ID   OR2Y1_HUMAN             Reviewed;         311 AA.
AC   Q8NGV0; B9EIP1; Q6IFB1; Q96R16;
DT   10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   27-MAR-2024, entry version 153.
DE   RecName: Full=Olfactory receptor 2Y1;
DE   AltName: Full=Olfactory receptor OR5-2;
GN   Name=OR2Y1;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA   Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT   "Genome-wide discovery and analysis of human seven transmembrane helix
RT   receptor genes.";
RL   Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT LEU-200.
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT LEU-200.
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-282.
RX   PubMed=12213199; DOI=10.1006/geno.2002.6830;
RA   Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R.,
RA   Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U.,
RA   Lehrach H., Lancet D., Shamir R.;
RT   "DEFOG: a practical scheme for deciphering families of genes.";
RL   Genomics 80:295-302(2002).
RN   [5]
RP   IDENTIFICATION.
RX   PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA   Malnic B., Godfrey P.A., Buck L.B.;
RT   "The human olfactory receptor gene family.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN   [6]
RP   ERRATUM OF PUBMED:14983052.
RA   Malnic B., Godfrey P.A., Buck L.B.;
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC   -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC   -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC       URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR2Y1";
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DR   EMBL; AB065676; BAC05901.1; -; Genomic_DNA.
DR   EMBL; CH471165; EAW53748.1; -; Genomic_DNA.
DR   EMBL; BC140756; AAI40757.1; -; mRNA.
DR   EMBL; AF399629; AAK95114.1; -; Genomic_DNA.
DR   EMBL; BK004351; DAA04749.1; -; Genomic_DNA.
DR   CCDS; CCDS34323.1; -.
DR   RefSeq; NP_001001657.1; NM_001001657.1.
DR   AlphaFoldDB; Q8NGV0; -.
DR   SMR; Q8NGV0; -.
DR   STRING; 9606.ENSP00000312403; -.
DR   GlyCosmos; Q8NGV0; 2 sites, No reported glycans.
DR   GlyGen; Q8NGV0; 2 sites.
DR   iPTMnet; Q8NGV0; -.
DR   PhosphoSitePlus; Q8NGV0; -.
DR   BioMuta; OR2Y1; -.
DR   DMDM; 38372774; -.
DR   MassIVE; Q8NGV0; -.
DR   PaxDb; 9606-ENSP00000312403; -.
DR   PeptideAtlas; Q8NGV0; -.
DR   Antibodypedia; 29640; 102 antibodies from 21 providers.
DR   DNASU; 134083; -.
DR   Ensembl; ENST00000307832.3; ENSP00000312403.2; ENSG00000174339.3.
DR   GeneID; 134083; -.
DR   KEGG; hsa:134083; -.
DR   MANE-Select; ENST00000307832.3; ENSP00000312403.2; NM_001001657.1; NP_001001657.1.
DR   UCSC; uc003mmf.2; human.
DR   AGR; HGNC:14837; -.
DR   CTD; 134083; -.
DR   DisGeNET; 134083; -.
DR   GeneCards; OR2Y1; -.
DR   HGNC; HGNC:14837; OR2Y1.
DR   HPA; ENSG00000174339; Not detected.
DR   neXtProt; NX_Q8NGV0; -.
DR   OpenTargets; ENSG00000174339; -.
DR   PharmGKB; PA32220; -.
DR   VEuPathDB; HostDB:ENSG00000174339; -.
DR   eggNOG; ENOG502SI2C; Eukaryota.
DR   GeneTree; ENSGT01100000263486; -.
DR   HOGENOM; CLU_012526_0_1_1; -.
DR   InParanoid; Q8NGV0; -.
DR   OMA; LWKVLWR; -.
DR   OrthoDB; 4790557at2759; -.
DR   PhylomeDB; Q8NGV0; -.
DR   TreeFam; TF336512; -.
DR   PathwayCommons; Q8NGV0; -.
DR   Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR   BioGRID-ORCS; 134083; 5 hits in 749 CRISPR screens.
DR   GeneWiki; OR2Y1; -.
DR   GenomeRNAi; 134083; -.
DR   Pharos; Q8NGV0; Tdark.
DR   PRO; PR:Q8NGV0; -.
DR   Proteomes; UP000005640; Chromosome 5.
DR   RNAct; Q8NGV0; Protein.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR   GO; GO:0050911; P:detection of chemical stimulus involved in sensory perception of smell; IBA:GO_Central.
DR   CDD; cd15433; 7tmA_OR2Y-like; 1.
DR   Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR000725; Olfact_rcpt.
DR   PANTHER; PTHR26453; OLFACTORY RECEPTOR; 1.
DR   PANTHER; PTHR26453:SF303; OLFACTORY RECEPTOR 2Y1; 1.
DR   Pfam; PF13853; 7tm_4; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR00245; OLFACTORYR.
DR   SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW   Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW   Transducer; Transmembrane; Transmembrane helix.
FT   CHAIN           1..311
FT                   /note="Olfactory receptor 2Y1"
FT                   /id="PRO_0000150513"
FT   TOPO_DOM        1..25
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        26..49
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        50..57
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        58..79
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        80..100
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        101..120
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        121..139
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        140..158
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        159..194
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        195..218
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        219..235
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        236..258
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        259..271
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        272..291
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        292..311
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        5
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        264
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        97..188
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT   VARIANT         128
FT                   /note="R -> C (in dbSNP:rs11960429)"
FT                   /id="VAR_053162"
FT   VARIANT         154
FT                   /note="V -> M (in dbSNP:rs11954074)"
FT                   /id="VAR_053163"
FT   VARIANT         200
FT                   /note="V -> L (in dbSNP:rs10464105)"
FT                   /evidence="ECO:0000269|PubMed:15489334, ECO:0000269|Ref.2"
FT                   /id="VAR_034186"
SQ   SEQUENCE   311 AA;  34731 MW;  2CD89C3B48805949 CRC64;
     MGSFNTSFED GFILVGFSDW PQLEPILFVF IFIFYSLTLF GNTIIIALSW LDLRLHTPMY
     FFLSHLSLLD LCFTTSTVPQ LLINLCGVDR TITRGGCVAQ LFIYLALGST ECVLLVVMAF
     DRYAAVCRPL HYMAIMHPHL CQTLAIASWG AGFVNSLIQT GLAMAMPLCG HRLNHFFCEM
     PVFLKLACAD TEGTEAKMFV ARVIVVAVPA ALILGSYVHI AHAVLRVKST AGRRKAFGTC
     GSHLLVVFLF YGSAIYTYLQ SIHNYSEREG KFVALFYTII TPILNPLIYT LRNKDVKGAL
     WKVLWRGRDS G
//