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Protein

Olfactory receptor 13C3

Gene

OR13C3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

BioCyciZFISH:ENSG00000179110-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 13C3
Alternative name(s):
Olfactory receptor OR9-8
Gene namesi
Name:OR13C3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:14704. OR13C3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 55ExtracellularSequence analysisAdd BLAST55
Transmembranei56 – 76Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini77 – 84CytoplasmicSequence analysis8
Transmembranei85 – 105Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini106 – 129ExtracellularSequence analysisAdd BLAST24
Transmembranei130 – 150Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini151 – 169CytoplasmicSequence analysisAdd BLAST19
Transmembranei170 – 190Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini191 – 227ExtracellularSequence analysisAdd BLAST37
Transmembranei228 – 247Helical; Name=5Sequence analysisAdd BLAST20
Topological domaini248 – 267CytoplasmicSequence analysisAdd BLAST20
Transmembranei268 – 288Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini289 – 307ExtracellularSequence analysisAdd BLAST19
Transmembranei308 – 328Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini329 – 347CytoplasmicSequence analysisAdd BLAST19

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi138803.
OpenTargetsiENSG00000204246.
PharmGKBiPA32033.

Polymorphism and mutation databases

BioMutaiOR13C3.
DMDMi218511724.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001507321 – 347Olfactory receptor 13C3Add BLAST347

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi35N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi127 ↔ 219PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGS6.
PRIDEiQ8NGS6.

PTM databases

iPTMnetiQ8NGS6.
PhosphoSitePlusiQ8NGS6.

Expressioni

Gene expression databases

BgeeiENSG00000204246.
CleanExiHS_OR13C3.
ExpressionAtlasiQ8NGS6. baseline and differential.

Organism-specific databases

HPAiHPA053978.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000363913.

Structurei

3D structure databases

ProteinModelPortaliQ8NGS6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IENR. Eukaryota.
ENOG4111CQX. LUCA.
GeneTreeiENSGT00760000119058.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiQ8NGS6.
KOiK04257.
OMAiIEIVYFA.
OrthoDBiEOG091G0CU6.
PhylomeDBiQ8NGS6.
TreeFamiTF352686.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGS6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIVQLICTVC FLAVNTFHVR SSFDFLKADD MGEINQTLVS EFLLLGLSGY
60 70 80 90 100
PKIEIVYFAL ILVMYLVILI GNGVLIIASI FDSHFHTPMY FFLGNLSFLD
110 120 130 140 150
ICYTSSSVPS TLVSLISKKR NISFSGCAVQ MFFGFAMGST ECLLLGMMAF
160 170 180 190 200
DRYVAICNPL RYPIILSKVA YVLMASVSWL SGGINSAVQT LLAMRLPFCG
210 220 230 240 250
NNIINHFACE ILAVLKLACA DISLNIITMV ISNMAFLVLP LMVIFFSYMF
260 270 280 290 300
ILYTILQMNS ATGRRKAFST CSAHLTVVII FYGTIFFMYA KPKSQDLIGE
310 320 330 340
EKLQALDKLI SLFYGVVTPM LNPILYSLRN KDVKAAVKYL LNKKPIH
Length:347
Mass (Da):38,729
Last modified:December 16, 2008 - v2
Checksum:i6318EA2A850871D7
GO

Sequence cautioni

The sequence BAC05934 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAH72411 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_024131293K → T.Corresponds to variant rs10512330dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065713 Genomic DNA. Translation: BAC05934.1. Different initiation.
AL450426 Genomic DNA. Translation: CAH72411.1. Different initiation.
BC136949 mRNA. Translation: AAI36950.1.
BC136952 mRNA. Translation: AAI36953.1.
BK004410 Genomic DNA. Translation: DAA04808.1.
CCDSiCCDS35089.1.
RefSeqiNP_001001961.1. NM_001001961.1.
UniGeneiHs.553600.

Genome annotation databases

EnsembliENST00000374781; ENSP00000363913; ENSG00000204246.
GeneIDi138803.
KEGGihsa:138803.
UCSCiuc004bcb.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065713 Genomic DNA. Translation: BAC05934.1. Different initiation.
AL450426 Genomic DNA. Translation: CAH72411.1. Different initiation.
BC136949 mRNA. Translation: AAI36950.1.
BC136952 mRNA. Translation: AAI36953.1.
BK004410 Genomic DNA. Translation: DAA04808.1.
CCDSiCCDS35089.1.
RefSeqiNP_001001961.1. NM_001001961.1.
UniGeneiHs.553600.

3D structure databases

ProteinModelPortaliQ8NGS6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000363913.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ8NGS6.
PhosphoSitePlusiQ8NGS6.

Polymorphism and mutation databases

BioMutaiOR13C3.
DMDMi218511724.

Proteomic databases

PaxDbiQ8NGS6.
PRIDEiQ8NGS6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000374781; ENSP00000363913; ENSG00000204246.
GeneIDi138803.
KEGGihsa:138803.
UCSCiuc004bcb.2. human.

Organism-specific databases

CTDi138803.
DisGeNETi138803.
GeneCardsiOR13C3.
HGNCiHGNC:14704. OR13C3.
HPAiHPA053978.
neXtProtiNX_Q8NGS6.
OpenTargetsiENSG00000204246.
PharmGKBiPA32033.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IENR. Eukaryota.
ENOG4111CQX. LUCA.
GeneTreeiENSGT00760000119058.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiQ8NGS6.
KOiK04257.
OMAiIEIVYFA.
OrthoDBiEOG091G0CU6.
PhylomeDBiQ8NGS6.
TreeFamiTF352686.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000179110-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR13C3.
GenomeRNAii138803.
PROiQ8NGS6.

Gene expression databases

BgeeiENSG00000204246.
CleanExiHS_OR13C3.
ExpressionAtlasiQ8NGS6. baseline and differential.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO13C3_HUMAN
AccessioniPrimary (citable) accession number: Q8NGS6
Secondary accession number(s): Q5VVG1, Q6IF52
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2003
Last sequence update: December 16, 2008
Last modified: November 30, 2016
This is version 127 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-31 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.