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Q8NGT5

- OR9A2_HUMAN

UniProt

Q8NGT5 - OR9A2_HUMAN

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Protein

Olfactory receptor 9A2

Gene

OR9A2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 9A2
Alternative name(s):
Olfactory receptor OR7-2
Gene namesi
Name:OR9A2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:15093. OR9A2.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32785.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 310310Olfactory receptor 9A2PRO_0000150676Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi4 – 41N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8NGT5.
PRIDEiQ8NGT5.

Expressioni

Gene expression databases

CleanExiHS_OR9A2.
GenevestigatoriQ8NGT5.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000316518.

Structurei

3D structure databases

ProteinModelPortaliQ8NGT5.
SMRiQ8NGT5. Positions 37-146.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2424ExtracellularSequence AnalysisAdd
BLAST
Topological domaini46 – 538CytoplasmicSequence Analysis
Topological domaini75 – 9824ExtracellularSequence AnalysisAdd
BLAST
Topological domaini117 – 13519CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini157 – 19337ExtracellularSequence AnalysisAdd
BLAST
Topological domaini214 – 23320CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini255 – 26713ExtracellularSequence AnalysisAdd
BLAST
Topological domaini289 – 31022CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei25 – 4521Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei54 – 7421Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei136 – 15621Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei194 – 21320Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei234 – 25421Helical; Name=6Sequence AnalysisAdd
BLAST
Transmembranei268 – 28821Helical; Name=7Sequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG119442.
GeneTreeiENSGT00760000119169.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ8NGT5.
KOiK04257.
OMAiHYILFAI.
OrthoDBiEOG7KM5TB.
PhylomeDBiQ8NGT5.
TreeFamiTF336833.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGT5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MMDNHSSATE FHLLGFPGSQ GLHHILFAIF FFFYLVTLMG NTVIIVIVCV
60 70 80 90 100
DKRLQSPMYF FLSHLSTLEI LVTTIIVPMM LWGLLFLGCR QYLSLHVSLN
110 120 130 140 150
FSCGTMEFAL LGVMAVDRYV AVCNPLRYNI IMNSSTCIWV VIVSWVFGFL
160 170 180 190 200
SEIWPIYATF QFTFRKSNSL DHFYCDRGQL LKLSCDNTLL TEFILFLMAV
210 220 230 240 250
FILIGSLIPT IVSYTYIIST ILKIPSASGR RKAFSTFASH FTCVVIGYGS
260 270 280 290 300
CLFLYVKPKQ TQGVEYNKIV SLLVSVLTPF LNPFIFTLRN DKVKEALRDG
310
MKRCCQLLKD
Length:310
Mass (Da):35,330
Last modified:October 1, 2002 - v1
Checksum:i276463E878614FE0
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti53 – 531R → H.
Corresponds to variant rs9885986 [ dbSNP | Ensembl ].
VAR_053253

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB065696 Genomic DNA. Translation: BAC05919.1.
AB065874 Genomic DNA. Translation: BAC06092.1.
CH471198 Genomic DNA. Translation: EAW51890.1.
BC137048 mRNA. Translation: AAI37049.1.
BC137049 mRNA. Translation: AAI37050.1.
BK004391 Genomic DNA. Translation: DAA04789.1.
CCDSiCCDS34767.1.
RefSeqiNP_001001658.1. NM_001001658.1.
UniGeneiHs.553594.

Genome annotation databases

EnsembliENST00000350513; ENSP00000316518; ENSG00000179468.
GeneIDi135924.
KEGGihsa:135924.
UCSCiuc003wcc.1. human.

Polymorphism databases

DMDMi38372770.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB065696 Genomic DNA. Translation: BAC05919.1 .
AB065874 Genomic DNA. Translation: BAC06092.1 .
CH471198 Genomic DNA. Translation: EAW51890.1 .
BC137048 mRNA. Translation: AAI37049.1 .
BC137049 mRNA. Translation: AAI37050.1 .
BK004391 Genomic DNA. Translation: DAA04789.1 .
CCDSi CCDS34767.1.
RefSeqi NP_001001658.1. NM_001001658.1.
UniGenei Hs.553594.

3D structure databases

ProteinModelPortali Q8NGT5.
SMRi Q8NGT5. Positions 37-146.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000316518.

Protein family/group databases

GPCRDBi Search...

Polymorphism databases

DMDMi 38372770.

Proteomic databases

PaxDbi Q8NGT5.
PRIDEi Q8NGT5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000350513 ; ENSP00000316518 ; ENSG00000179468 .
GeneIDi 135924.
KEGGi hsa:135924.
UCSCi uc003wcc.1. human.

Organism-specific databases

CTDi 135924.
GeneCardsi GC07M142723.
HGNCi HGNC:15093. OR9A2.
neXtProti NX_Q8NGT5.
PharmGKBi PA32785.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG119442.
GeneTreei ENSGT00760000119169.
HOGENOMi HOG000041364.
HOVERGENi HBG017625.
InParanoidi Q8NGT5.
KOi K04257.
OMAi HYILFAI.
OrthoDBi EOG7KM5TB.
PhylomeDBi Q8NGT5.
TreeFami TF336833.

Enzyme and pathway databases

Reactomei REACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikii OR9A2.
GenomeRNAii 135924.
NextBioi 83510.
PROi Q8NGT5.

Gene expression databases

CleanExi HS_OR9A2.
Genevestigatori Q8NGT5.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  4. Cited for: IDENTIFICATION.
  5. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiOR9A2_HUMAN
AccessioniPrimary (citable) accession number: Q8NGT5
Secondary accession number(s): B9EH51, Q6IF71, Q8NGD9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: October 29, 2014
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3