Q8NGS8 (O13C5_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Olfactory receptor 13C5

Alternative name(s):
Olfactory receptor OR9-11

Gene names

Name:

OR13C5

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	318 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Odorant receptor Potential.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Biological process	Olfaction Sensory transduction
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	detection of chemical stimulus involved in sensory perception of smell Inferred from electronic annotation. Source: GOC
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	G-protein coupled receptor activity Inferred from electronic annotation. Source: UniProtKB-KW olfactory receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 318	318	Olfactory receptor 13C5		PRO_0000150734
Regions
	Topological domain	1 – 25	25	Extracellular Potential
	Transmembrane	26 – 46	21	Helical; Name=1; Potential
	Topological domain	47 – 54	8	Cytoplasmic Potential
	Transmembrane	55 – 75	21	Helical; Name=2; Potential
	Topological domain	76 – 99	24	Extracellular Potential
	Transmembrane	100 – 120	21	Helical; Name=3; Potential
	Topological domain	121 – 139	19	Cytoplasmic Potential
	Transmembrane	140 – 160	21	Helical; Name=4; Potential
	Topological domain	161 – 197	37	Extracellular Potential
	Transmembrane	198 – 217	20	Helical; Name=5; Potential
	Topological domain	218 – 237	20	Cytoplasmic Potential
	Transmembrane	238 – 258	21	Helical; Name=6; Potential
	Topological domain	259 – 277	19	Extracellular Potential
	Transmembrane	278 – 298	21	Helical; Name=7; Potential
	Topological domain	299 – 318	20	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	5	1	N-linked (GlcNAc...) Potential
	Disulfide bond	97 ↔ 189		By similarity
Natural variations
	Natural variant	18	1	S → F. Corresponds to variant rs1851722 [ dbSNP | Ensembl ].		VAR_053299
	Natural variant	32	1	F → L. Corresponds to variant rs6479260 [ dbSNP | Ensembl ].		VAR_034306
	Natural variant	69	1	L → M. Corresponds to variant rs7042502 [ dbSNP | Ensembl ].		VAR_060032
	Natural variant	86	1	L → V. Corresponds to variant rs4629933 [ dbSNP | Ensembl ].		VAR_060033
	Natural variant	117	1	V → M. Corresponds to variant rs2417534 [ dbSNP | Ensembl ].		VAR_060034
	Natural variant	189	1	C → Y. Corresponds to variant rs4117966 [ dbSNP | Ensembl ].		VAR_024132
	Natural variant	195	1	N → S. Corresponds to variant rs6479259 [ dbSNP | Ensembl ].		VAR_053300
	Natural variant	258	1	M → T. Corresponds to variant rs1851724 [ dbSNP | Ensembl ].		VAR_024133
	Natural variant	282	1	I → V. Corresponds to variant rs1523678 [ dbSNP | Ensembl ].		VAR_024134
	Natural variant	290	1	M → T. Corresponds to variant rs1851725 [ dbSNP | Ensembl ].		VAR_024135

Sequences

	Sequence		Length	Mass (Da)
	Q8NGS8 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: 6865DEBF95217C51	FASTA	318	35,796
	10 20 30 40 50 60 MEWENHTILV EFFLKGLSGH PRLELLFFVL IFIMYVVILL GNGTLILISI LDPHLHTPMY 70 80 90 100 110 120 FFLGNLSFLD ICYTTTSIPS TLVSFLSERK TISLSGCAVQ MFLSLAMGTT ECVLLGVMAF 130 140 150 160 170 180 DRYVAICNPL RYPIIMSKDA YVPMAAGSWI IGAVNSAVQT VFVVQLPFCR NNIINHFTCE 190 200 210 220 230 240 ILAVMKLACA DISGNEFILL VTTTLFLLTP LLLIIVSYTL IILSIFKISS SEGRSKPSST 250 260 270 280 290 300 CSARLTVVIT FCGTIFLMYM KPKSQETLNS DDLDATDKLI FIFYRVMTPM MNPLIYSLRN 310 KDVKEAVKHL LRRKNFNK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes." Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y. Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"DNA sequence and analysis of human chromosome 9." Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I. Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.
[4]	"The human olfactory receptor gene family." Malnic B., Godfrey P.A., Buck L.B. Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION.
[5]	Erratum Malnic B., Godfrey P.A., Buck L.B. Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Web resources

Human Olfactory Receptor Data Exploratorium (HORDE)

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB065710 Genomic DNA. Translation: BAC05932.1. AL450426 Genomic DNA. Translation: CAH72414.1. BC136842 mRNA. Translation: AAI36843.1. BC136843 mRNA. Translation: AAI36844.1. BK004409 Genomic DNA. Translation: DAA04807.1.
IPI	IPI00062312.
RefSeq	NP_001004482.1. NM_001004482.1.
UniGene	Hs.553598.
3D structure databases
ProteinModelPortal	Q8NGS8.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000363911.
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	Q8NGS8.
Polymorphism databases
DMDM	38372765.
Proteomic databases
PaxDb	Q8NGS8.
PRIDE	Q8NGS8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000374779; ENSP00000363911; ENSG00000255800.
GeneID	138799.
KEGG	hsa:138799.
UCSC	uc011lvp.2. human.
Organism-specific databases
CTD	138799.
GeneCards	GC09M107360.
HGNC	HGNC:15100. OR13C5.
neXtProt	NX_Q8NGS8.
PharmGKB	PA32035.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG307869.
HOGENOM	HOG000041365.
HOVERGEN	HBG017625.
InParanoid	Q8NGS8.
KO	K04257.
OMA	KLIFIFY.
OrthoDB	EOG4933JC.
Gene expression databases
CleanEx	HS_OR13C5.
Genevestigator	Q8NGS8.
Family and domain databases
InterPro	IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. IPR000725. Olfact_rcpt. [Graphical view]
PANTHER	PTHR24236. PTHR24236. 1 hit.
PRINTS	PR00237. GPCRRHODOPSN. PR00245. OLFACTORYR.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	138799.
NextBio	83835.

Entry information

Entry name

O13C5_HUMAN

Accession

Primary (citable) accession number: Q8NGS8
Secondary accession number(s): B2RNE5, B9EGW5, Q6IF53

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 10, 2003
Last sequence update:	October 1, 2002
Last modified:	May 1, 2013
This is version 96 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.