ID   O13C4_HUMAN             Reviewed;         318 AA.
AC   Q8NGS5; Q6IF51; Q96R41;
DT   26-SEP-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   24-JAN-2024, entry version 159.
DE   RecName: Full=Olfactory receptor 13C4;
DE   AltName: Full=Olfactory receptor OR9-7;
GN   Name=OR13C4;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA   Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT   "Genome-wide discovery and analysis of human seven transmembrane helix
RT   receptor genes.";
RL   Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15164053; DOI=10.1038/nature02465;
RA   Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L.,
RA   Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R.,
RA   Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S.,
RA   Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K.,
RA   Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y.,
RA   Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C.,
RA   Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E.,
RA   Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M.,
RA   Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J.,
RA   Frankish A., Frankland J.A., French L., Fricker D.G., Garner P.,
RA   Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA   Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA   Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA   Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA   Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA   Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S.,
RA   Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J.,
RA   Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E.,
RA   McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V.,
RA   Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S.,
RA   Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K.,
RA   Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J.,
RA   Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M.,
RA   West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L.,
RA   Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M.,
RA   Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J.,
RA   Dunham I.;
RT   "DNA sequence and analysis of human chromosome 9.";
RL   Nature 429:369-374(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-289.
RX   PubMed=12213199; DOI=10.1006/geno.2002.6830;
RA   Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R.,
RA   Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U.,
RA   Lehrach H., Lancet D., Shamir R.;
RT   "DEFOG: a practical scheme for deciphering families of genes.";
RL   Genomics 80:295-302(2002).
RN   [4]
RP   IDENTIFICATION.
RX   PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA   Malnic B., Godfrey P.A., Buck L.B.;
RT   "The human olfactory receptor gene family.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN   [5]
RP   ERRATUM OF PUBMED:14983052.
RA   Malnic B., Godfrey P.A., Buck L.B.;
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC   -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC   -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC       URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR13C4";
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DR   EMBL; AB065714; BAC05935.1; -; Genomic_DNA.
DR   EMBL; AL450426; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AF399602; AAK95087.1; -; Genomic_DNA.
DR   EMBL; BK004411; DAA04809.1; -; Genomic_DNA.
DR   CCDS; CCDS35088.1; -.
DR   RefSeq; NP_001001919.1; NM_001001919.1.
DR   AlphaFoldDB; Q8NGS5; -.
DR   SMR; Q8NGS5; -.
DR   BioGRID; 126525; 1.
DR   STRING; 9606.ENSP00000277216; -.
DR   GlyCosmos; Q8NGS5; 1 site, No reported glycans.
DR   GlyGen; Q8NGS5; 1 site.
DR   iPTMnet; Q8NGS5; -.
DR   PhosphoSitePlus; Q8NGS5; -.
DR   BioMuta; OR13C4; -.
DR   DMDM; 37081371; -.
DR   MassIVE; Q8NGS5; -.
DR   PaxDb; 9606-ENSP00000277216; -.
DR   PeptideAtlas; Q8NGS5; -.
DR   Antibodypedia; 54611; 47 antibodies from 15 providers.
DR   DNASU; 138804; -.
DR   Ensembl; ENST00000277216.3; ENSP00000277216.3; ENSG00000148136.5.
DR   GeneID; 138804; -.
DR   KEGG; hsa:138804; -.
DR   MANE-Select; ENST00000277216.3; ENSP00000277216.3; NM_001001919.1; NP_001001919.1.
DR   UCSC; uc011lvn.2; human.
DR   AGR; HGNC:14722; -.
DR   CTD; 138804; -.
DR   GeneCards; OR13C4; -.
DR   HGNC; HGNC:14722; OR13C4.
DR   HPA; ENSG00000148136; Not detected.
DR   neXtProt; NX_Q8NGS5; -.
DR   OpenTargets; ENSG00000148136; -.
DR   PharmGKB; PA32034; -.
DR   VEuPathDB; HostDB:ENSG00000148136; -.
DR   eggNOG; ENOG502R7ES; Eukaryota.
DR   GeneTree; ENSGT01040000240406; -.
DR   HOGENOM; CLU_012526_1_2_1; -.
DR   InParanoid; Q8NGS5; -.
DR   OMA; RINKTFV; -.
DR   OrthoDB; 4632618at2759; -.
DR   PhylomeDB; Q8NGS5; -.
DR   TreeFam; TF352686; -.
DR   PathwayCommons; Q8NGS5; -.
DR   Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR   BioGRID-ORCS; 138804; 8 hits in 749 CRISPR screens.
DR   GeneWiki; OR13C4; -.
DR   GenomeRNAi; 138804; -.
DR   Pharos; Q8NGS5; Tdark.
DR   PRO; PR:Q8NGS5; -.
DR   Proteomes; UP000005640; Chromosome 9.
DR   RNAct; Q8NGS5; Protein.
DR   Bgee; ENSG00000148136; Expressed in adrenal tissue.
DR   ExpressionAtlas; Q8NGS5; baseline and differential.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR   GO; GO:0050911; P:detection of chemical stimulus involved in sensory perception of smell; IBA:GO_Central.
DR   CDD; cd15430; 7tmA_OR13-like; 1.
DR   Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR000725; Olfact_rcpt.
DR   PANTHER; PTHR26453; OLFACTORY RECEPTOR; 1.
DR   PANTHER; PTHR26453:SF14; OLFACTORY RECEPTOR 13C4; 1.
DR   Pfam; PF13853; 7tm_4; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR00245; OLFACTORYR.
DR   SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW   Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW   Transducer; Transmembrane; Transmembrane helix.
FT   CHAIN           1..318
FT                   /note="Olfactory receptor 13C4"
FT                   /id="PRO_0000150733"
FT   TOPO_DOM        1..25
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        26..46
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        47..54
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        55..75
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        76..99
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        100..120
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        121..139
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        140..160
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        161..197
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        198..217
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        218..237
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        238..258
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        259..277
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        278..298
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        299..318
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        5
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        97..189
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ   SEQUENCE   318 AA;  35576 MW;  A2E9E00E9D2F818B CRC64;
     MDKINQTFVR EFILLGLSGY PKLEIIFFAL ILVMYVVILI GNGVLIIASI LDSRLHMPMY
     FFLGNLSFLD ICYTTSSIPS TLVSLISKKR NISFSGCAVQ MFFGFAMGST ECFLLGMMAF
     DRYVAICNPL RYPIIMNKVV YVLLTSVSWL SGGINSTVQT SLAMRWPFCG NNIINHFLCE
     ILAVLKLACS DISVNIVTLA VSNIAFLVLP LLVIFFSYMF ILYTILRTNS ATGRHKAFST
     CSAHLTVVII FYGTIFFMYA KPKSQDLLGK DNLQATEGLV SMFYGVVTPM LNPIIYSLRN
     KDVKAAIKYL LSRKAINQ
//