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Q8NGS6 (O13C3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 106. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Olfactory receptor 13C3
Alternative name(s):
Olfactory receptor OR9-8
Gene names
Name:OR13C3
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length347 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Odorant receptor Potential.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Caution

It is uncertain whether Met-1 or Met-31 is the initiator.

Sequence caution

The sequence BAC05934.1 differs from that shown. Reason: Erroneous initiation.

The sequence CAH72411.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 347347Olfactory receptor 13C3
PRO_0000150732

Regions

Topological domain1 – 5555Extracellular Potential
Transmembrane56 – 7621Helical; Name=1; Potential
Topological domain77 – 848Cytoplasmic Potential
Transmembrane85 – 10521Helical; Name=2; Potential
Topological domain106 – 12924Extracellular Potential
Transmembrane130 – 15021Helical; Name=3; Potential
Topological domain151 – 16919Cytoplasmic Potential
Transmembrane170 – 19021Helical; Name=4; Potential
Topological domain191 – 22737Extracellular Potential
Transmembrane228 – 24720Helical; Name=5; Potential
Topological domain248 – 26720Cytoplasmic Potential
Transmembrane268 – 28821Helical; Name=6; Potential
Topological domain289 – 30719Extracellular Potential
Transmembrane308 – 32821Helical; Name=7; Potential
Topological domain329 – 34719Cytoplasmic Potential

Amino acid modifications

Glycosylation351N-linked (GlcNAc...) Potential
Disulfide bond127 ↔ 219 By similarity

Natural variations

Natural variant2931K → T.
Corresponds to variant rs10512330 [ dbSNP | Ensembl ].
VAR_024131

Sequences

Sequence LengthMass (Da)Tools
Q8NGS6 [UniParc].

Last modified December 16, 2008. Version 2.
Checksum: 6318EA2A850871D7

FASTA34738,729
        10         20         30         40         50         60 
MIVQLICTVC FLAVNTFHVR SSFDFLKADD MGEINQTLVS EFLLLGLSGY PKIEIVYFAL 

        70         80         90        100        110        120 
ILVMYLVILI GNGVLIIASI FDSHFHTPMY FFLGNLSFLD ICYTSSSVPS TLVSLISKKR 

       130        140        150        160        170        180 
NISFSGCAVQ MFFGFAMGST ECLLLGMMAF DRYVAICNPL RYPIILSKVA YVLMASVSWL 

       190        200        210        220        230        240 
SGGINSAVQT LLAMRLPFCG NNIINHFACE ILAVLKLACA DISLNIITMV ISNMAFLVLP 

       250        260        270        280        290        300 
LMVIFFSYMF ILYTILQMNS ATGRRKAFST CSAHLTVVII FYGTIFFMYA KPKSQDLIGE 

       310        320        330        340 
EKLQALDKLI SLFYGVVTPM LNPILYSLRN KDVKAAVKYL LNKKPIH 

« Hide

References

« Hide 'large scale' references
[1]"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"DNA sequence and analysis of human chromosome 9."
Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. expand/collapse author list , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]"The human olfactory receptor gene family."
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
[5]Erratum
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB065713 Genomic DNA. Translation: BAC05934.1. Different initiation.
AL450426 Genomic DNA. Translation: CAH72411.1. Different initiation.
BC136949 mRNA. Translation: AAI36950.1.
BC136952 mRNA. Translation: AAI36953.1.
BK004410 Genomic DNA. Translation: DAA04808.1.
RefSeqNP_001001961.1. NM_001001961.1.
UniGeneHs.553600.

3D structure databases

ProteinModelPortalQ8NGS6.
SMRQ8NGS6. Positions 56-195, 313-343.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000363913.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteQ8NGS6.

Polymorphism databases

DMDM218511724.

Proteomic databases

PaxDbQ8NGS6.
PRIDEQ8NGS6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000374781; ENSP00000363913; ENSG00000204246.
GeneID138803.
KEGGhsa:138803.
UCSCuc004bcb.1. human.

Organism-specific databases

CTD138803.
GeneCardsGC09M107298.
HGNCHGNC:14704. OR13C3.
HPAHPA053978.
neXtProtNX_Q8NGS6.
PharmGKBPA32033.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG42676.
HOGENOMHOG000041365.
HOVERGENHBG017625.
InParanoidQ8NGS6.
KOK04257.
OMANIITMVI.
OrthoDBEOG7GXPC0.
PhylomeDBQ8NGS6.
TreeFamTF352686.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

BgeeQ8NGS6.
CleanExHS_OR13C3.
GenevestigatorQ8NGS6.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiOR13C3.
GenomeRNAi138803.
NextBio83843.
PROQ8NGS6.

Entry information

Entry nameO13C3_HUMAN
AccessionPrimary (citable) accession number: Q8NGS6
Secondary accession number(s): Q5VVG1, Q6IF52
Entry history
Integrated into UniProtKB/Swiss-Prot: September 26, 2003
Last sequence update: December 16, 2008
Last modified: April 16, 2014
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 9

Human chromosome 9: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries