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Q8NGU2 (OR9A4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 102. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Olfactory receptor 9A4
Alternative name(s):
Olfactory receptor OR7-1
Gene names
Name:OR9A4
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length314 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Odorant receptor Potential.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 314314Olfactory receptor 9A4
PRO_0000150677

Regions

Topological domain1 – 2424Extracellular Potential
Transmembrane25 – 4521Helical; Name=1; Potential
Topological domain46 – 538Cytoplasmic Potential
Transmembrane54 – 7421Helical; Name=2; Potential
Topological domain75 – 9925Extracellular Potential
Transmembrane100 – 12021Helical; Name=3; Potential
Topological domain121 – 13919Cytoplasmic Potential
Transmembrane140 – 16021Helical; Name=4; Potential
Topological domain161 – 19737Extracellular Potential
Transmembrane198 – 21720Helical; Name=5; Potential
Topological domain218 – 23720Cytoplasmic Potential
Transmembrane238 – 25821Helical; Name=6; Potential
Topological domain259 – 27113Extracellular Potential
Transmembrane272 – 29221Helical; Name=7; Potential
Topological domain293 – 31422Cytoplasmic Potential

Amino acid modifications

Glycosylation41N-linked (GlcNAc...) Potential
Glycosylation1901N-linked (GlcNAc...) Potential
Disulfide bond97 ↔ 189 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8NGU2 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: 4F961C5C93750D1A

FASTA31435,758
        10         20         30         40         50         60 
MLMNYSSATE FYLLGFPGSE ELHHILFAIF FFFYLVTLMG NTVIIMIVCV DKRLQSPMYF 

        70         80         90        100        110        120 
FLGHLSALEI LVTTIIVPVM LWGLLLPGMQ TIYLSACVVQ LFLYLAVGTT EFALLGAMAV 

       130        140        150        160        170        180 
DRYVAVCNPL RYNIIMNRHT CNFVVLVSWV FGFLFQIWPV YVMFQLTYCK SNVVNNFFCD 

       190        200        210        220        230        240 
RGQLLKLSCN NTLFTEFILF LMAVFVLFGS LIPTIVSNAY IISTILKIPS SSGRRKSFST 

       250        260        270        280        290        300 
CASHFTCVVI GYGSCLFLYV KPKQTQAADY NWVVSLMVSV VTPFLNPFIF TLRNDKVIEA 

       310 
LRDGVKRCCQ LFRN 

« Hide

References

« Hide 'large scale' references
[1]"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Human chromosome 7: DNA sequence and biology."
Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S. expand/collapse author list , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.
[5]"The human olfactory receptor gene family."
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
[6]Erratum
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB065689 Genomic DNA. Translation: BAC05912.1.
CH236950 Genomic DNA. Translation: EAL24013.1.
CH471070 Genomic DNA. Translation: EAW83990.1.
BC136819 mRNA. Translation: AAI36820.1.
BC136821 mRNA. Translation: AAI36822.1.
BK004278 Genomic DNA. Translation: DAA04676.1.
CCDSCCDS43661.1.
RefSeqNP_001001656.1. NM_001001656.1.
UniGeneHs.690171.

3D structure databases

ProteinModelPortalQ8NGU2.
SMRQ8NGU2. Positions 35-306.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000386148.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteQ8NGU2.

Polymorphism databases

DMDM38372772.

Proteomic databases

PaxDbQ8NGU2.
PRIDEQ8NGU2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000548136; ENSP00000448789; ENSG00000258083.
ENST00000562967; ENSP00000458040; ENSG00000261301.
GeneID130075.
KEGGhsa:130075.
UCSCuc003vwu.1. human.

Organism-specific databases

CTD130075.
GeneCardsGC07P141622.
HGNCHGNC:15095. OR9A4.
neXtProtNX_Q8NGU2.
PharmGKBPA32787.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG119442.
HOGENOMHOG000041364.
HOVERGENHBG017625.
InParanoidQ8NGU2.
KOK04257.
OMACNNTLFT.
OrthoDBEOG7KM5TB.
PhylomeDBQ8NGU2.
TreeFamTF336833.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

CleanExHS_OR9A4.
GenevestigatorQ8NGU2.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiOR9A4.
NextBio82699.
PROQ8NGU2.

Entry information

Entry nameOR9A4_HUMAN
AccessionPrimary (citable) accession number: Q8NGU2
Secondary accession number(s): B9EGV6, Q6IFI4
Entry history
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: July 9, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 7

Human chromosome 7: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries