Q8NGV5 (O13D1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Olfactory receptor 13D1

Alternative name(s):
Olfactory receptor OR9-15

Gene names

Name:

OR13D1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	346 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Odorant receptor Potential.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.
Caution	It is uncertain whether Met-1 or Met-33 is the initiator.

Ontologies

Keywords
Biological process	Olfaction Sensory transduction
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	detection of chemical stimulus involved in sensory perception of smell Inferred from electronic annotation. Source: GOC
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	G-protein coupled receptor activity Inferred from electronic annotation. Source: UniProtKB-KW olfactory receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 346	346	Olfactory receptor 13D1		PRO_0000150737
Regions
	Topological domain	1 – 57	57	Extracellular Potential
	Transmembrane	58 – 78	21	Helical; Name=1; Potential
	Topological domain	79 – 86	8	Cytoplasmic Potential
	Transmembrane	87 – 107	21	Helical; Name=2; Potential
	Topological domain	108 – 131	24	Extracellular Potential
	Transmembrane	132 – 152	21	Helical; Name=3; Potential
	Topological domain	153 – 171	19	Cytoplasmic Potential
	Transmembrane	172 – 192	21	Helical; Name=4; Potential
	Topological domain	193 – 229	37	Extracellular Potential
	Transmembrane	230 – 249	20	Helical; Name=5; Potential
	Topological domain	250 – 269	20	Cytoplasmic Potential
	Transmembrane	270 – 290	21	Helical; Name=6; Potential
	Topological domain	291 – 303	13	Extracellular Potential
	Transmembrane	304 – 324	21	Helical; Name=7; Potential
	Topological domain	325 – 346	22	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	37	1	N-linked (GlcNAc...) Potential
	Glycosylation	300	1	N-linked (GlcNAc...) Potential
	Disulfide bond	129 ↔ 221		By similarity
Natural variations
	Natural variant	21	1	F → L. Corresponds to variant rs10991359 [ dbSNP | Ensembl ].		VAR_055070
	Natural variant	64	1	L → V. Ref.3 Corresponds to variant rs13294411 [ dbSNP | Ensembl ].		VAR_055071
	Natural variant	113	1	M → V. Corresponds to variant rs56241491 [ dbSNP | Ensembl ].		VAR_062066
	Natural variant	191	1	Q → H. Ref.3 Corresponds to variant rs10820709 [ dbSNP | Ensembl ].		VAR_055072
	Natural variant	277	1	S → L. Ref.3 Corresponds to variant rs10761073 [ dbSNP | Ensembl ].		VAR_055073

Sequences

	Sequence		Length	Mass (Da)
	Q8NGV5 [UniParc]. Last modified May 5, 2009. Version 3. Checksum: D7E7908A875922D8	FASTA	346	39,125
	10 20 30 40 50 60 MYRFTDFDVS NISIYLNHVL FYTTQQAGDL EHMETRNYSA MTEFFLVGLS QYPELQLFLF 70 80 90 100 110 120 LLCLIMYMII LLGNSLLIII TILDSRLHTP MYFFLGNLSF LDICYTSSSI PPMLIIFMSE 130 140 150 160 170 180 RKSISFIGCA LQMVVSLGLG STECVLLAVM AYDHYVAICN PLRYSIIMNG VLYVQMAAWS 190 200 210 220 230 240 WIIGCLTSLL QTVLTMMLPF CGNNVIDHIT CEILALLKLV CSDITINVLI MTVTNIVSLV 250 260 270 280 290 300 ILLLLIFISY VFILSSILRI NCAEGRKKAF STCSAHSIVV ILFYGSALFM YMKPKSKNTN 310 320 330 340 TSDEIIGLSY GVVSPMLNPI IYSLRNKEVK EAVKKVLSRH LHLLKM

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes." Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y. Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"DNA sequence and analysis of human chromosome 9." Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I. Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS VAL-64; HIS-191 AND LEU-277.
[4]	"The human olfactory receptor gene family." Malnic B., Godfrey P.A., Buck L.B. Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION.
[5]	Erratum Malnic B., Godfrey P.A., Buck L.B. Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Web resources

Human Olfactory Receptor Data Exploratorium (HORDE)

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB065671 Genomic DNA. Translation: BAC05896.1. AL359846 Genomic DNA. Translation: CAH73577.1. BC140916 mRNA. Translation: AAI40917.1. BK004251 Genomic DNA. Translation: DAA04649.1.
IPI	IPI00374256.
RefSeq	NP_001004484.1. NM_001004484.1.
UniGene	Hs.553683.
3D structure databases
ProteinModelPortal	Q8NGV5.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000317357.
Protein family/group databases
GPCRDB	Search...
Polymorphism databases
DMDM	229462944.
Proteomic databases
PRIDE	Q8NGV5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000318763; ENSP00000317357; ENSG00000179055.
GeneID	286365.
KEGG	hsa:286365.
UCSC	uc011lvs.2. human.
Organism-specific databases
CTD	286365.
GeneCards	GC09P107456.
HGNC	HGNC:14695. OR13D1.
HPA	HPA055921.
neXtProt	NX_Q8NGV5.
PharmGKB	PA32040.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG72440.
HOGENOM	HOG000041362.
HOVERGEN	HBG017625.
InParanoid	Q8NGV5.
KO	K04257.
OMA	LIIFMSE.
OrthoDB	EOG4QRH4K.
Gene expression databases
CleanEx	HS_OR13D1.
Genevestigator	Q8NGV5.
Family and domain databases
InterPro	IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. IPR000725. Olfact_rcpt. [Graphical view]
PANTHER	PTHR24236. PTHR24236. 1 hit.
PRINTS	PR00237. GPCRRHODOPSN. PR00245. OLFACTORYR.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. False negative. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	286365.
NextBio	96176.

Entry information

Entry name

O13D1_HUMAN

Accession

Primary (citable) accession number: Q8NGV5
Secondary accession number(s): B9EIS1, Q6IFL1

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 10, 2003
Last sequence update:	May 5, 2009
Last modified:	May 1, 2013
This is version 88 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.