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Q8NGT5

- OR9A2_HUMAN

UniProt

Q8NGT5 - OR9A2_HUMAN

Protein

Olfactory receptor 9A2

Gene

OR9A2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 103 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    Odorant receptor.Curated

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW
    2. olfactory receptor activity Source: InterPro

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Olfaction, Sensory transduction

    Enzyme and pathway databases

    ReactomeiREACT_15488. Olfactory Signaling Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Olfactory receptor 9A2
    Alternative name(s):
    Olfactory receptor OR7-2
    Gene namesi
    Name:OR9A2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:15093. OR9A2.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA32785.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 310310Olfactory receptor 9A2PRO_0000150676Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi4 – 41N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ8NGT5.
    PRIDEiQ8NGT5.

    Expressioni

    Gene expression databases

    CleanExiHS_OR9A2.
    GenevestigatoriQ8NGT5.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000316518.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8NGT5.
    SMRiQ8NGT5. Positions 37-146.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2424ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini46 – 538CytoplasmicSequence Analysis
    Topological domaini75 – 9824ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini117 – 13519CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini157 – 19337ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini214 – 23320CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini255 – 26713ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini289 – 31022CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei25 – 4521Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei54 – 7421Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei136 – 15621Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei194 – 21320Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei234 – 25421Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei268 – 28821Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG119442.
    HOGENOMiHOG000041364.
    HOVERGENiHBG017625.
    InParanoidiQ8NGT5.
    KOiK04257.
    OMAiHYILFAI.
    OrthoDBiEOG7KM5TB.
    PhylomeDBiQ8NGT5.
    TreeFamiTF336833.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8NGT5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MMDNHSSATE FHLLGFPGSQ GLHHILFAIF FFFYLVTLMG NTVIIVIVCV    50
    DKRLQSPMYF FLSHLSTLEI LVTTIIVPMM LWGLLFLGCR QYLSLHVSLN 100
    FSCGTMEFAL LGVMAVDRYV AVCNPLRYNI IMNSSTCIWV VIVSWVFGFL 150
    SEIWPIYATF QFTFRKSNSL DHFYCDRGQL LKLSCDNTLL TEFILFLMAV 200
    FILIGSLIPT IVSYTYIIST ILKIPSASGR RKAFSTFASH FTCVVIGYGS 250
    CLFLYVKPKQ TQGVEYNKIV SLLVSVLTPF LNPFIFTLRN DKVKEALRDG 300
    MKRCCQLLKD 310
    Length:310
    Mass (Da):35,330
    Last modified:October 1, 2002 - v1
    Checksum:i276463E878614FE0
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti53 – 531R → H.
    Corresponds to variant rs9885986 [ dbSNP | Ensembl ].
    VAR_053253

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065696 Genomic DNA. Translation: BAC05919.1.
    AB065874 Genomic DNA. Translation: BAC06092.1.
    CH471198 Genomic DNA. Translation: EAW51890.1.
    BC137048 mRNA. Translation: AAI37049.1.
    BC137049 mRNA. Translation: AAI37050.1.
    BK004391 Genomic DNA. Translation: DAA04789.1.
    CCDSiCCDS34767.1.
    RefSeqiNP_001001658.1. NM_001001658.1.
    UniGeneiHs.553594.

    Genome annotation databases

    EnsembliENST00000350513; ENSP00000316518; ENSG00000179468.
    GeneIDi135924.
    KEGGihsa:135924.
    UCSCiuc003wcc.1. human.

    Polymorphism databases

    DMDMi38372770.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Human Olfactory Receptor Data Exploratorium (HORDE)

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065696 Genomic DNA. Translation: BAC05919.1 .
    AB065874 Genomic DNA. Translation: BAC06092.1 .
    CH471198 Genomic DNA. Translation: EAW51890.1 .
    BC137048 mRNA. Translation: AAI37049.1 .
    BC137049 mRNA. Translation: AAI37050.1 .
    BK004391 Genomic DNA. Translation: DAA04789.1 .
    CCDSi CCDS34767.1.
    RefSeqi NP_001001658.1. NM_001001658.1.
    UniGenei Hs.553594.

    3D structure databases

    ProteinModelPortali Q8NGT5.
    SMRi Q8NGT5. Positions 37-146.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000316518.

    Protein family/group databases

    GPCRDBi Search...

    Polymorphism databases

    DMDMi 38372770.

    Proteomic databases

    PaxDbi Q8NGT5.
    PRIDEi Q8NGT5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000350513 ; ENSP00000316518 ; ENSG00000179468 .
    GeneIDi 135924.
    KEGGi hsa:135924.
    UCSCi uc003wcc.1. human.

    Organism-specific databases

    CTDi 135924.
    GeneCardsi GC07M142723.
    HGNCi HGNC:15093. OR9A2.
    neXtProti NX_Q8NGT5.
    PharmGKBi PA32785.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG119442.
    HOGENOMi HOG000041364.
    HOVERGENi HBG017625.
    InParanoidi Q8NGT5.
    KOi K04257.
    OMAi HYILFAI.
    OrthoDBi EOG7KM5TB.
    PhylomeDBi Q8NGT5.
    TreeFami TF336833.

    Enzyme and pathway databases

    Reactomei REACT_15488. Olfactory Signaling Pathway.

    Miscellaneous databases

    GeneWikii OR9A2.
    GenomeRNAii 135924.
    NextBioi 83510.
    PROi Q8NGT5.

    Gene expression databases

    CleanExi HS_OR9A2.
    Genevestigatori Q8NGT5.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
      Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
      Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.
    4. Cited for: IDENTIFICATION.
    5. Erratum
      Malnic B., Godfrey P.A., Buck L.B.
      Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

    Entry informationi

    Entry nameiOR9A2_HUMAN
    AccessioniPrimary (citable) accession number: Q8NGT5
    Secondary accession number(s): B9EH51, Q6IF71, Q8NGD9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 10, 2003
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 103 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3