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Protein

Olfactory receptor 9A2

Gene

OR9A2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 9A2
Alternative name(s):
Olfactory receptor OR7-2
Gene namesi
Name:OR9A2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:15093. OR9A2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 24ExtracellularSequence analysisAdd BLAST24
Transmembranei25 – 45Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini46 – 53CytoplasmicSequence analysis8
Transmembranei54 – 74Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini75 – 98ExtracellularSequence analysisAdd BLAST24
Topological domaini117 – 135CytoplasmicSequence analysisAdd BLAST19
Transmembranei136 – 156Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini157 – 193ExtracellularSequence analysisAdd BLAST37
Transmembranei194 – 213Helical; Name=5Sequence analysisAdd BLAST20
Topological domaini214 – 233CytoplasmicSequence analysisAdd BLAST20
Transmembranei234 – 254Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini255 – 267ExtracellularSequence analysisAdd BLAST13
Transmembranei268 – 288Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini289 – 310CytoplasmicSequence analysisAdd BLAST22

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000179468.
ENSG00000273914.
PharmGKBiPA32785.

Polymorphism and mutation databases

BioMutaiOR9A2.
DMDMi38372770.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001506761 – 310Olfactory receptor 9A2Add BLAST310

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi4N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ8NGT5.
PaxDbiQ8NGT5.
PRIDEiQ8NGT5.

PTM databases

PhosphoSitePlusiQ8NGT5.

Expressioni

Gene expression databases

CleanExiHS_OR9A2.

Structurei

3D structure databases

ProteinModelPortaliQ8NGT5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410JB8S. Eukaryota.
ENOG41114F3. LUCA.
GeneTreeiENSGT00760000119169.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ8NGT5.
KOiK04257.
OMAiMMSNHSS.
OrthoDBiEOG091G0AZH.
PhylomeDBiQ8NGT5.
TreeFamiTF336833.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGT5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMDNHSSATE FHLLGFPGSQ GLHHILFAIF FFFYLVTLMG NTVIIVIVCV
60 70 80 90 100
DKRLQSPMYF FLSHLSTLEI LVTTIIVPMM LWGLLFLGCR QYLSLHVSLN
110 120 130 140 150
FSCGTMEFAL LGVMAVDRYV AVCNPLRYNI IMNSSTCIWV VIVSWVFGFL
160 170 180 190 200
SEIWPIYATF QFTFRKSNSL DHFYCDRGQL LKLSCDNTLL TEFILFLMAV
210 220 230 240 250
FILIGSLIPT IVSYTYIIST ILKIPSASGR RKAFSTFASH FTCVVIGYGS
260 270 280 290 300
CLFLYVKPKQ TQGVEYNKIV SLLVSVLTPF LNPFIFTLRN DKVKEALRDG
310
MKRCCQLLKD
Length:310
Mass (Da):35,330
Last modified:October 1, 2002 - v1
Checksum:i276463E878614FE0
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05325353R → H.Corresponds to variant rs9885986dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065696 Genomic DNA. Translation: BAC05919.1.
AB065874 Genomic DNA. Translation: BAC06092.1.
CH471198 Genomic DNA. Translation: EAW51890.1.
BC137048 mRNA. Translation: AAI37049.1.
BC137049 mRNA. Translation: AAI37050.1.
BK004391 Genomic DNA. Translation: DAA04789.1.
CCDSiCCDS34767.1.
RefSeqiNP_001001658.1. NM_001001658.1.
UniGeneiHs.553594.

Genome annotation databases

EnsembliENST00000350513; ENSP00000316518; ENSG00000179468.
ENST00000619330; ENSP00000479412; ENSG00000273914.
GeneIDi135924.
KEGGihsa:135924.
UCSCiuc003wcc.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065696 Genomic DNA. Translation: BAC05919.1.
AB065874 Genomic DNA. Translation: BAC06092.1.
CH471198 Genomic DNA. Translation: EAW51890.1.
BC137048 mRNA. Translation: AAI37049.1.
BC137049 mRNA. Translation: AAI37050.1.
BK004391 Genomic DNA. Translation: DAA04789.1.
CCDSiCCDS34767.1.
RefSeqiNP_001001658.1. NM_001001658.1.
UniGeneiHs.553594.

3D structure databases

ProteinModelPortaliQ8NGT5.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSitePlusiQ8NGT5.

Polymorphism and mutation databases

BioMutaiOR9A2.
DMDMi38372770.

Proteomic databases

EPDiQ8NGT5.
PaxDbiQ8NGT5.
PRIDEiQ8NGT5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000350513; ENSP00000316518; ENSG00000179468.
ENST00000619330; ENSP00000479412; ENSG00000273914.
GeneIDi135924.
KEGGihsa:135924.
UCSCiuc003wcc.2. human.

Organism-specific databases

CTDi135924.
GeneCardsiOR9A2.
HGNCiHGNC:15093. OR9A2.
neXtProtiNX_Q8NGT5.
OpenTargetsiENSG00000179468.
ENSG00000273914.
PharmGKBiPA32785.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JB8S. Eukaryota.
ENOG41114F3. LUCA.
GeneTreeiENSGT00760000119169.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ8NGT5.
KOiK04257.
OMAiMMSNHSS.
OrthoDBiEOG091G0AZH.
PhylomeDBiQ8NGT5.
TreeFamiTF336833.

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR9A2.
GenomeRNAii135924.
PROiQ8NGT5.

Gene expression databases

CleanExiHS_OR9A2.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOR9A2_HUMAN
AccessioniPrimary (citable) accession number: Q8NGT5
Secondary accession number(s): B9EH51, Q6IF71, Q8NGD9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: November 2, 2016
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.