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Q8NGT9

- OR2A1_HUMAN

UniProt

Q8NGT9 - OR2A1_HUMAN

Protein

Olfactory receptor 2A1/2A42

Gene

OR2A1

more
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 105 (01 Oct 2014)
      Sequence version 2 (10 Oct 2003)
      Previous versions | rss
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    Functioni

    Odorant receptor.Curated

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW
    2. olfactory receptor activity Source: InterPro

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Olfaction, Sensory transduction

    Enzyme and pathway databases

    ReactomeiREACT_15488. Olfactory Signaling Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Olfactory receptor 2A1/2A42
    Alternative name(s):
    Olfactory receptor OR7-16
    Olfactory receptor OR7-19
    Gene namesi
    Name:OR2A1
    AND
    Name:OR2A42
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:8229. OR2A1.
    HGNC:31230. OR2A42.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134971566.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 310310Olfactory receptor 2A1/2A42PRO_0000150459Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi4 – 41N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi96 ↔ 188PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ8NGT9.
    PRIDEiQ8NGT9.

    Expressioni

    Gene expression databases

    BgeeiQ8NGT9.
    CleanExiHS_OR2A1.
    HS_OR2A42.
    GenevestigatoriQ8NGT9.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8NGT9.
    SMRiQ8NGT9. Positions 22-302.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2424ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini49 – 568CytoplasmicSequence Analysis
    Topological domaini79 – 9921ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini120 – 13819CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini158 – 19538ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini219 – 23517CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini259 – 27113ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini292 – 31019CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei25 – 4824Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei57 – 7822Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei100 – 11920Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei139 – 15719Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei196 – 21823Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei236 – 25823Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei272 – 29120Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG45258.
    HOGENOMiHOG000041362.
    HOVERGENiHBG017625.
    InParanoidiQ8NGT9.
    KOiK04257.
    OMAiFGHSECL.
    OrthoDBiEOG793B85.
    PhylomeDBiQ8NGT9.
    TreeFamiTF337251.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8NGT9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGENQTMVTE FLLLGFLLGP RIQMLLFGLF SLFYIFTLLG NGAILGLISL    50
    DSRLHTPMYF FLSHLAVVDI AYTRNTVPQM LANLLHPAKP ISFAGCMTQT 100
    FLCLSFGHSE CLLLVLMSYD RYVAICHPLR YSVIMTWRVC ITLAVTSWTC 150
    GSLLALAHVV LILRLPFSGP HEINHFFCEI LSVLRLACAD TWLNQVVIFA 200
    ACVFFLVGPP SLVLVSYSHI LAAILRIQSG EGRRKAFSTC SSHLCVVGLF 250
    FGSAIIMYMA PKSRHPEEQQ KVFFLFYSFF NPTLNPLIYS LRNGEVKGAL 300
    RRALGKESHS 310
    Length:310
    Mass (Da):34,714
    Last modified:October 10, 2003 - v2
    Checksum:iCE5E0170B025E871
    GO

    Sequence cautioni

    The sequence BAC05915.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065692 Genomic DNA. Translation: BAC05915.1. Different initiation.
    AF399597 Genomic DNA. Translation: AAK95082.1.
    BK004217 Genomic DNA. Translation: DAA04615.1.
    BK004418 Genomic DNA. Translation: DAA04816.1.
    CCDSiCCDS43673.1.
    CCDS56515.1.
    RefSeqiNP_001001802.2. NM_001001802.2.
    NP_001005287.1. NM_001005287.1.
    XP_005250044.1. XM_005249987.1.
    UniGeneiHs.528398.
    Hs.591830.

    Genome annotation databases

    EnsembliENST00000391496; ENSP00000375334; ENSG00000212807.
    ENST00000408951; ENSP00000386175; ENSG00000221970.
    GeneIDi346528.
    402317.
    KEGGihsa:346528.
    hsa:402317.
    UCSCiuc011kub.2. human.

    Polymorphism databases

    DMDMi38372771.

    Cross-referencesi

    Web resourcesi

    Human Olfactory Receptor Data Exploratorium (HORDE)
    Human Olfactory Receptor Data Exploratorium (HORDE)

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065692 Genomic DNA. Translation: BAC05915.1 . Different initiation.
    AF399597 Genomic DNA. Translation: AAK95082.1 .
    BK004217 Genomic DNA. Translation: DAA04615.1 .
    BK004418 Genomic DNA. Translation: DAA04816.1 .
    CCDSi CCDS43673.1.
    CCDS56515.1.
    RefSeqi NP_001001802.2. NM_001001802.2.
    NP_001005287.1. NM_001005287.1.
    XP_005250044.1. XM_005249987.1.
    UniGenei Hs.528398.
    Hs.591830.

    3D structure databases

    ProteinModelPortali Q8NGT9.
    SMRi Q8NGT9. Positions 22-302.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    GPCRDBi Search...

    Polymorphism databases

    DMDMi 38372771.

    Proteomic databases

    PaxDbi Q8NGT9.
    PRIDEi Q8NGT9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000391496 ; ENSP00000375334 ; ENSG00000212807 .
    ENST00000408951 ; ENSP00000386175 ; ENSG00000221970 .
    GeneIDi 346528.
    402317.
    KEGGi hsa:346528.
    hsa:402317.
    UCSCi uc011kub.2. human.

    Organism-specific databases

    CTDi 346528.
    402317.
    GeneCardsi GC07M143929.
    GC07P144015.
    H-InvDB HIX0033551.
    HGNCi HGNC:8229. OR2A1.
    HGNC:31230. OR2A42.
    neXtProti NX_Q8NGT9.
    PharmGKBi PA134971566.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG45258.
    HOGENOMi HOG000041362.
    HOVERGENi HBG017625.
    InParanoidi Q8NGT9.
    KOi K04257.
    OMAi FGHSECL.
    OrthoDBi EOG793B85.
    PhylomeDBi Q8NGT9.
    TreeFami TF337251.

    Enzyme and pathway databases

    Reactomei REACT_15488. Olfactory Signaling Pathway.

    Miscellaneous databases

    GeneWikii OR2A1.
    NextBioi 98970.
    PROi Q8NGT9.

    Gene expression databases

    Bgeei Q8NGT9.
    CleanExi HS_OR2A1.
    HS_OR2A42.
    Genevestigatori Q8NGT9.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
      Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
      Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 67-283.
    3. Cited for: IDENTIFICATION.
    4. Erratum
      Malnic B., Godfrey P.A., Buck L.B.
      Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

    Entry informationi

    Entry nameiOR2A1_HUMAN
    AccessioniPrimary (citable) accession number: Q8NGT9
    Secondary accession number(s): Q6IF44, Q96R46
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 10, 2003
    Last sequence update: October 10, 2003
    Last modified: October 1, 2014
    This is version 105 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3