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Q8NGT7 (O2A12_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 92. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Olfactory receptor 2A12
Alternative name(s):
Olfactory receptor OR7-10
Gene names
Name:OR2A12
Synonyms:OR2A12P
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length310 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Odorant receptor Potential.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 310310Olfactory receptor 2A12
PRO_0000150457

Regions

Topological domain1 – 2424Extracellular Potential
Transmembrane25 – 4824Helical; Name=1; Potential
Topological domain49 – 568Cytoplasmic Potential
Transmembrane57 – 7822Helical; Name=2; Potential
Topological domain79 – 9921Extracellular Potential
Transmembrane100 – 11920Helical; Name=3; Potential
Topological domain120 – 13819Cytoplasmic Potential
Transmembrane139 – 15719Helical; Name=4; Potential
Topological domain158 – 19437Extracellular Potential
Transmembrane195 – 21824Helical; Name=5; Potential
Topological domain219 – 23517Cytoplasmic Potential
Transmembrane236 – 25823Helical; Name=6; Potential
Topological domain259 – 27113Extracellular Potential
Transmembrane272 – 29120Helical; Name=7; Potential
Topological domain292 – 31019Cytoplasmic Potential

Amino acid modifications

Glycosylation41N-linked (GlcNAc...) Potential
Disulfide bond96 ↔ 188 By similarity

Natural variations

Natural variant2231A → T.
Corresponds to variant rs9655672 [ dbSNP | Ensembl ].
VAR_034171

Sequences

Sequence LengthMass (Da)Tools
Q8NGT7 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: 5A25409ADB5BC857

FASTA31035,213
        10         20         30         40         50         60 
MESNQTWITE VILLGFQVDP ALELFLFGFF LLFYSLTLMG NGIILGLIYL DSRLHTPMYV 

        70         80         90        100        110        120 
FLSHLAIVDM SYASSTVPKM LANLVMHKKV ISFAPCILQT FLYLAFAITE CLILVMMCYD 

       130        140        150        160        170        180 
RYVAICHPLQ YTLIMNWRVC TVLASTCWIF SFLLALVHIT LILRLPFCGP QKINHFFCQI 

       190        200        210        220        230        240 
MSVFKLACAD TRLNQVVLFA GSAFILVGPL CLVLVSYLHI LVAILRIQSG EGRRKAFSTC 

       250        260        270        280        290        300 
SSHLCVVGLF FGSAIVMYMA PKSSHSQERR KILSLFYSLF NPILNPLIYS LRNAEVKGAL 

       310 
KRVLWKQRSM 

« Hide

References

[1]"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The human olfactory receptor gene family."
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
[3]Erratum
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB065694 Genomic DNA. Translation: BAC05917.1.
BK004419 Genomic DNA. Translation: DAA04817.1.
RefSeqNP_001004135.1. NM_001004135.1.
UniGeneHs.553708.

3D structure databases

ProteinModelPortalQ8NGT7.
SMRQ8NGT7. Positions 36-305.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000386174.

Protein family/group databases

GPCRDBSearch...

Polymorphism databases

DMDM38372499.

Proteomic databases

PaxDbQ8NGT7.
PRIDEQ8NGT7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000408949; ENSP00000386174; ENSG00000221858.
GeneID346525.
KEGGhsa:346525.
UCSCuc011kty.2. human.

Organism-specific databases

CTD346525.
GeneCardsGC07P143792.
HGNCHGNC:15082. OR2A12.
neXtProtNX_Q8NGT7.
PharmGKBPA32104.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG149322.
HOGENOMHOG000041365.
HOVERGENHBG017625.
InParanoidQ8NGT7.
KOK04257.
OMAFFCQIMS.
OrthoDBEOG793B85.
PhylomeDBQ8NGT7.
TreeFamTF337251.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

GenevestigatorQ8NGT7.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiOR2A12.
NextBio98966.
PROQ8NGT7.

Entry information

Entry nameO2A12_HUMAN
AccessionPrimary (citable) accession number: Q8NGT7
Secondary accession number(s): Q6IF43
Entry history
Integrated into UniProtKB/Swiss-Prot: November 14, 2003
Last sequence update: October 1, 2002
Last modified: April 16, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 7

Human chromosome 7: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries