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Q8NGU2

- OR9A4_HUMAN

UniProt

Q8NGU2 - OR9A4_HUMAN

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Protein

Olfactory receptor 9A4

Gene

OR9A4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 9A4
Alternative name(s):
Olfactory receptor OR7-1
Gene namesi
Name:OR9A4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:15095. OR9A4.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32787.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 314314Olfactory receptor 9A4PRO_0000150677Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi4 – 41N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi97 ↔ 189PROSITE-ProRule annotation
Glycosylationi190 – 1901N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGU2.
PRIDEiQ8NGU2.

PTM databases

PhosphoSiteiQ8NGU2.

Expressioni

Gene expression databases

CleanExiHS_OR9A4.
GenevestigatoriQ8NGU2.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000386148.

Structurei

3D structure databases

ProteinModelPortaliQ8NGU2.
SMRiQ8NGU2. Positions 35-306.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2424ExtracellularSequence AnalysisAdd
BLAST
Topological domaini46 – 538CytoplasmicSequence Analysis
Topological domaini75 – 9925ExtracellularSequence AnalysisAdd
BLAST
Topological domaini121 – 13919CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini161 – 19737ExtracellularSequence AnalysisAdd
BLAST
Topological domaini218 – 23720CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini259 – 27113ExtracellularSequence AnalysisAdd
BLAST
Topological domaini293 – 31422CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei25 – 4521Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei54 – 7421Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei100 – 12021Helical; Name=3Sequence AnalysisAdd
BLAST
Transmembranei140 – 16021Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei198 – 21720Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei238 – 25821Helical; Name=6Sequence AnalysisAdd
BLAST
Transmembranei272 – 29221Helical; Name=7Sequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG119442.
GeneTreeiENSGT00760000119169.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ8NGU2.
KOiK04257.
OMAiCNNTLFT.
OrthoDBiEOG7KM5TB.
PhylomeDBiQ8NGU2.
TreeFamiTF336833.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGU2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLMNYSSATE FYLLGFPGSE ELHHILFAIF FFFYLVTLMG NTVIIMIVCV
60 70 80 90 100
DKRLQSPMYF FLGHLSALEI LVTTIIVPVM LWGLLLPGMQ TIYLSACVVQ
110 120 130 140 150
LFLYLAVGTT EFALLGAMAV DRYVAVCNPL RYNIIMNRHT CNFVVLVSWV
160 170 180 190 200
FGFLFQIWPV YVMFQLTYCK SNVVNNFFCD RGQLLKLSCN NTLFTEFILF
210 220 230 240 250
LMAVFVLFGS LIPTIVSNAY IISTILKIPS SSGRRKSFST CASHFTCVVI
260 270 280 290 300
GYGSCLFLYV KPKQTQAADY NWVVSLMVSV VTPFLNPFIF TLRNDKVIEA
310
LRDGVKRCCQ LFRN
Length:314
Mass (Da):35,758
Last modified:October 1, 2002 - v1
Checksum:i4F961C5C93750D1A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB065689 Genomic DNA. Translation: BAC05912.1.
CH236950 Genomic DNA. Translation: EAL24013.1.
CH471070 Genomic DNA. Translation: EAW83990.1.
BC136819 mRNA. Translation: AAI36820.1.
BC136821 mRNA. Translation: AAI36822.1.
BK004278 Genomic DNA. Translation: DAA04676.1.
CCDSiCCDS43661.1.
RefSeqiNP_001001656.1. NM_001001656.1.
UniGeneiHs.690171.

Genome annotation databases

EnsembliENST00000548136; ENSP00000448789; ENSG00000258083.
GeneIDi130075.
KEGGihsa:130075.
UCSCiuc003vwu.1. human.

Polymorphism databases

DMDMi38372772.

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB065689 Genomic DNA. Translation: BAC05912.1 .
CH236950 Genomic DNA. Translation: EAL24013.1 .
CH471070 Genomic DNA. Translation: EAW83990.1 .
BC136819 mRNA. Translation: AAI36820.1 .
BC136821 mRNA. Translation: AAI36822.1 .
BK004278 Genomic DNA. Translation: DAA04676.1 .
CCDSi CCDS43661.1.
RefSeqi NP_001001656.1. NM_001001656.1.
UniGenei Hs.690171.

3D structure databases

ProteinModelPortali Q8NGU2.
SMRi Q8NGU2. Positions 35-306.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000386148.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei Q8NGU2.

Polymorphism databases

DMDMi 38372772.

Proteomic databases

PaxDbi Q8NGU2.
PRIDEi Q8NGU2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000548136 ; ENSP00000448789 ; ENSG00000258083 .
GeneIDi 130075.
KEGGi hsa:130075.
UCSCi uc003vwu.1. human.

Organism-specific databases

CTDi 130075.
GeneCardsi GC07P141622.
HGNCi HGNC:15095. OR9A4.
neXtProti NX_Q8NGU2.
PharmGKBi PA32787.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG119442.
GeneTreei ENSGT00760000119169.
HOGENOMi HOG000041364.
HOVERGENi HBG017625.
InParanoidi Q8NGU2.
KOi K04257.
OMAi CNNTLFT.
OrthoDBi EOG7KM5TB.
PhylomeDBi Q8NGU2.
TreeFami TF336833.

Enzyme and pathway databases

Reactomei REACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikii OR9A4.
GenomeRNAii 130075.
NextBioi 82699.
PROi Q8NGU2.

Gene expression databases

CleanExi HS_OR9A4.
Genevestigatori Q8NGU2.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Human chromosome 7: DNA sequence and biology."
    Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
    , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
    Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  5. Cited for: IDENTIFICATION.
  6. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiOR9A4_HUMAN
AccessioniPrimary (citable) accession number: Q8NGU2
Secondary accession number(s): B9EGV6, Q6IFI4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: October 29, 2014
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3