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Protein

Olfactory receptor 9A4

Gene

OR9A4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 9A4
Alternative name(s):
Olfactory receptor OR7-1
Gene namesi
Name:OR9A4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000258083.1.
HGNCiHGNC:15095. OR9A4.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 24ExtracellularSequence analysisAdd BLAST24
Transmembranei25 – 45Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini46 – 53CytoplasmicSequence analysis8
Transmembranei54 – 74Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini75 – 99ExtracellularSequence analysisAdd BLAST25
Transmembranei100 – 120Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini121 – 139CytoplasmicSequence analysisAdd BLAST19
Transmembranei140 – 160Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini161 – 197ExtracellularSequence analysisAdd BLAST37
Transmembranei198 – 217Helical; Name=5Sequence analysisAdd BLAST20
Topological domaini218 – 237CytoplasmicSequence analysisAdd BLAST20
Transmembranei238 – 258Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini259 – 271ExtracellularSequence analysisAdd BLAST13
Transmembranei272 – 292Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini293 – 314CytoplasmicSequence analysisAdd BLAST22

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000258083.
PharmGKBiPA32787.

Polymorphism and mutation databases

BioMutaiOR9A4.
DMDMi38372772.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001506771 – 314Olfactory receptor 9A4Add BLAST314

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi4N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi97 ↔ 189
Glycosylationi190N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGU2.
PRIDEiQ8NGU2.

PTM databases

iPTMnetiQ8NGU2.
PhosphoSitePlusiQ8NGU2.

Expressioni

Gene expression databases

BgeeiENSG00000258083.
CleanExiHS_OR9A4.
ExpressionAtlasiQ8NGU2. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000448789.

Structurei

3D structure databases

ProteinModelPortaliQ8NGU2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410JB8S. Eukaryota.
ENOG41114F3. LUCA.
GeneTreeiENSGT00760000119169.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ8NGU2.
KOiK04257.
OMAiMNSRTCN.
OrthoDBiEOG091G0FC8.
PhylomeDBiQ8NGU2.
TreeFamiTF336833.

Family and domain databases

InterProiView protein in InterPro
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
PfamiView protein in Pfam
PF13853. 7tm_4. 1 hit.
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiView protein in PROSITE
PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8NGU2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLMNYSSATE FYLLGFPGSE ELHHILFAIF FFFYLVTLMG NTVIIMIVCV
60 70 80 90 100
DKRLQSPMYF FLGHLSALEI LVTTIIVPVM LWGLLLPGMQ TIYLSACVVQ
110 120 130 140 150
LFLYLAVGTT EFALLGAMAV DRYVAVCNPL RYNIIMNRHT CNFVVLVSWV
160 170 180 190 200
FGFLFQIWPV YVMFQLTYCK SNVVNNFFCD RGQLLKLSCN NTLFTEFILF
210 220 230 240 250
LMAVFVLFGS LIPTIVSNAY IISTILKIPS SSGRRKSFST CASHFTCVVI
260 270 280 290 300
GYGSCLFLYV KPKQTQAADY NWVVSLMVSV VTPFLNPFIF TLRNDKVIEA
310
LRDGVKRCCQ LFRN
Length:314
Mass (Da):35,758
Last modified:October 1, 2002 - v1
Checksum:i4F961C5C93750D1A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065689 Genomic DNA. Translation: BAC05912.1.
CH236950 Genomic DNA. Translation: EAL24013.1.
CH471070 Genomic DNA. Translation: EAW83990.1.
BC136819 mRNA. Translation: AAI36820.1.
BC136821 mRNA. Translation: AAI36822.1.
BK004278 Genomic DNA. Translation: DAA04676.1.
CCDSiCCDS43661.1.
RefSeqiNP_001001656.1. NM_001001656.1.
UniGeneiHs.690171.

Genome annotation databases

EnsembliENST00000548136; ENSP00000448789; ENSG00000258083.
ENST00000641559; ENSP00000493151; ENSG00000258083.
GeneIDi130075.
KEGGihsa:130075.
UCSCiuc003vwu.2. human.

Similar proteinsi

Entry informationi

Entry nameiOR9A4_HUMAN
AccessioniPrimary (citable) accession number: Q8NGU2
Secondary accession number(s): B9EGV6, Q6IFI4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: November 22, 2017
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  3. SIMILARITY comments
    Index of protein domains and families