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Protein

Olfactory receptor 2K2

Gene

OR2K2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 2K2
Alternative name(s):
HTPCRH06
Olfactory receptor OR9-17
Gene namesi
Name:OR2K2
Synonyms:OR2AR1P
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:8264. OR2K2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 5454ExtracellularSequence AnalysisAdd
BLAST
Transmembranei55 – 7824Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini79 – 868CytoplasmicSequence Analysis
Transmembranei87 – 10822Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini109 – 12921ExtracellularSequence AnalysisAdd
BLAST
Transmembranei130 – 14920Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini150 – 16819CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei169 – 18719Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini188 – 22336ExtracellularSequence AnalysisAdd
BLAST
Transmembranei224 – 24724Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini248 – 26417CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei265 – 28723Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini288 – 30013ExtracellularSequence AnalysisAdd
BLAST
Transmembranei301 – 32020Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini321 – 34525CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32181.

Polymorphism and mutation databases

BioMutaiOR2K2.
DMDMi218511729.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 345345Olfactory receptor 2K2PRO_0000150485Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi34 – 341N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi126 ↔ 217PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGT1.
PRIDEiQ8NGT1.

PTM databases

PhosphoSiteiQ8NGT1.

Expressioni

Gene expression databases

CleanExiHS_OR2K2.
GenevestigatoriQ8NGT1.

Organism-specific databases

HPAiHPA024261.

Interactioni

Protein-protein interaction databases

BioGridi117636. 1 interaction.
STRINGi9606.ENSP00000305055.

Structurei

3D structure databases

ProteinModelPortaliQ8NGT1.
SMRiQ8NGT1. Positions 51-332.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG146062.
GeneTreeiENSGT00760000119058.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiQ8NGT1.
KOiK04257.
OMAiCARMATV.
OrthoDBiEOG71K63J.
PhylomeDBiQ8NGT1.
TreeFamiTF352686.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGT1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNITLYSFLY VLRLNEGNST GRNIDERKKM QGENFTIWSI FFLEGFSQYP
60 70 80 90 100
GLEVVLFVFS LVMYLTTLLG NSTLILITIL DSRLKTPMYL FLGNLSFMDI
110 120 130 140 150
CYTSASVPTL LVNLLSSQKT IIFSGCAVQM YLSLAMGSTE CVLLAVMAYD
160 170 180 190 200
RYVAICNPLR YSIIMNRCVC ARMATVSWVT GCLTALLETS FALQIPLCGN
210 220 230 240 250
LIDHFTCEIL AVLKLACTSS LLMNTIMLVV SILLLPIPML LVCISYIFIL
260 270 280 290 300
STILRITSAE GRNKAFSTCG AHLTVVILYY GAALSMYLKP SSSNAQKIDK
310 320 330 340
IISLLYGVLT PMLNPIIYSL RNKEVKDAMK KLLGKITLHQ THEHL
Length:345
Mass (Da):38,473
Last modified:December 16, 2008 - v2
Checksum:iDEFA8BE03AF4428D
GO

Sequence cautioni

The sequence BAC05929.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAH73239.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065707 Genomic DNA. Translation: BAC05929.1. Different initiation.
AL354661 Genomic DNA. Translation: CAH73239.1. Different initiation.
BC111086 mRNA. Translation: AAI11087.1.
BK004277 Genomic DNA. Translation: DAA04675.1.
RefSeqiNP_995581.1. NM_205859.1.
XP_005251971.1. XM_005251914.2.
UniGeneiHs.381312.

Genome annotation databases

EnsembliENST00000374428; ENSP00000363550; ENSG00000171133.
GeneIDi26248.
KEGGihsa:26248.
UCSCiuc011lwp.2. human.

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065707 Genomic DNA. Translation: BAC05929.1. Different initiation.
AL354661 Genomic DNA. Translation: CAH73239.1. Different initiation.
BC111086 mRNA. Translation: AAI11087.1.
BK004277 Genomic DNA. Translation: DAA04675.1.
RefSeqiNP_995581.1. NM_205859.1.
XP_005251971.1. XM_005251914.2.
UniGeneiHs.381312.

3D structure databases

ProteinModelPortaliQ8NGT1.
SMRiQ8NGT1. Positions 51-332.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117636. 1 interaction.
STRINGi9606.ENSP00000305055.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiQ8NGT1.

Polymorphism and mutation databases

BioMutaiOR2K2.
DMDMi218511729.

Proteomic databases

PaxDbiQ8NGT1.
PRIDEiQ8NGT1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000374428; ENSP00000363550; ENSG00000171133.
GeneIDi26248.
KEGGihsa:26248.
UCSCiuc011lwp.2. human.

Organism-specific databases

CTDi26248.
GeneCardsiGC09M114089.
HGNCiHGNC:8264. OR2K2.
HPAiHPA024261.
neXtProtiNX_Q8NGT1.
PharmGKBiPA32181.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG146062.
GeneTreeiENSGT00760000119058.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiQ8NGT1.
KOiK04257.
OMAiCARMATV.
OrthoDBiEOG71K63J.
PhylomeDBiQ8NGT1.
TreeFamiTF352686.

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR2K2.
GenomeRNAii26248.
NextBioi48456.
PROiQ8NGT1.

Gene expression databases

CleanExiHS_OR2K2.
GenevestigatoriQ8NGT1.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 30-345.
  4. Cited for: IDENTIFICATION.
  5. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiOR2K2_HUMAN
AccessioniPrimary (citable) accession number: Q8NGT1
Secondary accession number(s): Q2TA61, Q5VYK4, Q6IFI5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: December 16, 2008
Last modified: May 27, 2015
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-30 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.