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Protein

Olfactory receptor 2A12

Gene

OR2A12

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 2A12
Alternative name(s):
Olfactory receptor OR7-10
Gene namesi
Name:OR2A12
Synonyms:OR2A12P
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:15082. OR2A12.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2424ExtracellularSequence AnalysisAdd
BLAST
Transmembranei25 – 4824Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini49 – 568CytoplasmicSequence Analysis
Transmembranei57 – 7822Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini79 – 9921ExtracellularSequence AnalysisAdd
BLAST
Transmembranei100 – 11920Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini120 – 13819CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei139 – 15719Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini158 – 19437ExtracellularSequence AnalysisAdd
BLAST
Transmembranei195 – 21824Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini219 – 23517CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei236 – 25823Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini259 – 27113ExtracellularSequence AnalysisAdd
BLAST
Transmembranei272 – 29120Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini292 – 31019CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32104.

Polymorphism and mutation databases

BioMutaiOR2A12.
DMDMi38372499.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 310310Olfactory receptor 2A12PRO_0000150457Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi4 – 41N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi96 ↔ 188PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGT7.
PRIDEiQ8NGT7.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000386174.

Structurei

3D structure databases

ProteinModelPortaliQ8NGT7.
SMRiQ8NGT7. Positions 36-304.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG149322.
GeneTreeiENSGT00760000119029.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiQ8NGT7.
KOiK04257.
OMAiFFCQIMS.
OrthoDBiEOG793B85.
PhylomeDBiQ8NGT7.
TreeFamiTF337251.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGT7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESNQTWITE VILLGFQVDP ALELFLFGFF LLFYSLTLMG NGIILGLIYL
60 70 80 90 100
DSRLHTPMYV FLSHLAIVDM SYASSTVPKM LANLVMHKKV ISFAPCILQT
110 120 130 140 150
FLYLAFAITE CLILVMMCYD RYVAICHPLQ YTLIMNWRVC TVLASTCWIF
160 170 180 190 200
SFLLALVHIT LILRLPFCGP QKINHFFCQI MSVFKLACAD TRLNQVVLFA
210 220 230 240 250
GSAFILVGPL CLVLVSYLHI LVAILRIQSG EGRRKAFSTC SSHLCVVGLF
260 270 280 290 300
FGSAIVMYMA PKSSHSQERR KILSLFYSLF NPILNPLIYS LRNAEVKGAL
310
KRVLWKQRSM
Length:310
Mass (Da):35,213
Last modified:October 1, 2002 - v1
Checksum:i5A25409ADB5BC857
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti223 – 2231A → T.
Corresponds to variant rs9655672 [ dbSNP | Ensembl ].
VAR_034171

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065694 Genomic DNA. Translation: BAC05917.1.
BK004419 Genomic DNA. Translation: DAA04817.1.
CCDSiCCDS43670.1.
RefSeqiNP_001004135.1. NM_001004135.1.
UniGeneiHs.553708.

Genome annotation databases

EnsembliENST00000408949; ENSP00000386174; ENSG00000221858.
GeneIDi346525.
KEGGihsa:346525.
UCSCiuc011kty.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065694 Genomic DNA. Translation: BAC05917.1.
BK004419 Genomic DNA. Translation: DAA04817.1.
CCDSiCCDS43670.1.
RefSeqiNP_001004135.1. NM_001004135.1.
UniGeneiHs.553708.

3D structure databases

ProteinModelPortaliQ8NGT7.
SMRiQ8NGT7. Positions 36-304.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000386174.

Protein family/group databases

GPCRDBiSearch...

Polymorphism and mutation databases

BioMutaiOR2A12.
DMDMi38372499.

Proteomic databases

PaxDbiQ8NGT7.
PRIDEiQ8NGT7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000408949; ENSP00000386174; ENSG00000221858.
GeneIDi346525.
KEGGihsa:346525.
UCSCiuc011kty.2. human.

Organism-specific databases

CTDi346525.
GeneCardsiGC07P143792.
HGNCiHGNC:15082. OR2A12.
neXtProtiNX_Q8NGT7.
PharmGKBiPA32104.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG149322.
GeneTreeiENSGT00760000119029.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiQ8NGT7.
KOiK04257.
OMAiFFCQIMS.
OrthoDBiEOG793B85.
PhylomeDBiQ8NGT7.
TreeFamiTF337251.

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR2A12.
GenomeRNAii346525.
NextBioi98966.
PROiQ8NGT7.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: IDENTIFICATION.
  3. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiO2A12_HUMAN
AccessioniPrimary (citable) accession number: Q8NGT7
Secondary accession number(s): Q6IF43
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 14, 2003
Last sequence update: October 1, 2002
Last modified: June 24, 2015
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.