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Protein

Olfactory receptor 9A2

Gene

OR9A2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 9A2
Alternative name(s):
Olfactory receptor OR7-2
Gene namesi
Name:OR9A2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7, UP000005640: Unplaced

Organism-specific databases

HGNCiHGNC:15093. OR9A2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2424ExtracellularSequence AnalysisAdd
BLAST
Transmembranei25 – 4521Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini46 – 538CytoplasmicSequence Analysis
Transmembranei54 – 7421Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini75 – 9824ExtracellularSequence AnalysisAdd
BLAST
Topological domaini117 – 13519CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei136 – 15621Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini157 – 19337ExtracellularSequence AnalysisAdd
BLAST
Transmembranei194 – 21320Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini214 – 23320CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei234 – 25421Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini255 – 26713ExtracellularSequence AnalysisAdd
BLAST
Transmembranei268 – 28821Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini289 – 31022CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32785.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 310310Olfactory receptor 9A2PRO_0000150676Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi4 – 41N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8NGT5.
PRIDEiQ8NGT5.

Expressioni

Gene expression databases

CleanExiHS_OR9A2.
ExpressionAtlasiQ8NGT5. baseline.
GenevestigatoriQ8NGT5.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000316518.

Structurei

3D structure databases

ProteinModelPortaliQ8NGT5.
SMRiQ8NGT5. Positions 37-146.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG119442.
GeneTreeiENSGT00760000119169.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ8NGT5.
KOiK04257.
OMAiMMSNHSS.
OrthoDBiEOG7KM5TB.
PhylomeDBiQ8NGT5.
TreeFamiTF336833.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGT5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMDNHSSATE FHLLGFPGSQ GLHHILFAIF FFFYLVTLMG NTVIIVIVCV
60 70 80 90 100
DKRLQSPMYF FLSHLSTLEI LVTTIIVPMM LWGLLFLGCR QYLSLHVSLN
110 120 130 140 150
FSCGTMEFAL LGVMAVDRYV AVCNPLRYNI IMNSSTCIWV VIVSWVFGFL
160 170 180 190 200
SEIWPIYATF QFTFRKSNSL DHFYCDRGQL LKLSCDNTLL TEFILFLMAV
210 220 230 240 250
FILIGSLIPT IVSYTYIIST ILKIPSASGR RKAFSTFASH FTCVVIGYGS
260 270 280 290 300
CLFLYVKPKQ TQGVEYNKIV SLLVSVLTPF LNPFIFTLRN DKVKEALRDG
310
MKRCCQLLKD
Length:310
Mass (Da):35,330
Last modified:October 1, 2002 - v1
Checksum:i276463E878614FE0
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti53 – 531R → H.
Corresponds to variant rs9885986 [ dbSNP | Ensembl ].
VAR_053253

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065696 Genomic DNA. Translation: BAC05919.1.
AB065874 Genomic DNA. Translation: BAC06092.1.
CH471198 Genomic DNA. Translation: EAW51890.1.
BC137048 mRNA. Translation: AAI37049.1.
BC137049 mRNA. Translation: AAI37050.1.
BK004391 Genomic DNA. Translation: DAA04789.1.
CCDSiCCDS34767.1.
RefSeqiNP_001001658.1. NM_001001658.1.
UniGeneiHs.553594.

Genome annotation databases

EnsembliENST00000350513; ENSP00000316518; ENSG00000179468.
ENST00000619330; ENSP00000479412; ENSG00000273914.
GeneIDi135924.
KEGGihsa:135924.
UCSCiuc003wcc.1. human.

Polymorphism databases

DMDMi38372770.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065696 Genomic DNA. Translation: BAC05919.1.
AB065874 Genomic DNA. Translation: BAC06092.1.
CH471198 Genomic DNA. Translation: EAW51890.1.
BC137048 mRNA. Translation: AAI37049.1.
BC137049 mRNA. Translation: AAI37050.1.
BK004391 Genomic DNA. Translation: DAA04789.1.
CCDSiCCDS34767.1.
RefSeqiNP_001001658.1. NM_001001658.1.
UniGeneiHs.553594.

3D structure databases

ProteinModelPortaliQ8NGT5.
SMRiQ8NGT5. Positions 37-146.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000316518.

Protein family/group databases

GPCRDBiSearch...

Polymorphism databases

DMDMi38372770.

Proteomic databases

PaxDbiQ8NGT5.
PRIDEiQ8NGT5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000350513; ENSP00000316518; ENSG00000179468.
ENST00000619330; ENSP00000479412; ENSG00000273914.
GeneIDi135924.
KEGGihsa:135924.
UCSCiuc003wcc.1. human.

Organism-specific databases

CTDi135924.
GeneCardsiGC07M142723.
HGNCiHGNC:15093. OR9A2.
neXtProtiNX_Q8NGT5.
PharmGKBiPA32785.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG119442.
GeneTreeiENSGT00760000119169.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ8NGT5.
KOiK04257.
OMAiMMSNHSS.
OrthoDBiEOG7KM5TB.
PhylomeDBiQ8NGT5.
TreeFamiTF336833.

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR9A2.
GenomeRNAii135924.
NextBioi83510.
PROiQ8NGT5.

Gene expression databases

CleanExiHS_OR9A2.
ExpressionAtlasiQ8NGT5. baseline.
GenevestigatoriQ8NGT5.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  4. Cited for: IDENTIFICATION.
  5. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiOR9A2_HUMAN
AccessioniPrimary (citable) accession number: Q8NGT5
Secondary accession number(s): B9EH51, Q6IF71, Q8NGD9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: March 4, 2015
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.