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Q8NGS4

- O13F1_HUMAN

UniProt

Q8NGS4 - O13F1_HUMAN

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Protein

Olfactory receptor 13F1

Gene
OR13F1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Odorant receptor Reviewed prediction.

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 13F1
Alternative name(s):
Olfactory receptor OR9-6
Gene namesi
Name:OR13F1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 9

Organism-specific databases

HGNCiHGNC:14723. OR13F1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2525Extracellular Reviewed predictionAdd
BLAST
Transmembranei26 – 4621Helical; Name=1; Reviewed predictionAdd
BLAST
Topological domaini47 – 548Cytoplasmic Reviewed prediction
Transmembranei55 – 7521Helical; Name=2; Reviewed predictionAdd
BLAST
Topological domaini76 – 9924Extracellular Reviewed predictionAdd
BLAST
Transmembranei100 – 12021Helical; Name=3; Reviewed predictionAdd
BLAST
Topological domaini121 – 13919Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei140 – 16021Helical; Name=4; Reviewed predictionAdd
BLAST
Topological domaini161 – 19737Extracellular Reviewed predictionAdd
BLAST
Transmembranei198 – 21720Helical; Name=5; Reviewed predictionAdd
BLAST
Topological domaini218 – 23720Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei238 – 25821Helical; Name=6; Reviewed predictionAdd
BLAST
Topological domaini259 – 27113Extracellular Reviewed predictionAdd
BLAST
Transmembranei272 – 29221Helical; Name=7; Reviewed predictionAdd
BLAST
Topological domaini293 – 31927Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32045.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 319319Olfactory receptor 13F1PRO_0000150738Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi97 ↔ 189 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGS4.
PRIDEiQ8NGS4.

PTM databases

PhosphoSiteiQ8NGS4.

Expressioni

Gene expression databases

CleanExiHS_OR13F1.
GenevestigatoriQ8NGS4.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000334452.

Structurei

3D structure databases

ProteinModelPortaliQ8NGS4.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG47530.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiQ8NGS4.
KOiK04257.
OMAiIAAGSWM.
OrthoDBiEOG71K63J.
PhylomeDBiQ8NGS4.
TreeFamiTF352686.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGS4-1 [UniParc]FASTAAdd to Basket

« Hide

MFPANWTSVK VFFFLGFFHY PKVQVIIFAV CLLMYLITLL GNIFLISITI    50
LDSHLHTPMY LFLSNLSFLD IWYSSSALSP MLANFVSGRN TISFSGCATQ 100
MYLSLAMGST ECVLLPMMAY DRYVAICNPL RYPVIMNRRT CVQIAAGSWM 150
TGCLTAMVEM MSVLPLSLCG NSIINHFTCE ILAILKLVCV DTSLVQLIML 200
VISVLLLPMP MLLICISYAF ILASILRISS VEGRSKAFST CTAHLMVVVL 250
FYGTALSMHL KPSAVDSQEI DKFMALVYAG QTPMLNPIIY SLRNKEVKVA 300
LKKLLIRNHF NTAFISILK 319
Length:319
Mass (Da):35,646
Last modified:October 1, 2002 - v1
Checksum:iE94042C324763A39
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti18 – 181F → S.
Corresponds to variant rs7049042 [ dbSNP | Ensembl ].
VAR_034309
Natural varianti94 – 941F → S.
Corresponds to variant rs7018553 [ dbSNP | Ensembl ].
VAR_034310
Natural varianti101 – 1011M → V.
Corresponds to variant rs1403812 [ dbSNP | Ensembl ].
VAR_024137
Natural varianti134 – 1341V → I.
Corresponds to variant rs1403811 [ dbSNP | Ensembl ].
VAR_053302
Natural varianti254 – 2541T → M.
Corresponds to variant rs7030820 [ dbSNP | Ensembl ].
VAR_034311
Natural varianti270 – 2701I → T.
Corresponds to variant rs7847413 [ dbSNP | Ensembl ].
VAR_053303

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB065715 Genomic DNA. Translation: BAC05936.1.
AL450426 Genomic DNA. Translation: CAH72409.1.
BK004412 Genomic DNA. Translation: DAA04810.1.
CCDSiCCDS35087.1.
RefSeqiNP_001004485.1. NM_001004485.1.
UniGeneiHs.553602.

Genome annotation databases

EnsembliENST00000334726; ENSP00000334452; ENSG00000186881.
GeneIDi138805.
KEGGihsa:138805.
UCSCiuc011lvm.2. human.

Polymorphism databases

DMDMi38372763.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB065715 Genomic DNA. Translation: BAC05936.1 .
AL450426 Genomic DNA. Translation: CAH72409.1 .
BK004412 Genomic DNA. Translation: DAA04810.1 .
CCDSi CCDS35087.1.
RefSeqi NP_001004485.1. NM_001004485.1.
UniGenei Hs.553602.

3D structure databases

ProteinModelPortali Q8NGS4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000334452.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei Q8NGS4.

Polymorphism databases

DMDMi 38372763.

Proteomic databases

PaxDbi Q8NGS4.
PRIDEi Q8NGS4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000334726 ; ENSP00000334452 ; ENSG00000186881 .
GeneIDi 138805.
KEGGi hsa:138805.
UCSCi uc011lvm.2. human.

Organism-specific databases

CTDi 138805.
GeneCardsi GC09P107266.
HGNCi HGNC:14723. OR13F1.
neXtProti NX_Q8NGS4.
PharmGKBi PA32045.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG47530.
HOGENOMi HOG000041365.
HOVERGENi HBG017625.
InParanoidi Q8NGS4.
KOi K04257.
OMAi IAAGSWM.
OrthoDBi EOG71K63J.
PhylomeDBi Q8NGS4.
TreeFami TF352686.

Enzyme and pathway databases

Reactomei REACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikii OR13F1.
GenomeRNAii 138805.
NextBioi 83851.
PROi Q8NGS4.

Gene expression databases

CleanExi HS_OR13F1.
Genevestigatori Q8NGS4.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: IDENTIFICATION.
  4. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiO13F1_HUMAN
AccessioniPrimary (citable) accession number: Q8NGS4
Secondary accession number(s): Q6IF50
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: September 3, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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