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Q8NGT5 (OR9A2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 101. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Olfactory receptor 9A2
Alternative name(s):
Olfactory receptor OR7-2
Gene names
Name:OR9A2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length310 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Odorant receptor Potential.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 310310Olfactory receptor 9A2
PRO_0000150676

Regions

Topological domain1 – 2424Extracellular Potential
Transmembrane25 – 4521Helical; Name=1; Potential
Topological domain46 – 538Cytoplasmic Potential
Transmembrane54 – 7421Helical; Name=2; Potential
Topological domain75 – 9824Extracellular Potential
Topological domain117 – 13519Cytoplasmic Potential
Transmembrane136 – 15621Helical; Name=4; Potential
Topological domain157 – 19337Extracellular Potential
Transmembrane194 – 21320Helical; Name=5; Potential
Topological domain214 – 23320Cytoplasmic Potential
Transmembrane234 – 25421Helical; Name=6; Potential
Topological domain255 – 26713Extracellular Potential
Transmembrane268 – 28821Helical; Name=7; Potential
Topological domain289 – 31022Cytoplasmic Potential

Amino acid modifications

Glycosylation41N-linked (GlcNAc...) Potential

Natural variations

Natural variant531R → H.
Corresponds to variant rs9885986 [ dbSNP | Ensembl ].
VAR_053253

Sequences

Sequence LengthMass (Da)Tools
Q8NGT5 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: 276463E878614FE0

FASTA31035,330
        10         20         30         40         50         60 
MMDNHSSATE FHLLGFPGSQ GLHHILFAIF FFFYLVTLMG NTVIIVIVCV DKRLQSPMYF 

        70         80         90        100        110        120 
FLSHLSTLEI LVTTIIVPMM LWGLLFLGCR QYLSLHVSLN FSCGTMEFAL LGVMAVDRYV 

       130        140        150        160        170        180 
AVCNPLRYNI IMNSSTCIWV VIVSWVFGFL SEIWPIYATF QFTFRKSNSL DHFYCDRGQL 

       190        200        210        220        230        240 
LKLSCDNTLL TEFILFLMAV FILIGSLIPT IVSYTYIIST ILKIPSASGR RKAFSTFASH 

       250        260        270        280        290        300 
FTCVVIGYGS CLFLYVKPKQ TQGVEYNKIV SLLVSVLTPF LNPFIFTLRN DKVKEALRDG 

       310 
MKRCCQLLKD 

« Hide

References

« Hide 'large scale' references
[1]"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.
[4]"The human olfactory receptor gene family."
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
[5]Erratum
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB065696 Genomic DNA. Translation: BAC05919.1.
AB065874 Genomic DNA. Translation: BAC06092.1.
CH471198 Genomic DNA. Translation: EAW51890.1.
BC137048 mRNA. Translation: AAI37049.1.
BC137049 mRNA. Translation: AAI37050.1.
BK004391 Genomic DNA. Translation: DAA04789.1.
CCDSCCDS34767.1.
RefSeqNP_001001658.1. NM_001001658.1.
UniGeneHs.553594.

3D structure databases

ProteinModelPortalQ8NGT5.
SMRQ8NGT5. Positions 37-146.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000316518.

Protein family/group databases

GPCRDBSearch...

Polymorphism databases

DMDM38372770.

Proteomic databases

PaxDbQ8NGT5.
PRIDEQ8NGT5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000350513; ENSP00000316518; ENSG00000179468.
ENST00000564856; ENSP00000455243; ENSG00000261686.
GeneID135924.
KEGGhsa:135924.
UCSCuc003wcc.1. human.

Organism-specific databases

CTD135924.
GeneCardsGC07M142723.
HGNCHGNC:15093. OR9A2.
neXtProtNX_Q8NGT5.
PharmGKBPA32785.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG119442.
HOGENOMHOG000041364.
HOVERGENHBG017625.
InParanoidQ8NGT5.
KOK04257.
OMAHYILFAI.
OrthoDBEOG7KM5TB.
PhylomeDBQ8NGT5.
TreeFamTF336833.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

CleanExHS_OR9A2.
GenevestigatorQ8NGT5.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiOR9A2.
GenomeRNAi135924.
NextBio83510.
PROQ8NGT5.

Entry information

Entry nameOR9A2_HUMAN
AccessionPrimary (citable) accession number: Q8NGT5
Secondary accession number(s): B9EH51, Q6IF71, Q8NGD9
Entry history
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: July 9, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 7

Human chromosome 7: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries