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Protein

Olfactory receptor 13F1

Gene

OR13F1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

BioCyciZFISH:G66-32917-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 13F1
Alternative name(s):
Olfactory receptor OR9-6
Gene namesi
Name:OR13F1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:14723. OR13F1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 25ExtracellularSequence analysisAdd BLAST25
Transmembranei26 – 46Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini47 – 54CytoplasmicSequence analysis8
Transmembranei55 – 75Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini76 – 99ExtracellularSequence analysisAdd BLAST24
Transmembranei100 – 120Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini121 – 139CytoplasmicSequence analysisAdd BLAST19
Transmembranei140 – 160Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini161 – 197ExtracellularSequence analysisAdd BLAST37
Transmembranei198 – 217Helical; Name=5Sequence analysisAdd BLAST20
Topological domaini218 – 237CytoplasmicSequence analysisAdd BLAST20
Transmembranei238 – 258Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini259 – 271ExtracellularSequence analysisAdd BLAST13
Transmembranei272 – 292Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini293 – 319CytoplasmicSequence analysisAdd BLAST27

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000186881.
PharmGKBiPA32045.

Polymorphism and mutation databases

BioMutaiOR13F1.
DMDMi38372763.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001507381 – 319Olfactory receptor 13F1Add BLAST319

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGS4.
PeptideAtlasiQ8NGS4.
PRIDEiQ8NGS4.

PTM databases

iPTMnetiQ8NGS4.
PhosphoSitePlusiQ8NGS4.

Expressioni

Gene expression databases

CleanExiHS_OR13F1.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000334452.

Structurei

3D structure databases

ProteinModelPortaliQ8NGS4.
SMRiQ8NGS4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J8ZB. Eukaryota.
ENOG41118ID. LUCA.
GeneTreeiENSGT00760000119058.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiQ8NGS4.
KOiK04257.
OMAiLHQSLCG.
OrthoDBiEOG091G0CU6.
PhylomeDBiQ8NGS4.
TreeFamiTF352686.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGS4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFPANWTSVK VFFFLGFFHY PKVQVIIFAV CLLMYLITLL GNIFLISITI
60 70 80 90 100
LDSHLHTPMY LFLSNLSFLD IWYSSSALSP MLANFVSGRN TISFSGCATQ
110 120 130 140 150
MYLSLAMGST ECVLLPMMAY DRYVAICNPL RYPVIMNRRT CVQIAAGSWM
160 170 180 190 200
TGCLTAMVEM MSVLPLSLCG NSIINHFTCE ILAILKLVCV DTSLVQLIML
210 220 230 240 250
VISVLLLPMP MLLICISYAF ILASILRISS VEGRSKAFST CTAHLMVVVL
260 270 280 290 300
FYGTALSMHL KPSAVDSQEI DKFMALVYAG QTPMLNPIIY SLRNKEVKVA
310
LKKLLIRNHF NTAFISILK
Length:319
Mass (Da):35,646
Last modified:October 1, 2002 - v1
Checksum:iE94042C324763A39
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03430918F → S.Corresponds to variant rs7049042dbSNPEnsembl.1
Natural variantiVAR_03431094F → S.Corresponds to variant rs7018553dbSNPEnsembl.1
Natural variantiVAR_024137101M → V.Corresponds to variant rs1403812dbSNPEnsembl.1
Natural variantiVAR_053302134V → I.Corresponds to variant rs1403811dbSNPEnsembl.1
Natural variantiVAR_034311254T → M.Corresponds to variant rs7030820dbSNPEnsembl.1
Natural variantiVAR_053303270I → T.Corresponds to variant rs7847413dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065715 Genomic DNA. Translation: BAC05936.1.
AL450426 Genomic DNA. Translation: CAH72409.1.
BK004412 Genomic DNA. Translation: DAA04810.1.
CCDSiCCDS35087.1.
RefSeqiNP_001004485.1. NM_001004485.1.
UniGeneiHs.553602.

Genome annotation databases

EnsembliENST00000334726; ENSP00000334452; ENSG00000186881.
GeneIDi138805.
KEGGihsa:138805.
UCSCiuc011lvm.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065715 Genomic DNA. Translation: BAC05936.1.
AL450426 Genomic DNA. Translation: CAH72409.1.
BK004412 Genomic DNA. Translation: DAA04810.1.
CCDSiCCDS35087.1.
RefSeqiNP_001004485.1. NM_001004485.1.
UniGeneiHs.553602.

3D structure databases

ProteinModelPortaliQ8NGS4.
SMRiQ8NGS4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000334452.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ8NGS4.
PhosphoSitePlusiQ8NGS4.

Polymorphism and mutation databases

BioMutaiOR13F1.
DMDMi38372763.

Proteomic databases

PaxDbiQ8NGS4.
PeptideAtlasiQ8NGS4.
PRIDEiQ8NGS4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000334726; ENSP00000334452; ENSG00000186881.
GeneIDi138805.
KEGGihsa:138805.
UCSCiuc011lvm.2. human.

Organism-specific databases

CTDi138805.
GeneCardsiOR13F1.
HGNCiHGNC:14723. OR13F1.
neXtProtiNX_Q8NGS4.
OpenTargetsiENSG00000186881.
PharmGKBiPA32045.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J8ZB. Eukaryota.
ENOG41118ID. LUCA.
GeneTreeiENSGT00760000119058.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiQ8NGS4.
KOiK04257.
OMAiLHQSLCG.
OrthoDBiEOG091G0CU6.
PhylomeDBiQ8NGS4.
TreeFamiTF352686.

Enzyme and pathway databases

BioCyciZFISH:G66-32917-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR13F1.
GenomeRNAii138805.
PROiQ8NGS4.

Gene expression databases

CleanExiHS_OR13F1.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO13F1_HUMAN
AccessioniPrimary (citable) accession number: Q8NGS4
Secondary accession number(s): Q6IF50
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: November 2, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.