ID   OR9A2_HUMAN             Reviewed;         310 AA.
AC   Q8NGT5; B9EH51; Q6IF71; Q8NGD9;
DT   10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   27-MAR-2024, entry version 160.
DE   RecName: Full=Olfactory receptor 9A2;
DE   AltName: Full=Olfactory receptor OR7-2;
GN   Name=OR9A2;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA   Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT   "Genome-wide discovery and analysis of human seven transmembrane helix
RT   receptor genes.";
RL   Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   IDENTIFICATION.
RX   PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA   Malnic B., Godfrey P.A., Buck L.B.;
RT   "The human olfactory receptor gene family.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN   [5]
RP   ERRATUM OF PUBMED:14983052.
RA   Malnic B., Godfrey P.A., Buck L.B.;
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC   -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC   -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC       URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR9A2";
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AB065696; BAC05919.1; -; Genomic_DNA.
DR   EMBL; AB065874; BAC06092.1; -; Genomic_DNA.
DR   EMBL; CH471198; EAW51890.1; -; Genomic_DNA.
DR   EMBL; BC137048; AAI37049.1; -; mRNA.
DR   EMBL; BC137049; AAI37050.1; -; mRNA.
DR   EMBL; BK004391; DAA04789.1; -; Genomic_DNA.
DR   CCDS; CCDS34767.1; -.
DR   RefSeq; NP_001001658.1; NM_001001658.1.
DR   AlphaFoldDB; Q8NGT5; -.
DR   SMR; Q8NGT5; -.
DR   STRING; 9606.ENSP00000316518; -.
DR   GlyCosmos; Q8NGT5; 1 site, No reported glycans.
DR   GlyGen; Q8NGT5; 1 site.
DR   PhosphoSitePlus; Q8NGT5; -.
DR   BioMuta; OR9A2; -.
DR   DMDM; 38372770; -.
DR   PaxDb; 9606-ENSP00000316518; -.
DR   Antibodypedia; 64633; 65 antibodies from 17 providers.
DR   DNASU; 135924; -.
DR   Ensembl; ENST00000350513.3; ENSP00000316518.3; ENSG00000179468.6.
DR   Ensembl; ENST00000619330.2; ENSP00000479412.1; ENSG00000273914.2.
DR   GeneID; 135924; -.
DR   KEGG; hsa:135924; -.
DR   MANE-Select; ENST00000350513.3; ENSP00000316518.3; NM_001001658.1; NP_001001658.1.
DR   UCSC; uc003wcc.2; human.
DR   AGR; HGNC:15093; -.
DR   CTD; 135924; -.
DR   GeneCards; OR9A2; -.
DR   HGNC; HGNC:15093; OR9A2.
DR   HPA; ENSG00000179468; Not detected.
DR   neXtProt; NX_Q8NGT5; -.
DR   OpenTargets; ENSG00000179468; -.
DR   PharmGKB; PA32785; -.
DR   VEuPathDB; HostDB:ENSG00000179468; -.
DR   eggNOG; ENOG502QVH7; Eukaryota.
DR   GeneTree; ENSGT00940000163070; -.
DR   HOGENOM; CLU_012526_1_1_1; -.
DR   InParanoid; Q8NGT5; -.
DR   OMA; HHILFAM; -.
DR   OrthoDB; 5401587at2759; -.
DR   PhylomeDB; Q8NGT5; -.
DR   TreeFam; TF336833; -.
DR   PathwayCommons; Q8NGT5; -.
DR   Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR   BioGRID-ORCS; 135924; 10 hits in 741 CRISPR screens.
DR   GeneWiki; OR9A2; -.
DR   GenomeRNAi; 135924; -.
DR   Pharos; Q8NGT5; Tdark.
DR   PRO; PR:Q8NGT5; -.
DR   Proteomes; UP000005640; Chromosome 7.
DR   RNAct; Q8NGT5; Protein.
DR   Bgee; ENSG00000179468; Expressed in male germ line stem cell (sensu Vertebrata) in testis and 12 other cell types or tissues.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0004984; F:olfactory receptor activity; IEA:InterPro.
DR   Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR000725; Olfact_rcpt.
DR   PANTHER; PTHR24242; G-PROTEIN COUPLED RECEPTOR; 1.
DR   PANTHER; PTHR24242:SF387; OLFACTORY RECEPTOR 9A2; 1.
DR   Pfam; PF13853; 7tm_4; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR00245; OLFACTORYR.
DR   SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; G-protein coupled receptor; Glycoprotein; Membrane;
KW   Olfaction; Receptor; Reference proteome; Sensory transduction; Transducer;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..310
FT                   /note="Olfactory receptor 9A2"
FT                   /id="PRO_0000150676"
FT   TOPO_DOM        1..24
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        25..45
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        46..53
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        54..74
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        75..98
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        117..135
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        136..156
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        157..193
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        194..213
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        214..233
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        234..254
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        255..267
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        268..288
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        289..310
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        4
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   VARIANT         53
FT                   /note="R -> H (in dbSNP:rs9885986)"
FT                   /id="VAR_053253"
SQ   SEQUENCE   310 AA;  35330 MW;  276463E878614FE0 CRC64;
     MMDNHSSATE FHLLGFPGSQ GLHHILFAIF FFFYLVTLMG NTVIIVIVCV DKRLQSPMYF
     FLSHLSTLEI LVTTIIVPMM LWGLLFLGCR QYLSLHVSLN FSCGTMEFAL LGVMAVDRYV
     AVCNPLRYNI IMNSSTCIWV VIVSWVFGFL SEIWPIYATF QFTFRKSNSL DHFYCDRGQL
     LKLSCDNTLL TEFILFLMAV FILIGSLIPT IVSYTYIIST ILKIPSASGR RKAFSTFASH
     FTCVVIGYGS CLFLYVKPKQ TQGVEYNKIV SLLVSVLTPF LNPFIFTLRN DKVKEALRDG
     MKRCCQLLKD
//