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Q8NGV5

- O13D1_HUMAN

UniProt

Q8NGV5 - O13D1_HUMAN

Protein

Olfactory receptor 13D1

Gene

OR13D1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 3 (05 May 2009)
      Previous versions | rss
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    Functioni

    Odorant receptor.Curated

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW
    2. olfactory receptor activity Source: InterPro

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Olfaction, Sensory transduction

    Enzyme and pathway databases

    ReactomeiREACT_15488. Olfactory Signaling Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Olfactory receptor 13D1
    Alternative name(s):
    Olfactory receptor OR9-15
    Gene namesi
    Name:OR13D1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 9

    Organism-specific databases

    HGNCiHGNC:14695. OR13D1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA32040.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 346346Olfactory receptor 13D1PRO_0000150737Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi37 – 371N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi129 ↔ 221PROSITE-ProRule annotation
    Glycosylationi300 – 3001N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiQ8NGV5.

    Expressioni

    Gene expression databases

    CleanExiHS_OR13D1.
    GenevestigatoriQ8NGV5.

    Organism-specific databases

    HPAiHPA055921.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000317357.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8NGV5.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 5757ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini79 – 868CytoplasmicSequence Analysis
    Topological domaini108 – 13124ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini153 – 17119CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini193 – 22937ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini250 – 26920CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini291 – 30313ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini325 – 34622CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei58 – 7821Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei87 – 10721Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei132 – 15221Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei172 – 19221Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei230 – 24920Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei270 – 29021Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei304 – 32421Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG72440.
    HOGENOMiHOG000041362.
    HOVERGENiHBG017625.
    InParanoidiQ8NGV5.
    KOiK04257.
    OMAiLIIFMSE.
    OrthoDBiEOG71K63J.
    PhylomeDBiQ8NGV5.
    TreeFamiTF352686.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8NGV5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MYRFTDFDVS NISIYLNHVL FYTTQQAGDL EHMETRNYSA MTEFFLVGLS    50
    QYPELQLFLF LLCLIMYMII LLGNSLLIII TILDSRLHTP MYFFLGNLSF 100
    LDICYTSSSI PPMLIIFMSE RKSISFIGCA LQMVVSLGLG STECVLLAVM 150
    AYDHYVAICN PLRYSIIMNG VLYVQMAAWS WIIGCLTSLL QTVLTMMLPF 200
    CGNNVIDHIT CEILALLKLV CSDITINVLI MTVTNIVSLV ILLLLIFISY 250
    VFILSSILRI NCAEGRKKAF STCSAHSIVV ILFYGSALFM YMKPKSKNTN 300
    TSDEIIGLSY GVVSPMLNPI IYSLRNKEVK EAVKKVLSRH LHLLKM 346
    Length:346
    Mass (Da):39,125
    Last modified:May 5, 2009 - v3
    Checksum:iD7E7908A875922D8
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti21 – 211F → L.
    Corresponds to variant rs10991359 [ dbSNP | Ensembl ].
    VAR_055070
    Natural varianti64 – 641L → V.1 Publication
    Corresponds to variant rs13294411 [ dbSNP | Ensembl ].
    VAR_055071
    Natural varianti113 – 1131M → V.
    Corresponds to variant rs56241491 [ dbSNP | Ensembl ].
    VAR_062066
    Natural varianti191 – 1911Q → H.1 Publication
    Corresponds to variant rs10820709 [ dbSNP | Ensembl ].
    VAR_055072
    Natural varianti277 – 2771S → L.1 Publication
    Corresponds to variant rs10761073 [ dbSNP | Ensembl ].
    VAR_055073

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065671 Genomic DNA. Translation: BAC05896.1.
    AL359846 Genomic DNA. Translation: CAH73577.1.
    BC140916 mRNA. Translation: AAI40917.1.
    BK004251 Genomic DNA. Translation: DAA04649.1.
    CCDSiCCDS35094.1.
    RefSeqiNP_001004484.1. NM_001004484.1.
    UniGeneiHs.553683.

    Genome annotation databases

    EnsembliENST00000318763; ENSP00000317357; ENSG00000179055.
    GeneIDi286365.
    KEGGihsa:286365.
    UCSCiuc011lvs.2. human.

    Polymorphism databases

    DMDMi229462944.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Human Olfactory Receptor Data Exploratorium (HORDE)

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065671 Genomic DNA. Translation: BAC05896.1 .
    AL359846 Genomic DNA. Translation: CAH73577.1 .
    BC140916 mRNA. Translation: AAI40917.1 .
    BK004251 Genomic DNA. Translation: DAA04649.1 .
    CCDSi CCDS35094.1.
    RefSeqi NP_001004484.1. NM_001004484.1.
    UniGenei Hs.553683.

    3D structure databases

    ProteinModelPortali Q8NGV5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000317357.

    Protein family/group databases

    GPCRDBi Search...

    Polymorphism databases

    DMDMi 229462944.

    Proteomic databases

    PRIDEi Q8NGV5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000318763 ; ENSP00000317357 ; ENSG00000179055 .
    GeneIDi 286365.
    KEGGi hsa:286365.
    UCSCi uc011lvs.2. human.

    Organism-specific databases

    CTDi 286365.
    GeneCardsi GC09P107456.
    HGNCi HGNC:14695. OR13D1.
    HPAi HPA055921.
    neXtProti NX_Q8NGV5.
    PharmGKBi PA32040.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG72440.
    HOGENOMi HOG000041362.
    HOVERGENi HBG017625.
    InParanoidi Q8NGV5.
    KOi K04257.
    OMAi LIIFMSE.
    OrthoDBi EOG71K63J.
    PhylomeDBi Q8NGV5.
    TreeFami TF352686.

    Enzyme and pathway databases

    Reactomei REACT_15488. Olfactory Signaling Pathway.

    Miscellaneous databases

    GeneWikii OR13D1.
    GenomeRNAii 286365.
    NextBioi 96176.
    PROi Q8NGV5.

    Gene expression databases

    CleanExi HS_OR13D1.
    Genevestigatori Q8NGV5.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
      Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
      Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "DNA sequence and analysis of human chromosome 9."
      Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
      , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
      Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS VAL-64; HIS-191 AND LEU-277.
    4. Cited for: IDENTIFICATION.
    5. Erratum
      Malnic B., Godfrey P.A., Buck L.B.
      Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

    Entry informationi

    Entry nameiO13D1_HUMAN
    AccessioniPrimary (citable) accession number: Q8NGV5
    Secondary accession number(s): B9EIS1, Q6IFL1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 10, 2003
    Last sequence update: May 5, 2009
    Last modified: October 1, 2014
    This is version 100 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    It is uncertain whether Met-1 or Met-33 is the initiator.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 9
      Human chromosome 9: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3