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Q8NGS7

- O13C8_HUMAN

UniProt

Q8NGS7 - O13C8_HUMAN

Protein

Olfactory receptor 13C8

Gene

OR13C8

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    Odorant receptor.Curated

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW
    2. olfactory receptor activity Source: InterPro

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Olfaction, Sensory transduction

    Enzyme and pathway databases

    ReactomeiREACT_15488. Olfactory Signaling Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Olfactory receptor 13C8
    Gene namesi
    Name:OR13C8
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 9

    Organism-specific databases

    HGNCiHGNC:15103. OR13C8.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA32038.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 320320Olfactory receptor 13C8PRO_0000150735Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi5 – 51N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ8NGS7.
    PRIDEiQ8NGS7.

    Expressioni

    Gene expression databases

    CleanExiHS_OR13C8.
    GenevestigatoriQ8NGS7.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000334068.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8NGS7.
    SMRiQ8NGS7. Positions 29-312.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2525ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini47 – 548CytoplasmicSequence Analysis
    Topological domaini76 – 9924ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini121 – 13919CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini161 – 19737ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini218 – 23720CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini259 – 27719ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini299 – 32022CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei26 – 4621Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei55 – 7521Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei100 – 12021Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei140 – 16021Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei198 – 21720Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei238 – 25821Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei278 – 29821Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG43489.
    HOGENOMiHOG000041365.
    HOVERGENiHBG017625.
    InParanoidiQ8NGS7.
    KOiK04257.
    OMAiWVTGLVD.
    OrthoDBiEOG7GXPC0.
    PhylomeDBiQ8NGS7.
    TreeFamiTF352686.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8NGS7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MERTNDSTST EFFLVGLSAH PKLQTVFFVL ILWMYLMILL GNGVLISVII    50
    FDSHLHTPMY FFLCNLSFLD VCYTSSSVPL ILASFLAVKK KVSFSGCMVQ 100
    MFISFAMGAT ECMILGTMAL DRYVAICYPL RYPVIMSKGA YVAMAAGSWV 150
    TGLVDSVVQT AFAMQLPFCA NNVIKHFVCE ILAILKLACA DISINVISMT 200
    GSNLIVLVIP LLVISISYIF IVATILRIPS TEGKHKAFST CSAHLTVVII 250
    FYGTIFFMYA KPESKASVDS GNEDIIEALI SLFYGVMTPM LNPLIYSLRN 300
    KDVKAAVKNI LCRKNFSDGK 320
    Length:320
    Mass (Da):35,294
    Last modified:October 1, 2002 - v1
    Checksum:i79406A7B52865E56
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti19 – 191A → D.
    Corresponds to variant rs7026705 [ dbSNP | Ensembl ].
    VAR_034307

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065711 Genomic DNA. Translation: BAC05933.1.
    AL450426 Genomic DNA. Translation: CAH72412.1.
    AF399599 Genomic DNA. Translation: AAK95084.1.
    CCDSiCCDS35090.1.
    RefSeqiNP_001004483.1. NM_001004483.1.
    UniGeneiHs.553599.

    Genome annotation databases

    EnsembliENST00000335040; ENSP00000334068; ENSG00000186943.
    GeneIDi138802.
    KEGGihsa:138802.
    UCSCiuc011lvo.2. human.

    Polymorphism databases

    DMDMi38372764.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Human Olfactory Receptor Data Exploratorium (HORDE)

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065711 Genomic DNA. Translation: BAC05933.1 .
    AL450426 Genomic DNA. Translation: CAH72412.1 .
    AF399599 Genomic DNA. Translation: AAK95084.1 .
    CCDSi CCDS35090.1.
    RefSeqi NP_001004483.1. NM_001004483.1.
    UniGenei Hs.553599.

    3D structure databases

    ProteinModelPortali Q8NGS7.
    SMRi Q8NGS7. Positions 29-312.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000334068.

    Protein family/group databases

    GPCRDBi Search...

    Polymorphism databases

    DMDMi 38372764.

    Proteomic databases

    PaxDbi Q8NGS7.
    PRIDEi Q8NGS7.

    Protocols and materials databases

    DNASUi 138802.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000335040 ; ENSP00000334068 ; ENSG00000186943 .
    GeneIDi 138802.
    KEGGi hsa:138802.
    UCSCi uc011lvo.2. human.

    Organism-specific databases

    CTDi 138802.
    GeneCardsi GC09P107331.
    HGNCi HGNC:15103. OR13C8.
    neXtProti NX_Q8NGS7.
    PharmGKBi PA32038.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG43489.
    HOGENOMi HOG000041365.
    HOVERGENi HBG017625.
    InParanoidi Q8NGS7.
    KOi K04257.
    OMAi WVTGLVD.
    OrthoDBi EOG7GXPC0.
    PhylomeDBi Q8NGS7.
    TreeFami TF352686.

    Enzyme and pathway databases

    Reactomei REACT_15488. Olfactory Signaling Pathway.

    Miscellaneous databases

    GeneWikii OR13C8.
    NextBioi 83839.
    PROi Q8NGS7.

    Gene expression databases

    CleanExi HS_OR13C8.
    Genevestigatori Q8NGS7.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
      Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
      Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "DNA sequence and analysis of human chromosome 9."
      Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
      , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
      Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-289.

    Entry informationi

    Entry nameiO13C8_HUMAN
    AccessioniPrimary (citable) accession number: Q8NGS7
    Secondary accession number(s): Q5VVG0, Q96R44
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 10, 2003
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 102 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 9
      Human chromosome 9: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3