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Q8NGS5

- O13C4_HUMAN

UniProt

Q8NGS5 - O13C4_HUMAN

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Protein
Olfactory receptor 13C4
Gene
OR13C4
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Odorant receptor Reviewed prediction.

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 13C4
Alternative name(s):
Olfactory receptor OR9-7
Gene namesi
Name:OR13C4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 9

Organism-specific databases

HGNCiHGNC:14722. OR13C4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2525Extracellular Reviewed prediction
Add
BLAST
Transmembranei26 – 4621Helical; Name=1; Reviewed prediction
Add
BLAST
Topological domaini47 – 548Cytoplasmic Reviewed prediction
Transmembranei55 – 7521Helical; Name=2; Reviewed prediction
Add
BLAST
Topological domaini76 – 9924Extracellular Reviewed prediction
Add
BLAST
Transmembranei100 – 12021Helical; Name=3; Reviewed prediction
Add
BLAST
Topological domaini121 – 13919Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei140 – 16021Helical; Name=4; Reviewed prediction
Add
BLAST
Topological domaini161 – 19737Extracellular Reviewed prediction
Add
BLAST
Transmembranei198 – 21720Helical; Name=5; Reviewed prediction
Add
BLAST
Topological domaini218 – 23720Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei238 – 25821Helical; Name=6; Reviewed prediction
Add
BLAST
Topological domaini259 – 27719Extracellular Reviewed prediction
Add
BLAST
Transmembranei278 – 29821Helical; Name=7; Reviewed prediction
Add
BLAST
Topological domaini299 – 31820Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32034.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 318318Olfactory receptor 13C4
PRO_0000150733Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi97 ↔ 189 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGS5.
PRIDEiQ8NGS5.

PTM databases

PhosphoSiteiQ8NGS5.

Expressioni

Gene expression databases

CleanExiHS_OR13C4.
GenevestigatoriQ8NGS5.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000277216.

Structurei

3D structure databases

ProteinModelPortaliQ8NGS5.
SMRiQ8NGS5. Positions 21-311.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG42676.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiQ8NGS5.
KOiK04257.
OMAiISVNIVT.
OrthoDBiEOG7GXPC0.
PhylomeDBiQ8NGS5.
TreeFamiTF352686.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGS5-1 [UniParc]FASTAAdd to Basket

« Hide

MDKINQTFVR EFILLGLSGY PKLEIIFFAL ILVMYVVILI GNGVLIIASI    50
LDSRLHMPMY FFLGNLSFLD ICYTTSSIPS TLVSLISKKR NISFSGCAVQ 100
MFFGFAMGST ECFLLGMMAF DRYVAICNPL RYPIIMNKVV YVLLTSVSWL 150
SGGINSTVQT SLAMRWPFCG NNIINHFLCE ILAVLKLACS DISVNIVTLA 200
VSNIAFLVLP LLVIFFSYMF ILYTILRTNS ATGRHKAFST CSAHLTVVII 250
FYGTIFFMYA KPKSQDLLGK DNLQATEGLV SMFYGVVTPM LNPIIYSLRN 300
KDVKAAIKYL LSRKAINQ 318
Length:318
Mass (Da):35,576
Last modified:October 1, 2002 - v1
Checksum:iA2E9E00E9D2F818B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB065714 Genomic DNA. Translation: BAC05935.1.
AL450426 Genomic DNA. Translation: CAH72410.1.
AF399602 Genomic DNA. Translation: AAK95087.1.
BK004411 Genomic DNA. Translation: DAA04809.1.
CCDSiCCDS35088.1.
RefSeqiNP_001001919.1. NM_001001919.1.
UniGeneiHs.553601.

Genome annotation databases

EnsembliENST00000277216; ENSP00000277216; ENSG00000148136.
GeneIDi138804.
KEGGihsa:138804.
UCSCiuc011lvn.2. human.

Polymorphism databases

DMDMi37081371.

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB065714 Genomic DNA. Translation: BAC05935.1 .
AL450426 Genomic DNA. Translation: CAH72410.1 .
AF399602 Genomic DNA. Translation: AAK95087.1 .
BK004411 Genomic DNA. Translation: DAA04809.1 .
CCDSi CCDS35088.1.
RefSeqi NP_001001919.1. NM_001001919.1.
UniGenei Hs.553601.

3D structure databases

ProteinModelPortali Q8NGS5.
SMRi Q8NGS5. Positions 21-311.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000277216.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei Q8NGS5.

Polymorphism databases

DMDMi 37081371.

Proteomic databases

PaxDbi Q8NGS5.
PRIDEi Q8NGS5.

Protocols and materials databases

DNASUi 138804.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000277216 ; ENSP00000277216 ; ENSG00000148136 .
GeneIDi 138804.
KEGGi hsa:138804.
UCSCi uc011lvn.2. human.

Organism-specific databases

CTDi 138804.
GeneCardsi GC09M107288.
HGNCi HGNC:14722. OR13C4.
neXtProti NX_Q8NGS5.
PharmGKBi PA32034.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG42676.
HOGENOMi HOG000041365.
HOVERGENi HBG017625.
InParanoidi Q8NGS5.
KOi K04257.
OMAi ISVNIVT.
OrthoDBi EOG7GXPC0.
PhylomeDBi Q8NGS5.
TreeFami TF352686.

Enzyme and pathway databases

Reactomei REACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikii OR13C4.
NextBioi 83847.
PROi Q8NGS5.

Gene expression databases

CleanExi HS_OR13C4.
Genevestigatori Q8NGS5.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-289.
  4. Cited for: IDENTIFICATION.
  5. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiO13C4_HUMAN
AccessioniPrimary (citable) accession number: Q8NGS5
Secondary accession number(s): Q6IF51, Q96R41
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2003
Last sequence update: October 1, 2002
Last modified: September 3, 2014
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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