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Protein

Olfactory receptor 2Y1

Gene

OR2Y1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

BioCyciZFISH:ENSG00000174339-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 2Y1
Alternative name(s):
Olfactory receptor OR5-2
Gene namesi
Name:OR2Y1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:14837. OR2Y1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 25ExtracellularSequence analysisAdd BLAST25
Transmembranei26 – 49Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini50 – 57CytoplasmicSequence analysis8
Transmembranei58 – 79Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini80 – 100ExtracellularSequence analysisAdd BLAST21
Transmembranei101 – 120Helical; Name=3Sequence analysisAdd BLAST20
Topological domaini121 – 139CytoplasmicSequence analysisAdd BLAST19
Transmembranei140 – 158Helical; Name=4Sequence analysisAdd BLAST19
Topological domaini159 – 194ExtracellularSequence analysisAdd BLAST36
Transmembranei195 – 218Helical; Name=5Sequence analysisAdd BLAST24
Topological domaini219 – 235CytoplasmicSequence analysisAdd BLAST17
Transmembranei236 – 258Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini259 – 271ExtracellularSequence analysisAdd BLAST13
Transmembranei272 – 291Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini292 – 311CytoplasmicSequence analysisAdd BLAST20

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi134083.
OpenTargetsiENSG00000174339.
PharmGKBiPA32220.

Polymorphism and mutation databases

BioMutaiOR2Y1.
DMDMi38372774.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001505131 – 311Olfactory receptor 2Y1Add BLAST311

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi97 ↔ 188PROSITE-ProRule annotation
Glycosylationi264N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGV0.
PRIDEiQ8NGV0.

PTM databases

iPTMnetiQ8NGV0.
PhosphoSitePlusiQ8NGV0.

Expressioni

Gene expression databases

CleanExiHS_OR2Y1.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000312403.

Structurei

3D structure databases

ProteinModelPortaliQ8NGV0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IK52. Eukaryota.
ENOG41118P0. LUCA.
GeneTreeiENSGT00760000118914.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiQ8NGV0.
KOiK04257.
OMAiACADTEG.
OrthoDBiEOG091G0BXJ.
PhylomeDBiQ8NGV0.
TreeFamiTF336512.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGV0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSFNTSFED GFILVGFSDW PQLEPILFVF IFIFYSLTLF GNTIIIALSW
60 70 80 90 100
LDLRLHTPMY FFLSHLSLLD LCFTTSTVPQ LLINLCGVDR TITRGGCVAQ
110 120 130 140 150
LFIYLALGST ECVLLVVMAF DRYAAVCRPL HYMAIMHPHL CQTLAIASWG
160 170 180 190 200
AGFVNSLIQT GLAMAMPLCG HRLNHFFCEM PVFLKLACAD TEGTEAKMFV
210 220 230 240 250
ARVIVVAVPA ALILGSYVHI AHAVLRVKST AGRRKAFGTC GSHLLVVFLF
260 270 280 290 300
YGSAIYTYLQ SIHNYSEREG KFVALFYTII TPILNPLIYT LRNKDVKGAL
310
WKVLWRGRDS G
Length:311
Mass (Da):34,731
Last modified:October 1, 2002 - v1
Checksum:i2CD89C3B48805949
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_053162128R → C.Corresponds to variant rs11960429dbSNPEnsembl.1
Natural variantiVAR_053163154V → M.Corresponds to variant rs11954074dbSNPEnsembl.1
Natural variantiVAR_034186200V → L.2 PublicationsCorresponds to variant rs10464105dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065676 Genomic DNA. Translation: BAC05901.1.
CH471165 Genomic DNA. Translation: EAW53748.1.
BC140756 mRNA. Translation: AAI40757.1.
AF399629 Genomic DNA. Translation: AAK95114.1.
BK004351 Genomic DNA. Translation: DAA04749.1.
CCDSiCCDS34323.1.
RefSeqiNP_001001657.1. NM_001001657.1.
UniGeneiHs.554719.

Genome annotation databases

EnsembliENST00000307832; ENSP00000312403; ENSG00000174339.
GeneIDi134083.
KEGGihsa:134083.
UCSCiuc003mmf.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065676 Genomic DNA. Translation: BAC05901.1.
CH471165 Genomic DNA. Translation: EAW53748.1.
BC140756 mRNA. Translation: AAI40757.1.
AF399629 Genomic DNA. Translation: AAK95114.1.
BK004351 Genomic DNA. Translation: DAA04749.1.
CCDSiCCDS34323.1.
RefSeqiNP_001001657.1. NM_001001657.1.
UniGeneiHs.554719.

3D structure databases

ProteinModelPortaliQ8NGV0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000312403.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ8NGV0.
PhosphoSitePlusiQ8NGV0.

Polymorphism and mutation databases

BioMutaiOR2Y1.
DMDMi38372774.

Proteomic databases

PaxDbiQ8NGV0.
PRIDEiQ8NGV0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000307832; ENSP00000312403; ENSG00000174339.
GeneIDi134083.
KEGGihsa:134083.
UCSCiuc003mmf.2. human.

Organism-specific databases

CTDi134083.
DisGeNETi134083.
GeneCardsiOR2Y1.
HGNCiHGNC:14837. OR2Y1.
neXtProtiNX_Q8NGV0.
OpenTargetsiENSG00000174339.
PharmGKBiPA32220.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IK52. Eukaryota.
ENOG41118P0. LUCA.
GeneTreeiENSGT00760000118914.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiQ8NGV0.
KOiK04257.
OMAiACADTEG.
OrthoDBiEOG091G0BXJ.
PhylomeDBiQ8NGV0.
TreeFamiTF336512.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000174339-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR2Y1.
GenomeRNAii134083.
PROiQ8NGV0.

Gene expression databases

CleanExiHS_OR2Y1.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOR2Y1_HUMAN
AccessioniPrimary (citable) accession number: Q8NGV0
Secondary accession number(s): B9EIP1, Q6IFB1, Q96R16
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: November 2, 2016
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.