Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q8NGS8 (O13C5_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 104. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Olfactory receptor 13C5
Alternative name(s):
Olfactory receptor OR9-11
Gene names
Name:OR13C5
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length318 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Odorant receptor Potential.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 318318Olfactory receptor 13C5
PRO_0000150734

Regions

Topological domain1 – 2525Extracellular Potential
Transmembrane26 – 4621Helical; Name=1; Potential
Topological domain47 – 548Cytoplasmic Potential
Transmembrane55 – 7521Helical; Name=2; Potential
Topological domain76 – 9924Extracellular Potential
Transmembrane100 – 12021Helical; Name=3; Potential
Topological domain121 – 13919Cytoplasmic Potential
Transmembrane140 – 16021Helical; Name=4; Potential
Topological domain161 – 19737Extracellular Potential
Transmembrane198 – 21720Helical; Name=5; Potential
Topological domain218 – 23720Cytoplasmic Potential
Transmembrane238 – 25821Helical; Name=6; Potential
Topological domain259 – 27719Extracellular Potential
Transmembrane278 – 29821Helical; Name=7; Potential
Topological domain299 – 31820Cytoplasmic Potential

Amino acid modifications

Glycosylation51N-linked (GlcNAc...) Potential
Disulfide bond97 ↔ 189 By similarity

Natural variations

Natural variant181S → F.
Corresponds to variant rs1851722 [ dbSNP | Ensembl ].
VAR_053299
Natural variant321F → L.
Corresponds to variant rs6479260 [ dbSNP | Ensembl ].
VAR_034306
Natural variant691L → M.
Corresponds to variant rs7042502 [ dbSNP | Ensembl ].
VAR_060032
Natural variant861L → V.
Corresponds to variant rs4629933 [ dbSNP | Ensembl ].
VAR_060033
Natural variant1171V → M.
Corresponds to variant rs2417534 [ dbSNP | Ensembl ].
VAR_060034
Natural variant1891C → Y.
Corresponds to variant rs4117966 [ dbSNP | Ensembl ].
VAR_024132
Natural variant1951N → S.
Corresponds to variant rs6479259 [ dbSNP | Ensembl ].
VAR_053300
Natural variant2581M → T.
Corresponds to variant rs1851724 [ dbSNP | Ensembl ].
VAR_024133
Natural variant2821I → V.
Corresponds to variant rs1523678 [ dbSNP | Ensembl ].
VAR_024134
Natural variant2901M → T.
Corresponds to variant rs1851725 [ dbSNP | Ensembl ].
VAR_024135

Sequences

Sequence LengthMass (Da)Tools
Q8NGS8 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: 6865DEBF95217C51

FASTA31835,796
        10         20         30         40         50         60 
MEWENHTILV EFFLKGLSGH PRLELLFFVL IFIMYVVILL GNGTLILISI LDPHLHTPMY 

        70         80         90        100        110        120 
FFLGNLSFLD ICYTTTSIPS TLVSFLSERK TISLSGCAVQ MFLSLAMGTT ECVLLGVMAF 

       130        140        150        160        170        180 
DRYVAICNPL RYPIIMSKDA YVPMAAGSWI IGAVNSAVQT VFVVQLPFCR NNIINHFTCE 

       190        200        210        220        230        240 
ILAVMKLACA DISGNEFILL VTTTLFLLTP LLLIIVSYTL IILSIFKISS SEGRSKPSST 

       250        260        270        280        290        300 
CSARLTVVIT FCGTIFLMYM KPKSQETLNS DDLDATDKLI FIFYRVMTPM MNPLIYSLRN 

       310 
KDVKEAVKHL LRRKNFNK 

« Hide

References

« Hide 'large scale' references
[1]"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"DNA sequence and analysis of human chromosome 9."
Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. expand/collapse author list , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.
[4]"The human olfactory receptor gene family."
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
[5]Erratum
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB065710 Genomic DNA. Translation: BAC05932.1.
AL450426 Genomic DNA. Translation: CAH72414.1.
BC136842 mRNA. Translation: AAI36843.1.
BC136843 mRNA. Translation: AAI36844.1.
BK004409 Genomic DNA. Translation: DAA04807.1.
RefSeqNP_001004482.1. NM_001004482.1.
UniGeneHs.553598.

3D structure databases

ProteinModelPortalQ8NGS8.
SMRQ8NGS8. Positions 110-140, 281-313.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000363911.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteQ8NGS8.

Polymorphism databases

DMDM38372765.

Proteomic databases

PaxDbQ8NGS8.
PRIDEQ8NGS8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000374779; ENSP00000363911; ENSG00000255800.
GeneID138799.
KEGGhsa:138799.
UCSCuc011lvp.2. human.

Organism-specific databases

CTD138799.
GeneCardsGC09M107360.
HGNCHGNC:15100. OR13C5.
neXtProtNX_Q8NGS8.
PharmGKBPA32035.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG307869.
HOGENOMHOG000041365.
HOVERGENHBG017625.
InParanoidQ8NGS8.
KOK04257.
OMAKLIFIFY.
OrthoDBEOG7GXPC0.
PhylomeDBQ8NGS8.
TreeFamTF352686.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

CleanExHS_OR13C5.
GenevestigatorQ8NGS8.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiOR13C5.
GenomeRNAi138799.
NextBio83835.
PROQ8NGS8.

Entry information

Entry nameO13C5_HUMAN
AccessionPrimary (citable) accession number: Q8NGS8
Secondary accession number(s): B2RNE5, B9EGW5, Q6IF53
Entry history
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: April 16, 2014
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 9

Human chromosome 9: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries