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Protein

Olfactory receptor 2K2

Gene

OR2K2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

BioCyciZFISH:ENSG00000171133-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 2K2
Alternative name(s):
HTPCRH06
Olfactory receptor OR9-17
Gene namesi
Name:OR2K2
Synonyms:OR2AR1P
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:8264. OR2K2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 54ExtracellularSequence analysisAdd BLAST54
Transmembranei55 – 78Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini79 – 86CytoplasmicSequence analysis8
Transmembranei87 – 108Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini109 – 129ExtracellularSequence analysisAdd BLAST21
Transmembranei130 – 149Helical; Name=3Sequence analysisAdd BLAST20
Topological domaini150 – 168CytoplasmicSequence analysisAdd BLAST19
Transmembranei169 – 187Helical; Name=4Sequence analysisAdd BLAST19
Topological domaini188 – 223ExtracellularSequence analysisAdd BLAST36
Transmembranei224 – 247Helical; Name=5Sequence analysisAdd BLAST24
Topological domaini248 – 264CytoplasmicSequence analysisAdd BLAST17
Transmembranei265 – 287Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini288 – 300ExtracellularSequence analysisAdd BLAST13
Transmembranei301 – 320Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini321 – 345CytoplasmicSequence analysisAdd BLAST25

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000171133.
PharmGKBiPA32181.

Polymorphism and mutation databases

BioMutaiOR2K2.
DMDMi218511729.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001504851 – 345Olfactory receptor 2K2Add BLAST345

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi34N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi126 ↔ 217PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGT1.
PRIDEiQ8NGT1.

PTM databases

iPTMnetiQ8NGT1.
PhosphoSitePlusiQ8NGT1.

Expressioni

Gene expression databases

CleanExiHS_OR2K2.
ExpressionAtlasiQ8NGT1. baseline and differential.
GenevisibleiQ8NGT1. HS.

Organism-specific databases

HPAiHPA024261.

Interactioni

Protein-protein interaction databases

BioGridi117636. 2 interactors.
STRINGi9606.ENSP00000305055.

Structurei

3D structure databases

ProteinModelPortaliQ8NGT1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IIC1. Eukaryota.
ENOG41114NH. LUCA.
GeneTreeiENSGT00760000119058.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiQ8NGT1.
KOiK04257.
OMAiTSFALQI.
OrthoDBiEOG091G0CU6.
PhylomeDBiQ8NGT1.
TreeFamiTF352686.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGT1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNITLYSFLY VLRLNEGNST GRNIDERKKM QGENFTIWSI FFLEGFSQYP
60 70 80 90 100
GLEVVLFVFS LVMYLTTLLG NSTLILITIL DSRLKTPMYL FLGNLSFMDI
110 120 130 140 150
CYTSASVPTL LVNLLSSQKT IIFSGCAVQM YLSLAMGSTE CVLLAVMAYD
160 170 180 190 200
RYVAICNPLR YSIIMNRCVC ARMATVSWVT GCLTALLETS FALQIPLCGN
210 220 230 240 250
LIDHFTCEIL AVLKLACTSS LLMNTIMLVV SILLLPIPML LVCISYIFIL
260 270 280 290 300
STILRITSAE GRNKAFSTCG AHLTVVILYY GAALSMYLKP SSSNAQKIDK
310 320 330 340
IISLLYGVLT PMLNPIIYSL RNKEVKDAMK KLLGKITLHQ THEHL
Length:345
Mass (Da):38,473
Last modified:December 16, 2008 - v2
Checksum:iDEFA8BE03AF4428D
GO

Sequence cautioni

The sequence BAC05929 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAH73239 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065707 Genomic DNA. Translation: BAC05929.1. Different initiation.
AL354661 Genomic DNA. Translation: CAH73239.1. Different initiation.
BC111086 mRNA. Translation: AAI11087.1.
BK004277 Genomic DNA. Translation: DAA04675.1.
RefSeqiNP_995581.1. NM_205859.1.
XP_011516822.1. XM_011518520.2.
UniGeneiHs.381312.

Genome annotation databases

EnsembliENST00000374428; ENSP00000363550; ENSG00000171133.
GeneIDi26248.
KEGGihsa:26248.
UCSCiuc011lwp.2. human.

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065707 Genomic DNA. Translation: BAC05929.1. Different initiation.
AL354661 Genomic DNA. Translation: CAH73239.1. Different initiation.
BC111086 mRNA. Translation: AAI11087.1.
BK004277 Genomic DNA. Translation: DAA04675.1.
RefSeqiNP_995581.1. NM_205859.1.
XP_011516822.1. XM_011518520.2.
UniGeneiHs.381312.

3D structure databases

ProteinModelPortaliQ8NGT1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117636. 2 interactors.
STRINGi9606.ENSP00000305055.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ8NGT1.
PhosphoSitePlusiQ8NGT1.

Polymorphism and mutation databases

BioMutaiOR2K2.
DMDMi218511729.

Proteomic databases

PaxDbiQ8NGT1.
PRIDEiQ8NGT1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000374428; ENSP00000363550; ENSG00000171133.
GeneIDi26248.
KEGGihsa:26248.
UCSCiuc011lwp.2. human.

Organism-specific databases

CTDi26248.
GeneCardsiOR2K2.
HGNCiHGNC:8264. OR2K2.
HPAiHPA024261.
neXtProtiNX_Q8NGT1.
OpenTargetsiENSG00000171133.
PharmGKBiPA32181.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IIC1. Eukaryota.
ENOG41114NH. LUCA.
GeneTreeiENSGT00760000119058.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiQ8NGT1.
KOiK04257.
OMAiTSFALQI.
OrthoDBiEOG091G0CU6.
PhylomeDBiQ8NGT1.
TreeFamiTF352686.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000171133-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR2K2.
GenomeRNAii26248.
PROiQ8NGT1.

Gene expression databases

CleanExiHS_OR2K2.
ExpressionAtlasiQ8NGT1. baseline and differential.
GenevisibleiQ8NGT1. HS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOR2K2_HUMAN
AccessioniPrimary (citable) accession number: Q8NGT1
Secondary accession number(s): Q2TA61, Q5VYK4, Q6IFI5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: December 16, 2008
Last modified: November 2, 2016
This is version 125 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-30 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.