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Q8NGV0

- OR2Y1_HUMAN

UniProt

Q8NGV0 - OR2Y1_HUMAN

Protein

Olfactory receptor 2Y1

Gene

OR2Y1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    Odorant receptor.Curated

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW
    2. olfactory receptor activity Source: InterPro

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Olfaction, Sensory transduction

    Enzyme and pathway databases

    ReactomeiREACT_15488. Olfactory Signaling Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Olfactory receptor 2Y1
    Alternative name(s):
    Olfactory receptor OR5-2
    Gene namesi
    Name:OR2Y1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 5

    Organism-specific databases

    HGNCiHGNC:14837. OR2Y1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA32220.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 311311Olfactory receptor 2Y1PRO_0000150513Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi5 – 51N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi97 ↔ 188PROSITE-ProRule annotation
    Glycosylationi264 – 2641N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ8NGV0.
    PRIDEiQ8NGV0.

    Expressioni

    Gene expression databases

    CleanExiHS_OR2Y1.
    GenevestigatoriQ8NGV0.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000312403.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8NGV0.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2525ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini50 – 578CytoplasmicSequence Analysis
    Topological domaini80 – 10021ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini121 – 13919CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini159 – 19436ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini219 – 23517CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini259 – 27113ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini292 – 31120CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei26 – 4924Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei58 – 7922Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei101 – 12020Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei140 – 15819Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei195 – 21824Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei236 – 25823Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei272 – 29120Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG39798.
    HOGENOMiHOG000041365.
    HOVERGENiHBG017625.
    InParanoidiQ8NGV0.
    KOiK04257.
    OMAiACADTEG.
    OrthoDBiEOG751NFX.
    PhylomeDBiQ8NGV0.
    TreeFamiTF336512.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8NGV0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGSFNTSFED GFILVGFSDW PQLEPILFVF IFIFYSLTLF GNTIIIALSW    50
    LDLRLHTPMY FFLSHLSLLD LCFTTSTVPQ LLINLCGVDR TITRGGCVAQ 100
    LFIYLALGST ECVLLVVMAF DRYAAVCRPL HYMAIMHPHL CQTLAIASWG 150
    AGFVNSLIQT GLAMAMPLCG HRLNHFFCEM PVFLKLACAD TEGTEAKMFV 200
    ARVIVVAVPA ALILGSYVHI AHAVLRVKST AGRRKAFGTC GSHLLVVFLF 250
    YGSAIYTYLQ SIHNYSEREG KFVALFYTII TPILNPLIYT LRNKDVKGAL 300
    WKVLWRGRDS G 311
    Length:311
    Mass (Da):34,731
    Last modified:October 1, 2002 - v1
    Checksum:i2CD89C3B48805949
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti128 – 1281R → C.
    Corresponds to variant rs11960429 [ dbSNP | Ensembl ].
    VAR_053162
    Natural varianti154 – 1541V → M.
    Corresponds to variant rs11954074 [ dbSNP | Ensembl ].
    VAR_053163
    Natural varianti200 – 2001V → L.2 Publications
    Corresponds to variant rs10464105 [ dbSNP | Ensembl ].
    VAR_034186

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065676 Genomic DNA. Translation: BAC05901.1.
    CH471165 Genomic DNA. Translation: EAW53748.1.
    BC140756 mRNA. Translation: AAI40757.1.
    AF399629 Genomic DNA. Translation: AAK95114.1.
    BK004351 Genomic DNA. Translation: DAA04749.1.
    CCDSiCCDS34323.1.
    RefSeqiNP_001001657.1. NM_001001657.1.
    UniGeneiHs.554719.

    Genome annotation databases

    EnsembliENST00000307832; ENSP00000312403; ENSG00000174339.
    GeneIDi134083.
    KEGGihsa:134083.
    UCSCiuc003mmf.1. human.

    Polymorphism databases

    DMDMi38372774.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Human Olfactory Receptor Data Exploratorium (HORDE)

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065676 Genomic DNA. Translation: BAC05901.1 .
    CH471165 Genomic DNA. Translation: EAW53748.1 .
    BC140756 mRNA. Translation: AAI40757.1 .
    AF399629 Genomic DNA. Translation: AAK95114.1 .
    BK004351 Genomic DNA. Translation: DAA04749.1 .
    CCDSi CCDS34323.1.
    RefSeqi NP_001001657.1. NM_001001657.1.
    UniGenei Hs.554719.

    3D structure databases

    ProteinModelPortali Q8NGV0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000312403.

    Protein family/group databases

    GPCRDBi Search...

    Polymorphism databases

    DMDMi 38372774.

    Proteomic databases

    PaxDbi Q8NGV0.
    PRIDEi Q8NGV0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000307832 ; ENSP00000312403 ; ENSG00000174339 .
    GeneIDi 134083.
    KEGGi hsa:134083.
    UCSCi uc003mmf.1. human.

    Organism-specific databases

    CTDi 134083.
    GeneCardsi GC05M180166.
    HGNCi HGNC:14837. OR2Y1.
    neXtProti NX_Q8NGV0.
    PharmGKBi PA32220.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG39798.
    HOGENOMi HOG000041365.
    HOVERGENi HBG017625.
    InParanoidi Q8NGV0.
    KOi K04257.
    OMAi ACADTEG.
    OrthoDBi EOG751NFX.
    PhylomeDBi Q8NGV0.
    TreeFami TF336512.

    Enzyme and pathway databases

    Reactomei REACT_15488. Olfactory Signaling Pathway.

    Miscellaneous databases

    GeneWikii OR2Y1.
    GenomeRNAii 134083.
    NextBioi 83309.
    PROi Q8NGV0.

    Gene expression databases

    CleanExi HS_OR2Y1.
    Genevestigatori Q8NGV0.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
      Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
      Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT LEU-200.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT LEU-200.
    4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-282.
    5. Cited for: IDENTIFICATION.
    6. Erratum
      Malnic B., Godfrey P.A., Buck L.B.
      Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

    Entry informationi

    Entry nameiOR2Y1_HUMAN
    AccessioniPrimary (citable) accession number: Q8NGV0
    Secondary accession number(s): B9EIP1, Q6IFB1, Q96R16
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 10, 2003
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 100 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 5
      Human chromosome 5: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3