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Q8NGS8

- O13C5_HUMAN

UniProt

Q8NGS8 - O13C5_HUMAN

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Protein

Olfactory receptor 13C5

Gene
OR13C5
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Odorant receptor Reviewed prediction.

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 13C5
Alternative name(s):
Olfactory receptor OR9-11
Gene namesi
Name:OR13C5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 9

Organism-specific databases

HGNCiHGNC:15100. OR13C5.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2525Extracellular Reviewed predictionAdd
BLAST
Transmembranei26 – 4621Helical; Name=1; Reviewed predictionAdd
BLAST
Topological domaini47 – 548Cytoplasmic Reviewed prediction
Transmembranei55 – 7521Helical; Name=2; Reviewed predictionAdd
BLAST
Topological domaini76 – 9924Extracellular Reviewed predictionAdd
BLAST
Transmembranei100 – 12021Helical; Name=3; Reviewed predictionAdd
BLAST
Topological domaini121 – 13919Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei140 – 16021Helical; Name=4; Reviewed predictionAdd
BLAST
Topological domaini161 – 19737Extracellular Reviewed predictionAdd
BLAST
Transmembranei198 – 21720Helical; Name=5; Reviewed predictionAdd
BLAST
Topological domaini218 – 23720Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei238 – 25821Helical; Name=6; Reviewed predictionAdd
BLAST
Topological domaini259 – 27719Extracellular Reviewed predictionAdd
BLAST
Transmembranei278 – 29821Helical; Name=7; Reviewed predictionAdd
BLAST
Topological domaini299 – 31820Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32035.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 318318Olfactory receptor 13C5PRO_0000150734Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi97 ↔ 189 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGS8.
PRIDEiQ8NGS8.

PTM databases

PhosphoSiteiQ8NGS8.

Expressioni

Gene expression databases

CleanExiHS_OR13C5.
GenevestigatoriQ8NGS8.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000363911.

Structurei

3D structure databases

ProteinModelPortaliQ8NGS8.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG307869.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiQ8NGS8.
KOiK04257.
OMAiKLIFIFY.
OrthoDBiEOG7GXPC0.
PhylomeDBiQ8NGS8.
TreeFamiTF352686.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGS8-1 [UniParc]FASTAAdd to Basket

« Hide

MEWENHTILV EFFLKGLSGH PRLELLFFVL IFIMYVVILL GNGTLILISI    50
LDPHLHTPMY FFLGNLSFLD ICYTTTSIPS TLVSFLSERK TISLSGCAVQ 100
MFLSLAMGTT ECVLLGVMAF DRYVAICNPL RYPIIMSKDA YVPMAAGSWI 150
IGAVNSAVQT VFVVQLPFCR NNIINHFTCE ILAVMKLACA DISGNEFILL 200
VTTTLFLLTP LLLIIVSYTL IILSIFKISS SEGRSKPSST CSARLTVVIT 250
FCGTIFLMYM KPKSQETLNS DDLDATDKLI FIFYRVMTPM MNPLIYSLRN 300
KDVKEAVKHL LRRKNFNK 318
Length:318
Mass (Da):35,796
Last modified:October 1, 2002 - v1
Checksum:i6865DEBF95217C51
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti18 – 181S → F.
Corresponds to variant rs1851722 [ dbSNP | Ensembl ].
VAR_053299
Natural varianti32 – 321F → L.
Corresponds to variant rs6479260 [ dbSNP | Ensembl ].
VAR_034306
Natural varianti69 – 691L → M.
Corresponds to variant rs7042502 [ dbSNP | Ensembl ].
VAR_060032
Natural varianti86 – 861L → V.
Corresponds to variant rs4629933 [ dbSNP | Ensembl ].
VAR_060033
Natural varianti117 – 1171V → M.
Corresponds to variant rs2417534 [ dbSNP | Ensembl ].
VAR_060034
Natural varianti189 – 1891C → Y.
Corresponds to variant rs4117966 [ dbSNP | Ensembl ].
VAR_024132
Natural varianti195 – 1951N → S.
Corresponds to variant rs6479259 [ dbSNP | Ensembl ].
VAR_053300
Natural varianti258 – 2581M → T.
Corresponds to variant rs1851724 [ dbSNP | Ensembl ].
VAR_024133
Natural varianti282 – 2821I → V.
Corresponds to variant rs1523678 [ dbSNP | Ensembl ].
VAR_024134
Natural varianti290 – 2901M → T.
Corresponds to variant rs1851725 [ dbSNP | Ensembl ].
VAR_024135

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB065710 Genomic DNA. Translation: BAC05932.1.
AL450426 Genomic DNA. Translation: CAH72414.1.
BC136842 mRNA. Translation: AAI36843.1.
BC136843 mRNA. Translation: AAI36844.1.
BK004409 Genomic DNA. Translation: DAA04807.1.
CCDSiCCDS35091.1.
RefSeqiNP_001004482.1. NM_001004482.1.
UniGeneiHs.553598.

Genome annotation databases

EnsembliENST00000374779; ENSP00000363911; ENSG00000255800.
GeneIDi138799.
KEGGihsa:138799.
UCSCiuc011lvp.2. human.

Polymorphism databases

DMDMi38372765.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB065710 Genomic DNA. Translation: BAC05932.1 .
AL450426 Genomic DNA. Translation: CAH72414.1 .
BC136842 mRNA. Translation: AAI36843.1 .
BC136843 mRNA. Translation: AAI36844.1 .
BK004409 Genomic DNA. Translation: DAA04807.1 .
CCDSi CCDS35091.1.
RefSeqi NP_001004482.1. NM_001004482.1.
UniGenei Hs.553598.

3D structure databases

ProteinModelPortali Q8NGS8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000363911.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei Q8NGS8.

Polymorphism databases

DMDMi 38372765.

Proteomic databases

PaxDbi Q8NGS8.
PRIDEi Q8NGS8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000374779 ; ENSP00000363911 ; ENSG00000255800 .
GeneIDi 138799.
KEGGi hsa:138799.
UCSCi uc011lvp.2. human.

Organism-specific databases

CTDi 138799.
GeneCardsi GC09M107360.
HGNCi HGNC:15100. OR13C5.
neXtProti NX_Q8NGS8.
PharmGKBi PA32035.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG307869.
HOGENOMi HOG000041365.
HOVERGENi HBG017625.
InParanoidi Q8NGS8.
KOi K04257.
OMAi KLIFIFY.
OrthoDBi EOG7GXPC0.
PhylomeDBi Q8NGS8.
TreeFami TF352686.

Enzyme and pathway databases

Reactomei REACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikii OR13C5.
GenomeRNAii 138799.
NextBioi 83835.
PROi Q8NGS8.

Gene expression databases

CleanExi HS_OR13C5.
Genevestigatori Q8NGS8.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  4. Cited for: IDENTIFICATION.
  5. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiO13C5_HUMAN
AccessioniPrimary (citable) accession number: Q8NGS8
Secondary accession number(s): B2RNE5, B9EGW5, Q6IF53
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: September 3, 2014
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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