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Q8NGV5 (O13D1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 98. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Olfactory receptor 13D1
Alternative name(s):
Olfactory receptor OR9-15
Gene names
Name:OR13D1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length346 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Odorant receptor Potential.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Caution

It is uncertain whether Met-1 or Met-33 is the initiator.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 346346Olfactory receptor 13D1
PRO_0000150737

Regions

Topological domain1 – 5757Extracellular Potential
Transmembrane58 – 7821Helical; Name=1; Potential
Topological domain79 – 868Cytoplasmic Potential
Transmembrane87 – 10721Helical; Name=2; Potential
Topological domain108 – 13124Extracellular Potential
Transmembrane132 – 15221Helical; Name=3; Potential
Topological domain153 – 17119Cytoplasmic Potential
Transmembrane172 – 19221Helical; Name=4; Potential
Topological domain193 – 22937Extracellular Potential
Transmembrane230 – 24920Helical; Name=5; Potential
Topological domain250 – 26920Cytoplasmic Potential
Transmembrane270 – 29021Helical; Name=6; Potential
Topological domain291 – 30313Extracellular Potential
Transmembrane304 – 32421Helical; Name=7; Potential
Topological domain325 – 34622Cytoplasmic Potential

Amino acid modifications

Glycosylation371N-linked (GlcNAc...) Potential
Glycosylation3001N-linked (GlcNAc...) Potential
Disulfide bond129 ↔ 221 By similarity

Natural variations

Natural variant211F → L.
Corresponds to variant rs10991359 [ dbSNP | Ensembl ].
VAR_055070
Natural variant641L → V. Ref.3
Corresponds to variant rs13294411 [ dbSNP | Ensembl ].
VAR_055071
Natural variant1131M → V.
Corresponds to variant rs56241491 [ dbSNP | Ensembl ].
VAR_062066
Natural variant1911Q → H. Ref.3
Corresponds to variant rs10820709 [ dbSNP | Ensembl ].
VAR_055072
Natural variant2771S → L. Ref.3
Corresponds to variant rs10761073 [ dbSNP | Ensembl ].
VAR_055073

Sequences

Sequence LengthMass (Da)Tools
Q8NGV5 [UniParc].

Last modified May 5, 2009. Version 3.
Checksum: D7E7908A875922D8

FASTA34639,125
        10         20         30         40         50         60 
MYRFTDFDVS NISIYLNHVL FYTTQQAGDL EHMETRNYSA MTEFFLVGLS QYPELQLFLF 

        70         80         90        100        110        120 
LLCLIMYMII LLGNSLLIII TILDSRLHTP MYFFLGNLSF LDICYTSSSI PPMLIIFMSE 

       130        140        150        160        170        180 
RKSISFIGCA LQMVVSLGLG STECVLLAVM AYDHYVAICN PLRYSIIMNG VLYVQMAAWS 

       190        200        210        220        230        240 
WIIGCLTSLL QTVLTMMLPF CGNNVIDHIT CEILALLKLV CSDITINVLI MTVTNIVSLV 

       250        260        270        280        290        300 
ILLLLIFISY VFILSSILRI NCAEGRKKAF STCSAHSIVV ILFYGSALFM YMKPKSKNTN 

       310        320        330        340 
TSDEIIGLSY GVVSPMLNPI IYSLRNKEVK EAVKKVLSRH LHLLKM 

« Hide

References

« Hide 'large scale' references
[1]"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"DNA sequence and analysis of human chromosome 9."
Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. expand/collapse author list , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS VAL-64; HIS-191 AND LEU-277.
[4]"The human olfactory receptor gene family."
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
[5]Erratum
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB065671 Genomic DNA. Translation: BAC05896.1.
AL359846 Genomic DNA. Translation: CAH73577.1.
BC140916 mRNA. Translation: AAI40917.1.
BK004251 Genomic DNA. Translation: DAA04649.1.
CCDSCCDS35094.1.
RefSeqNP_001004484.1. NM_001004484.1.
UniGeneHs.553683.

3D structure databases

ProteinModelPortalQ8NGV5.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000317357.

Protein family/group databases

GPCRDBSearch...

Polymorphism databases

DMDM229462944.

Proteomic databases

PRIDEQ8NGV5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000318763; ENSP00000317357; ENSG00000179055.
GeneID286365.
KEGGhsa:286365.
UCSCuc011lvs.2. human.

Organism-specific databases

CTD286365.
GeneCardsGC09P107456.
HGNCHGNC:14695. OR13D1.
HPAHPA055921.
neXtProtNX_Q8NGV5.
PharmGKBPA32040.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG72440.
HOGENOMHOG000041362.
HOVERGENHBG017625.
InParanoidQ8NGV5.
KOK04257.
OMALIIFMSE.
OrthoDBEOG71K63J.
PhylomeDBQ8NGV5.
TreeFamTF352686.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

CleanExHS_OR13D1.
GenevestigatorQ8NGV5.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiOR13D1.
GenomeRNAi286365.
NextBio96176.
PROQ8NGV5.

Entry information

Entry nameO13D1_HUMAN
AccessionPrimary (citable) accession number: Q8NGV5
Secondary accession number(s): B9EIS1, Q6IFL1
Entry history
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: May 5, 2009
Last modified: July 9, 2014
This is version 98 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 9

Human chromosome 9: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries