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Protein

Olfactory receptor 13D1

Gene

OR13D1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 13D1
Alternative name(s):
Olfactory receptor OR9-15
Gene namesi
Name:OR13D1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:14695. OR13D1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 57ExtracellularSequence analysisAdd BLAST57
Transmembranei58 – 78Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini79 – 86CytoplasmicSequence analysis8
Transmembranei87 – 107Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini108 – 131ExtracellularSequence analysisAdd BLAST24
Transmembranei132 – 152Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini153 – 171CytoplasmicSequence analysisAdd BLAST19
Transmembranei172 – 192Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini193 – 229ExtracellularSequence analysisAdd BLAST37
Transmembranei230 – 249Helical; Name=5Sequence analysisAdd BLAST20
Topological domaini250 – 269CytoplasmicSequence analysisAdd BLAST20
Transmembranei270 – 290Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini291 – 303ExtracellularSequence analysisAdd BLAST13
Transmembranei304 – 324Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini325 – 346CytoplasmicSequence analysisAdd BLAST22

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000179055.
PharmGKBiPA32040.

Polymorphism and mutation databases

BioMutaiOR13D1.
DMDMi229462944.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001507371 – 346Olfactory receptor 13D1Add BLAST346

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi37N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi129 ↔ 221PROSITE-ProRule annotation
Glycosylationi300N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGV5.
PeptideAtlasiQ8NGV5.
PRIDEiQ8NGV5.

PTM databases

PhosphoSitePlusiQ8NGV5.

Expressioni

Gene expression databases

CleanExiHS_OR13D1.

Organism-specific databases

HPAiHPA055921.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000317357.

Structurei

3D structure databases

ProteinModelPortaliQ8NGV5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410ITEU. Eukaryota.
ENOG41113G1. LUCA.
GeneTreeiENSGT00760000119058.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiQ8NGV5.
KOiK04257.
OMAiLIIFMSE.
OrthoDBiEOG091G0CU6.
PhylomeDBiQ8NGV5.
TreeFamiTF352686.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
IPR030787. OR13D1.
[Graphical view]
PANTHERiPTHR26453:SF268. PTHR26453:SF268. 1 hit.
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGV5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYRFTDFDVS NISIYLNHVL FYTTQQAGDL EHMETRNYSA MTEFFLVGLS
60 70 80 90 100
QYPELQLFLF LLCLIMYMII LLGNSLLIII TILDSRLHTP MYFFLGNLSF
110 120 130 140 150
LDICYTSSSI PPMLIIFMSE RKSISFIGCA LQMVVSLGLG STECVLLAVM
160 170 180 190 200
AYDHYVAICN PLRYSIIMNG VLYVQMAAWS WIIGCLTSLL QTVLTMMLPF
210 220 230 240 250
CGNNVIDHIT CEILALLKLV CSDITINVLI MTVTNIVSLV ILLLLIFISY
260 270 280 290 300
VFILSSILRI NCAEGRKKAF STCSAHSIVV ILFYGSALFM YMKPKSKNTN
310 320 330 340
TSDEIIGLSY GVVSPMLNPI IYSLRNKEVK EAVKKVLSRH LHLLKM
Length:346
Mass (Da):39,125
Last modified:May 5, 2009 - v3
Checksum:iD7E7908A875922D8
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05507021F → L.Corresponds to variant rs10991359dbSNPEnsembl.1
Natural variantiVAR_05507164L → V.1 PublicationCorresponds to variant rs13294411dbSNPEnsembl.1
Natural variantiVAR_062066113M → V.Corresponds to variant rs56241491dbSNPEnsembl.1
Natural variantiVAR_055072191Q → H.1 PublicationCorresponds to variant rs10820709dbSNPEnsembl.1
Natural variantiVAR_055073277S → L.1 PublicationCorresponds to variant rs10761073dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065671 Genomic DNA. Translation: BAC05896.1.
AL359846 Genomic DNA. Translation: CAH73577.1.
BC140916 mRNA. Translation: AAI40917.1.
BK004251 Genomic DNA. Translation: DAA04649.1.
CCDSiCCDS35094.1.
RefSeqiNP_001004484.1. NM_001004484.1.
UniGeneiHs.553683.

Genome annotation databases

EnsembliENST00000318763; ENSP00000317357; ENSG00000179055.
GeneIDi286365.
KEGGihsa:286365.
UCSCiuc011lvs.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065671 Genomic DNA. Translation: BAC05896.1.
AL359846 Genomic DNA. Translation: CAH73577.1.
BC140916 mRNA. Translation: AAI40917.1.
BK004251 Genomic DNA. Translation: DAA04649.1.
CCDSiCCDS35094.1.
RefSeqiNP_001004484.1. NM_001004484.1.
UniGeneiHs.553683.

3D structure databases

ProteinModelPortaliQ8NGV5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000317357.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSitePlusiQ8NGV5.

Polymorphism and mutation databases

BioMutaiOR13D1.
DMDMi229462944.

Proteomic databases

PaxDbiQ8NGV5.
PeptideAtlasiQ8NGV5.
PRIDEiQ8NGV5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000318763; ENSP00000317357; ENSG00000179055.
GeneIDi286365.
KEGGihsa:286365.
UCSCiuc011lvs.2. human.

Organism-specific databases

CTDi286365.
GeneCardsiOR13D1.
HGNCiHGNC:14695. OR13D1.
HPAiHPA055921.
neXtProtiNX_Q8NGV5.
OpenTargetsiENSG00000179055.
PharmGKBiPA32040.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410ITEU. Eukaryota.
ENOG41113G1. LUCA.
GeneTreeiENSGT00760000119058.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiQ8NGV5.
KOiK04257.
OMAiLIIFMSE.
OrthoDBiEOG091G0CU6.
PhylomeDBiQ8NGV5.
TreeFamiTF352686.

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR13D1.
GenomeRNAii286365.
PROiQ8NGV5.

Gene expression databases

CleanExiHS_OR13D1.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
IPR030787. OR13D1.
[Graphical view]
PANTHERiPTHR26453:SF268. PTHR26453:SF268. 1 hit.
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO13D1_HUMAN
AccessioniPrimary (citable) accession number: Q8NGV5
Secondary accession number(s): B9EIS1, Q6IFL1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: May 5, 2009
Last modified: November 2, 2016
This is version 113 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-33 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.