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Q8NGS6

- O13C3_HUMAN

UniProt

Q8NGS6 - O13C3_HUMAN

Protein

Olfactory receptor 13C3

Gene

OR13C3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 110 (01 Oct 2014)
      Sequence version 2 (16 Dec 2008)
      Previous versions | rss
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    Functioni

    Odorant receptor.Curated

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW
    2. olfactory receptor activity Source: InterPro

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Olfaction, Sensory transduction

    Enzyme and pathway databases

    ReactomeiREACT_15488. Olfactory Signaling Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Olfactory receptor 13C3
    Alternative name(s):
    Olfactory receptor OR9-8
    Gene namesi
    Name:OR13C3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 9

    Organism-specific databases

    HGNCiHGNC:14704. OR13C3.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA32033.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 347347Olfactory receptor 13C3PRO_0000150732Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi35 – 351N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi127 ↔ 219PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ8NGS6.
    PRIDEiQ8NGS6.

    PTM databases

    PhosphoSiteiQ8NGS6.

    Expressioni

    Gene expression databases

    BgeeiQ8NGS6.
    CleanExiHS_OR13C3.
    GenevestigatoriQ8NGS6.

    Organism-specific databases

    HPAiHPA053978.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000363913.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8NGS6.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 5555ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini77 – 848CytoplasmicSequence Analysis
    Topological domaini106 – 12924ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini151 – 16919CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini191 – 22737ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini248 – 26720CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini289 – 30719ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini329 – 34719CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei56 – 7621Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei85 – 10521Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei130 – 15021Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei170 – 19021Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei228 – 24720Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei268 – 28821Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei308 – 32821Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG42676.
    HOGENOMiHOG000041365.
    HOVERGENiHBG017625.
    InParanoidiQ8NGS6.
    KOiK04257.
    OMAiNIITMVI.
    OrthoDBiEOG7GXPC0.
    PhylomeDBiQ8NGS6.
    TreeFamiTF352686.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8NGS6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIVQLICTVC FLAVNTFHVR SSFDFLKADD MGEINQTLVS EFLLLGLSGY    50
    PKIEIVYFAL ILVMYLVILI GNGVLIIASI FDSHFHTPMY FFLGNLSFLD 100
    ICYTSSSVPS TLVSLISKKR NISFSGCAVQ MFFGFAMGST ECLLLGMMAF 150
    DRYVAICNPL RYPIILSKVA YVLMASVSWL SGGINSAVQT LLAMRLPFCG 200
    NNIINHFACE ILAVLKLACA DISLNIITMV ISNMAFLVLP LMVIFFSYMF 250
    ILYTILQMNS ATGRRKAFST CSAHLTVVII FYGTIFFMYA KPKSQDLIGE 300
    EKLQALDKLI SLFYGVVTPM LNPILYSLRN KDVKAAVKYL LNKKPIH 347
    Length:347
    Mass (Da):38,729
    Last modified:December 16, 2008 - v2
    Checksum:i6318EA2A850871D7
    GO

    Sequence cautioni

    The sequence BAC05934.1 differs from that shown. Reason: Erroneous initiation.
    The sequence CAH72411.1 differs from that shown. Reason: Erroneous initiation.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti293 – 2931K → T.
    Corresponds to variant rs10512330 [ dbSNP | Ensembl ].
    VAR_024131

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065713 Genomic DNA. Translation: BAC05934.1. Different initiation.
    AL450426 Genomic DNA. Translation: CAH72411.1. Different initiation.
    BC136949 mRNA. Translation: AAI36950.1.
    BC136952 mRNA. Translation: AAI36953.1.
    BK004410 Genomic DNA. Translation: DAA04808.1.
    CCDSiCCDS35089.1.
    RefSeqiNP_001001961.1. NM_001001961.1.
    UniGeneiHs.553600.

    Genome annotation databases

    EnsembliENST00000374781; ENSP00000363913; ENSG00000204246.
    GeneIDi138803.
    KEGGihsa:138803.
    UCSCiuc004bcb.1. human.

    Polymorphism databases

    DMDMi218511724.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Human Olfactory Receptor Data Exploratorium (HORDE)

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065713 Genomic DNA. Translation: BAC05934.1 . Different initiation.
    AL450426 Genomic DNA. Translation: CAH72411.1 . Different initiation.
    BC136949 mRNA. Translation: AAI36950.1 .
    BC136952 mRNA. Translation: AAI36953.1 .
    BK004410 Genomic DNA. Translation: DAA04808.1 .
    CCDSi CCDS35089.1.
    RefSeqi NP_001001961.1. NM_001001961.1.
    UniGenei Hs.553600.

    3D structure databases

    ProteinModelPortali Q8NGS6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000363913.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q8NGS6.

    Polymorphism databases

    DMDMi 218511724.

    Proteomic databases

    PaxDbi Q8NGS6.
    PRIDEi Q8NGS6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000374781 ; ENSP00000363913 ; ENSG00000204246 .
    GeneIDi 138803.
    KEGGi hsa:138803.
    UCSCi uc004bcb.1. human.

    Organism-specific databases

    CTDi 138803.
    GeneCardsi GC09M107298.
    HGNCi HGNC:14704. OR13C3.
    HPAi HPA053978.
    neXtProti NX_Q8NGS6.
    PharmGKBi PA32033.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG42676.
    HOGENOMi HOG000041365.
    HOVERGENi HBG017625.
    InParanoidi Q8NGS6.
    KOi K04257.
    OMAi NIITMVI.
    OrthoDBi EOG7GXPC0.
    PhylomeDBi Q8NGS6.
    TreeFami TF352686.

    Enzyme and pathway databases

    Reactomei REACT_15488. Olfactory Signaling Pathway.

    Miscellaneous databases

    GeneWikii OR13C3.
    GenomeRNAii 138803.
    NextBioi 83843.
    PROi Q8NGS6.

    Gene expression databases

    Bgeei Q8NGS6.
    CleanExi HS_OR13C3.
    Genevestigatori Q8NGS6.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
      Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
      Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "DNA sequence and analysis of human chromosome 9."
      Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
      , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
      Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. Cited for: IDENTIFICATION.
    5. Erratum
      Malnic B., Godfrey P.A., Buck L.B.
      Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

    Entry informationi

    Entry nameiO13C3_HUMAN
    AccessioniPrimary (citable) accession number: Q8NGS6
    Secondary accession number(s): Q5VVG1, Q6IF52
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 26, 2003
    Last sequence update: December 16, 2008
    Last modified: October 1, 2014
    This is version 110 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    It is uncertain whether Met-1 or Met-31 is the initiator.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 9
      Human chromosome 9: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3