179055 .
GeneIDi 286365.
KEGGi hsa:286365.
UCSCi uc011lvs.2. human.

Organism-specific databases

CTDi 286365.
GeneCardsi GC09P107456.
HGNCi HGNC:14695. OR13D1.
HPAi HPA055921.
neXtProti NX_Q8NGV5.
PharmGKBi PA32040.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG72440.
GeneTreei ENSGT00760000119058.
HOGENOMi HOG000041362.
HOVERGENi HBG017625.
InParanoidi Q8NGV5.
KOi K04257.
OMAi LIIFMSE.
OrthoDBi EOG71K63J.
PhylomeDBi Q8NGV5.
TreeFami TF352686.

Enzyme and pathway databases

Reactomei REACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikii OR13D1.
GenomeRNAii 286365.
NextBioi 96176.
PROi Q8NGV5.

Gene expression databases

CleanExi HS_OR13D1.
Genevestigatori Q8NGV5.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS VAL-64; HIS-191 AND LEU-277.
  4. Cited for: IDENTIFICATION.
  5. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiO13D1_HUMAN
AccessioniPrimary (citable) accession number: Q8NGV5
Secondary accession number(s): B9EIS1, Q6IFL1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: May 5, 2009
Last modified: October 29, 2014
This is version 101 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-33 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3