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Q8NGT2

- O13J1_HUMAN

UniProt

Q8NGT2 - O13J1_HUMAN

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Protein

Olfactory receptor 13J1

Gene

OR13J1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 13J1
Alternative name(s):
Olfactory receptor OR9-2
Gene namesi
Name:OR13J1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 9

Organism-specific databases

HGNCiHGNC:15108. OR13J1.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32049.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 312312Olfactory receptor 13J1PRO_0000150741Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi97 ↔ 189PROSITE-ProRule annotation
Glycosylationi191 – 1911N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGT2.
PRIDEiQ8NGT2.

Expressioni

Gene expression databases

BgeeiQ8NGT2.
CleanExiHS_OR13J1.
GenevestigatoriQ8NGT2.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000367219.

Structurei

3D structure databases

ProteinModelPortaliQ8NGT2.
SMRiQ8NGT2. Positions 30-299.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2525ExtracellularSequence AnalysisAdd
BLAST
Topological domaini47 – 548CytoplasmicSequence Analysis
Topological domaini76 – 9924ExtracellularSequence AnalysisAdd
BLAST
Topological domaini121 – 13919CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini161 – 19737ExtracellularSequence AnalysisAdd
BLAST
Topological domaini218 – 23720CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini259 – 27113ExtracellularSequence AnalysisAdd
BLAST
Topological domaini293 – 31220CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei26 – 4621Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei55 – 7521Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei100 – 12021Helical; Name=3Sequence AnalysisAdd
BLAST
Transmembranei140 – 16021Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei198 – 21720Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei238 – 25821Helical; Name=6Sequence AnalysisAdd
BLAST
Transmembranei272 – 29221Helical; Name=7Sequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG134444.
GeneTreeiENSGT00760000119058.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiQ8NGT2.
KOiK04257.
OMAiFTVLYAM.
OrthoDBiEOG71K63J.
PhylomeDBiQ8NGT2.
TreeFamiTF352686.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGT2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEPLNRTEVS EFFLKGFSGY PALEHLLFPL CSAMYLVTLL GNTAIMAVSV
60 70 80 90 100
LDIHLHTPVY FFLGNLSTLD ICYTPTFVPL MLVHLLSSRK TISFAVCAIQ
110 120 130 140 150
MCLSLSTGST ECLLLAITAY DRYLAICQPL RYHVLMSHRL CVLLMGAAWV
160 170 180 190 200
LCLLKSVTEM VISMRLPFCG HHVVSHFTCK ILAVLKLACG NTSVSEDFLL
210 220 230 240 250
AGSILLLPVP LAFICLSYLL ILATILRVPS AARCCKAFST CLAHLAVVLL
260 270 280 290 300
FYGTIIFMYL KPKSKEAHIS DEVFTVLYAM VTTMLNPTIY SLRNKEVKEA
310
ARKVWGRSRA SR
Length:312
Mass (Da):34,689
Last modified:October 1, 2002 - v1
Checksum:i7AE2FAB223A9218B
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti133 – 1331H → R.
Corresponds to variant rs7044405 [ dbSNP | Ensembl ].
VAR_053304

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB065705 Genomic DNA. Translation: BAC05928.1.
AL133410 Genomic DNA. Translation: CAI10998.1.
CH471071 Genomic DNA. Translation: EAW58323.1.
BC136715 mRNA. Translation: AAI36716.1.
BC136716 mRNA. Translation: AAI36717.1.
AF399603 Genomic DNA. Translation: AAK95088.1.
BK004442 Genomic DNA. Translation: DAA04840.1.
CCDSiCCDS35011.1.
RefSeqiNP_001004487.1. NM_001004487.1.
UniGeneiHs.527480.

Genome annotation databases

EnsembliENST00000377981; ENSP00000367219; ENSG00000168828.
GeneIDi392309.
KEGGihsa:392309.
UCSCiuc011lph.2. human.

Polymorphism databases

DMDMi38372769.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB065705 Genomic DNA. Translation: BAC05928.1 .
AL133410 Genomic DNA. Translation: CAI10998.1 .
CH471071 Genomic DNA. Translation: EAW58323.1 .
BC136715 mRNA. Translation: AAI36716.1 .
BC136716 mRNA. Translation: AAI36717.1 .
AF399603 Genomic DNA. Translation: AAK95088.1 .
BK004442 Genomic DNA. Translation: DAA04840.1 .
CCDSi CCDS35011.1.
RefSeqi NP_001004487.1. NM_001004487.1.
UniGenei Hs.527480.

3D structure databases

ProteinModelPortali Q8NGT2.
SMRi Q8NGT2. Positions 30-299.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000367219.

Protein family/group databases

GPCRDBi Search...

Polymorphism databases

DMDMi 38372769.

Proteomic databases

PaxDbi Q8NGT2.
PRIDEi Q8NGT2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000377981 ; ENSP00000367219 ; ENSG00000168828 .
GeneIDi 392309.
KEGGi hsa:392309.
UCSCi uc011lph.2. human.

Organism-specific databases

CTDi 392309.
GeneCardsi GC09M035861.
HGNCi HGNC:15108. OR13J1.
neXtProti NX_Q8NGT2.
PharmGKBi PA32049.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG134444.
GeneTreei ENSGT00760000119058.
HOGENOMi HOG000041365.
HOVERGENi HBG017625.
InParanoidi Q8NGT2.
KOi K04257.
OMAi FTVLYAM.
OrthoDBi EOG71K63J.
PhylomeDBi Q8NGT2.
TreeFami TF352686.

Enzyme and pathway databases

Reactomei REACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikii OR13J1.
GenomeRNAii 392309.
NextBioi 105088.
PROi Q8NGT2.

Gene expression databases

Bgeei Q8NGT2.
CleanExi HS_OR13J1.
Genevestigatori Q8NGT2.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  5. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-283.
  6. Cited for: IDENTIFICATION.
  7. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiO13J1_HUMAN
AccessioniPrimary (citable) accession number: Q8NGT2
Secondary accession number(s): B2RN66, Q6IF20, Q96R40
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: October 29, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3