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Q8NGT1

- OR2K2_HUMAN

UniProt

Q8NGT1 - OR2K2_HUMAN

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Protein

Olfactory receptor 2K2

Gene

OR2K2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 2K2
Alternative name(s):
HTPCRH06
Olfactory receptor OR9-17
Gene namesi
Name:OR2K2
Synonyms:OR2AR1P
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 9

Organism-specific databases

HGNCiHGNC:8264. OR2K2.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32181.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 345345Olfactory receptor 2K2PRO_0000150485Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi34 – 341N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi126 ↔ 217PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGT1.
PRIDEiQ8NGT1.

PTM databases

PhosphoSiteiQ8NGT1.

Expressioni

Gene expression databases

CleanExiHS_OR2K2.
GenevestigatoriQ8NGT1.

Organism-specific databases

HPAiHPA024261.

Interactioni

Protein-protein interaction databases

BioGridi117636. 1 interaction.
STRINGi9606.ENSP00000305055.

Structurei

3D structure databases

ProteinModelPortaliQ8NGT1.
SMRiQ8NGT1. Positions 51-332.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 5454ExtracellularSequence AnalysisAdd
BLAST
Topological domaini79 – 868CytoplasmicSequence Analysis
Topological domaini109 – 12921ExtracellularSequence AnalysisAdd
BLAST
Topological domaini150 – 16819CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini188 – 22336ExtracellularSequence AnalysisAdd
BLAST
Topological domaini248 – 26417CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini288 – 30013ExtracellularSequence AnalysisAdd
BLAST
Topological domaini321 – 34525CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei55 – 7824Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei87 – 10822Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei130 – 14920Helical; Name=3Sequence AnalysisAdd
BLAST
Transmembranei169 – 18719Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei224 – 24724Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei265 – 28723Helical; Name=6Sequence AnalysisAdd
BLAST
Transmembranei301 – 32020Helical; Name=7Sequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG146062.
GeneTreeiENSGT00760000119058.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiQ8NGT1.
KOiK04257.
OMAiCARMATV.
OrthoDBiEOG71K63J.
PhylomeDBiQ8NGT1.
TreeFamiTF352686.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGT1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNITLYSFLY VLRLNEGNST GRNIDERKKM QGENFTIWSI FFLEGFSQYP
60 70 80 90 100
GLEVVLFVFS LVMYLTTLLG NSTLILITIL DSRLKTPMYL FLGNLSFMDI
110 120 130 140 150
CYTSASVPTL LVNLLSSQKT IIFSGCAVQM YLSLAMGSTE CVLLAVMAYD
160 170 180 190 200
RYVAICNPLR YSIIMNRCVC ARMATVSWVT GCLTALLETS FALQIPLCGN
210 220 230 240 250
LIDHFTCEIL AVLKLACTSS LLMNTIMLVV SILLLPIPML LVCISYIFIL
260 270 280 290 300
STILRITSAE GRNKAFSTCG AHLTVVILYY GAALSMYLKP SSSNAQKIDK
310 320 330 340
IISLLYGVLT PMLNPIIYSL RNKEVKDAMK KLLGKITLHQ THEHL
Length:345
Mass (Da):38,473
Last modified:December 16, 2008 - v2
Checksum:iDEFA8BE03AF4428D
GO

Sequence cautioni

The sequence BAC05929.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence CAH73239.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB065707 Genomic DNA. Translation: BAC05929.1. Different initiation.
AL354661 Genomic DNA. Translation: CAH73239.1. Different initiation.
BC111086 mRNA. Translation: AAI11087.1.
BK004277 Genomic DNA. Translation: DAA04675.1.
RefSeqiNP_995581.1. NM_205859.1.
XP_005251971.1. XM_005251914.1.
UniGeneiHs.381312.

Genome annotation databases

EnsembliENST00000302681; ENSP00000305055; ENSG00000171133.
ENST00000374428; ENSP00000363550; ENSG00000171133.
GeneIDi26248.
KEGGihsa:26248.
UCSCiuc011lwp.2. human.

Polymorphism databases

DMDMi218511729.

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB065707 Genomic DNA. Translation: BAC05929.1 . Different initiation.
AL354661 Genomic DNA. Translation: CAH73239.1 . Different initiation.
BC111086 mRNA. Translation: AAI11087.1 .
BK004277 Genomic DNA. Translation: DAA04675.1 .
RefSeqi NP_995581.1. NM_205859.1.
XP_005251971.1. XM_005251914.1.
UniGenei Hs.381312.

3D structure databases

ProteinModelPortali Q8NGT1.
SMRi Q8NGT1. Positions 51-332.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 117636. 1 interaction.
STRINGi 9606.ENSP00000305055.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei Q8NGT1.

Polymorphism databases

DMDMi 218511729.

Proteomic databases

PaxDbi Q8NGT1.
PRIDEi Q8NGT1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000302681 ; ENSP00000305055 ; ENSG00000171133 .
ENST00000374428 ; ENSP00000363550 ; ENSG00000171133 .
GeneIDi 26248.
KEGGi hsa:26248.
UCSCi uc011lwp.2. human.

Organism-specific databases

CTDi 26248.
GeneCardsi GC09M114089.
HGNCi HGNC:8264. OR2K2.
HPAi HPA024261.
neXtProti NX_Q8NGT1.
PharmGKBi PA32181.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG146062.
GeneTreei ENSGT00760000119058.
HOGENOMi HOG000041365.
HOVERGENi HBG017625.
InParanoidi Q8NGT1.
KOi K04257.
OMAi CARMATV.
OrthoDBi EOG71K63J.
PhylomeDBi Q8NGT1.
TreeFami TF352686.

Enzyme and pathway databases

Reactomei REACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikii OR2K2.
GenomeRNAii 26248.
NextBioi 48456.
PROi Q8NGT1.

Gene expression databases

CleanExi HS_OR2K2.
Genevestigatori Q8NGT1.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 30-345.
  4. Cited for: IDENTIFICATION.
  5. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiOR2K2_HUMAN
AccessioniPrimary (citable) accession number: Q8NGT1
Secondary accession number(s): Q2TA61, Q5VYK4, Q6IFI5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: December 16, 2008
Last modified: October 29, 2014
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-30 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3