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Q8NGT1

- OR2K2_HUMAN

UniProt

Q8NGT1 - OR2K2_HUMAN

Protein

Olfactory receptor 2K2

Gene

OR2K2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 110 (01 Oct 2014)
      Sequence version 2 (16 Dec 2008)
      Previous versions | rss
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    Functioni

    Odorant receptor.Curated

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW
    2. olfactory receptor activity Source: InterPro

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Olfaction, Sensory transduction

    Enzyme and pathway databases

    ReactomeiREACT_15488. Olfactory Signaling Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Olfactory receptor 2K2
    Alternative name(s):
    HTPCRH06
    Olfactory receptor OR9-17
    Gene namesi
    Name:OR2K2
    Synonyms:OR2AR1P
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 9

    Organism-specific databases

    HGNCiHGNC:8264. OR2K2.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA32181.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 345345Olfactory receptor 2K2PRO_0000150485Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi34 – 341N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi126 ↔ 217PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ8NGT1.
    PRIDEiQ8NGT1.

    PTM databases

    PhosphoSiteiQ8NGT1.

    Expressioni

    Gene expression databases

    CleanExiHS_OR2K2.
    GenevestigatoriQ8NGT1.

    Organism-specific databases

    HPAiHPA024261.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000305055.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8NGT1.
    SMRiQ8NGT1. Positions 51-332.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 5454ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini79 – 868CytoplasmicSequence Analysis
    Topological domaini109 – 12921ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini150 – 16819CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini188 – 22336ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini248 – 26417CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini288 – 30013ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini321 – 34525CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei55 – 7824Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei87 – 10822Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei130 – 14920Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei169 – 18719Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei224 – 24724Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei265 – 28723Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei301 – 32020Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG146062.
    HOGENOMiHOG000041365.
    HOVERGENiHBG017625.
    InParanoidiQ8NGT1.
    KOiK04257.
    OMAiCARMATV.
    OrthoDBiEOG71K63J.
    PhylomeDBiQ8NGT1.
    TreeFamiTF352686.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8NGT1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNITLYSFLY VLRLNEGNST GRNIDERKKM QGENFTIWSI FFLEGFSQYP    50
    GLEVVLFVFS LVMYLTTLLG NSTLILITIL DSRLKTPMYL FLGNLSFMDI 100
    CYTSASVPTL LVNLLSSQKT IIFSGCAVQM YLSLAMGSTE CVLLAVMAYD 150
    RYVAICNPLR YSIIMNRCVC ARMATVSWVT GCLTALLETS FALQIPLCGN 200
    LIDHFTCEIL AVLKLACTSS LLMNTIMLVV SILLLPIPML LVCISYIFIL 250
    STILRITSAE GRNKAFSTCG AHLTVVILYY GAALSMYLKP SSSNAQKIDK 300
    IISLLYGVLT PMLNPIIYSL RNKEVKDAMK KLLGKITLHQ THEHL 345
    Length:345
    Mass (Da):38,473
    Last modified:December 16, 2008 - v2
    Checksum:iDEFA8BE03AF4428D
    GO

    Sequence cautioni

    The sequence BAC05929.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence CAH73239.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065707 Genomic DNA. Translation: BAC05929.1. Different initiation.
    AL354661 Genomic DNA. Translation: CAH73239.1. Different initiation.
    BC111086 mRNA. Translation: AAI11087.1.
    BK004277 Genomic DNA. Translation: DAA04675.1.
    RefSeqiNP_995581.1. NM_205859.1.
    XP_005251971.1. XM_005251914.1.
    UniGeneiHs.381312.

    Genome annotation databases

    EnsembliENST00000302681; ENSP00000305055; ENSG00000171133.
    ENST00000374428; ENSP00000363550; ENSG00000171133.
    GeneIDi26248.
    KEGGihsa:26248.
    UCSCiuc011lwp.2. human.

    Polymorphism databases

    DMDMi218511729.

    Cross-referencesi

    Web resourcesi

    Human Olfactory Receptor Data Exploratorium (HORDE)

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065707 Genomic DNA. Translation: BAC05929.1 . Different initiation.
    AL354661 Genomic DNA. Translation: CAH73239.1 . Different initiation.
    BC111086 mRNA. Translation: AAI11087.1 .
    BK004277 Genomic DNA. Translation: DAA04675.1 .
    RefSeqi NP_995581.1. NM_205859.1.
    XP_005251971.1. XM_005251914.1.
    UniGenei Hs.381312.

    3D structure databases

    ProteinModelPortali Q8NGT1.
    SMRi Q8NGT1. Positions 51-332.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000305055.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q8NGT1.

    Polymorphism databases

    DMDMi 218511729.

    Proteomic databases

    PaxDbi Q8NGT1.
    PRIDEi Q8NGT1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000302681 ; ENSP00000305055 ; ENSG00000171133 .
    ENST00000374428 ; ENSP00000363550 ; ENSG00000171133 .
    GeneIDi 26248.
    KEGGi hsa:26248.
    UCSCi uc011lwp.2. human.

    Organism-specific databases

    CTDi 26248.
    GeneCardsi GC09M114089.
    HGNCi HGNC:8264. OR2K2.
    HPAi HPA024261.
    neXtProti NX_Q8NGT1.
    PharmGKBi PA32181.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG146062.
    HOGENOMi HOG000041365.
    HOVERGENi HBG017625.
    InParanoidi Q8NGT1.
    KOi K04257.
    OMAi CARMATV.
    OrthoDBi EOG71K63J.
    PhylomeDBi Q8NGT1.
    TreeFami TF352686.

    Enzyme and pathway databases

    Reactomei REACT_15488. Olfactory Signaling Pathway.

    Miscellaneous databases

    GeneWikii OR2K2.
    GenomeRNAii 26248.
    NextBioi 48456.
    PROi Q8NGT1.

    Gene expression databases

    CleanExi HS_OR2K2.
    Genevestigatori Q8NGT1.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
      Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
      Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "DNA sequence and analysis of human chromosome 9."
      Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
      , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
      Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 30-345.
    4. Cited for: IDENTIFICATION.
    5. Erratum
      Malnic B., Godfrey P.A., Buck L.B.
      Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

    Entry informationi

    Entry nameiOR2K2_HUMAN
    AccessioniPrimary (citable) accession number: Q8NGT1
    Secondary accession number(s): Q2TA61, Q5VYK4, Q6IFI5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 10, 2003
    Last sequence update: December 16, 2008
    Last modified: October 1, 2014
    This is version 110 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    It is uncertain whether Met-1 or Met-30 is the initiator.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 9
      Human chromosome 9: entries, gene names and cross-references to MIM
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3