Q8NGT1 (OR2K2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Olfactory receptor 2K2

Alternative name(s):
HTPCRH06
Olfactory receptor OR9-17

Gene names

Name:	OR2K2
Synonyms:	OR2AR1P

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	345 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Odorant receptor Potential.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.
Caution	It is uncertain whether Met-1 or Met-30 is the initiator.
Sequence caution	The sequence BAC05929.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence CAH73239.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
Biological process	Olfaction Sensory transduction
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	detection of chemical stimulus involved in sensory perception of smell Inferred from electronic annotation. Source: GOC
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Traceable author statement. Source: Reactome
Molecular_function	G-protein coupled receptor activity Inferred from electronic annotation. Source: UniProtKB-KW olfactory receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 345	345	Olfactory receptor 2K2		PRO_0000150485
Regions
	Topological domain	1 – 54	54	Extracellular Potential
	Transmembrane	55 – 78	24	Helical; Name=1; Potential
	Topological domain	79 – 86	8	Cytoplasmic Potential
	Transmembrane	87 – 108	22	Helical; Name=2; Potential
	Topological domain	109 – 129	21	Extracellular Potential
	Transmembrane	130 – 149	20	Helical; Name=3; Potential
	Topological domain	150 – 168	19	Cytoplasmic Potential
	Transmembrane	169 – 187	19	Helical; Name=4; Potential
	Topological domain	188 – 223	36	Extracellular Potential
	Transmembrane	224 – 247	24	Helical; Name=5; Potential
	Topological domain	248 – 264	17	Cytoplasmic Potential
	Transmembrane	265 – 287	23	Helical; Name=6; Potential
	Topological domain	288 – 300	13	Extracellular Potential
	Transmembrane	301 – 320	20	Helical; Name=7; Potential
	Topological domain	321 – 345	25	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	34	1	N-linked (GlcNAc...) Potential
	Disulfide bond	126 ↔ 217		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8NGT1 [UniParc]. Last modified December 16, 2008. Version 2. Checksum: DEFA8BE03AF4428D	FASTA	345	38,473
	10 20 30 40 50 60 MNITLYSFLY VLRLNEGNST GRNIDERKKM QGENFTIWSI FFLEGFSQYP GLEVVLFVFS 70 80 90 100 110 120 LVMYLTTLLG NSTLILITIL DSRLKTPMYL FLGNLSFMDI CYTSASVPTL LVNLLSSQKT 130 140 150 160 170 180 IIFSGCAVQM YLSLAMGSTE CVLLAVMAYD RYVAICNPLR YSIIMNRCVC ARMATVSWVT 190 200 210 220 230 240 GCLTALLETS FALQIPLCGN LIDHFTCEIL AVLKLACTSS LLMNTIMLVV SILLLPIPML 250 260 270 280 290 300 LVCISYIFIL STILRITSAE GRNKAFSTCG AHLTVVILYY GAALSMYLKP SSSNAQKIDK 310 320 330 340 IISLLYGVLT PMLNPIIYSL RNKEVKDAMK KLLGKITLHQ THEHL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes." Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y. Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"DNA sequence and analysis of human chromosome 9." Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I. Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 30-345.
[4]	"The human olfactory receptor gene family." Malnic B., Godfrey P.A., Buck L.B. Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION.
[5]	Erratum Malnic B., Godfrey P.A., Buck L.B. Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Web resources

Human Olfactory Receptor Data Exploratorium (HORDE)

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB065707 Genomic DNA. Translation: BAC05929.1. Different initiation. AL354661 Genomic DNA. Translation: CAH73239.1. Different initiation. BC111086 mRNA. Translation: AAI11087.1. BK004277 Genomic DNA. Translation: DAA04675.1.
IPI	IPI00743548.
RefSeq	NP_995581.1. NM_205859.1.
UniGene	Hs.381312.
3D structure databases
ProteinModelPortal	Q8NGT1.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000305055.
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	Q8NGT1.
Polymorphism databases
DMDM	218511729.
Proteomic databases
PaxDb	Q8NGT1.
PRIDE	Q8NGT1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000302681; ENSP00000305055; ENSG00000171133. ENST00000374428; ENSP00000363550; ENSG00000171133.
GeneID	26248.
KEGG	hsa:26248.
UCSC	uc011lwp.2. human.
Organism-specific databases
CTD	26248.
GeneCards	GC09M114089.
HGNC	HGNC:8264. OR2K2.
HPA	HPA024261.
neXtProt	NX_Q8NGT1.
PharmGKB	PA32181.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG146062.
HOGENOM	HOG000041365.
HOVERGEN	HBG017625.
InParanoid	Q8NGT1.
KO	K04257.
OMA	CARMATV.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction.
Gene expression databases
CleanEx	HS_OR2K2.
Genevestigator	Q8NGT1.
GermOnline	ENSG00000171133. Homo sapiens.
Family and domain databases
InterPro	IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. IPR000725. Olfact_rcpt. [Graphical view]
PANTHER	PTHR24236. PTHR24236. 1 hit.
PRINTS	PR00237. GPCRRHODOPSN. PR00245. OLFACTORYR.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	26248.
NextBio	48456.

Entry information

Entry name

OR2K2_HUMAN

Accession

Primary (citable) accession number: Q8NGT1
Secondary accession number(s): Q2TA61, Q5VYK4, Q6IFI5

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 10, 2003
Last sequence update:	December 16, 2008
Last modified:	May 1, 2013
This is version 100 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.