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Protein

Olfactory receptor 2Y1

Gene

OR2Y1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 2Y1
Alternative name(s):
Olfactory receptor OR5-2
Gene namesi
Name:OR2Y1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 5

Organism-specific databases

HGNCiHGNC:14837. OR2Y1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2525ExtracellularSequence AnalysisAdd
BLAST
Transmembranei26 – 4924Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini50 – 578CytoplasmicSequence Analysis
Transmembranei58 – 7922Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini80 – 10021ExtracellularSequence AnalysisAdd
BLAST
Transmembranei101 – 12020Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini121 – 13919CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei140 – 15819Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini159 – 19436ExtracellularSequence AnalysisAdd
BLAST
Transmembranei195 – 21824Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini219 – 23517CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei236 – 25823Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini259 – 27113ExtracellularSequence AnalysisAdd
BLAST
Transmembranei272 – 29120Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini292 – 31120CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32220.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 311311Olfactory receptor 2Y1PRO_0000150513Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi97 ↔ 188PROSITE-ProRule annotation
Glycosylationi264 – 2641N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGV0.
PRIDEiQ8NGV0.

Expressioni

Gene expression databases

CleanExiHS_OR2Y1.
GenevestigatoriQ8NGV0.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000312403.

Structurei

3D structure databases

ProteinModelPortaliQ8NGV0.
SMRiQ8NGV0. Positions 109-140.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG39798.
GeneTreeiENSGT00760000118914.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiQ8NGV0.
KOiK04257.
OMAiACADTEG.
OrthoDBiEOG751NFX.
PhylomeDBiQ8NGV0.
TreeFamiTF336512.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGV0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSFNTSFED GFILVGFSDW PQLEPILFVF IFIFYSLTLF GNTIIIALSW
60 70 80 90 100
LDLRLHTPMY FFLSHLSLLD LCFTTSTVPQ LLINLCGVDR TITRGGCVAQ
110 120 130 140 150
LFIYLALGST ECVLLVVMAF DRYAAVCRPL HYMAIMHPHL CQTLAIASWG
160 170 180 190 200
AGFVNSLIQT GLAMAMPLCG HRLNHFFCEM PVFLKLACAD TEGTEAKMFV
210 220 230 240 250
ARVIVVAVPA ALILGSYVHI AHAVLRVKST AGRRKAFGTC GSHLLVVFLF
260 270 280 290 300
YGSAIYTYLQ SIHNYSEREG KFVALFYTII TPILNPLIYT LRNKDVKGAL
310
WKVLWRGRDS G
Length:311
Mass (Da):34,731
Last modified:October 1, 2002 - v1
Checksum:i2CD89C3B48805949
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti128 – 1281R → C.
Corresponds to variant rs11960429 [ dbSNP | Ensembl ].
VAR_053162
Natural varianti154 – 1541V → M.
Corresponds to variant rs11954074 [ dbSNP | Ensembl ].
VAR_053163
Natural varianti200 – 2001V → L.2 Publications
Corresponds to variant rs10464105 [ dbSNP | Ensembl ].
VAR_034186

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065676 Genomic DNA. Translation: BAC05901.1.
CH471165 Genomic DNA. Translation: EAW53748.1.
BC140756 mRNA. Translation: AAI40757.1.
AF399629 Genomic DNA. Translation: AAK95114.1.
BK004351 Genomic DNA. Translation: DAA04749.1.
CCDSiCCDS34323.1.
RefSeqiNP_001001657.1. NM_001001657.1.
UniGeneiHs.554719.

Genome annotation databases

EnsembliENST00000307832; ENSP00000312403; ENSG00000174339.
GeneIDi134083.
KEGGihsa:134083.
UCSCiuc003mmf.1. human.

Polymorphism databases

DMDMi38372774.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065676 Genomic DNA. Translation: BAC05901.1.
CH471165 Genomic DNA. Translation: EAW53748.1.
BC140756 mRNA. Translation: AAI40757.1.
AF399629 Genomic DNA. Translation: AAK95114.1.
BK004351 Genomic DNA. Translation: DAA04749.1.
CCDSiCCDS34323.1.
RefSeqiNP_001001657.1. NM_001001657.1.
UniGeneiHs.554719.

3D structure databases

ProteinModelPortaliQ8NGV0.
SMRiQ8NGV0. Positions 109-140.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000312403.

Protein family/group databases

GPCRDBiSearch...

Polymorphism databases

DMDMi38372774.

Proteomic databases

PaxDbiQ8NGV0.
PRIDEiQ8NGV0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000307832; ENSP00000312403; ENSG00000174339.
GeneIDi134083.
KEGGihsa:134083.
UCSCiuc003mmf.1. human.

Organism-specific databases

CTDi134083.
GeneCardsiGC05M180166.
HGNCiHGNC:14837. OR2Y1.
neXtProtiNX_Q8NGV0.
PharmGKBiPA32220.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG39798.
GeneTreeiENSGT00760000118914.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiQ8NGV0.
KOiK04257.
OMAiACADTEG.
OrthoDBiEOG751NFX.
PhylomeDBiQ8NGV0.
TreeFamiTF336512.

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR2Y1.
GenomeRNAii134083.
NextBioi83309.
PROiQ8NGV0.

Gene expression databases

CleanExiHS_OR2Y1.
GenevestigatoriQ8NGV0.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT LEU-200.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT LEU-200.
  4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-282.
  5. Cited for: IDENTIFICATION.
  6. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiOR2Y1_HUMAN
AccessioniPrimary (citable) accession number: Q8NGV0
Secondary accession number(s): B9EIP1, Q6IFB1, Q96R16
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: February 4, 2015
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.