ID   OR2K2_HUMAN             Reviewed;         316 AA.
AC   Q8NGT1; Q2TA61; Q5VYK4; Q6IFI5;
DT   10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT   10-APR-2019, sequence version 3.
DT   24-JAN-2024, entry version 163.
DE   RecName: Full=Olfactory receptor 2K2;
DE   AltName: Full=HTPCRH06;
DE   AltName: Full=Olfactory receptor OR9-17;
GN   Name=OR2K2; Synonyms=OR2AR1P;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA   Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT   "Genome-wide discovery and analysis of human seven transmembrane helix
RT   receptor genes.";
RL   Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15164053; DOI=10.1038/nature02465;
RA   Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L.,
RA   Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R.,
RA   Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S.,
RA   Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K.,
RA   Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y.,
RA   Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C.,
RA   Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E.,
RA   Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M.,
RA   Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J.,
RA   Frankish A., Frankland J.A., French L., Fricker D.G., Garner P.,
RA   Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA   Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA   Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA   Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA   Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA   Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S.,
RA   Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J.,
RA   Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E.,
RA   McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V.,
RA   Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S.,
RA   Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K.,
RA   Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J.,
RA   Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M.,
RA   West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L.,
RA   Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M.,
RA   Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J.,
RA   Dunham I.;
RT   "DNA sequence and analysis of human chromosome 9.";
RL   Nature 429:369-374(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   IDENTIFICATION.
RX   PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA   Malnic B., Godfrey P.A., Buck L.B.;
RT   "The human olfactory receptor gene family.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN   [5]
RP   ERRATUM OF PUBMED:14983052.
RA   Malnic B., Godfrey P.A., Buck L.B.;
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC   -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=DAA04675.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC   -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC       URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR2K2";
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DR   EMBL; AB065707; BAC05929.1; -; Genomic_DNA.
DR   EMBL; AL354661; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC111086; AAI11087.1; -; mRNA.
DR   EMBL; BK004277; DAA04675.1; ALT_INIT; Genomic_DNA.
DR   CCDS; CCDS6778.1; -.
DR   RefSeq; NP_995581.1; NM_205859.1.
DR   RefSeq; XP_011516822.1; XM_011518520.2.
DR   AlphaFoldDB; Q8NGT1; -.
DR   SMR; Q8NGT1; -.
DR   BioGRID; 117636; 9.
DR   IntAct; Q8NGT1; 2.
DR   STRING; 9606.ENSP00000305055; -.
DR   GlyCosmos; Q8NGT1; 1 site, No reported glycans.
DR   GlyGen; Q8NGT1; 1 site.
DR   iPTMnet; Q8NGT1; -.
DR   PhosphoSitePlus; Q8NGT1; -.
DR   BioMuta; OR2K2; -.
DR   DMDM; 218511729; -.
DR   MassIVE; Q8NGT1; -.
DR   PaxDb; 9606-ENSP00000305055; -.
DR   Antibodypedia; 15116; 118 antibodies from 22 providers.
DR   DNASU; 26248; -.
DR   Ensembl; ENST00000302681.3; ENSP00000305055.1; ENSG00000171133.4.
DR   GeneID; 26248; -.
DR   KEGG; hsa:26248; -.
DR   MANE-Select; ENST00000302681.3; ENSP00000305055.1; NM_205859.2; NP_995581.1.
DR   UCSC; uc011lwp.2; human.
DR   AGR; HGNC:8264; -.
DR   CTD; 26248; -.
DR   GeneCards; OR2K2; -.
DR   HGNC; HGNC:8264; OR2K2.
DR   HPA; ENSG00000171133; Not detected.
DR   neXtProt; NX_Q8NGT1; -.
DR   OpenTargets; ENSG00000171133; -.
DR   PharmGKB; PA32181; -.
DR   VEuPathDB; HostDB:ENSG00000171133; -.
DR   eggNOG; ENOG502R18M; Eukaryota.
DR   GeneTree; ENSGT01040000240406; -.
DR   HOGENOM; CLU_012526_0_1_1; -.
DR   InParanoid; Q8NGT1; -.
DR   OrthoDB; 5260598at2759; -.
DR   PhylomeDB; Q8NGT1; -.
DR   TreeFam; TF352686; -.
DR   PathwayCommons; Q8NGT1; -.
DR   Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR   SignaLink; Q8NGT1; -.
DR   BioGRID-ORCS; 26248; 6 hits in 724 CRISPR screens.
DR   GeneWiki; OR2K2; -.
DR   GenomeRNAi; 26248; -.
DR   Pharos; Q8NGT1; Tdark.
DR   PRO; PR:Q8NGT1; -.
DR   Proteomes; UP000005640; Chromosome 9.
DR   RNAct; Q8NGT1; Protein.
DR   Bgee; ENSG00000171133; Expressed in male germ line stem cell (sensu Vertebrata) in testis and 19 other cell types or tissues.
DR   ExpressionAtlas; Q8NGT1; baseline and differential.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR   GO; GO:0050911; P:detection of chemical stimulus involved in sensory perception of smell; IBA:GO_Central.
DR   CDD; cd15430; 7tmA_OR13-like; 1.
DR   Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR000725; Olfact_rcpt.
DR   PANTHER; PTHR26453; OLFACTORY RECEPTOR; 1.
DR   PANTHER; PTHR26453:SF198; OLFACTORY RECEPTOR 2K2; 1.
DR   Pfam; PF13853; 7tm_4; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR00245; OLFACTORYR.
DR   SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
DR   Genevisible; Q8NGT1; HS.
PE   2: Evidence at transcript level;
KW   Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW   Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW   Transducer; Transmembrane; Transmembrane helix.
FT   CHAIN           1..316
FT                   /note="Olfactory receptor 2K2"
FT                   /id="PRO_0000150485"
FT   TOPO_DOM        1..20
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        21..41
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        42..65
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        66..86
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        87..97
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        98..118
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        119..143
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        144..164
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        165..199
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        200..220
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        221..238
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        239..259
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        260..270
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        271..291
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        292..316
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        5
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        97..188
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ   SEQUENCE   316 AA;  35045 MW;  BA48E3C2E6DF7A79 CRC64;
     MQGENFTIWS IFFLEGFSQY PGLEVVLFVF SLVMYLTTLL GNSTLILITI LDSRLKTPMY
     LFLGNLSFMD ICYTSASVPT LLVNLLSSQK TIIFSGCAVQ MYLSLAMGST ECVLLAVMAY
     DRYVAICNPL RYSIIMNRCV CARMATVSWV TGCLTALLET SFALQIPLCG NLIDHFTCEI
     LAVLKLACTS SLLMNTIMLV VSILLLPIPM LLVCISYIFI LSTILRITSA EGRNKAFSTC
     GAHLTVVILY YGAALSMYLK PSSSNAQKID KIISLLYGVL TPMLNPIIYS LRNKEVKDAM
     KKLLGKITLH QTHEHL
//