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Protein

Olfactory receptor 13C8

Gene

OR13C8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 13C8
Gene namesi
Name:OR13C8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:15103. OR13C8.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2525ExtracellularSequence AnalysisAdd
BLAST
Transmembranei26 – 4621Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini47 – 548CytoplasmicSequence Analysis
Transmembranei55 – 7521Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini76 – 9924ExtracellularSequence AnalysisAdd
BLAST
Transmembranei100 – 12021Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini121 – 13919CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei140 – 16021Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini161 – 19737ExtracellularSequence AnalysisAdd
BLAST
Transmembranei198 – 21720Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini218 – 23720CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei238 – 25821Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini259 – 27719ExtracellularSequence AnalysisAdd
BLAST
Transmembranei278 – 29821Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini299 – 32022CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32038.

Polymorphism and mutation databases

BioMutaiOR13C8.
DMDMi38372764.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 320320Olfactory receptor 13C8PRO_0000150735Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGS7.
PRIDEiQ8NGS7.

Expressioni

Gene expression databases

CleanExiHS_OR13C8.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000334068.

Structurei

3D structure databases

ProteinModelPortaliQ8NGS7.
SMRiQ8NGS7. Positions 29-312.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG43489.
GeneTreeiENSGT00760000119058.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiQ8NGS7.
KOiK04257.
OMAiWVTGLVD.
OrthoDBiEOG7GXPC0.
PhylomeDBiQ8NGS7.
TreeFamiTF352686.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGS7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MERTNDSTST EFFLVGLSAH PKLQTVFFVL ILWMYLMILL GNGVLISVII
60 70 80 90 100
FDSHLHTPMY FFLCNLSFLD VCYTSSSVPL ILASFLAVKK KVSFSGCMVQ
110 120 130 140 150
MFISFAMGAT ECMILGTMAL DRYVAICYPL RYPVIMSKGA YVAMAAGSWV
160 170 180 190 200
TGLVDSVVQT AFAMQLPFCA NNVIKHFVCE ILAILKLACA DISINVISMT
210 220 230 240 250
GSNLIVLVIP LLVISISYIF IVATILRIPS TEGKHKAFST CSAHLTVVII
260 270 280 290 300
FYGTIFFMYA KPESKASVDS GNEDIIEALI SLFYGVMTPM LNPLIYSLRN
310 320
KDVKAAVKNI LCRKNFSDGK
Length:320
Mass (Da):35,294
Last modified:October 1, 2002 - v1
Checksum:i79406A7B52865E56
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti19 – 191A → D.
Corresponds to variant rs7026705 [ dbSNP | Ensembl ].
VAR_034307

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065711 Genomic DNA. Translation: BAC05933.1.
AL450426 Genomic DNA. Translation: CAH72412.1.
AF399599 Genomic DNA. Translation: AAK95084.1.
CCDSiCCDS35090.1.
RefSeqiNP_001004483.1. NM_001004483.1.
UniGeneiHs.553599.

Genome annotation databases

EnsembliENST00000335040; ENSP00000334068; ENSG00000186943.
GeneIDi138802.
KEGGihsa:138802.
UCSCiuc011lvo.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065711 Genomic DNA. Translation: BAC05933.1.
AL450426 Genomic DNA. Translation: CAH72412.1.
AF399599 Genomic DNA. Translation: AAK95084.1.
CCDSiCCDS35090.1.
RefSeqiNP_001004483.1. NM_001004483.1.
UniGeneiHs.553599.

3D structure databases

ProteinModelPortaliQ8NGS7.
SMRiQ8NGS7. Positions 29-312.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000334068.

Protein family/group databases

GPCRDBiSearch...

Polymorphism and mutation databases

BioMutaiOR13C8.
DMDMi38372764.

Proteomic databases

PaxDbiQ8NGS7.
PRIDEiQ8NGS7.

Protocols and materials databases

DNASUi138802.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000335040; ENSP00000334068; ENSG00000186943.
GeneIDi138802.
KEGGihsa:138802.
UCSCiuc011lvo.2. human.

Organism-specific databases

CTDi138802.
GeneCardsiGC09P107331.
HGNCiHGNC:15103. OR13C8.
neXtProtiNX_Q8NGS7.
PharmGKBiPA32038.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG43489.
GeneTreeiENSGT00760000119058.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiQ8NGS7.
KOiK04257.
OMAiWVTGLVD.
OrthoDBiEOG7GXPC0.
PhylomeDBiQ8NGS7.
TreeFamiTF352686.

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR13C8.
GenomeRNAii138802.
NextBioi83839.
PROiQ8NGS7.

Gene expression databases

CleanExiHS_OR13C8.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-289.

Entry informationi

Entry nameiO13C8_HUMAN
AccessioniPrimary (citable) accession number: Q8NGS7
Secondary accession number(s): Q5VVG0, Q96R44
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: June 24, 2015
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.