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Q8NGT7

- O2A12_HUMAN

UniProt

Q8NGT7 - O2A12_HUMAN

Protein

Olfactory receptor 2A12

Gene

OR2A12

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 95 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    Odorant receptor.Curated

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW
    2. olfactory receptor activity Source: InterPro

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Olfaction, Sensory transduction

    Enzyme and pathway databases

    ReactomeiREACT_15488. Olfactory Signaling Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Olfactory receptor 2A12
    Alternative name(s):
    Olfactory receptor OR7-10
    Gene namesi
    Name:OR2A12
    Synonyms:OR2A12P
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:15082. OR2A12.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA32104.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 310310Olfactory receptor 2A12PRO_0000150457Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi4 – 41N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi96 ↔ 188PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ8NGT7.
    PRIDEiQ8NGT7.

    Expressioni

    Gene expression databases

    GenevestigatoriQ8NGT7.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000386174.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8NGT7.
    SMRiQ8NGT7. Positions 36-305.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2424ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini49 – 568CytoplasmicSequence Analysis
    Topological domaini79 – 9921ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini120 – 13819CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini158 – 19437ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini219 – 23517CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini259 – 27113ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini292 – 31019CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei25 – 4824Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei57 – 7822Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei100 – 11920Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei139 – 15719Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei195 – 21824Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei236 – 25823Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei272 – 29120Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG149322.
    HOGENOMiHOG000041365.
    HOVERGENiHBG017625.
    InParanoidiQ8NGT7.
    KOiK04257.
    OMAiFFCQIMS.
    OrthoDBiEOG793B85.
    PhylomeDBiQ8NGT7.
    TreeFamiTF337251.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8NGT7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MESNQTWITE VILLGFQVDP ALELFLFGFF LLFYSLTLMG NGIILGLIYL    50
    DSRLHTPMYV FLSHLAIVDM SYASSTVPKM LANLVMHKKV ISFAPCILQT 100
    FLYLAFAITE CLILVMMCYD RYVAICHPLQ YTLIMNWRVC TVLASTCWIF 150
    SFLLALVHIT LILRLPFCGP QKINHFFCQI MSVFKLACAD TRLNQVVLFA 200
    GSAFILVGPL CLVLVSYLHI LVAILRIQSG EGRRKAFSTC SSHLCVVGLF 250
    FGSAIVMYMA PKSSHSQERR KILSLFYSLF NPILNPLIYS LRNAEVKGAL 300
    KRVLWKQRSM 310
    Length:310
    Mass (Da):35,213
    Last modified:October 1, 2002 - v1
    Checksum:i5A25409ADB5BC857
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti223 – 2231A → T.
    Corresponds to variant rs9655672 [ dbSNP | Ensembl ].
    VAR_034171

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065694 Genomic DNA. Translation: BAC05917.1.
    BK004419 Genomic DNA. Translation: DAA04817.1.
    CCDSiCCDS43670.1.
    RefSeqiNP_001004135.1. NM_001004135.1.
    UniGeneiHs.553708.

    Genome annotation databases

    EnsembliENST00000408949; ENSP00000386174; ENSG00000221858.
    GeneIDi346525.
    KEGGihsa:346525.
    UCSCiuc011kty.2. human.

    Polymorphism databases

    DMDMi38372499.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Human Olfactory Receptor Data Exploratorium (HORDE)

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065694 Genomic DNA. Translation: BAC05917.1 .
    BK004419 Genomic DNA. Translation: DAA04817.1 .
    CCDSi CCDS43670.1.
    RefSeqi NP_001004135.1. NM_001004135.1.
    UniGenei Hs.553708.

    3D structure databases

    ProteinModelPortali Q8NGT7.
    SMRi Q8NGT7. Positions 36-305.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000386174.

    Protein family/group databases

    GPCRDBi Search...

    Polymorphism databases

    DMDMi 38372499.

    Proteomic databases

    PaxDbi Q8NGT7.
    PRIDEi Q8NGT7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000408949 ; ENSP00000386174 ; ENSG00000221858 .
    GeneIDi 346525.
    KEGGi hsa:346525.
    UCSCi uc011kty.2. human.

    Organism-specific databases

    CTDi 346525.
    GeneCardsi GC07P143792.
    HGNCi HGNC:15082. OR2A12.
    neXtProti NX_Q8NGT7.
    PharmGKBi PA32104.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG149322.
    HOGENOMi HOG000041365.
    HOVERGENi HBG017625.
    InParanoidi Q8NGT7.
    KOi K04257.
    OMAi FFCQIMS.
    OrthoDBi EOG793B85.
    PhylomeDBi Q8NGT7.
    TreeFami TF337251.

    Enzyme and pathway databases

    Reactomei REACT_15488. Olfactory Signaling Pathway.

    Miscellaneous databases

    GeneWikii OR2A12.
    NextBioi 98966.
    PROi Q8NGT7.

    Gene expression databases

    Genevestigatori Q8NGT7.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
      Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
      Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: IDENTIFICATION.
    3. Erratum
      Malnic B., Godfrey P.A., Buck L.B.
      Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

    Entry informationi

    Entry nameiO2A12_HUMAN
    AccessioniPrimary (citable) accession number: Q8NGT7
    Secondary accession number(s): Q6IF43
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 14, 2003
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 95 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3