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Q8NGT9 (OR2A1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 103. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Olfactory receptor 2A1/2A42
Alternative name(s):
Olfactory receptor OR7-16
Olfactory receptor OR7-19
Gene names
Name:OR2A1
AND
Name:OR2A42
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length310 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Odorant receptor Potential.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence caution

The sequence BAC05915.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 310310Olfactory receptor 2A1/2A42
PRO_0000150459

Regions

Topological domain1 – 2424Extracellular Potential
Transmembrane25 – 4824Helical; Name=1; Potential
Topological domain49 – 568Cytoplasmic Potential
Transmembrane57 – 7822Helical; Name=2; Potential
Topological domain79 – 9921Extracellular Potential
Transmembrane100 – 11920Helical; Name=3; Potential
Topological domain120 – 13819Cytoplasmic Potential
Transmembrane139 – 15719Helical; Name=4; Potential
Topological domain158 – 19538Extracellular Potential
Transmembrane196 – 21823Helical; Name=5; Potential
Topological domain219 – 23517Cytoplasmic Potential
Transmembrane236 – 25823Helical; Name=6; Potential
Topological domain259 – 27113Extracellular Potential
Transmembrane272 – 29120Helical; Name=7; Potential
Topological domain292 – 31019Cytoplasmic Potential

Amino acid modifications

Glycosylation41N-linked (GlcNAc...) Potential
Disulfide bond96 ↔ 188 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8NGT9 [UniParc].

Last modified October 10, 2003. Version 2.
Checksum: CE5E0170B025E871

FASTA31034,714
        10         20         30         40         50         60 
MGENQTMVTE FLLLGFLLGP RIQMLLFGLF SLFYIFTLLG NGAILGLISL DSRLHTPMYF 

        70         80         90        100        110        120 
FLSHLAVVDI AYTRNTVPQM LANLLHPAKP ISFAGCMTQT FLCLSFGHSE CLLLVLMSYD 

       130        140        150        160        170        180 
RYVAICHPLR YSVIMTWRVC ITLAVTSWTC GSLLALAHVV LILRLPFSGP HEINHFFCEI 

       190        200        210        220        230        240 
LSVLRLACAD TWLNQVVIFA ACVFFLVGPP SLVLVSYSHI LAAILRIQSG EGRRKAFSTC 

       250        260        270        280        290        300 
SSHLCVVGLF FGSAIIMYMA PKSRHPEEQQ KVFFLFYSFF NPTLNPLIYS LRNGEVKGAL 

       310 
RRALGKESHS 

« Hide

References

[1]"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"DEFOG: a practical scheme for deciphering families of genes."
Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R., Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U., Lehrach H., Lancet D., Shamir R.
Genomics 80:295-302(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 67-283.
[3]"The human olfactory receptor gene family."
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
[4]Erratum
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB065692 Genomic DNA. Translation: BAC05915.1. Different initiation.
AF399597 Genomic DNA. Translation: AAK95082.1.
BK004217 Genomic DNA. Translation: DAA04615.1.
BK004418 Genomic DNA. Translation: DAA04816.1.
CCDSCCDS43673.1.
CCDS56515.1.
RefSeqNP_001001802.2. NM_001001802.2.
NP_001005287.1. NM_001005287.1.
XP_005250044.1. XM_005249987.1.
UniGeneHs.528398.
Hs.591830.

3D structure databases

ProteinModelPortalQ8NGT9.
SMRQ8NGT9. Positions 22-302.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

GPCRDBSearch...

Polymorphism databases

DMDM38372771.

Proteomic databases

PaxDbQ8NGT9.
PRIDEQ8NGT9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000391496; ENSP00000375334; ENSG00000212807.
ENST00000408951; ENSP00000386175; ENSG00000221970.
GeneID346528.
402317.
KEGGhsa:346528.
hsa:402317.
UCSCuc011kub.2. human.

Organism-specific databases

CTD346528.
402317.
GeneCardsGC07M143929.
GC07P144015.
H-InvDBHIX0033551.
HGNCHGNC:8229. OR2A1.
HGNC:31230. OR2A42.
neXtProtNX_Q8NGT9.
PharmGKBPA134971566.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG45258.
HOGENOMHOG000041362.
HOVERGENHBG017625.
InParanoidQ8NGT9.
KOK04257.
OMAFGHSECL.
OrthoDBEOG793B85.
PhylomeDBQ8NGT9.
TreeFamTF337251.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

BgeeQ8NGT9.
CleanExHS_OR2A1.
HS_OR2A42.
GenevestigatorQ8NGT9.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiOR2A1.
NextBio98970.
PROQ8NGT9.

Entry information

Entry nameOR2A1_HUMAN
AccessionPrimary (citable) accession number: Q8NGT9
Secondary accession number(s): Q6IF44, Q96R46
Entry history
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 10, 2003
Last modified: July 9, 2014
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 7

Human chromosome 7: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries