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Protein

Olfactory receptor 2A1/2A42

Gene

OR2A1

more
Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

BioCyciZFISH:ENSG00000170356-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 2A1/2A42
Alternative name(s):
Olfactory receptor OR7-16
Olfactory receptor OR7-19
Gene namesi
Name:OR2A1
AND
Name:OR2A42
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:8229. OR2A1.
HGNC:31230. OR2A42.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 24ExtracellularSequence analysisAdd BLAST24
Transmembranei25 – 48Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini49 – 56CytoplasmicSequence analysis8
Transmembranei57 – 78Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini79 – 99ExtracellularSequence analysisAdd BLAST21
Transmembranei100 – 119Helical; Name=3Sequence analysisAdd BLAST20
Topological domaini120 – 138CytoplasmicSequence analysisAdd BLAST19
Transmembranei139 – 157Helical; Name=4Sequence analysisAdd BLAST19
Topological domaini158 – 195ExtracellularSequence analysisAdd BLAST38
Transmembranei196 – 218Helical; Name=5Sequence analysisAdd BLAST23
Topological domaini219 – 235CytoplasmicSequence analysisAdd BLAST17
Transmembranei236 – 258Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini259 – 271ExtracellularSequence analysisAdd BLAST13
Transmembranei272 – 291Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini292 – 310CytoplasmicSequence analysisAdd BLAST19

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000212807.
ENSG00000221970.
PharmGKBiPA134971566.

Polymorphism and mutation databases

BioMutaiOR2A1.
DMDMi38372771.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001504591 – 310Olfactory receptor 2A1/2A42Add BLAST310

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi4N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi96 ↔ 188PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGT9.
PRIDEiQ8NGT9.

Expressioni

Gene expression databases

CleanExiHS_OR2A1.
HS_OR2A42.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000386175.

Structurei

3D structure databases

ProteinModelPortaliQ8NGT9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IHHV. Eukaryota.
ENOG410Z9E8. LUCA.
GeneTreeiENSGT00820000127003.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiQ8NGT9.
KOiK04257.
OMAiCVFFLVG.
OrthoDBiEOG091G0CU6.
PhylomeDBiQ8NGT9.
TreeFamiTF337251.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGT9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGENQTMVTE FLLLGFLLGP RIQMLLFGLF SLFYIFTLLG NGAILGLISL
60 70 80 90 100
DSRLHTPMYF FLSHLAVVDI AYTRNTVPQM LANLLHPAKP ISFAGCMTQT
110 120 130 140 150
FLCLSFGHSE CLLLVLMSYD RYVAICHPLR YSVIMTWRVC ITLAVTSWTC
160 170 180 190 200
GSLLALAHVV LILRLPFSGP HEINHFFCEI LSVLRLACAD TWLNQVVIFA
210 220 230 240 250
ACVFFLVGPP SLVLVSYSHI LAAILRIQSG EGRRKAFSTC SSHLCVVGLF
260 270 280 290 300
FGSAIIMYMA PKSRHPEEQQ KVFFLFYSFF NPTLNPLIYS LRNGEVKGAL
310
RRALGKESHS
Length:310
Mass (Da):34,714
Last modified:October 10, 2003 - v2
Checksum:iCE5E0170B025E871
GO

Sequence cautioni

The sequence BAC05915 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065692 Genomic DNA. Translation: BAC05915.1. Different initiation.
AF399597 Genomic DNA. Translation: AAK95082.1.
BK004217 Genomic DNA. Translation: DAA04615.1.
BK004418 Genomic DNA. Translation: DAA04816.1.
CCDSiCCDS43673.1.
CCDS56515.1.
RefSeqiNP_001001802.2. NM_001001802.2.
NP_001005287.1. NM_001005287.1.
UniGeneiHs.528398.
Hs.591830.

Genome annotation databases

EnsembliENST00000391496; ENSP00000375334; ENSG00000212807.
ENST00000408951; ENSP00000386175; ENSG00000221970.
GeneIDi346528.
402317.
KEGGihsa:346528.
hsa:402317.
UCSCiuc011kub.2. human.

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)
Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065692 Genomic DNA. Translation: BAC05915.1. Different initiation.
AF399597 Genomic DNA. Translation: AAK95082.1.
BK004217 Genomic DNA. Translation: DAA04615.1.
BK004418 Genomic DNA. Translation: DAA04816.1.
CCDSiCCDS43673.1.
CCDS56515.1.
RefSeqiNP_001001802.2. NM_001001802.2.
NP_001005287.1. NM_001005287.1.
UniGeneiHs.528398.
Hs.591830.

3D structure databases

ProteinModelPortaliQ8NGT9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000386175.

Protein family/group databases

GPCRDBiSearch...

Polymorphism and mutation databases

BioMutaiOR2A1.
DMDMi38372771.

Proteomic databases

PaxDbiQ8NGT9.
PRIDEiQ8NGT9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000391496; ENSP00000375334; ENSG00000212807.
ENST00000408951; ENSP00000386175; ENSG00000221970.
GeneIDi346528.
402317.
KEGGihsa:346528.
hsa:402317.
UCSCiuc011kub.2. human.

Organism-specific databases

CTDi346528.
402317.
GeneCardsiOR2A1.
OR2A42.
H-InvDBHIX0033551.
HGNCiHGNC:8229. OR2A1.
HGNC:31230. OR2A42.
neXtProtiNX_Q8NGT9.
OpenTargetsiENSG00000212807.
ENSG00000221970.
PharmGKBiPA134971566.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IHHV. Eukaryota.
ENOG410Z9E8. LUCA.
GeneTreeiENSGT00820000127003.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiQ8NGT9.
KOiK04257.
OMAiCVFFLVG.
OrthoDBiEOG091G0CU6.
PhylomeDBiQ8NGT9.
TreeFamiTF337251.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000170356-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR2A1.

Gene expression databases

CleanExiHS_OR2A1.
HS_OR2A42.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOR2A1_HUMAN
AccessioniPrimary (citable) accession number: Q8NGT9
Secondary accession number(s): Q6IF44, Q96R46
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 10, 2003
Last modified: November 2, 2016
This is version 120 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.