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Q8NGT2

- O13J1_HUMAN

UniProt

Q8NGT2 - O13J1_HUMAN

Protein

Olfactory receptor 13J1

Gene

OR13J1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    Odorant receptor.Curated

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW
    2. olfactory receptor activity Source: InterPro

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Olfaction, Sensory transduction

    Enzyme and pathway databases

    ReactomeiREACT_15488. Olfactory Signaling Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Olfactory receptor 13J1
    Alternative name(s):
    Olfactory receptor OR9-2
    Gene namesi
    Name:OR13J1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 9

    Organism-specific databases

    HGNCiHGNC:15108. OR13J1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA32049.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 312312Olfactory receptor 13J1PRO_0000150741Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi5 – 51N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi97 ↔ 189PROSITE-ProRule annotation
    Glycosylationi191 – 1911N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ8NGT2.
    PRIDEiQ8NGT2.

    Expressioni

    Gene expression databases

    BgeeiQ8NGT2.
    CleanExiHS_OR13J1.
    GenevestigatoriQ8NGT2.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000367219.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8NGT2.
    SMRiQ8NGT2. Positions 30-299.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2525ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini47 – 548CytoplasmicSequence Analysis
    Topological domaini76 – 9924ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini121 – 13919CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini161 – 19737ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini218 – 23720CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini259 – 27113ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini293 – 31220CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei26 – 4621Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei55 – 7521Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei100 – 12021Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei140 – 16021Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei198 – 21720Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei238 – 25821Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei272 – 29221Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG134444.
    HOGENOMiHOG000041365.
    HOVERGENiHBG017625.
    InParanoidiQ8NGT2.
    KOiK04257.
    OMAiFTVLYAM.
    OrthoDBiEOG71K63J.
    PhylomeDBiQ8NGT2.
    TreeFamiTF352686.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8NGT2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEPLNRTEVS EFFLKGFSGY PALEHLLFPL CSAMYLVTLL GNTAIMAVSV    50
    LDIHLHTPVY FFLGNLSTLD ICYTPTFVPL MLVHLLSSRK TISFAVCAIQ 100
    MCLSLSTGST ECLLLAITAY DRYLAICQPL RYHVLMSHRL CVLLMGAAWV 150
    LCLLKSVTEM VISMRLPFCG HHVVSHFTCK ILAVLKLACG NTSVSEDFLL 200
    AGSILLLPVP LAFICLSYLL ILATILRVPS AARCCKAFST CLAHLAVVLL 250
    FYGTIIFMYL KPKSKEAHIS DEVFTVLYAM VTTMLNPTIY SLRNKEVKEA 300
    ARKVWGRSRA SR 312
    Length:312
    Mass (Da):34,689
    Last modified:October 1, 2002 - v1
    Checksum:i7AE2FAB223A9218B
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti133 – 1331H → R.
    Corresponds to variant rs7044405 [ dbSNP | Ensembl ].
    VAR_053304

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065705 Genomic DNA. Translation: BAC05928.1.
    AL133410 Genomic DNA. Translation: CAI10998.1.
    CH471071 Genomic DNA. Translation: EAW58323.1.
    BC136715 mRNA. Translation: AAI36716.1.
    BC136716 mRNA. Translation: AAI36717.1.
    AF399603 Genomic DNA. Translation: AAK95088.1.
    BK004442 Genomic DNA. Translation: DAA04840.1.
    CCDSiCCDS35011.1.
    RefSeqiNP_001004487.1. NM_001004487.1.
    UniGeneiHs.527480.

    Genome annotation databases

    EnsembliENST00000377981; ENSP00000367219; ENSG00000168828.
    GeneIDi392309.
    KEGGihsa:392309.
    UCSCiuc011lph.2. human.

    Polymorphism databases

    DMDMi38372769.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Human Olfactory Receptor Data Exploratorium (HORDE)

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065705 Genomic DNA. Translation: BAC05928.1 .
    AL133410 Genomic DNA. Translation: CAI10998.1 .
    CH471071 Genomic DNA. Translation: EAW58323.1 .
    BC136715 mRNA. Translation: AAI36716.1 .
    BC136716 mRNA. Translation: AAI36717.1 .
    AF399603 Genomic DNA. Translation: AAK95088.1 .
    BK004442 Genomic DNA. Translation: DAA04840.1 .
    CCDSi CCDS35011.1.
    RefSeqi NP_001004487.1. NM_001004487.1.
    UniGenei Hs.527480.

    3D structure databases

    ProteinModelPortali Q8NGT2.
    SMRi Q8NGT2. Positions 30-299.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000367219.

    Protein family/group databases

    GPCRDBi Search...

    Polymorphism databases

    DMDMi 38372769.

    Proteomic databases

    PaxDbi Q8NGT2.
    PRIDEi Q8NGT2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000377981 ; ENSP00000367219 ; ENSG00000168828 .
    GeneIDi 392309.
    KEGGi hsa:392309.
    UCSCi uc011lph.2. human.

    Organism-specific databases

    CTDi 392309.
    GeneCardsi GC09M035861.
    HGNCi HGNC:15108. OR13J1.
    neXtProti NX_Q8NGT2.
    PharmGKBi PA32049.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG134444.
    HOGENOMi HOG000041365.
    HOVERGENi HBG017625.
    InParanoidi Q8NGT2.
    KOi K04257.
    OMAi FTVLYAM.
    OrthoDBi EOG71K63J.
    PhylomeDBi Q8NGT2.
    TreeFami TF352686.

    Enzyme and pathway databases

    Reactomei REACT_15488. Olfactory Signaling Pathway.

    Miscellaneous databases

    GeneWikii OR13J1.
    GenomeRNAii 392309.
    NextBioi 105088.
    PROi Q8NGT2.

    Gene expression databases

    Bgeei Q8NGT2.
    CleanExi HS_OR13J1.
    Genevestigatori Q8NGT2.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
      Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
      Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "DNA sequence and analysis of human chromosome 9."
      Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
      , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
      Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    5. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-283.
    6. Cited for: IDENTIFICATION.
    7. Erratum
      Malnic B., Godfrey P.A., Buck L.B.
      Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

    Entry informationi

    Entry nameiO13J1_HUMAN
    AccessioniPrimary (citable) accession number: Q8NGT2
    Secondary accession number(s): B2RN66, Q6IF20, Q96R40
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 10, 2003
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 101 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 9
      Human chromosome 9: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3