Q8NGT9 (OR2A1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Olfactory receptor 2A1/2A42

Alternative name(s):
Olfactory receptor OR7-16
Olfactory receptor OR7-19

Gene names

Name:	OR2A1
AND
Name:	OR2A42

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	310 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Odorant receptor Potential.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.
Sequence caution	The sequence BAC05915.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Olfaction Sensory transduction
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	detection of chemical stimulus involved in sensory perception of smell Inferred from electronic annotation. Source: GOC
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Traceable author statement. Source: Reactome
Molecular_function	G-protein coupled receptor activity Inferred from electronic annotation. Source: UniProtKB-KW olfactory receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 310	310	Olfactory receptor 2A1/2A42		PRO_0000150459
Regions
	Topological domain	1 – 24	24	Extracellular Potential
	Transmembrane	25 – 48	24	Helical; Name=1; Potential
	Topological domain	49 – 56	8	Cytoplasmic Potential
	Transmembrane	57 – 78	22	Helical; Name=2; Potential
	Topological domain	79 – 99	21	Extracellular Potential
	Transmembrane	100 – 119	20	Helical; Name=3; Potential
	Topological domain	120 – 138	19	Cytoplasmic Potential
	Transmembrane	139 – 157	19	Helical; Name=4; Potential
	Topological domain	158 – 195	38	Extracellular Potential
	Transmembrane	196 – 218	23	Helical; Name=5; Potential
	Topological domain	219 – 235	17	Cytoplasmic Potential
	Transmembrane	236 – 258	23	Helical; Name=6; Potential
	Topological domain	259 – 271	13	Extracellular Potential
	Transmembrane	272 – 291	20	Helical; Name=7; Potential
	Topological domain	292 – 310	19	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	4	1	N-linked (GlcNAc...) Potential
	Disulfide bond	96 ↔ 188		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8NGT9 [UniParc]. Last modified October 10, 2003. Version 2. Checksum: CE5E0170B025E871	FASTA	310	34,714
	10 20 30 40 50 60 MGENQTMVTE FLLLGFLLGP RIQMLLFGLF SLFYIFTLLG NGAILGLISL DSRLHTPMYF 70 80 90 100 110 120 FLSHLAVVDI AYTRNTVPQM LANLLHPAKP ISFAGCMTQT FLCLSFGHSE CLLLVLMSYD 130 140 150 160 170 180 RYVAICHPLR YSVIMTWRVC ITLAVTSWTC GSLLALAHVV LILRLPFSGP HEINHFFCEI 190 200 210 220 230 240 LSVLRLACAD TWLNQVVIFA ACVFFLVGPP SLVLVSYSHI LAAILRIQSG EGRRKAFSTC 250 260 270 280 290 300 SSHLCVVGLF FGSAIIMYMA PKSRHPEEQQ KVFFLFYSFF NPTLNPLIYS LRNGEVKGAL 310 RRALGKESHS

References

[1]	"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes." Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y. Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"DEFOG: a practical scheme for deciphering families of genes." Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R., Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U., Lehrach H., Lancet D., Shamir R. Genomics 80:295-302(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 67-283.
[3]	"The human olfactory receptor gene family." Malnic B., Godfrey P.A., Buck L.B. Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION.
[4]	Erratum Malnic B., Godfrey P.A., Buck L.B. Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Web resources

Human Olfactory Receptor Data Exploratorium (HORDE)

Human Olfactory Receptor Data Exploratorium (HORDE)

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB065692 Genomic DNA. Translation: BAC05915.1. Different initiation. AF399597 Genomic DNA. Translation: AAK95082.1. BK004217 Genomic DNA. Translation: DAA04615.1. BK004418 Genomic DNA. Translation: DAA04816.1.
IPI	IPI00414176.
RefSeq	NP_001001802.2. NM_001001802.2. NP_001005287.1. NM_001005287.1.
UniGene	Hs.528398. Hs.591830.
3D structure databases
ProteinModelPortal	Q8NGT9.
ModBase	Search...
Protein family/group databases
GPCRDB	Search...
Polymorphism databases
DMDM	38372771.
Proteomic databases
PaxDb	Q8NGT9.
PRIDE	Q8NGT9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000391496; ENSP00000375334; ENSG00000212807. ENST00000408951; ENSP00000386175; ENSG00000221970.
GeneID	346528. 402317.
KEGG	hsa:346528. hsa:402317.
UCSC	uc011kub.2. human.
Organism-specific databases
CTD	346528. 402317.
GeneCards	GC07M143929. GC07P144015.
H-InvDB	HIX0033551.
HGNC	HGNC:8229. OR2A1. HGNC:31230. OR2A42.
neXtProt	NX_Q8NGT9.
PharmGKB	PA134971566.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG45258.
HOGENOM	HOG000041362.
HOVERGEN	HBG017625.
InParanoid	Q8NGT9.
KO	K04257.
OMA	FGHSECL.
OrthoDB	EOG4ZKJMV.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction.
Gene expression databases
ArrayExpress	Q8NGT9.
Bgee	Q8NGT9.
CleanEx	HS_OR2A1. HS_OR2A42.
Genevestigator	Q8NGT9.
Family and domain databases
InterPro	IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. IPR000725. Olfact_rcpt. [Graphical view]
PANTHER	PTHR24236. PTHR24236. 1 hit.
PRINTS	PR00237. GPCRRHODOPSN. PR00245. OLFACTORYR.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	98970.

Entry information

Entry name

OR2A1_HUMAN

Accession

Primary (citable) accession number: Q8NGT9
Secondary accession number(s): Q6IF44, Q96R46

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 10, 2003
Last sequence update:	October 10, 2003
Last modified:	May 1, 2013
This is version 93 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.