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Protein

Probable G-protein coupled receptor 150

Gene

GPR150

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Orphan receptor.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-HSA-418555. G alpha (s) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable G-protein coupled receptor 150
Gene namesi
Name:GPR150
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:23628. GPR150.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 33ExtracellularSequence analysis
Transmembranei4 – 2421Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini25 – 4319CytoplasmicSequence analysisAdd
BLAST
Transmembranei44 – 6421Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini65 – 8117ExtracellularSequence analysisAdd
BLAST
Transmembranei82 – 10221Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini103 – 16260CytoplasmicSequence analysisAdd
BLAST
Transmembranei163 – 18321Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini184 – 23754ExtracellularSequence analysisAdd
BLAST
Transmembranei238 – 25821Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini259 – 29335CytoplasmicSequence analysisAdd
BLAST
Transmembranei294 – 31421Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini315 – 33420ExtracellularSequence analysisAdd
BLAST
Transmembranei335 – 35521Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini356 – 43479CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134984082.

Polymorphism and mutation databases

BioMutaiGPR150.
DMDMi54037146.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 434434Probable G-protein coupled receptor 150PRO_0000069630Add
BLAST

Proteomic databases

PaxDbiQ8NGU9.
PRIDEiQ8NGU9.

PTM databases

iPTMnetiQ8NGU9.
PhosphoSiteiQ8NGU9.

Expressioni

Gene expression databases

BgeeiQ8NGU9.
CleanExiHS_GPR150.
ExpressionAtlasiQ8NGU9. baseline and differential.

Organism-specific databases

HPAiHPA026635.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000369344.

Structurei

3D structure databases

ProteinModelPortaliQ8NGU9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi188 – 19710Poly-Pro
Compositional biasi418 – 42710Poly-Pro

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000119156.
HOGENOMiHOG000112773.
HOVERGENiHBG051786.
InParanoidiQ8NGU9.
KOiK08434.
OMAiWHLQVYA.
OrthoDBiEOG78WKS0.
PhylomeDBiQ8NGU9.
TreeFamiTF106499.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGU9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEDLFSPSIL PPAPNISVPI LLGWGLNLTL GQGAPASGPP SRRVRLVFLG
60 70 80 90 100
VILVVAVAGN TTVLCRLCGG GGPWAGPKRR KMDFLLVQLA LADLYACGGT
110 120 130 140 150
ALSQLAWELL GEPRAATGDL ACRFLQLLQA SGRGASAHLV VLIALERRRA
160 170 180 190 200
VRLPHGRPLP ARALAALGWL LALLLALPPA FVVRGDSPSP LPPPPPPTSL
210 220 230 240 250
QPGAPPAARA WPGERRCHGI FAPLPRWHLQ VYAFYEAVAG FVAPVTVLGV
260 270 280 290 300
ACGHLLSVWW RHRPQAPAAA APWSASPGRA PAPSALPRAK VQSLKMSLLL
310 320 330 340 350
ALLFVGCELP YFAARLAAAW SSGPAGDWEG EGLSAALRVV AMANSALNPF
360 370 380 390 400
VYLFFQAGDC RLRRQLRKRL GSLCCAPQGG AEDEEGPRGH QALYRQRWPH
410 420 430
PHYHHARREP LDEGGLRPPP PRPRPLPCSC ESAF
Length:434
Mass (Da):46,353
Last modified:October 1, 2002 - v1
Checksum:i853429D1CF59253C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065678 Genomic DNA. Translation: BAC05903.1.
CCDSiCCDS4074.1.
RefSeqiNP_954713.1. NM_199243.1.
UniGeneiHs.143315.

Genome annotation databases

EnsembliENST00000380007; ENSP00000369344; ENSG00000178015.
GeneIDi285601.
KEGGihsa:285601.
UCSCiuc003kle.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065678 Genomic DNA. Translation: BAC05903.1.
CCDSiCCDS4074.1.
RefSeqiNP_954713.1. NM_199243.1.
UniGeneiHs.143315.

3D structure databases

ProteinModelPortaliQ8NGU9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000369344.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ8NGU9.
PhosphoSiteiQ8NGU9.

Polymorphism and mutation databases

BioMutaiGPR150.
DMDMi54037146.

Proteomic databases

PaxDbiQ8NGU9.
PRIDEiQ8NGU9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000380007; ENSP00000369344; ENSG00000178015.
GeneIDi285601.
KEGGihsa:285601.
UCSCiuc003kle.2. human.

Organism-specific databases

CTDi285601.
GeneCardsiGPR150.
HGNCiHGNC:23628. GPR150.
HPAiHPA026635.
neXtProtiNX_Q8NGU9.
PharmGKBiPA134984082.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000119156.
HOGENOMiHOG000112773.
HOVERGENiHBG051786.
InParanoidiQ8NGU9.
KOiK08434.
OMAiWHLQVYA.
OrthoDBiEOG78WKS0.
PhylomeDBiQ8NGU9.
TreeFamiTF106499.

Enzyme and pathway databases

ReactomeiR-HSA-418555. G alpha (s) signalling events.

Miscellaneous databases

GeneWikiiGPR150.
GenomeRNAii285601.
PROiQ8NGU9.

Gene expression databases

BgeeiQ8NGU9.
CleanExiHS_GPR150.
ExpressionAtlasiQ8NGU9. baseline and differential.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiGP150_HUMAN
AccessioniPrimary (citable) accession number: Q8NGU9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2004
Last sequence update: October 1, 2002
Last modified: June 8, 2016
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.