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Q8NGV0 (OR2Y1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 96. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Olfactory receptor 2Y1
Alternative name(s):
Olfactory receptor OR5-2
Gene names
Name:OR2Y1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length311 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Odorant receptor Potential.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 311311Olfactory receptor 2Y1
PRO_0000150513

Regions

Topological domain1 – 2525Extracellular Potential
Transmembrane26 – 4924Helical; Name=1; Potential
Topological domain50 – 578Cytoplasmic Potential
Transmembrane58 – 7922Helical; Name=2; Potential
Topological domain80 – 10021Extracellular Potential
Transmembrane101 – 12020Helical; Name=3; Potential
Topological domain121 – 13919Cytoplasmic Potential
Transmembrane140 – 15819Helical; Name=4; Potential
Topological domain159 – 19436Extracellular Potential
Transmembrane195 – 21824Helical; Name=5; Potential
Topological domain219 – 23517Cytoplasmic Potential
Transmembrane236 – 25823Helical; Name=6; Potential
Topological domain259 – 27113Extracellular Potential
Transmembrane272 – 29120Helical; Name=7; Potential
Topological domain292 – 31120Cytoplasmic Potential

Amino acid modifications

Glycosylation51N-linked (GlcNAc...) Potential
Glycosylation2641N-linked (GlcNAc...) Potential
Disulfide bond97 ↔ 188 By similarity

Natural variations

Natural variant1281R → C.
Corresponds to variant rs11960429 [ dbSNP | Ensembl ].
VAR_053162
Natural variant1541V → M.
Corresponds to variant rs11954074 [ dbSNP | Ensembl ].
VAR_053163
Natural variant2001V → L. Ref.2 Ref.3
Corresponds to variant rs10464105 [ dbSNP | Ensembl ].
VAR_034186

Sequences

Sequence LengthMass (Da)Tools
Q8NGV0 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: 2CD89C3B48805949

FASTA31134,731
        10         20         30         40         50         60 
MGSFNTSFED GFILVGFSDW PQLEPILFVF IFIFYSLTLF GNTIIIALSW LDLRLHTPMY 

        70         80         90        100        110        120 
FFLSHLSLLD LCFTTSTVPQ LLINLCGVDR TITRGGCVAQ LFIYLALGST ECVLLVVMAF 

       130        140        150        160        170        180 
DRYAAVCRPL HYMAIMHPHL CQTLAIASWG AGFVNSLIQT GLAMAMPLCG HRLNHFFCEM 

       190        200        210        220        230        240 
PVFLKLACAD TEGTEAKMFV ARVIVVAVPA ALILGSYVHI AHAVLRVKST AGRRKAFGTC 

       250        260        270        280        290        300 
GSHLLVVFLF YGSAIYTYLQ SIHNYSEREG KFVALFYTII TPILNPLIYT LRNKDVKGAL 

       310 
WKVLWRGRDS G 

« Hide

References

« Hide 'large scale' references
[1]"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT LEU-200.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT LEU-200.
[4]"DEFOG: a practical scheme for deciphering families of genes."
Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R., Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U., Lehrach H., Lancet D., Shamir R.
Genomics 80:295-302(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-282.
[5]"The human olfactory receptor gene family."
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
[6]Erratum
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB065676 Genomic DNA. Translation: BAC05901.1.
CH471165 Genomic DNA. Translation: EAW53748.1.
BC140756 mRNA. Translation: AAI40757.1.
AF399629 Genomic DNA. Translation: AAK95114.1.
BK004351 Genomic DNA. Translation: DAA04749.1.
RefSeqNP_001001657.1. NM_001001657.1.
UniGeneHs.554719.

3D structure databases

ProteinModelPortalQ8NGV0.
SMRQ8NGV0. Positions 109-140, 277-306.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000312403.

Protein family/group databases

GPCRDBSearch...

Polymorphism databases

DMDM38372774.

Proteomic databases

PaxDbQ8NGV0.
PRIDEQ8NGV0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000307832; ENSP00000312403; ENSG00000174339.
GeneID134083.
KEGGhsa:134083.
UCSCuc003mmf.1. human.

Organism-specific databases

CTD134083.
GeneCardsGC05M180166.
HGNCHGNC:14837. OR2Y1.
neXtProtNX_Q8NGV0.
PharmGKBPA32220.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG39798.
HOGENOMHOG000041365.
HOVERGENHBG017625.
InParanoidQ8NGV0.
KOK04257.
OMAACADTEG.
OrthoDBEOG751NFX.
PhylomeDBQ8NGV0.
TreeFamTF336512.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

CleanExHS_OR2Y1.
GenevestigatorQ8NGV0.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiOR2Y1.
GenomeRNAi134083.
NextBio83309.
PROQ8NGV0.

Entry information

Entry nameOR2Y1_HUMAN
AccessionPrimary (citable) accession number: Q8NGV0
Secondary accession number(s): B9EIP1, Q6IFB1, Q96R16
Entry history
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: April 16, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 5

Human chromosome 5: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries