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Q8NGT9

- OR2A1_HUMAN

UniProt

Q8NGT9 - OR2A1_HUMAN

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Protein

Olfactory receptor 2A1/2A42

Gene

OR2A1

more
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 2A1/2A42
Alternative name(s):
Olfactory receptor OR7-16
Olfactory receptor OR7-19
Gene namesi
Name:OR2A1
AND
Name:OR2A42
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:8229. OR2A1.
HGNC:31230. OR2A42.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134971566.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 310310Olfactory receptor 2A1/2A42PRO_0000150459Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi4 – 41N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi96 ↔ 188PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGT9.
PRIDEiQ8NGT9.

Expressioni

Gene expression databases

BgeeiQ8NGT9.
CleanExiHS_OR2A1.
HS_OR2A42.
ExpressionAtlasiQ8NGT9. baseline.
GenevestigatoriQ8NGT9.

Structurei

3D structure databases

ProteinModelPortaliQ8NGT9.
SMRiQ8NGT9. Positions 22-302.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2424ExtracellularSequence AnalysisAdd
BLAST
Topological domaini49 – 568CytoplasmicSequence Analysis
Topological domaini79 – 9921ExtracellularSequence AnalysisAdd
BLAST
Topological domaini120 – 13819CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini158 – 19538ExtracellularSequence AnalysisAdd
BLAST
Topological domaini219 – 23517CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini259 – 27113ExtracellularSequence AnalysisAdd
BLAST
Topological domaini292 – 31019CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei25 – 4824Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei57 – 7822Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei100 – 11920Helical; Name=3Sequence AnalysisAdd
BLAST
Transmembranei139 – 15719Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei196 – 21823Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei236 – 25823Helical; Name=6Sequence AnalysisAdd
BLAST
Transmembranei272 – 29120Helical; Name=7Sequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG45258.
GeneTreeiENSGT00760000119029.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiQ8NGT9.
KOiK04257.
OMAiFGHSECL.
OrthoDBiEOG793B85.
PhylomeDBiQ8NGT9.
TreeFamiTF337251.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGT9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGENQTMVTE FLLLGFLLGP RIQMLLFGLF SLFYIFTLLG NGAILGLISL
60 70 80 90 100
DSRLHTPMYF FLSHLAVVDI AYTRNTVPQM LANLLHPAKP ISFAGCMTQT
110 120 130 140 150
FLCLSFGHSE CLLLVLMSYD RYVAICHPLR YSVIMTWRVC ITLAVTSWTC
160 170 180 190 200
GSLLALAHVV LILRLPFSGP HEINHFFCEI LSVLRLACAD TWLNQVVIFA
210 220 230 240 250
ACVFFLVGPP SLVLVSYSHI LAAILRIQSG EGRRKAFSTC SSHLCVVGLF
260 270 280 290 300
FGSAIIMYMA PKSRHPEEQQ KVFFLFYSFF NPTLNPLIYS LRNGEVKGAL
310
RRALGKESHS
Length:310
Mass (Da):34,714
Last modified:October 10, 2003 - v2
Checksum:iCE5E0170B025E871
GO

Sequence cautioni

The sequence BAC05915.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB065692 Genomic DNA. Translation: BAC05915.1. Different initiation.
AF399597 Genomic DNA. Translation: AAK95082.1.
BK004217 Genomic DNA. Translation: DAA04615.1.
BK004418 Genomic DNA. Translation: DAA04816.1.
CCDSiCCDS43673.1.
CCDS56515.1.
RefSeqiNP_001001802.2. NM_001001802.2.
NP_001005287.1. NM_001005287.1.
XP_005250044.1. XM_005249987.1.
UniGeneiHs.528398.
Hs.591830.

Genome annotation databases

EnsembliENST00000391496; ENSP00000375334; ENSG00000212807.
ENST00000408951; ENSP00000386175; ENSG00000221970.
GeneIDi346528.
402317.
KEGGihsa:346528.
hsa:402317.
UCSCiuc011kub.2. human.

Polymorphism databases

DMDMi38372771.

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)
Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB065692 Genomic DNA. Translation: BAC05915.1 . Different initiation.
AF399597 Genomic DNA. Translation: AAK95082.1 .
BK004217 Genomic DNA. Translation: DAA04615.1 .
BK004418 Genomic DNA. Translation: DAA04816.1 .
CCDSi CCDS43673.1.
CCDS56515.1.
RefSeqi NP_001001802.2. NM_001001802.2.
NP_001005287.1. NM_001005287.1.
XP_005250044.1. XM_005249987.1.
UniGenei Hs.528398.
Hs.591830.

3D structure databases

ProteinModelPortali Q8NGT9.
SMRi Q8NGT9. Positions 22-302.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

GPCRDBi Search...

Polymorphism databases

DMDMi 38372771.

Proteomic databases

PaxDbi Q8NGT9.
PRIDEi Q8NGT9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000391496 ; ENSP00000375334 ; ENSG00000212807 .
ENST00000408951 ; ENSP00000386175 ; ENSG00000221970 .
GeneIDi 346528.
402317.
KEGGi hsa:346528.
hsa:402317.
UCSCi uc011kub.2. human.

Organism-specific databases

CTDi 346528.
402317.
GeneCardsi GC07M143929.
GC07P144015.
H-InvDB HIX0033551.
HGNCi HGNC:8229. OR2A1.
HGNC:31230. OR2A42.
neXtProti NX_Q8NGT9.
PharmGKBi PA134971566.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG45258.
GeneTreei ENSGT00760000119029.
HOGENOMi HOG000041362.
HOVERGENi HBG017625.
InParanoidi Q8NGT9.
KOi K04257.
OMAi FGHSECL.
OrthoDBi EOG793B85.
PhylomeDBi Q8NGT9.
TreeFami TF337251.

Enzyme and pathway databases

Reactomei REACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikii OR2A1.
NextBioi 98970.
PROi Q8NGT9.

Gene expression databases

Bgeei Q8NGT9.
CleanExi HS_OR2A1.
HS_OR2A42.
ExpressionAtlasi Q8NGT9. baseline.
Genevestigatori Q8NGT9.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 67-283.
  3. Cited for: IDENTIFICATION.
  4. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiOR2A1_HUMAN
AccessioniPrimary (citable) accession number: Q8NGT9
Secondary accession number(s): Q6IF44, Q96R46
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 10, 2003
Last modified: October 29, 2014
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3