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Q8NGS8

- O13C5_HUMAN

UniProt

Q8NGS8 - O13C5_HUMAN

Protein

Olfactory receptor 13C5

Gene

OR13C5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 108 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    Odorant receptor.Curated

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW
    2. olfactory receptor activity Source: InterPro

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Olfaction, Sensory transduction

    Enzyme and pathway databases

    ReactomeiREACT_15488. Olfactory Signaling Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Olfactory receptor 13C5
    Alternative name(s):
    Olfactory receptor OR9-11
    Gene namesi
    Name:OR13C5
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 9

    Organism-specific databases

    HGNCiHGNC:15100. OR13C5.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA32035.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 318318Olfactory receptor 13C5PRO_0000150734Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi5 – 51N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ8NGS8.
    PRIDEiQ8NGS8.

    PTM databases

    PhosphoSiteiQ8NGS8.

    Expressioni

    Gene expression databases

    CleanExiHS_OR13C5.
    GenevestigatoriQ8NGS8.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000363911.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8NGS8.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2525ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini47 – 548CytoplasmicSequence Analysis
    Topological domaini76 – 9924ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini121 – 13919CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini161 – 19737ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini218 – 23720CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini259 – 27719ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini299 – 31820CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei26 – 4621Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei55 – 7521Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei100 – 12021Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei140 – 16021Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei198 – 21720Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei238 – 25821Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei278 – 29821Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG307869.
    HOGENOMiHOG000041365.
    HOVERGENiHBG017625.
    InParanoidiQ8NGS8.
    KOiK04257.
    OMAiKLIFIFY.
    OrthoDBiEOG7GXPC0.
    PhylomeDBiQ8NGS8.
    TreeFamiTF352686.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8NGS8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEWENHTILV EFFLKGLSGH PRLELLFFVL IFIMYVVILL GNGTLILISI    50
    LDPHLHTPMY FFLGNLSFLD ICYTTTSIPS TLVSFLSERK TISLSGCAVQ 100
    MFLSLAMGTT ECVLLGVMAF DRYVAICNPL RYPIIMSKDA YVPMAAGSWI 150
    IGAVNSAVQT VFVVQLPFCR NNIINHFTCE ILAVMKLACA DISGNEFILL 200
    VTTTLFLLTP LLLIIVSYTL IILSIFKISS SEGRSKPSST CSARLTVVIT 250
    FCGTIFLMYM KPKSQETLNS DDLDATDKLI FIFYRVMTPM MNPLIYSLRN 300
    KDVKEAVKHL LRRKNFNK 318
    Length:318
    Mass (Da):35,796
    Last modified:October 1, 2002 - v1
    Checksum:i6865DEBF95217C51
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti18 – 181S → F.
    Corresponds to variant rs1851722 [ dbSNP | Ensembl ].
    VAR_053299
    Natural varianti32 – 321F → L.
    Corresponds to variant rs6479260 [ dbSNP | Ensembl ].
    VAR_034306
    Natural varianti69 – 691L → M.
    Corresponds to variant rs7042502 [ dbSNP | Ensembl ].
    VAR_060032
    Natural varianti86 – 861L → V.
    Corresponds to variant rs4629933 [ dbSNP | Ensembl ].
    VAR_060033
    Natural varianti117 – 1171V → M.
    Corresponds to variant rs2417534 [ dbSNP | Ensembl ].
    VAR_060034
    Natural varianti189 – 1891C → Y.
    Corresponds to variant rs4117966 [ dbSNP | Ensembl ].
    VAR_024132
    Natural varianti195 – 1951N → S.
    Corresponds to variant rs6479259 [ dbSNP | Ensembl ].
    VAR_053300
    Natural varianti258 – 2581M → T.
    Corresponds to variant rs1851724 [ dbSNP | Ensembl ].
    VAR_024133
    Natural varianti282 – 2821I → V.
    Corresponds to variant rs1523678 [ dbSNP | Ensembl ].
    VAR_024134
    Natural varianti290 – 2901M → T.
    Corresponds to variant rs1851725 [ dbSNP | Ensembl ].
    VAR_024135

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065710 Genomic DNA. Translation: BAC05932.1.
    AL450426 Genomic DNA. Translation: CAH72414.1.
    BC136842 mRNA. Translation: AAI36843.1.
    BC136843 mRNA. Translation: AAI36844.1.
    BK004409 Genomic DNA. Translation: DAA04807.1.
    CCDSiCCDS35091.1.
    RefSeqiNP_001004482.1. NM_001004482.1.
    UniGeneiHs.553598.

    Genome annotation databases

    EnsembliENST00000374779; ENSP00000363911; ENSG00000277556.
    GeneIDi138799.
    KEGGihsa:138799.
    UCSCiuc011lvp.2. human.

    Polymorphism databases

    DMDMi38372765.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Human Olfactory Receptor Data Exploratorium (HORDE)

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065710 Genomic DNA. Translation: BAC05932.1 .
    AL450426 Genomic DNA. Translation: CAH72414.1 .
    BC136842 mRNA. Translation: AAI36843.1 .
    BC136843 mRNA. Translation: AAI36844.1 .
    BK004409 Genomic DNA. Translation: DAA04807.1 .
    CCDSi CCDS35091.1.
    RefSeqi NP_001004482.1. NM_001004482.1.
    UniGenei Hs.553598.

    3D structure databases

    ProteinModelPortali Q8NGS8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000363911.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q8NGS8.

    Polymorphism databases

    DMDMi 38372765.

    Proteomic databases

    PaxDbi Q8NGS8.
    PRIDEi Q8NGS8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000374779 ; ENSP00000363911 ; ENSG00000277556 .
    GeneIDi 138799.
    KEGGi hsa:138799.
    UCSCi uc011lvp.2. human.

    Organism-specific databases

    CTDi 138799.
    GeneCardsi GC09M107360.
    HGNCi HGNC:15100. OR13C5.
    neXtProti NX_Q8NGS8.
    PharmGKBi PA32035.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG307869.
    HOGENOMi HOG000041365.
    HOVERGENi HBG017625.
    InParanoidi Q8NGS8.
    KOi K04257.
    OMAi KLIFIFY.
    OrthoDBi EOG7GXPC0.
    PhylomeDBi Q8NGS8.
    TreeFami TF352686.

    Enzyme and pathway databases

    Reactomei REACT_15488. Olfactory Signaling Pathway.

    Miscellaneous databases

    GeneWikii OR13C5.
    GenomeRNAii 138799.
    NextBioi 83835.
    PROi Q8NGS8.

    Gene expression databases

    CleanExi HS_OR13C5.
    Genevestigatori Q8NGS8.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
      Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
      Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "DNA sequence and analysis of human chromosome 9."
      Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
      , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
      Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.
    4. Cited for: IDENTIFICATION.
    5. Erratum
      Malnic B., Godfrey P.A., Buck L.B.
      Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

    Entry informationi

    Entry nameiO13C5_HUMAN
    AccessioniPrimary (citable) accession number: Q8NGS8
    Secondary accession number(s): B2RNE5, B9EGW5, Q6IF53
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 10, 2003
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 108 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 9
      Human chromosome 9: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3