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Protein

Olfactory receptor 1J1

Gene

OR1J1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

BioCyciZFISH:ENSG00000136834-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 1J1
Alternative name(s):
Olfactory receptor OR9-18
Gene namesi
Name:OR1J1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:8208. OR1J1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 25ExtracellularSequence analysisAdd BLAST25
Transmembranei26 – 49Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini50 – 57CytoplasmicSequence analysis8
Transmembranei58 – 79Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini80 – 100ExtracellularSequence analysisAdd BLAST21
Transmembranei101 – 120Helical; Name=3Sequence analysisAdd BLAST20
Topological domaini121 – 139CytoplasmicSequence analysisAdd BLAST19
Transmembranei140 – 158Helical; Name=4Sequence analysisAdd BLAST19
Topological domaini159 – 196ExtracellularSequence analysisAdd BLAST38
Transmembranei197 – 219Helical; Name=5Sequence analysisAdd BLAST23
Topological domaini220 – 236CytoplasmicSequence analysisAdd BLAST17
Transmembranei237 – 259Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini260 – 272ExtracellularSequence analysisAdd BLAST13
Transmembranei273 – 292Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini293 – 322CytoplasmicSequence analysisAdd BLAST30

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000136834.
PharmGKBiPA32079.

Polymorphism and mutation databases

BioMutaiOR1J1.
DMDMi38372762.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001504381 – 322Olfactory receptor 1J1Add BLAST322

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NGS3.
PRIDEiQ8NGS3.

PTM databases

iPTMnetiQ8NGS3.
PhosphoSitePlusiQ8NGS3.

Expressioni

Gene expression databases

CleanExiHS_OR1J1.
ExpressionAtlasiQ8NGS3. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000259357.

Structurei

3D structure databases

ProteinModelPortaliQ8NGS3.
SMRiQ8NGS3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IVJ2. Eukaryota.
ENOG411198N. LUCA.
GeneTreeiENSGT00860000133705.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ8NGS3.
KOiK04257.
OMAiCADHIIP.
OrthoDBiEOG091G0B53.
PhylomeDBiQ8NGS3.
TreeFamiTF337210.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NGS3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSPENQSSVS EFLLLGLPIR PEQQAVFFAL FLGMYLTTVL GNLLIMLLIQ
60 70 80 90 100
LDSHLHTPMY FFLSHLALTD ISFSSVTVPK MLMNMQTQHL AVFYKGCISQ
110 120 130 140 150
TYFFIFFADL DSFLITSMAY DRYVAICHPL HYATIMTQSQ CVMLVAGSWV
160 170 180 190 200
IACACALLHT LLLAQLSFCA DHIIPHYFCD LGALLKLSCS DTSLNQLAIF
210 220 230 240 250
TAALTAIMLP FLCILVSYGH IGVTILQIPS TKGICKALST CGSHLSVVTI
260 270 280 290 300
YYRTIIGLYF LPPSSNTNDK NIIASVIYTA VTPMLNPFIY SLRNKDIKGA
310 320
LRKLLSRSGA VAHACNLNTL GG
Length:322
Mass (Da):35,493
Last modified:October 1, 2002 - v1
Checksum:iCC16D5230B280378
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_059978318N → S.1 PublicationCorresponds to variant rs1962091dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065716 Genomic DNA. Translation: BAC05937.1.
AL353767 Genomic DNA. No translation available.
AL359636 Genomic DNA. Translation: CAM45734.1.
BC136933 mRNA. Translation: AAI36934.1.
BC136938 mRNA. Translation: AAI36939.1.
AF399554 Genomic DNA. Translation: AAK95039.1.
BK004452 Genomic DNA. Translation: DAA04850.1.
CCDSiCCDS35120.1.
RefSeqiNP_001004451.1. NM_001004451.1.
UniGeneiHs.632692.

Genome annotation databases

EnsembliENST00000259357; ENSP00000259357; ENSG00000136834.
GeneIDi347168.
KEGGihsa:347168.
UCSCiuc011lyu.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065716 Genomic DNA. Translation: BAC05937.1.
AL353767 Genomic DNA. No translation available.
AL359636 Genomic DNA. Translation: CAM45734.1.
BC136933 mRNA. Translation: AAI36934.1.
BC136938 mRNA. Translation: AAI36939.1.
AF399554 Genomic DNA. Translation: AAK95039.1.
BK004452 Genomic DNA. Translation: DAA04850.1.
CCDSiCCDS35120.1.
RefSeqiNP_001004451.1. NM_001004451.1.
UniGeneiHs.632692.

3D structure databases

ProteinModelPortaliQ8NGS3.
SMRiQ8NGS3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000259357.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ8NGS3.
PhosphoSitePlusiQ8NGS3.

Polymorphism and mutation databases

BioMutaiOR1J1.
DMDMi38372762.

Proteomic databases

PaxDbiQ8NGS3.
PRIDEiQ8NGS3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000259357; ENSP00000259357; ENSG00000136834.
GeneIDi347168.
KEGGihsa:347168.
UCSCiuc011lyu.2. human.

Organism-specific databases

CTDi347168.
GeneCardsiOR1J1.
HGNCiHGNC:8208. OR1J1.
neXtProtiNX_Q8NGS3.
OpenTargetsiENSG00000136834.
PharmGKBiPA32079.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IVJ2. Eukaryota.
ENOG411198N. LUCA.
GeneTreeiENSGT00860000133705.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ8NGS3.
KOiK04257.
OMAiCADHIIP.
OrthoDBiEOG091G0B53.
PhylomeDBiQ8NGS3.
TreeFamiTF337210.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000136834-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR1J1.
GenomeRNAii347168.
PROiQ8NGS3.

Gene expression databases

CleanExiHS_OR1J1.
ExpressionAtlasiQ8NGS3. baseline and differential.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOR1J1_HUMAN
AccessioniPrimary (citable) accession number: Q8NGS3
Secondary accession number(s): A3KFL8, Q6IF10, Q96R88
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: November 30, 2016
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.