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Q8NGS7

- O13C8_HUMAN

UniProt

Q8NGS7 - O13C8_HUMAN

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Protein

Olfactory receptor 13C8

Gene

OR13C8

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 13C8
Gene namesi
Name:OR13C8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 9

Organism-specific databases

HGNCiHGNC:15103. OR13C8.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2525ExtracellularSequence AnalysisAdd
BLAST
Transmembranei26 – 4621Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini47 – 548CytoplasmicSequence Analysis
Transmembranei55 – 7521Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini76 – 9924ExtracellularSequence AnalysisAdd
BLAST
Transmembranei100 – 12021Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini121 – 13919CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei140 – 16021Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini161 – 19737ExtracellularSequence AnalysisAdd
BLAST
Transmembranei198 – 21720Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini218 – 23720CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei238 – 25821Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini259 – 27719ExtracellularSequence AnalysisAdd
BLAST
Transmembranei278 – 29821Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini299 – 32022CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32038.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 320320Olfactory receptor 13C8PRO_0000150735Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGS7.
PRIDEiQ8NGS7.

Expressioni

Gene expression databases

CleanExiHS_OR13C8.
GenevestigatoriQ8NGS7.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000334068.

Structurei

3D structure databases

ProteinModelPortaliQ8NGS7.
SMRiQ8NGS7. Positions 29-312.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG43489.
GeneTreeiENSGT00760000119058.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiQ8NGS7.
KOiK04257.
OMAiWVTGLVD.
OrthoDBiEOG7GXPC0.
PhylomeDBiQ8NGS7.
TreeFamiTF352686.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGS7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MERTNDSTST EFFLVGLSAH PKLQTVFFVL ILWMYLMILL GNGVLISVII
60 70 80 90 100
FDSHLHTPMY FFLCNLSFLD VCYTSSSVPL ILASFLAVKK KVSFSGCMVQ
110 120 130 140 150
MFISFAMGAT ECMILGTMAL DRYVAICYPL RYPVIMSKGA YVAMAAGSWV
160 170 180 190 200
TGLVDSVVQT AFAMQLPFCA NNVIKHFVCE ILAILKLACA DISINVISMT
210 220 230 240 250
GSNLIVLVIP LLVISISYIF IVATILRIPS TEGKHKAFST CSAHLTVVII
260 270 280 290 300
FYGTIFFMYA KPESKASVDS GNEDIIEALI SLFYGVMTPM LNPLIYSLRN
310 320
KDVKAAVKNI LCRKNFSDGK
Length:320
Mass (Da):35,294
Last modified:October 1, 2002 - v1
Checksum:i79406A7B52865E56
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti19 – 191A → D.
Corresponds to variant rs7026705 [ dbSNP | Ensembl ].
VAR_034307

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065711 Genomic DNA. Translation: BAC05933.1.
AL450426 Genomic DNA. Translation: CAH72412.1.
AF399599 Genomic DNA. Translation: AAK95084.1.
CCDSiCCDS35090.1.
RefSeqiNP_001004483.1. NM_001004483.1.
UniGeneiHs.553599.

Genome annotation databases

EnsembliENST00000335040; ENSP00000334068; ENSG00000186943.
GeneIDi138802.
KEGGihsa:138802.
UCSCiuc011lvo.2. human.

Polymorphism databases

DMDMi38372764.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065711 Genomic DNA. Translation: BAC05933.1 .
AL450426 Genomic DNA. Translation: CAH72412.1 .
AF399599 Genomic DNA. Translation: AAK95084.1 .
CCDSi CCDS35090.1.
RefSeqi NP_001004483.1. NM_001004483.1.
UniGenei Hs.553599.

3D structure databases

ProteinModelPortali Q8NGS7.
SMRi Q8NGS7. Positions 29-312.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000334068.

Protein family/group databases

GPCRDBi Search...

Polymorphism databases

DMDMi 38372764.

Proteomic databases

PaxDbi Q8NGS7.
PRIDEi Q8NGS7.

Protocols and materials databases

DNASUi 138802.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000335040 ; ENSP00000334068 ; ENSG00000186943 .
GeneIDi 138802.
KEGGi hsa:138802.
UCSCi uc011lvo.2. human.

Organism-specific databases

CTDi 138802.
GeneCardsi GC09P107331.
HGNCi HGNC:15103. OR13C8.
neXtProti NX_Q8NGS7.
PharmGKBi PA32038.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG43489.
GeneTreei ENSGT00760000119058.
HOGENOMi HOG000041365.
HOVERGENi HBG017625.
InParanoidi Q8NGS7.
KOi K04257.
OMAi WVTGLVD.
OrthoDBi EOG7GXPC0.
PhylomeDBi Q8NGS7.
TreeFami TF352686.

Enzyme and pathway databases

Reactomei REACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikii OR13C8.
GenomeRNAii 138802.
NextBioi 83839.
PROi Q8NGS7.

Gene expression databases

CleanExi HS_OR13C8.
Genevestigatori Q8NGS7.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-289.

Entry informationi

Entry nameiO13C8_HUMAN
AccessioniPrimary (citable) accession number: Q8NGS7
Secondary accession number(s): Q5VVG0, Q96R44
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: October 29, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3