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Q8NGU2

- OR9A4_HUMAN

UniProt

Q8NGU2 - OR9A4_HUMAN

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Protein
Olfactory receptor 9A4
Gene
OR9A4
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Odorant receptor Reviewed prediction.

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: InterPro
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Olfaction, Sensory transduction

    Enzyme and pathway databases

    ReactomeiREACT_15488. Olfactory Signaling Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Olfactory receptor 9A4
    Alternative name(s):
    Olfactory receptor OR7-1
    Gene namesi
    Name:OR9A4
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:15095. OR9A4.

    Subcellular locationi

    Topology

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2424Extracellular Reviewed prediction
    Add
    BLAST
    Transmembranei25 – 4521Helical; Name=1; Reviewed prediction
    Add
    BLAST
    Topological domaini46 – 538Cytoplasmic Reviewed prediction
    Transmembranei54 – 7421Helical; Name=2; Reviewed prediction
    Add
    BLAST
    Topological domaini75 – 9925Extracellular Reviewed prediction
    Add
    BLAST
    Transmembranei100 – 12021Helical; Name=3; Reviewed prediction
    Add
    BLAST
    Topological domaini121 – 13919Cytoplasmic Reviewed prediction
    Add
    BLAST
    Transmembranei140 – 16021Helical; Name=4; Reviewed prediction
    Add
    BLAST
    Topological domaini161 – 19737Extracellular Reviewed prediction
    Add
    BLAST
    Transmembranei198 – 21720Helical; Name=5; Reviewed prediction
    Add
    BLAST
    Topological domaini218 – 23720Cytoplasmic Reviewed prediction
    Add
    BLAST
    Transmembranei238 – 25821Helical; Name=6; Reviewed prediction
    Add
    BLAST
    Topological domaini259 – 27113Extracellular Reviewed prediction
    Add
    BLAST
    Transmembranei272 – 29221Helical; Name=7; Reviewed prediction
    Add
    BLAST
    Topological domaini293 – 31422Cytoplasmic Reviewed prediction
    Add
    BLAST

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: Reactome
    Complete GO annotation...

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA32787.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 314314Olfactory receptor 9A4
    PRO_0000150677Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi4 – 41N-linked (GlcNAc...) Reviewed prediction
    Disulfide bondi97 ↔ 189 By similarity
    Glycosylationi190 – 1901N-linked (GlcNAc...) Reviewed prediction

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ8NGU2.
    PRIDEiQ8NGU2.

    PTM databases

    PhosphoSiteiQ8NGU2.

    Expressioni

    Gene expression databases

    CleanExiHS_OR9A4.
    GenevestigatoriQ8NGU2.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000386148.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8NGU2.
    SMRiQ8NGU2. Positions 35-306.

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG119442.
    HOGENOMiHOG000041364.
    HOVERGENiHBG017625.
    InParanoidiQ8NGU2.
    KOiK04257.
    OMAiCNNTLFT.
    OrthoDBiEOG7KM5TB.
    PhylomeDBiQ8NGU2.
    TreeFamiTF336833.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8NGU2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLMNYSSATE FYLLGFPGSE ELHHILFAIF FFFYLVTLMG NTVIIMIVCV    50
    DKRLQSPMYF FLGHLSALEI LVTTIIVPVM LWGLLLPGMQ TIYLSACVVQ 100
    LFLYLAVGTT EFALLGAMAV DRYVAVCNPL RYNIIMNRHT CNFVVLVSWV 150
    FGFLFQIWPV YVMFQLTYCK SNVVNNFFCD RGQLLKLSCN NTLFTEFILF 200
    LMAVFVLFGS LIPTIVSNAY IISTILKIPS SSGRRKSFST CASHFTCVVI 250
    GYGSCLFLYV KPKQTQAADY NWVVSLMVSV VTPFLNPFIF TLRNDKVIEA 300
    LRDGVKRCCQ LFRN 314
    Length:314
    Mass (Da):35,758
    Last modified:October 1, 2002 - v1
    Checksum:i4F961C5C93750D1A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065689 Genomic DNA. Translation: BAC05912.1.
    CH236950 Genomic DNA. Translation: EAL24013.1.
    CH471070 Genomic DNA. Translation: EAW83990.1.
    BC136819 mRNA. Translation: AAI36820.1.
    BC136821 mRNA. Translation: AAI36822.1.
    BK004278 Genomic DNA. Translation: DAA04676.1.
    CCDSiCCDS43661.1.
    RefSeqiNP_001001656.1. NM_001001656.1.
    UniGeneiHs.690171.

    Genome annotation databases

    EnsembliENST00000548136; ENSP00000448789; ENSG00000258083.
    ENST00000562967; ENSP00000458040; ENSG00000261301.
    GeneIDi130075.
    KEGGihsa:130075.
    UCSCiuc003vwu.1. human.

    Polymorphism databases

    DMDMi38372772.

    Cross-referencesi

    Web resourcesi

    Human Olfactory Receptor Data Exploratorium (HORDE)

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065689 Genomic DNA. Translation: BAC05912.1 .
    CH236950 Genomic DNA. Translation: EAL24013.1 .
    CH471070 Genomic DNA. Translation: EAW83990.1 .
    BC136819 mRNA. Translation: AAI36820.1 .
    BC136821 mRNA. Translation: AAI36822.1 .
    BK004278 Genomic DNA. Translation: DAA04676.1 .
    CCDSi CCDS43661.1.
    RefSeqi NP_001001656.1. NM_001001656.1.
    UniGenei Hs.690171.

    3D structure databases

    ProteinModelPortali Q8NGU2.
    SMRi Q8NGU2. Positions 35-306.
    ModBasei Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000386148.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q8NGU2.

    Polymorphism databases

    DMDMi 38372772.

    Proteomic databases

    PaxDbi Q8NGU2.
    PRIDEi Q8NGU2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000548136 ; ENSP00000448789 ; ENSG00000258083 .
    ENST00000562967 ; ENSP00000458040 ; ENSG00000261301 .
    GeneIDi 130075.
    KEGGi hsa:130075.
    UCSCi uc003vwu.1. human.

    Organism-specific databases

    CTDi 130075.
    GeneCardsi GC07P141622.
    HGNCi HGNC:15095. OR9A4.
    neXtProti NX_Q8NGU2.
    PharmGKBi PA32787.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG119442.
    HOGENOMi HOG000041364.
    HOVERGENi HBG017625.
    InParanoidi Q8NGU2.
    KOi K04257.
    OMAi CNNTLFT.
    OrthoDBi EOG7KM5TB.
    PhylomeDBi Q8NGU2.
    TreeFami TF336833.

    Enzyme and pathway databases

    Reactomei REACT_15488. Olfactory Signaling Pathway.

    Miscellaneous databases

    GeneWikii OR9A4.
    NextBioi 82699.
    PROi Q8NGU2.

    Gene expression databases

    CleanExi HS_OR9A4.
    Genevestigatori Q8NGU2.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    « Hide 'large scale' publications
    1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
      Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
      Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Human chromosome 7: DNA sequence and biology."
      Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
      , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
      Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.
    5. Cited for: IDENTIFICATION.
    6. Erratum
      Malnic B., Godfrey P.A., Buck L.B.
      Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

    Entry informationi

    Entry nameiOR9A4_HUMAN
    AccessioniPrimary (citable) accession number: Q8NGU2
    Secondary accession number(s): B9EGV6, Q6IFI4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 10, 2003
    Last sequence update: October 1, 2002
    Last modified: September 3, 2014
    This is version 103 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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