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Protein

Olfactory receptor 13C5

Gene

OR13C5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

BioCyciZFISH:G66-32022-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 13C5
Alternative name(s):
Olfactory receptor OR9-11
Gene namesi
Name:OR13C5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:15100. OR13C5.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 25ExtracellularSequence analysisAdd BLAST25
Transmembranei26 – 46Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini47 – 54CytoplasmicSequence analysis8
Transmembranei55 – 75Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini76 – 99ExtracellularSequence analysisAdd BLAST24
Transmembranei100 – 120Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini121 – 139CytoplasmicSequence analysisAdd BLAST19
Transmembranei140 – 160Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini161 – 197ExtracellularSequence analysisAdd BLAST37
Transmembranei198 – 217Helical; Name=5Sequence analysisAdd BLAST20
Topological domaini218 – 237CytoplasmicSequence analysisAdd BLAST20
Transmembranei238 – 258Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini259 – 277ExtracellularSequence analysisAdd BLAST19
Transmembranei278 – 298Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini299 – 318CytoplasmicSequence analysisAdd BLAST20

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000277556.
PharmGKBiPA32035.

Polymorphism and mutation databases

BioMutaiOR13C5.
DMDMi38372765.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001507341 – 318Olfactory receptor 13C5Add BLAST318

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ8NGS8.
PaxDbiQ8NGS8.
PeptideAtlasiQ8NGS8.
PRIDEiQ8NGS8.

PTM databases

iPTMnetiQ8NGS8.
PhosphoSitePlusiQ8NGS8.

Expressioni

Gene expression databases

CleanExiHS_OR13C5.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000363911.

Structurei

3D structure databases

ProteinModelPortaliQ8NGS8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410KD4D. Eukaryota.
ENOG4110NTD. LUCA.
GeneTreeiENSGT00760000119058.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiQ8NGS8.
KOiK04257.
OMAiKLIFIFY.
OrthoDBiEOG091G0CU6.
PhylomeDBiQ8NGS8.
TreeFamiTF352686.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGS8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEWENHTILV EFFLKGLSGH PRLELLFFVL IFIMYVVILL GNGTLILISI
60 70 80 90 100
LDPHLHTPMY FFLGNLSFLD ICYTTTSIPS TLVSFLSERK TISLSGCAVQ
110 120 130 140 150
MFLSLAMGTT ECVLLGVMAF DRYVAICNPL RYPIIMSKDA YVPMAAGSWI
160 170 180 190 200
IGAVNSAVQT VFVVQLPFCR NNIINHFTCE ILAVMKLACA DISGNEFILL
210 220 230 240 250
VTTTLFLLTP LLLIIVSYTL IILSIFKISS SEGRSKPSST CSARLTVVIT
260 270 280 290 300
FCGTIFLMYM KPKSQETLNS DDLDATDKLI FIFYRVMTPM MNPLIYSLRN
310
KDVKEAVKHL LRRKNFNK
Length:318
Mass (Da):35,796
Last modified:October 1, 2002 - v1
Checksum:i6865DEBF95217C51
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05329918S → F.Corresponds to variant rs1851722dbSNPEnsembl.1
Natural variantiVAR_03430632F → L.Corresponds to variant rs6479260dbSNPEnsembl.1
Natural variantiVAR_06003269L → M.Corresponds to variant rs7042502dbSNPEnsembl.1
Natural variantiVAR_06003386L → V.Corresponds to variant rs4629933dbSNPEnsembl.1
Natural variantiVAR_060034117V → M.Corresponds to variant rs2417534dbSNPEnsembl.1
Natural variantiVAR_024132189C → Y.Corresponds to variant rs4117966dbSNPEnsembl.1
Natural variantiVAR_053300195N → S.Corresponds to variant rs6479259dbSNPEnsembl.1
Natural variantiVAR_024133258M → T.Corresponds to variant rs1851724dbSNPEnsembl.1
Natural variantiVAR_024134282I → V.Corresponds to variant rs1523678dbSNPEnsembl.1
Natural variantiVAR_024135290M → T.Corresponds to variant rs1851725dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065710 Genomic DNA. Translation: BAC05932.1.
AL450426 Genomic DNA. Translation: CAH72414.1.
BC136842 mRNA. Translation: AAI36843.1.
BC136843 mRNA. Translation: AAI36844.1.
BK004409 Genomic DNA. Translation: DAA04807.1.
CCDSiCCDS35091.1.
RefSeqiNP_001004482.1. NM_001004482.1.
UniGeneiHs.553598.

Genome annotation databases

EnsembliENST00000374779; ENSP00000363911; ENSG00000277556.
GeneIDi138799.
KEGGihsa:138799.
UCSCiuc011lvp.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065710 Genomic DNA. Translation: BAC05932.1.
AL450426 Genomic DNA. Translation: CAH72414.1.
BC136842 mRNA. Translation: AAI36843.1.
BC136843 mRNA. Translation: AAI36844.1.
BK004409 Genomic DNA. Translation: DAA04807.1.
CCDSiCCDS35091.1.
RefSeqiNP_001004482.1. NM_001004482.1.
UniGeneiHs.553598.

3D structure databases

ProteinModelPortaliQ8NGS8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000363911.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ8NGS8.
PhosphoSitePlusiQ8NGS8.

Polymorphism and mutation databases

BioMutaiOR13C5.
DMDMi38372765.

Proteomic databases

EPDiQ8NGS8.
PaxDbiQ8NGS8.
PeptideAtlasiQ8NGS8.
PRIDEiQ8NGS8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000374779; ENSP00000363911; ENSG00000277556.
GeneIDi138799.
KEGGihsa:138799.
UCSCiuc011lvp.2. human.

Organism-specific databases

CTDi138799.
GeneCardsiOR13C5.
HGNCiHGNC:15100. OR13C5.
neXtProtiNX_Q8NGS8.
OpenTargetsiENSG00000277556.
PharmGKBiPA32035.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410KD4D. Eukaryota.
ENOG4110NTD. LUCA.
GeneTreeiENSGT00760000119058.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiQ8NGS8.
KOiK04257.
OMAiKLIFIFY.
OrthoDBiEOG091G0CU6.
PhylomeDBiQ8NGS8.
TreeFamiTF352686.

Enzyme and pathway databases

BioCyciZFISH:G66-32022-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR13C5.
GenomeRNAii138799.
PROiQ8NGS8.

Gene expression databases

CleanExiHS_OR13C5.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO13C5_HUMAN
AccessioniPrimary (citable) accession number: Q8NGS8
Secondary accession number(s): B2RNE5, B9EGW5, Q6IF53
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: November 2, 2016
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.