Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q8NGS4 (O13F1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 100. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Olfactory receptor 13F1
Alternative name(s):
Olfactory receptor OR9-6
Gene names
Name:OR13F1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length319 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Odorant receptor Potential.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 319319Olfactory receptor 13F1
PRO_0000150738

Regions

Topological domain1 – 2525Extracellular Potential
Transmembrane26 – 4621Helical; Name=1; Potential
Topological domain47 – 548Cytoplasmic Potential
Transmembrane55 – 7521Helical; Name=2; Potential
Topological domain76 – 9924Extracellular Potential
Transmembrane100 – 12021Helical; Name=3; Potential
Topological domain121 – 13919Cytoplasmic Potential
Transmembrane140 – 16021Helical; Name=4; Potential
Topological domain161 – 19737Extracellular Potential
Transmembrane198 – 21720Helical; Name=5; Potential
Topological domain218 – 23720Cytoplasmic Potential
Transmembrane238 – 25821Helical; Name=6; Potential
Topological domain259 – 27113Extracellular Potential
Transmembrane272 – 29221Helical; Name=7; Potential
Topological domain293 – 31927Cytoplasmic Potential

Amino acid modifications

Glycosylation51N-linked (GlcNAc...) Potential
Disulfide bond97 ↔ 189 By similarity

Natural variations

Natural variant181F → S.
Corresponds to variant rs7049042 [ dbSNP | Ensembl ].
VAR_034309
Natural variant941F → S.
Corresponds to variant rs7018553 [ dbSNP | Ensembl ].
VAR_034310
Natural variant1011M → V.
Corresponds to variant rs1403812 [ dbSNP | Ensembl ].
VAR_024137
Natural variant1341V → I.
Corresponds to variant rs1403811 [ dbSNP | Ensembl ].
VAR_053302
Natural variant2541T → M.
Corresponds to variant rs7030820 [ dbSNP | Ensembl ].
VAR_034311
Natural variant2701I → T.
Corresponds to variant rs7847413 [ dbSNP | Ensembl ].
VAR_053303

Sequences

Sequence LengthMass (Da)Tools
Q8NGS4 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: E94042C324763A39

FASTA31935,646
        10         20         30         40         50         60 
MFPANWTSVK VFFFLGFFHY PKVQVIIFAV CLLMYLITLL GNIFLISITI LDSHLHTPMY 

        70         80         90        100        110        120 
LFLSNLSFLD IWYSSSALSP MLANFVSGRN TISFSGCATQ MYLSLAMGST ECVLLPMMAY 

       130        140        150        160        170        180 
DRYVAICNPL RYPVIMNRRT CVQIAAGSWM TGCLTAMVEM MSVLPLSLCG NSIINHFTCE 

       190        200        210        220        230        240 
ILAILKLVCV DTSLVQLIML VISVLLLPMP MLLICISYAF ILASILRISS VEGRSKAFST 

       250        260        270        280        290        300 
CTAHLMVVVL FYGTALSMHL KPSAVDSQEI DKFMALVYAG QTPMLNPIIY SLRNKEVKVA 

       310 
LKKLLIRNHF NTAFISILK 

« Hide

References

« Hide 'large scale' references
[1]"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"DNA sequence and analysis of human chromosome 9."
Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. expand/collapse author list , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The human olfactory receptor gene family."
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
[4]Erratum
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB065715 Genomic DNA. Translation: BAC05936.1.
AL450426 Genomic DNA. Translation: CAH72409.1.
BK004412 Genomic DNA. Translation: DAA04810.1.
CCDSCCDS35087.1.
RefSeqNP_001004485.1. NM_001004485.1.
UniGeneHs.553602.

3D structure databases

ProteinModelPortalQ8NGS4.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000334452.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteQ8NGS4.

Polymorphism databases

DMDM38372763.

Proteomic databases

PaxDbQ8NGS4.
PRIDEQ8NGS4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000334726; ENSP00000334452; ENSG00000186881.
GeneID138805.
KEGGhsa:138805.
UCSCuc011lvm.2. human.

Organism-specific databases

CTD138805.
GeneCardsGC09P107266.
HGNCHGNC:14723. OR13F1.
neXtProtNX_Q8NGS4.
PharmGKBPA32045.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG47530.
HOGENOMHOG000041365.
HOVERGENHBG017625.
InParanoidQ8NGS4.
KOK04257.
OMAIAAGSWM.
OrthoDBEOG71K63J.
PhylomeDBQ8NGS4.
TreeFamTF352686.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

CleanExHS_OR13F1.
GenevestigatorQ8NGS4.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiOR13F1.
GenomeRNAi138805.
NextBio83851.
PROQ8NGS4.

Entry information

Entry nameO13F1_HUMAN
AccessionPrimary (citable) accession number: Q8NGS4
Secondary accession number(s): Q6IF50
Entry history
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: July 9, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 9

Human chromosome 9: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries