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Protein

Olfactory receptor 13J1

Gene

OR13J1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 13J1
Alternative name(s):
Olfactory receptor OR9-2
Gene namesi
Name:OR13J1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000168828.5.
HGNCiHGNC:15108. OR13J1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 25ExtracellularSequence analysisAdd BLAST25
Transmembranei26 – 46Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini47 – 54CytoplasmicSequence analysis8
Transmembranei55 – 75Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini76 – 99ExtracellularSequence analysisAdd BLAST24
Transmembranei100 – 120Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini121 – 139CytoplasmicSequence analysisAdd BLAST19
Transmembranei140 – 160Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini161 – 197ExtracellularSequence analysisAdd BLAST37
Transmembranei198 – 217Helical; Name=5Sequence analysisAdd BLAST20
Topological domaini218 – 237CytoplasmicSequence analysisAdd BLAST20
Transmembranei238 – 258Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini259 – 271ExtracellularSequence analysisAdd BLAST13
Transmembranei272 – 292Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini293 – 312CytoplasmicSequence analysisAdd BLAST20

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi392309.
PharmGKBiPA32049.

Polymorphism and mutation databases

BioMutaiOR13J1.
DMDMi38372769.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001507411 – 312Olfactory receptor 13J1Add BLAST312

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi97 ↔ 189PROSITE-ProRule annotation
Glycosylationi191N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGT2.
PRIDEiQ8NGT2.

PTM databases

PhosphoSitePlusiQ8NGT2.

Expressioni

Gene expression databases

BgeeiENSG00000168828.
CleanExiHS_OR13J1.

Interactioni

Protein-protein interaction databases

BioGridi134172. 11 interactors.
STRINGi9606.ENSP00000367219.

Structurei

3D structure databases

ProteinModelPortaliQ8NGT2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJWF. Eukaryota.
ENOG41113GF. LUCA.
GeneTreeiENSGT00760000119058.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiQ8NGT2.
KOiK04257.
OMAiLCLFKSV.
OrthoDBiEOG091G0AZH.
PhylomeDBiQ8NGT2.
TreeFamiTF352686.

Family and domain databases

InterProiView protein in InterPro
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
PfamiView protein in Pfam
PF13853. 7tm_4. 1 hit.
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiView protein in PROSITE
PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8NGT2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPLNRTEVS EFFLKGFSGY PALEHLLFPL CSAMYLVTLL GNTAIMAVSV
60 70 80 90 100
LDIHLHTPVY FFLGNLSTLD ICYTPTFVPL MLVHLLSSRK TISFAVCAIQ
110 120 130 140 150
MCLSLSTGST ECLLLAITAY DRYLAICQPL RYHVLMSHRL CVLLMGAAWV
160 170 180 190 200
LCLLKSVTEM VISMRLPFCG HHVVSHFTCK ILAVLKLACG NTSVSEDFLL
210 220 230 240 250
AGSILLLPVP LAFICLSYLL ILATILRVPS AARCCKAFST CLAHLAVVLL
260 270 280 290 300
FYGTIIFMYL KPKSKEAHIS DEVFTVLYAM VTTMLNPTIY SLRNKEVKEA
310
ARKVWGRSRA SR
Length:312
Mass (Da):34,689
Last modified:October 1, 2002 - v1
Checksum:i7AE2FAB223A9218B
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_053304133H → R. Corresponds to variant dbSNP:rs7044405Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065705 Genomic DNA. Translation: BAC05928.1.
AL133410 Genomic DNA. No translation available.
CH471071 Genomic DNA. Translation: EAW58323.1.
BC136715 mRNA. Translation: AAI36716.1.
BC136716 mRNA. Translation: AAI36717.1.
AF399603 Genomic DNA. Translation: AAK95088.1.
BK004442 Genomic DNA. Translation: DAA04840.1.
CCDSiCCDS35011.1.
RefSeqiNP_001004487.1. NM_001004487.1.
UniGeneiHs.527480.

Genome annotation databases

EnsembliENST00000377981; ENSP00000367219; ENSG00000168828.
GeneIDi392309.
KEGGihsa:392309.
UCSCiuc011lph.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiO13J1_HUMAN
AccessioniPrimary (citable) accession number: Q8NGT2
Secondary accession number(s): B2RN66, Q6IF20, Q96R40
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: September 27, 2017
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families