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Q8NGS6

- O13C3_HUMAN

UniProt

Q8NGS6 - O13C3_HUMAN

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Protein

Olfactory receptor 13C3

Gene

OR13C3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 13C3
Alternative name(s):
Olfactory receptor OR9-8
Gene namesi
Name:OR13C3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 9

Organism-specific databases

HGNCiHGNC:14704. OR13C3.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32033.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 347347Olfactory receptor 13C3PRO_0000150732Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi35 – 351N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi127 ↔ 219PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGS6.
PRIDEiQ8NGS6.

PTM databases

PhosphoSiteiQ8NGS6.

Expressioni

Gene expression databases

BgeeiQ8NGS6.
CleanExiHS_OR13C3.
GenevestigatoriQ8NGS6.

Organism-specific databases

HPAiHPA053978.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000363913.

Structurei

3D structure databases

ProteinModelPortaliQ8NGS6.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 5555ExtracellularSequence AnalysisAdd
BLAST
Topological domaini77 – 848CytoplasmicSequence Analysis
Topological domaini106 – 12924ExtracellularSequence AnalysisAdd
BLAST
Topological domaini151 – 16919CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini191 – 22737ExtracellularSequence AnalysisAdd
BLAST
Topological domaini248 – 26720CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini289 – 30719ExtracellularSequence AnalysisAdd
BLAST
Topological domaini329 – 34719CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei56 – 7621Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei85 – 10521Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei130 – 15021Helical; Name=3Sequence AnalysisAdd
BLAST
Transmembranei170 – 19021Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei228 – 24720Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei268 – 28821Helical; Name=6Sequence AnalysisAdd
BLAST
Transmembranei308 – 32821Helical; Name=7Sequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG42676.
GeneTreeiENSGT00760000119058.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiQ8NGS6.
KOiK04257.
OMAiNIITMVI.
OrthoDBiEOG7GXPC0.
PhylomeDBiQ8NGS6.
TreeFamiTF352686.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGS6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIVQLICTVC FLAVNTFHVR SSFDFLKADD MGEINQTLVS EFLLLGLSGY
60 70 80 90 100
PKIEIVYFAL ILVMYLVILI GNGVLIIASI FDSHFHTPMY FFLGNLSFLD
110 120 130 140 150
ICYTSSSVPS TLVSLISKKR NISFSGCAVQ MFFGFAMGST ECLLLGMMAF
160 170 180 190 200
DRYVAICNPL RYPIILSKVA YVLMASVSWL SGGINSAVQT LLAMRLPFCG
210 220 230 240 250
NNIINHFACE ILAVLKLACA DISLNIITMV ISNMAFLVLP LMVIFFSYMF
260 270 280 290 300
ILYTILQMNS ATGRRKAFST CSAHLTVVII FYGTIFFMYA KPKSQDLIGE
310 320 330 340
EKLQALDKLI SLFYGVVTPM LNPILYSLRN KDVKAAVKYL LNKKPIH
Length:347
Mass (Da):38,729
Last modified:December 16, 2008 - v2
Checksum:i6318EA2A850871D7
GO

Sequence cautioni

The sequence BAC05934.1 differs from that shown. Reason: Erroneous initiation.
The sequence CAH72411.1 differs from that shown. Reason: Erroneous initiation.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti293 – 2931K → T.
Corresponds to variant rs10512330 [ dbSNP | Ensembl ].
VAR_024131

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB065713 Genomic DNA. Translation: BAC05934.1. Different initiation.
AL450426 Genomic DNA. Translation: CAH72411.1. Different initiation.
BC136949 mRNA. Translation: AAI36950.1.
BC136952 mRNA. Translation: AAI36953.1.
BK004410 Genomic DNA. Translation: DAA04808.1.
CCDSiCCDS35089.1.
RefSeqiNP_001001961.1. NM_001001961.1.
UniGeneiHs.553600.

Genome annotation databases

EnsembliENST00000374781; ENSP00000363913; ENSG00000204246.
GeneIDi138803.
KEGGihsa:138803.
UCSCiuc004bcb.1. human.

Polymorphism databases

DMDMi218511724.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB065713 Genomic DNA. Translation: BAC05934.1 . Different initiation.
AL450426 Genomic DNA. Translation: CAH72411.1 . Different initiation.
BC136949 mRNA. Translation: AAI36950.1 .
BC136952 mRNA. Translation: AAI36953.1 .
BK004410 Genomic DNA. Translation: DAA04808.1 .
CCDSi CCDS35089.1.
RefSeqi NP_001001961.1. NM_001001961.1.
UniGenei Hs.553600.

3D structure databases

ProteinModelPortali Q8NGS6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000363913.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei Q8NGS6.

Polymorphism databases

DMDMi 218511724.

Proteomic databases

PaxDbi Q8NGS6.
PRIDEi Q8NGS6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000374781 ; ENSP00000363913 ; ENSG00000204246 .
GeneIDi 138803.
KEGGi hsa:138803.
UCSCi uc004bcb.1. human.

Organism-specific databases

CTDi 138803.
GeneCardsi GC09M107298.
HGNCi HGNC:14704. OR13C3.
HPAi HPA053978.
neXtProti NX_Q8NGS6.
PharmGKBi PA32033.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG42676.
GeneTreei ENSGT00760000119058.
HOGENOMi HOG000041365.
HOVERGENi HBG017625.
InParanoidi Q8NGS6.
KOi K04257.
OMAi NIITMVI.
OrthoDBi EOG7GXPC0.
PhylomeDBi Q8NGS6.
TreeFami TF352686.

Enzyme and pathway databases

Reactomei REACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikii OR13C3.
GenomeRNAii 138803.
NextBioi 83843.
PROi Q8NGS6.

Gene expression databases

Bgeei Q8NGS6.
CleanExi HS_OR13C3.
Genevestigatori Q8NGS6.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. Cited for: IDENTIFICATION.
  5. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiO13C3_HUMAN
AccessioniPrimary (citable) accession number: Q8NGS6
Secondary accession number(s): Q5VVG1, Q6IF52
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2003
Last sequence update: December 16, 2008
Last modified: October 29, 2014
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-31 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3