Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q8NGT1 (OR2K2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 107. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Olfactory receptor 2K2
Alternative name(s):
HTPCRH06
Olfactory receptor OR9-17
Gene names
Name:OR2K2
Synonyms:OR2AR1P
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length345 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Odorant receptor Potential.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Caution

It is uncertain whether Met-1 or Met-30 is the initiator.

Sequence caution

The sequence BAC05929.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

The sequence CAH73239.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 345345Olfactory receptor 2K2
PRO_0000150485

Regions

Topological domain1 – 5454Extracellular Potential
Transmembrane55 – 7824Helical; Name=1; Potential
Topological domain79 – 868Cytoplasmic Potential
Transmembrane87 – 10822Helical; Name=2; Potential
Topological domain109 – 12921Extracellular Potential
Transmembrane130 – 14920Helical; Name=3; Potential
Topological domain150 – 16819Cytoplasmic Potential
Transmembrane169 – 18719Helical; Name=4; Potential
Topological domain188 – 22336Extracellular Potential
Transmembrane224 – 24724Helical; Name=5; Potential
Topological domain248 – 26417Cytoplasmic Potential
Transmembrane265 – 28723Helical; Name=6; Potential
Topological domain288 – 30013Extracellular Potential
Transmembrane301 – 32020Helical; Name=7; Potential
Topological domain321 – 34525Cytoplasmic Potential

Amino acid modifications

Glycosylation341N-linked (GlcNAc...) Potential
Disulfide bond126 ↔ 217 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8NGT1 [UniParc].

Last modified December 16, 2008. Version 2.
Checksum: DEFA8BE03AF4428D

FASTA34538,473
        10         20         30         40         50         60 
MNITLYSFLY VLRLNEGNST GRNIDERKKM QGENFTIWSI FFLEGFSQYP GLEVVLFVFS 

        70         80         90        100        110        120 
LVMYLTTLLG NSTLILITIL DSRLKTPMYL FLGNLSFMDI CYTSASVPTL LVNLLSSQKT 

       130        140        150        160        170        180 
IIFSGCAVQM YLSLAMGSTE CVLLAVMAYD RYVAICNPLR YSIIMNRCVC ARMATVSWVT 

       190        200        210        220        230        240 
GCLTALLETS FALQIPLCGN LIDHFTCEIL AVLKLACTSS LLMNTIMLVV SILLLPIPML 

       250        260        270        280        290        300 
LVCISYIFIL STILRITSAE GRNKAFSTCG AHLTVVILYY GAALSMYLKP SSSNAQKIDK 

       310        320        330        340 
IISLLYGVLT PMLNPIIYSL RNKEVKDAMK KLLGKITLHQ THEHL 

« Hide

References

« Hide 'large scale' references
[1]"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"DNA sequence and analysis of human chromosome 9."
Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. expand/collapse author list , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 30-345.
[4]"The human olfactory receptor gene family."
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
[5]Erratum
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB065707 Genomic DNA. Translation: BAC05929.1. Different initiation.
AL354661 Genomic DNA. Translation: CAH73239.1. Different initiation.
BC111086 mRNA. Translation: AAI11087.1.
BK004277 Genomic DNA. Translation: DAA04675.1.
RefSeqNP_995581.1. NM_205859.1.
XP_005251971.1. XM_005251914.1.
UniGeneHs.381312.

3D structure databases

ProteinModelPortalQ8NGT1.
SMRQ8NGT1. Positions 51-336.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000305055.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteQ8NGT1.

Polymorphism databases

DMDM218511729.

Proteomic databases

PaxDbQ8NGT1.
PRIDEQ8NGT1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000302681; ENSP00000305055; ENSG00000171133.
ENST00000374428; ENSP00000363550; ENSG00000171133.
GeneID26248.
KEGGhsa:26248.
UCSCuc011lwp.2. human.

Organism-specific databases

CTD26248.
GeneCardsGC09M114089.
HGNCHGNC:8264. OR2K2.
HPAHPA024261.
neXtProtNX_Q8NGT1.
PharmGKBPA32181.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG146062.
HOGENOMHOG000041365.
HOVERGENHBG017625.
InParanoidQ8NGT1.
KOK04257.
OMACARMATV.
OrthoDBEOG71K63J.
PhylomeDBQ8NGT1.
TreeFamTF352686.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

CleanExHS_OR2K2.
GenevestigatorQ8NGT1.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiOR2K2.
GenomeRNAi26248.
NextBio48456.
PROQ8NGT1.

Entry information

Entry nameOR2K2_HUMAN
AccessionPrimary (citable) accession number: Q8NGT1
Secondary accession number(s): Q2TA61, Q5VYK4, Q6IFI5
Entry history
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: December 16, 2008
Last modified: April 16, 2014
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 9

Human chromosome 9: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries